Volume 37; Issue 23

Journal of Medicinal Chemistry

Volume 37; Issue 23

1

[[.omega.-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents

Cantello, Barrie C. C., Cawthorne, Michael A., Cottam, Graham P., Duff, Peter T., Haigh, David, Hindley, Richard M., Lister, Carolyn A., Smith, Stephen A., Thurlby, Peter L.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.11 MB

english, 1994

2

Tricyclic Quinoxalinediones: 5,6-Dihydro-1H-pyrrolo[1,2,3-de]quinoxaline-2,3-diones and 6,7-Dihydro-1H,5H-pyrido[1,2,3-de]quinoxaline-2,3-diones as Potent Antagonists for the Glycine Binding Site of the NMDA Receptor

Nagata, Ryu, Tanno, Norihiko, Kodo, Toru, Ae, Nobuyuki, Yamaguchi, Hiroshi, Nishimura, Tamiki, Antoku, Fujio, Tatsuno, Tohru, Kato, Terufumi

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.50 MB

english, 1994

3

Dipeptide Phosphonates as Inhibitors of Dipeptidyl Peptidase IV

Boduszek, Bogdan, Oleksyszyn, Jozef, Kam, Chih-Min, Selzler, Joe, Smith, Robert E., Powers, James C.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.13 MB

english, 1994

4

Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles

Salimbeni, Aldo, Canevotti, Renato, Paleari, Fabio, Bonaccorsi, Fabrizio, Renzetti, Anna R., Belvisi, Laura, Bravi, Gianpaolo, Scolastico, Carlo

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.28 MB

english, 1994

5

Orally Active Non-Peptide Fibrinogen Receptor (GpIIb/IIIa) Antagonists: Identification of 4-[4-[4-(Aminoimino methyl)phenyl]-1-piperazinyl]-1- piperidineacetic Acid as a Long-Acting, Broad-Spectrum Antithrombotic Agent

Eldred, Colin D., Evans, Brian, Hindley, Sean, Judkins, Brian D., Kelly, Henry A., Kitchin, John, Lumley, Philip, Porter, Barry, Ross, Barry C.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.20 MB

english, 1994

6

4,7.beta.-Dimethyl-4-azacholestan-3-one (MK-386) and Related 4-Azasteroids as Selective Inhibitors of Human Type 1 5.alpha.-Reductase

Bakshi, Raman K., Patel, Gool F., Rasmusson, Gary H., Baginsky, Walter F., Cimis, George, Ellsworth, Kenneth, Chang, Benedict, Bull, Herb, Tolman, Richard L., Harris, Georgianna S.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 446 KB

english, 1994

7

Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors

Hilpert, Kurt, Ackermann, Jean, Banner, David W., Gast, Alain, Gubernator, Klaus, Hadvary, Paul, Labler, Ludvik, Mueller, Klaus, Schmid, Gerard

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.60 MB

english, 1994

8

Selective Ligands for Rat A3 Adenosine Receptors: Structure-Activity Relationships of 1,3-Dialkylxanthine 7-Riboside Derivatives

Kim, Hea Ok, Ji, Xiao-duo, Melman, Neli, Olah, Mark E., Stiles, Gary L., Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.52 MB

english, 1994

9

Chemical and Biological Evaluation of Hydrolysis Products of Cyclophosphamide

Gilard, Veronique, Martino, Robert, Malet-Martino, Marie-C., Kutscher, Bernhard, Mueller, Arndt, Niemeyer, Ulf, Pohl, Joerg, Polymeropoulos, Emmanuel E.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.49 MB

english, 1994

10

L-N6-(1-Iminoethyl)lysine: A Selective Inhibitor of Inducible Nitric Oxide Synthase

Moore, William M., Webber, R. Keith, Jerome, Gina M., Tjoeng, Foe S., Misko, Thomas P., Currie, Mark G.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 388 KB

english, 1994

11

Aspartyl .alpha.-((1-Phenyl-3-(trifluoromethyl)- pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1.beta. Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme-Peptide Inhibitor Binding

Dolle, Roland E., Singh, Jasbir, Rinker, James, Hoyer, Denton, Prasad, C. V. C., Graybill, Todd L., Salvino, Joseph M., Helaszek, Carla T., Miller, Robert E., Ator, Mark A.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 464 KB

english, 1994

12

Masthead

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 178 KB

english, 1994

13

Anti-AIDS Agents. 15. Synthesis and Anti-HIV Activity of Dihydroseselins and Related Analogs

Huang, Li, Kashiwada, Yoshiki, Cosentino, L. Mark, Fan, Sharon, Chen, Chin-Ho, McPhail, Andrew T., Fujioka, Toshihiro, Mihashi, Kunihide, Lee, Kuo-Hsiung

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.71 MB

english, 1994

14

Structure-Activity Relationships of C1 and C6 Side Chains of Zaragozic Acid A Derivatives

Ponpipom, Mitree M., Girotra, Narindar N., Bugianesi, Robert L., Roberts, Cathleen D., Berger, Gregory D., Burk, Robert M., Marquis, Robert W., Parsons, William H., Bartizal, Kenneth F.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 3.18 MB

english, 1994

15

Selective Cyclooxygenase Inhibitors: Novel 1,2-Diarylcyclopentenes Are Potent and Orally Active COX-2 Inhibitors

Reitz, David B., Li, James J., Norton, Monica B., Reinhard, Emily J., Collins, Joe T., Anderson, Gary D., Gregory, Susan A., Koboldt, Carol M., Perkins, William E.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 417 KB

english, 1994

16

Design, Synthesis, and Biological Properties of highly Potent Cyclic Dynorphin A Analogs. Analogs Cyclized between Positions 5 and 11

Meyer, Jean-Philippe, Collins, Nathan, Lung, Feng-Di, Davis, Peg, Zalewska, Teresa, Porreca, Frank, Yamamura, Henry I., Hruby, Victor J.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.12 MB

english, 1994

17

Synthesis and Antitumor Evaluation of Bis[(pivaloyloxy)methyl] 2'-Deoxy-5-fluorouridine 5'-Monophosphate (FdUMP): A Strategy To Introduce Nucleotides into Cells

Farquhar, David, Khan, Saeed, Srivastva, Devendra N., Saunders, Priscilla P.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.14 MB

english, 1994

18

Unambiguous Total Synthesis of the Enantiomers of myo-Inositol 1,3,4-Trisphosphate: 1L-myo-Inositol 1,3,4-Trisphosphate Mobilizes Intracellular Ca2+ in Limulus Photoreceptors

Riley, Andrew M., Payne, Richard, Potter, Barry V. L.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.39 MB

english, 1994

19

PRO_LIGAND: An Approach to de Novo Molecular Design. 2. Design of Novel Molecules from Molecular Field Analysis (MFA) Models and Pharmacophores

Waszkowycz, Bohdan, Clark, David E., Frenkel, David, Li, Jin, Murray, Christopher W., Robson, Barry, Westhead, David R.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.19 MB

english, 1994

20

Synthesis of Oxadiazolidinedione Derivatives as Quisqualic Acid Analogs and Their Evaluation at a Quisqualate-Sensitized Site in the Rat Hippocampus

Venkatraman, Shankar, Roon, Robert J., Schulte, Marvin K., Koerner, James F., Johnson, Rodney L.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.08 MB

english, 1994

21

Cephem Sulfones as Inactivators of Human Leukocyte Elastase. 5. 7.alpha.-Methoxy- and 7.alpha.-Chloro-1,1-dioxocephem 4-Ketones

Alpegiani, Marco, Bissolino, Pierluigi, Corigli, Riccardo, Del Nero, Stefano, Perrone, Ettore, Rizzo, Vincenzo, Sacchi, Nereo, Cassinelli, Giuseppe, Franceschi, Giovanni, Baici, Antonio

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.22 MB

english, 1994

22

(-)-11-Hydroxy-7'-isothiocyanato-1',1'- dimethylheptyl-.DELTA.8-THC: A Novel, High-Affinity Irreversible Probe for the Cannabinoid Receptor in the Brain

Guo, Yan, Abadji, Vasiliki, Morse, Kelley L., Fournier, Donna J., Li, Xiuyan, Makriyannis, Alexandros

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 459 KB

english, 1994

23

Synthesis, Cocaine Receptor Affinity, and Dopamine Uptake Inhibition of Several New 2.beta.-Substituted 3.beta.-Phenyltropanes

Kelkar, Shreekrishna V., Izenwasser, Sari, Katz, Jonathan L., Klein, Cheryl L., Zhu, Naijue, Trudell, Mark L.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 388 KB

english, 1994

24

Book Reviews

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 83 KB

english, 1994

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