Volume 42; Issue 13

Journal of Medicinal Chemistry

Volume 42; Issue 13

1

Structure−Activity Relationships for Substituted Bis(acridine-4-carboxamides): A New Class of Anticancer Agents

Gamage, Swarna A., Spicer, Julie A., Atwell, Graham J., Finlay, Graeme J., Baguley, Bruce C., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 205 KB

english, 1999

2

Molecular Modeling and Synthesis of Inhibitors of Herpes Simplex Virus Type 1 Uracil-DNA Glycosylase

Sun, Hongmao, Zhi, Chengxin, Wright, George E., Ubiali, Daniela, Pregnolato, Massimo, Verri, Annalisa, Focher, Federico, Spadari, Silvio

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 164 KB

english, 1999

3

Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor

Palmer, Brian D., Kraker, Alan J., Hartl, Brian G., Panopoulos, Athanasia D., Panek, Robert L., Batley, Brian L., Lu, Gina H., Trumpp-Kallmeyer, Susanne, Showalter, H. D. Hollis, Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 136 KB

english, 1999

4

Pneumocystis c arinii and Toxoplasma g ondii Dihydrofolate Reductase Inhibitors and Antitumor Agents: Synthesis and Biological Activities of 2,4-Diamino-5-methyl-6-[(monosubstituted anilino)methyl]- pyrido[2,3- d ]pyrimidines 1

Gangjee, Aleem, Adair, Ona, Queener, Sherry F.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 128 KB

english, 1999

5

Therapeutic Potential and Strategies for Inhibiting Tumor Necrosis Factor-α

Newton, Robert C., Decicco, Carl P.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 379 KB

english, 1999

6

Structure-Based Design, Synthesis, and X-ray Crystallography of a High-Affinity Antagonist of the Grb2-SH2 Domain Containing an Asparagine Mimetic

Furet, Pascal, García-Echeverría, Carlos, Gay, Brigitte, Schoepfer, Joseph, Zeller, Martin, Rahuel, Joseph

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 112 KB

english, 1999

7

Solution Structure of α-Conotoxin ImI by 1 H Nuclear Magnetic Resonance †

Gehrmann, John, Daly, Norelle L., Alewood, Paul F., Craik, David J.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 159 KB

english, 1999

8

Potent Inhibition of Influenza Sialidase by a Benzoic Acid Containing a 2-Pyrrolidinone Substituent

Atigadda, Venkatram R., Brouillette, Wayne J., Duarte, Franco, Ali, Shoukath M., Babu, Yarlagadda S., Bantia, Shanta, Chand, Pooran, Chu, Naiming, Montgomery, John A., Walsh, David A., Sudbeck, Elise

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 335 KB

english, 1999

9

γ-Aminobutyrate-A Receptor Modulation by 3-Aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines

Rybczynski, Philip J., Combs, Donald W., Jacobs, Kimberly, Shank, Richard P., Dubinsky, Barry

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 93 KB

english, 1999

10

Textbook of Organic Medicinal and Pharmaceutical Chemistry. Tenth Edition Edited by Jaime N. Delgado and William A. Remers. Lippincott-Raven, Philadelphia, PA. 1998. xv + 974 pp. 22 × 28.5 cm. ISBN 0-397-51583-9. $69.50.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 11 KB

english, 1999

11

Subtype-Selective N -Methyl- d -aspartate Receptor Antagonists: Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines

Wright, Jon L., Gregory, Tracy F., Bigge, Christopher F., Boxer, Peter A., Serpa, Kevin, Meltzer, Leonard T., Wise, Lawrence D., Cai, Sui Xiong, Hawkinson, Jon E., Konkoy, Christopher S., Whittemore,

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 155 KB

english, 1999

12

Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation

Egbertson, Melissa S., Cook, Jacquelynn J., Bednar, Bohumil, Prugh, John D., Bednar, Rodney A., Gaul, Stanley L., Gould, Robert J., Hartman, George D., Homnick, Carl F., Holahan, Marie A., Libby, Laur

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 151 KB

english, 1999

13

Antitumor Agents. 194. Synthesis and Biological Evaluations of 4-β-Mono-, -Di-, and -Trisubstituted Aniline-4‘- O -demethyl-podophyllotoxin and Related Compounds with Improved Pharmacological Profiles 1

Zhu, Xiao-Kang, Guan, Jian, Tachibana, Yoko, Bastow, Kenneth F., Cho, Sung Jin, Cheng, Huey-Hwa, Cheng, Yung-Chi, Gurwith, Marc, Lee, Kuo-Hsiung

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 133 KB

english, 1999

14

Synthesis and Biological Evaluation of Boron-Containing Polyamines as Potential Agents for Neutron Capture Therapy of Brain Tumors

Zhuo, Jin-Cong, Cai, Jianping, Soloway, Albert H., Barth, Rolf F., Adams, Dianne M., Ji, Weihua, Tjarks, Werner

Journal:

Journal of Medicinal Chemistry

Year:

1999

File:

PDF, 20 KB

1999

15

Organic Reactions. Volume 53 Leo A. Paquette, Editor-in-Chief. John Wiley & Sons, Inc., New York. 1998. vii + 654 pp. 16 x 24 cm. ISBN 0-471-32609-7. $95.00.

Kirschbaum, Karen S.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 11 KB

english, 1999

16

Self-Immolative Anthracycline Prodrugs for Suicide Gene Therapy

Niculescu-Duvaz, Ion, Niculescu-Duvaz, Dan, Friedlos, Frank, Spooner, Robert, Martin, Janet, Marais, Richard, Springer, Caroline J.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 64 KB

english, 1999

17

Apstatin Analogue Inhibitors of Aminopeptidase P, a Bradykinin-Degrading Enzyme

Maggiora, Linda L., Orawski, Arthur T., Simmons, William H.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 214 KB

english, 1999

18

Pharmacophore Development for Corticotropin-Releasing Hormone: New Insights into Inhibitor Activity

Keller, Paul A., Bowman, Maria, Dang, Kor Hin, Garner, James, Leach, Scott P., Smith, Roger, McCluskey, Adam

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 144 KB

english, 1999

19

Estrogen Receptor Subtype-Selective Ligands: Asymmetric Synthesis and Biological Evaluation of cis - and trans -5,11-Dialkyl- 5,6,11,12-tetrahydrochrysenes

Meyers, Marvin J., Sun, Jun, Carlson, Kathryn E., Katzenellenbogen, Benita S., Katzenellenbogen, John A.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 195 KB

english, 1999

20

4,5-Dihydro-1,2,4-triazolo[1,5- a ]quinoxalin-4-ones: Excitatory Amino Acid Antagonists with Combined Glycine/NMDA and AMPA Receptor Affinity

Catarzi, Daniela, Colotta, Vittoria, Varano, Flavia, Cecchi, Lucia, Filacchioni, Guido, Galli, Alessandro, Costagli, Chiara

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 151 KB

english, 1999

21

Structure−Activity Relationships for a Class of Inhibitors of Purine Nucleoside Phosphorylase

Farutin, Victor, Masterson, Lori, Andricopulo, Adriano D., Cheng, Jianming, Riley, Brad, Hakimi, Ryan, Frazer, Jack W., Cordes, Eugene H.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 477 KB

english, 1999

22

Effects of C-4 Stereochemistry and C-4‘ Hydroxylation on the Iron Clearing Efficiency and Toxicity of Desferrithiocin Analogues

Bergeron, Raymond J., Wiegand, Jan, McManis, James S., McCosar, Bruce H., Weimar, William R., Brittenham, Gary M., Smith, Richard E.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 123 KB

english, 1999

23

Nonapeptide Analogues Containing ( R )-3-Hydroxybutanoate and β-Homoalanine Oligomers: Synthesis and Binding Affinity to a Class I Major Histocompatibility Complex Protein

Poenaru, Sorana, Lamas, José R., Folkers, Gerd, López de Castro, José A., Seebach, Dieter, Rognan, Didier

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 408 KB

english, 1999

24

High-Throughput Nuclear Magnetic Resonance-Based Screening

Hajduk, Philip J., Gerfin, Tobias, Boehlen, Jean-Marc, Häberli, Markus, Marek, Daniel, Fesik, Stephen W.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 46 KB

english, 1999

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