Volume 45; Issue 25

Journal of Medicinal Chemistry

Volume 45; Issue 25

1

Antitumor Imidazotetrazines. 40.1 Radiosyntheses of [4-11C-Carbonyl]- and [3-N-11C-Methyl]-8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (Temozolomide) for Positron Emission Tomography (PET) Studies

Brown, Gavin D., Luthra, Sajinder K., Brock, Cathryn S., Stevens, Malcolm F. G., Price, Patricia M., Brady, Frank

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 382 KB

english, 2002

2

Discovery of 8-Hydroxyadenines as a Novel Type of Interferon Inducer

Hirota, Kosaku, Kazaoka, Kazunori, Niimoto, Itaru, Kumihara, Hiroshi, Sajiki, Hironao, Isobe, Yoshiaki, Takaku, Haruo, Tobe, Masanori, Ogita, Haruhisa, Ogino, Tetsuhiro

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 72 KB

english, 2002

3

Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors

Ward, Yancey D., Thomson, David S., Frye, Leah L., Cywin, Charles L., Morwick, Tina, Emmanuel, Michel J., Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy,

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 366 KB

english, 2002

4

Synthesis and Structure−Activity Relationships of Novel 7-Substituted 1,4-Dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acids as Antitumor Agents. Part 1

Tomita, Kyoji, Tsuzuki, Yasunori, Shibamori, Koh-ichiro, Tashima, Masanori, Kajikawa, Fumie, Sato, Yuji, Kashimoto, Shigeki, Chiba, Katsumi, Hino, Katsuhiko

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 357 KB

english, 2002

5

A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor β

Henke, Brad R., Consler, Thomas G., Go, Ning, Hale, Ron L., Hohman, Dana R., Jones, Stacey A., Lu, Amy T., Moore, Linda B., Moore, John T., Orband-Miller, Lisa A., Robinett, R. Graham, Shearin, Jean,

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 453 KB

english, 2002

6

Antitumor Imidazotetrazines. 41. 1 Conjugation of the Antitumor Agents Mitozolomide and Temozolomide to Peptides and Lexitropsins Bearing DNA Major and Minor Groove-Binding Structural Motifs

Arrowsmith, Jill, Jennings, Sharon A., Clark, Alan S., Stevens, Malcolm F. G.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 245 KB

english, 2002

7

Synthesis and Antimycobacterial Activity of Pyrazine and Quinoxaline Derivatives

Seitz, Lainne E., Suling, William J., Reynolds, Robert C.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 41 KB

english, 2002

8

Structural Basis for Understanding Structure−Activity Relationships for the Glutamate Binding Site of the NMDA Receptor.

Tikhonova, Irina G., Baskin, Igor I., Palyulin, Vladimir A., Zefirov, Nikolai S., Bachurin, Sergey O.

Journal:

Journal of Medicinal Chemistry

Year:

2002

File:

PDF, 296 KB

2002

9

Probing the Cysteine-34 Position of Endogenous Serum Albumin with Thiol-Binding Doxorubicin Derivatives. Improved Efficacy of an Acid-Sensitive Doxorubicin Derivative with Specific Albumin-Binding Properties Compared to That of the Parent Compound

Kratz, Felix, Warnecke, André, Scheuermann, Karin, Stockmar, Cornelia, Schwab, Jürgen, Lazar, Peter, Drückes, Peter, Esser, Norbert, Drevs, Joachim, Rognan, Didier, Bissantz, Caterina, Hinderling, Cat

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 330 KB

english, 2002

10

Crystal Structures of Dipeptides Containing the Dmt-Tic Pharmacophore

Bryant, Sharon D., George, Clifford, Flippen-Anderson, Judith L., Deschamps, Jeffrey R., Salvadori, Severo, Balboni, Gianfranco, Guerrini, Remo, Lazarus, Lawrence H.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 226 KB

english, 2002

11

Use of ab Initio Calculations To Predict the Biological Potency of Carboxylesterase Inhibitors

Wheelock, Craig E., Colvin, Michael E., Uemura, Ippei, Olmstead, Marilyn M., Sanborn, James R., Nakagawa, Yoshiaki, Jones, A. Daniel, Hammock, Bruce D.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 224 KB

english, 2002

12

Relationships between Structure and Interaction Kinetics for HIV-1 Protease Inhibitors

