Volume 54; Issue 11

Journal of Medicinal Chemistry

Volume 54; Issue 11

1

Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

Chung, Chun-wa, Coste, Hervé, White, Julia H., Mirguet, Olivier, Wilde, Jonathan, Gosmini, Romain L., Delves, Chris, Magny, Sylvie M., Woodward, Robert, Hughes, Stephen A.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.89 MB

english, 2011

2

Neurosteroid Analogues. 16. A New Explanation for the Lack of Anesthetic Effects of Δ16-Alphaxalone and Identification of a Δ17(20) Analogue with Potent Anesthetic Activity

Stastna, Eva, Krishnan, Kathiresan, Manion, Brad D., Taylor, Amanda, Rath, Nigam P., Chen, Zi-Wei, Evers, Alex. S., Zorumski, Charles F., Mennerick, Steven, Covey, Douglas F.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.20 MB

english, 2011

3

Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity in Mice

Gujjar, Ramesh, El Mazouni, Farah, White, Karen L., White, John, Creason, Sharon, Shackleford, David M., Deng, Xiaoyi, Charman, William N., Bathurst, Ian, Burrows, Jeremy

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.55 MB

english, 2011

4

Novel 4,4-Disubstituted Piperidine-Based C–C Chemokine Receptor-5 Inhibitors with High Potency against Human Immunodeficiency Virus-1 and an Improved human Ether-a-go-go Related Gene (hERG) Profile

Kazmierski, Wieslaw M., Anderson, Don L., Aquino, Christopher, Chauder, Brian A., Duan, Maosheng, Ferris, Robert, Kenakin, Terrence, Koble, Cecilia S., Lang, Dan G., Mcintyre, Maggie S

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.26 MB

english, 2011

5

Cystic Fibrosis: A New Target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines

Budriesi, Roberta, Ioan, Pierfranco, Leoni, Alberto, Pedemonte, Nicoletta, Locatelli, Alessandra, Micucci, Matteo, Chiarini, Alberto, Galietta, Luis J. V.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 964 KB

english, 2011

6

Unexpected Binding Orientation of Bulky-B-Ring Anti-Androgens and Implications for Future Drug Targets

Duke, Charles B., Jones, Amanda, Bohl, Casey E., Dalton, James T., Miller, Duane D.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.29 MB

english, 2011

7

Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis

Andersson, Hanna, Demaegdt, Heidi, Johnsson, Anders, Vauquelin, Georges, Lindeberg, Gunnar, Hallberg, Mathias, Erdélyi, Máté, Karlén, Anders, Hallberg, Anders

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.33 MB

english, 2011

8

Discovery and Characterization of a Nonphosphorylated Cyclic Peptide Inhibitor of the Peptidylprolyl Isomerase, Pin1

Duncan, Kelly E., Dempsey, Brian R., Killip, Lauren E., Adams, Jarrett, Bailey, Melanie L., Lajoie, Gilles A., Litchfield, David W., Brandl, Christopher J., Shaw, Gary S., Shilton, Brian H.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.12 MB

english, 2011

9

Development of the Fluorescent Biosensor h Calmodulin ( h CaM)L39C- monobromobimane ( mBBr )/V91C- mBBr , a Novel Tool for Discovering New Calmodulin Inhibitors and Detecting Calcium

González-Andrade, Martín, Rivera-Chávez, José, Sosa-Peinado, Alejandro, Figueroa, Mario, Rodríguez-Sotres, Rogelio, Mata, Rachel

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.20 MB

english, 2011

10

Synthesis and Antibacterial Activity of Pentacyclines: A Novel Class of Tetracycline Analogs

Sun, Cuixiang, Hunt, Diana K., Clark, Roger B., Lofland, Denene, O’Brien, William J., Plamondon, Louis, Xiao, Xiao-Yi

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.80 MB

english, 2011

11

Cyanine Dyes as Optical Contrast Agents for Ophthalmological Surgery

Langhals, Heinz, Varja, Ana, Laubichler, Peter, Kernt, Marcus, Eibl, Kirsten, Haritoglou, Christos

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.85 MB

english, 2011

12

Acenaphtho[1,2- b ]pyrrole-Based Selective Fibroblast Growth Factor Receptors 1 (FGFR1) Inhibitors: Design, Synthesis, and Biological Activity

Chen, Zhuo, Wang, Xin, Zhu, Weiping, Cao, Xianwen, Tong, Linjiang, Li, Honglin, Xie, Hua, Xu, Yufang, Tan, Shaoying, Kuang, Dong, Ding, Jian, Qian, Xuhong

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.54 MB

english, 2011

13

Highly Potent Activity of (1 R ,2 R ,6 S )-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson’s Disease

Ardashov, Oleg V., Pavlova, Alla V., Il’ina, Irina V., Morozova, Ekaterina A., Korchagina, Dina V., Karpova, Elena V., Volcho, Konstantin P., Tolstikova, Tat’yana G., Salakhutdinov, Nariman F.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.48 MB

english, 2011

14

Anticonvulsant 4-Aminobenzenesulfonamide Derivatives with Branched-Alkylamide Moieties: X-ray Crystallography and Inhibition Studies of Human Carbonic Anhydrase Isoforms I, II, VII, and XIV

