Volume 45; Issue 14

Journal of Medicinal Chemistry

Volume 45; Issue 14

1

Pyrazole Urea-Based Inhibitors of p38 MAP Kinase: From Lead Compound to Clinical Candidate

Regan, John, Breitfelder, Steffen, Cirillo, Pier, Gilmore, Thomas, Graham, Anne G., Hickey, Eugene, Klaus, Bernhard, Madwed, Jeffrey, Moriak, Monica, Moss, Neil

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 912 KB

english, 2002

2

Novel 2-Oxoamide Inhibitors of Human Group IVA Phospholipase A2

Kokotos, George, Kotsovolou, Stavroula, Six, David A., Constantinou-Kokotou, Violetta, Beltzner, Christopher C., Dennis, Edward A.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 98 KB

english, 2002

3

Prediction of Activity for Nonnucleoside Inhibitors with HIV-1 Reverse Transcriptase Based on Monte Carlo Simulations

Rizzo, Robert C., Udier-Blagović, Marina, Wang, De-Ping, Watkins, Edward K., Kroeger Smith, Marilyn B., Smith,, Richard H., Tirado-Rives, Julian, Jorgensen, William L.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 479 KB

english, 2002

4

Correlations between Cytotoxicity and Topography of Some 2-Arylidenebenzocycloalkanones Determined by X-ray Crystallography

Dimmock, Jonathan R., Zello, Gordon A., Oloo, Eliud O., Quail, J. Wilson, Kraatz, Heinz-Bernhard, Perjési, Pál, Aradi, Ferenc, Takács-Novák, Krisztina, Allen, Theresa M., Santos, Cheryl L., Balzarini,

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

5

Highly Antibacterial Active Aminoacyl Penicillin Conjugates with Acylated Bis-Catecholate Siderophores Based on Secondary Diamino Acids and Related Compounds

Heinisch, Lothar, Wittmann, Steffen, Stoiber, Thomas, Berg, Albrecht, Ankel-Fuchs, Dorothe, Möllmann, Ute

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 98 KB

english, 2002

6

Synthesis and Pharmacology of Benzoxazines as Highly Selective Antagonists at M 4 Muscarinic Receptors

Böhme, Thomas M., Augelli-Szafran, Corinne E., Hallak, Hussein, Pugsley, Thomas, Serpa, Kevin, Schwarz, Roy D.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 116 KB

english, 2002

7

Synthesis and Biological Evaluation at Nicotinic Acetylcholine Receptors of N -Arylalkyl- and N -Aryl-7-Azabicyclo[2.2.1]heptanes

Cheng, Jie, Zhang, Chunming, Stevens, Edwin D., Izenwasser, Sari, Wade, Dean, Chen, Shaoyi, Paul, Dennis, Trudell, Mark L.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 86 KB

english, 2002

8

An Investigation of Bone Resorption and Dictyostelium discoideum Growth Inhibition by Bisphosphonate Drugs

Szabo, Christina M., Martin, Michael B., Oldfield, Eric

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 372 KB

english, 2002

9

New p -Methylsulfonamido Phenylethylamine Analogues as Class III Antiarrhythmic Agents: Design, Synthesis, Biological Assay, and 3D-QSAR Analysis

Liu, Hong, Ji, Ming, Luo, Xiaomin, Shen, Jianhua, Huang, Xiaoqin, Hua, Weiyi, Jiang, Hualiang, Chen, Kaixian

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 593 KB

english, 2002

10

Activity of Bisphosphonates against Trypanosoma brucei rhodesiense

Martin, Michael B., Sanders, John M., Kendrick, Howard, de Luca-Fradley, Kate, Lewis, Jared C., Grimley, Joshua S., Van Brussel, Erin M., Olsen, Jeffrey R., Meints, Gary A., Burzynska, Agnieszka, Kafa

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 470 KB

english, 2002

11

II. Synthesis and Biological Evaluation of Some Bioisosteres and Congeners of the Antitumor Agent, 2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid (XK469)

Hazeldine, Stuart T., Polin, Lisa, Kushner, Juiwanna, White, Kathryn, Bouregeois, Nicole M., Crantz, Brianna, Palomino, Eduardo, Corbett, Thomas H., Horwitz, Jerome P.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 90 KB

english, 2002

12

Structure−Activity Relationships of the Melanocortin Tetrapeptide Ac-His-DPhe-Arg-Trp-NH 2 at the Mouse Melanocortin Receptors: Part 2 Modifications at the Phe Position

Holder, Jerry Ryan, Bauzo, Rayna M., Xiang, Zhimin, Haskell-Luevano, Carrie

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 104 KB

english, 2002

13

Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity

Palani, Anandan, Shapiro, Sherry, Josien, Hubert, Bara, Thomas, Clader, John W., Greenlee, William J., Cox, Kathleen, Strizki, Julie M., Baroudy, Bahige M.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 194 KB

english, 2002

14

Potent, Novel in Vitro Inhibitors of the Pseudomonas a eruginosa Deacetylase LpxC

Kline, Toni, Andersen, Niels H., Harwood, Eric A., Bowman, Jason, Malanda, Andre, Endsley, Stephanie, Erwin, Alice L., Doyle, Michael, Fong, Susan, Harris, Alex L., Mendelsohn, Brian, Mdluli, Khisimuz

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 234 KB

english, 2002

15

Naphthalene Dicarboxaldehyde as an Electrophilic Fluorogenic Moiety for Affinity Labeling: Application to Opioid Receptor Affinity Labels with Greatly Improved Fluorogenic Properties

McCurdy, Christopher R., Le Bourdonnec, Bertrand, Metzger, Thomas G., El Kouhen, Rachid, Zhang, Yan, Law, Ping Y., Portoghese, Philip S.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 71 KB

english, 2002

16

Further Characterization of Structural Requirements for Ligands at the Dopamine D 2 and D 3 Receptor: Exploring the Thiophene Moiety

Dijkstra, Durk, Rodenhuis, Nienke, Vermeulen, Erik S., Pugsley, Thomas A., Wise, Lawrence D., Wikström, Håkan V.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

17

Potent and Selective Inhibitors of Platelet-Derived Growth Factor Receptor Phosphorylation. 1. Synthesis, Structure−Activity Relationship, and Biological Effects of a New Class of Quinazoline Derivatives

Matsuno, Kenji, Ichimura, Michio, Nakajima, Takao, Tahara, Keiko, Fujiwara, Shigeki, Kase, Hiroshi, Ushiki, Junko, Giese, Neill A., Pandey, Anjali, Scarborough, Robert M., Lokker, Nathalie A., Yu, Jin

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 102 KB

english, 2002

18

Identification of Potent and Novel α4β1 Antagonists Using in Silico Screening

Singh, Juswinder, van Vlijmen, Herman, Liao, Yusheng, Lee, Wen-Cherng, Cornebise, Mark, Harris, Mary, Shu, I-hsiang, Gill, Alan, Cuervo, Julio H., Abraham, William M., Adams, Steven P.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 242 KB

english, 2002

19

Novel, Non-acylguanidine-type Na + /H + Exchanger Inhibitors: Synthesis and Pharmacology of 5-Tetrahydroquinolinylidene Aminoguanidine Derivatives

Fukumoto, Shoji, Imamiya, Eiko, Kusumoto, Keiji, Fujiwara, Shuji, Watanabe, Toshifumi, Shiraishi, Mitsuru

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 161 KB

english, 2002

20

Structural Requirements for Inhibition of the Neuronal Nitric Oxide Synthase (NOS-I): 3D-QSAR Analysis of 4-Oxo- and 4-Amino-Pteridine-Based Inhibitors

Matter, Hans, Kotsonis, Peter, Klingler, Otmar, Strobel, Hartmut, Fröhlich, Lothar G., Frey, Armin, Pfleiderer, Wolfgang, Schmidt, Harald H. H. W.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 1.45 MB

english, 2002

21

Principles Governing the Binding of a Class of Non-Peptidic Inhibitors to the SH2 Domain of src Studied by X-ray Analysis

Lange, Gudrun, Lesuisse, Dominique, Deprez, Pierre, Schoot, Bernard, Loenze, Petra, Bénard, Didier, Marquette, Jean-Pierre, Broto, Pierre, Sarubbi, Edoardo, Mandine, Eliane

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 629 KB

english, 2002

22

4,5-Diphenyltriazol-3-ones: Openers of Large-Conductance Ca 2+ -Activated Potassium (Maxi-K) Channels

Romine, Jeffrey L., Martin, Scott W., Gribkoff, Valentin K., Boissard, Christopher G., Dworetzky, Steven I., Natale, Joanne, Li, Yi, Gao, Qi, Meanwell, Nicholas A., Starrett, John E.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 202 KB

english, 2002

23

Lepadins D−F: Antiplasmodial and Antitrypanosomal Decahydroquinoline Derivatives from the Tropical Marine Tunicate Didemnum sp.

Wright, Anthony D., Goclik, Eva, König, Gabriele M., Kaminsky, Ronald

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 64 KB

english, 2002

24

Data Analysis of High-Throughput Screening Results: Application of Multidomain Clustering to the NCI Anti-HIV Data Set

Tamura, Susan Y., Bacha, Patricia A., Gruver, Heather S., Nutt, Ruth F.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 187 KB

english, 2002

25

2-Amino-6-arylthio-9-[2-(phosphonomethoxy)ethyl]purine Bis(2,2,2-trifluoroethyl) Esters as Novel HBV-Specific Antiviral Reagents

Sekiya, Kouichi, Takashima, Hideaki, Ueda, Naoko, Kamiya, Naohiro, Yuasa, Satoshi, Fujimura, Yoshiyuki, Ubasawa, Masaru

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 64 KB

english, 2002

26

Modification of the Structure of a Metallopeptide: Synthesis and Biological Evaluation of 111 In-Labeled DOTA-Conjugated Rhenium-Cyclized α-MSH Analogues

Cheng, Zhen, Chen, Jianqing, Miao, Yubin, Owen, Nellie K., Quinn, Thomas P., Jurisson, Silvia S.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 128 KB

english, 2002

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