Markgren, Per-Olof, Schaal, Wesley, Hämäläinen, Markku, Karlén, Anders, Hallberg, Anders, Samuelsson, Bertil, Danielson, U. Helena

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 257 KB

english, 2002

13

Pyrimidoquinazoline-Based Antitumor Agents. Design of Topoisomerase II to DNA Cross-linkers with Activity against Protein Kinases

Skibo, Edward B., Huang, Xiaofen, Martinez, Rogelio, Lemus, Robert H., Craigo, William A., Dorr, Robert T.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 301 KB

english, 2002

14

A Thymidine Phosphorylase-Stable Analogue of BVDU with Significant Antiviral Activity

Guenther, Sven, Balzarini, Jan, De Clercq, Erik, Nair, Vasu

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 231 KB

english, 2002

15

Telomerase Inhibition, Telomere Shortening, and Decreased Cell Proliferation by Cell Permeable 2‘- O -Methoxyethyl Oligonucleotides

Chen, Zhi, Monia, Brett P., Corey, David R.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 190 KB

english, 2002

16

Improving the Oral Efficacy of CNS Drug Candidates: Discovery of Highly Orally Efficacious Piperidinyl Piperidine M 2 Muscarinic Receptor Antagonists

Wang, Yuguang, Chackalamannil, Samuel, Hu, Zhiyong, Greenlee, William J., Clader, John, Boyle, Craig D., Kaminski, James J., Billard, William, Binch,, Crosby, Gordon, Ruperto, Vilma, Duffy, Ruth A.,

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 74 KB

english, 2002

17

Structural Studies on Hgr3 Orphan Receptor Ligand Prolactin-Releasing Peptide

D'Ursi, Anna Maria, Albrizio, Stefania, Di Fenza, Armida, Crescenzi, Orlando, Carotenuto, Alfonso, Picone, Delia, Novellino, Ettore, Rovero, Paolo

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 394 KB

english, 2002

18

QSAR Evaluation of the Ch'an Su and Related Bufadienolides against the Colchicine-Resistant Primary Liver Carcinoma Cell Line PLC/PRF/5 1

Kamano, Yoshiaki, Yamashita, Ayano, Nogawa, Toshihiko, Morita, Hiroshi, Takeya, Koichi, Itokawa, Hideji, Segawa, Toshiaki, Yukita, Ayako, Saito, Kyoko, Katsuyama, Mariko, Pettit, George R.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 562 KB

english, 2002

19

Perfluorooctyl Bromide Has Limited Membrane Solubility and Is Located at the Bilayer Center. Locating Small Molecules in Lipid Bilayers through Paramagnetic Enhancements of NMR Relaxation

Ellena, Jeffrey F., Obraztsov, Viktor V., Cumbea, Valerie L., Woods, Catherine M., Cafiso, David S.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 219 KB

english, 2002

20

Potent δ-Opioid Receptor Agonists Containing the Dmt−Tic Pharmacophore

Balboni, Gianfranco, Salvadori, Severo, Guerrini, Remo, Negri, Lucia, Giannini, Elisa, Jinsmaa, Yunden, Bryant, Sharon D., Lazarus, Lawrence H.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 169 KB

english, 2002

21

Comparative Molecular Field Analysis of Substrates for an Aryl Sulfotransferase Based on Catalytic Mechanism and Protein Homology Modeling

Sharma, Vyas, Duffel, Michael W.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 320 KB

english, 2002

22

Syntheses and Structure−Activity Relationships of Nonnatural β- C -Nucleoside 5‘-Triphosphates Bearing an Aromatic Nucleobase with Phenolic Hydroxy Groups: Inhibitory Activities against DNA Polymerases

Aketani, Saeko, Tanaka, Kentaro, Yamamoto, Kaneyoshi, Ishihama, Akira, Cao, Honghua, Tengeiji, Atsushi, Hiraoka, Shuichi, Shiro, Motoo, Shionoya, Mitsuhiko

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 191 KB

english, 2002

23

Enzymes. A Practical Introduction to Structure, Mechanism, and Data Analysis. Second Edition By Robert A. Copeland. Wiley-VCH, New York. 2000. xvi + 397 pp. 16 × 24.5 cm. ISBN 0-471-35929-7. $99.95.

Walters, D. Eric

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 11 KB

english, 2002

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