Hen, Naama, Bialer, Meir, Yagen, Boris, Maresca, Alfonso, Aggarwal, Mayank, Robbins, Arthur H., McKenna, Robert, Scozzafava, Andrea, Supuran, Claudiu T.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 773 KB

english, 2011

15

Toluidinesulfonamide Hypoxia-Induced Factor 1 Inhibitors: Alleviating Drug–Drug Interactions through Use of PubChem Data and Comparative Molecular Field Analysis Guided Synthesis

Wendt, Bernd, Mülbaier, Marcel, Wawro, Sabine, Schultes, Christoph, Alonso, Jorge, Janssen, Bernd, Lewis, Joe

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.34 MB

english, 2011

16

A Novel Monocarbonyl Analogue of Curcumin, (1 E ,4 E )-1,5-Bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one, Induced Cancer Cell H460 Apoptosis via Activation of Endoplasmic Reticulum Stress Signaling Pathway

Wang, Yi, Xiao, Jian, Zhou, Huiping, Yang, Shulin, Wu, Xiaoping, Jiang, Chengxi, Zhao, Yunjie, Liang, Donglou, Li, Xiaokun, Liang, Guang

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.33 MB

english, 2011

17

Nobilamides A–H, Long-Acting Transient Receptor Potential Vanilloid-1 (TRPV1) Antagonists from Mollusk-Associated Bacteria

Lin, Zhenjian, Reilly, Christopher A., Antemano, Rowena, Hughen, Ronald W., Marett, Lenny, Concepcion, Gisela P., Haygood, Margo G., Olivera, Baldomero M., Light, Alan, Schmidt, Eric W.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.07 MB

english, 2011

18

Organometallic Ruthenium(II) Arene Compounds with Antiangiogenic Activity

Nowak-Sliwinska, Patrycja, van Beijnum, Judy R., Casini, Angela, Nazarov, Alexey A., Wagnières, Georges, van den Bergh, Hubert, Dyson, Paul J., Griffioen, Arjan W.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.34 MB

english, 2011

19

Engineering an Antibiotic to Fight Cancer: Optimization of the Novobiocin Scaffold to Produce Anti-proliferative Agents

Zhao, Huiping, Donnelly, Alison C., Kusuma, Bhaskar R., Brandt, Gary E. L., Brown, Douglas, Rajewski, Roger A., Vielhauer, George, Holzbeierlein, Jeffrey, Cohen, Mark S., Blagg, Brian S. J.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.71 MB

english, 2011

20

Use of a HEHEHE Purification Tag Instead of a Hexahistidine Tag Improves Biodistribution of Affibody Molecules Site-Specifically Labeled with 99m Tc, 111 In, and 125 I

Hofström, Camilla, Orlova, Anna, Altai, Mohamed, Wångsell, Fredrik, Gräslund, Torbjörn, Tolmachev, Vladimir

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

21

Heteroatom-Substituted Analogues of Orphan Nuclear Receptor Small Heterodimer Partner Ligand and Apoptosis Inducer ( E )-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic Acid

Xia, Zebin, Farhana, Lulu, Correa, Ricardo G., Das, Jayanta K., Castro, David J., Yu, Jinghua, Oshima, Robert G., Reed, John C., Fontana, Joseph A., Dawson, Marcia I.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.99 MB

english, 2011

22

Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure–Activity Study

Preller, Matthias, Chinthalapudi, Krishna, Martin, René, Knölker, Hans-Joachim, Manstein, Dietmar J.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 5.43 MB

english, 2011

23

Book Review of New Frontiers in Chemical Biology New Frontiers in Chemical Biology . Edited by Mark E. Bunnage . Royal Society of Chemistry , Cambridge, U.K. 2011 . xi + 316 pp. 24 × 16 cm. ISBN 978-1-84973-125-6 . £126.34.

Filer, Crist N.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 622 KB

english, 2011

24

Quercetin Diacylglycoside Analogues Showing Dual Inhibition of DNA Gyrase and Topoisomerase IV as Novel Antibacterial Agents

Hossion, Abugafar M. L., Zamami, Yoshito, Kandahary, Rafiya K., Tsuchiya, Tomofusa, Ogawa, Wakano, Iwado, Akimasa, Sasaki, Kenji

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.72 MB

english, 2011

25

Synthesis and Biological Evaluation of 1α,25-Dihydroxyvitamin D 3 Analogues Hydroxymethylated at C-26

Regueira, María A., Samanta, Shaonly, Malloy, Peter J., Ordóñez-Morán, Paloma, Resende, Diana, Sussman, Fredy, Muñoz, Alberto, Mouriño, Antonio, Feldman, David, Torneiro, Mercedes

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.40 MB

english, 2011

26

Design, Synthesis, and Biological Activities of Closantel Analogues: Structural Promiscuity and Its Impact on Onchocerca volvulus

Garner, Amanda L., Gloeckner, Christian, Tricoche, Nancy, Zakhari, Joseph S., Samje, Moses, Cho-Ngwa, Fidelis, Lustigman, Sara, Janda, Kim D.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.88 MB

english, 2011

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Tor version

Z-Library

Z-Library Since 2009 support@1delivery.pm

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски