Volume 54; Issue 12

Journal of Medicinal Chemistry

Volume 54; Issue 12

1

Synthesis of a Novel Series of Tricyclic Dihydrofuran Derivatives: Discovery of 8,9-Dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as Melatonin Receptor (MT1/MT2) Ligands

Koike, Tatsuki, Takai, Takafumi, Hoashi, Yasutaka, Nakayama, Masaharu, Kosugi, Yohei, Nakashima, Masato, Yoshikubo, Shin-ichi, Hirai, Keisuke, Uchikawa, Osamu

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.26 MB

english, 2011

2

17(R),18(S)-Epoxyeicosatetraenoic Acid, a Potent Eicosapentaenoic Acid (EPA) Derived Regulator of Cardiomyocyte Contraction: Structure–Activity Relationships and Stable Analogues

Falck, John R., Wallukat, Gerd, Puli, Narender, Goli, Mohan, Arnold, Cosima, Konkel, Anne, Rothe, Michael, Fischer, Robert, Müller, Dominik N., Schunck, Wolf-Hagen

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.27 MB

english, 2011

3

Akt-Dependent Anabolic Activity of Natural and Synthetic Brassinosteroids in Rat Skeletal Muscle Cells

Esposito, Debora, Rathinasabapathy, Thirumurugan, Poulev, Alexander, Komarnytsky, Slavko, Raskin, Ilya

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.87 MB

english, 2011

4

Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication

Stachulski, Andrew V., Pidathala, Chandrakala, Row, Eleanor C., Sharma, Raman, Berry, Neil G., Iqbal, Mazhar, Bentley, Joanne, Allman, Sarah A., Edwards, Geoffrey, Helm, Alison

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.02 MB

english, 2011

5

Switching Reversibility to Irreversibility in Glycogen Synthase Kinase 3 Inhibitors: Clues for Specific Design of New Compounds

Perez, Daniel I., Palomo, Valle, Pérez, Concepción, Gil, Carmen, Dans, Pablo D., Luque, F. Javier, Conde, Santiago, Martínez, Ana

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.90 MB

english, 2011

6

Synthesis, Characterization, and in Vivo Delivery of siRNA-Squalene Nanoparticles Targeting Fusion Oncogene in Papillary Thyroid Carcinoma

Raouane, Mouna, Desmaele, Didier, Gilbert-Sirieix, Marie, Gueutin, Claire, Zouhiri, Fatima, Bourgaux, Claudie, Lepeltier, Elise, Gref, Ruxandra, Ben Salah, Ridha, Clayman, Gary

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.83 MB

english, 2011

7

Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing

Debdab, Mansour, Carreaux, François, Renault, Steven, Soundararajan, Meera, Fedorov, Oleg, Filippakopoulos, Panagis, Lozach, Olivier, Babault, Lucie, Tahtouh, Tania, Baratte, Blandine

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.32 MB

english, 2011

8

Factors Determining the Superior Performance of Lipid/DNA/Protammine Nanoparticles over Lipoplexes

Caracciolo, Giulio, Pozzi, Daniela, Capriotti, Anna Laura, Marianecci, Carlotta, Carafa, Maria, Marchini, Cristina, Montani, Maura, Amici, Augusto, Amenitsch, Heinz, Digman, Michelle A., Gratton, Enri

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.93 MB

english, 2011

9

Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis

Magedov, Igor V., Frolova, Liliya, Manpadi, Madhuri, Bhoga, Uma devi, Tang, Hong, Evdokimov, Nikolai M., George, Olivia, Hadje Georgiou, Kathy, Renner, Steffen, Getlik, Matthäus, Kinnibrugh, Tiffany

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

10

Synthesis of Novel Vitamin K 2 Analogues with Modification at the ω-Terminal Position and Their Biological Evaluation as Potent Steroid and Xenobiotic Receptor (SXR) Agonists

Suhara, Yoshitomo, Watanabe, Masato, Nakagawa, Kimie, Wada, Akimori, Ito, Yoichi, Takeda, Kazuyoshi, Takahashi, Kazuhiko, Okano, Toshio

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.61 MB

english, 2011

11

Discovery of N -(1-Ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98−2): An Orally Active Corticotropin Releasing Factor-1 (CRF-1) Receptor Antagonist

Hodgetts, Kevin J., Ge, Ping, Yoon, Taeyoung, Lombaert, Stéphane De, Brodbeck, Robbin, Gulianello, Michael, Kieltyka, Andrzej, Horvath, Raymond F., Kehne, John H., Krause, James E., Maynard, George D

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.07 MB

english, 2011

12

Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity

Macias, Alba T., Williamson, Douglas S., Allen, Nicola, Borgognoni, Jenifer, Clay, Alexandra, Daniels, Zoe, Dokurno, Pawel, Drysdale, Martin J., Francis, Geraint L., Graham, Christopher J., Howes, Rob

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.31 MB

english, 2011

13

Discovery of a 5 H -Benzo[4,5]cyclohepta[1,2- b ]pyridin-5-one (MK-2461) Inhibitor of c-Met Kinase for the Treatment of Cancer

Katz, Jason D., Jewell, James P., Guerin, David J., Lim, Jongwon, Dinsmore, Christopher J., Deshmukh, Sujal V., Pan, Bo-Sheng, Marshall, C. Gary, Lu, Wei, Altman, Michael D., Dahlberg, William K., Dav

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.29 MB

english, 2011

14

Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells

Kumar, Vineet, Kumar, Sarvesh, Hassan, Mohammad, Wu, Hailong, Thimmulappa, Rajesh K., Kumar, Amit, Sharma, Sunil K., Parmar, Virinder S., Biswal, Shyam, Malhotra, Sanjay V.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 979 KB

english, 2011

15

N -Benzoylated Phenoxazines and Phenothiazines: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization

Prinz, Helge, Chamasmani, Behfar, Vogel, Kirsten, Böhm, Konrad J., Aicher, Babette, Gerlach, Matthias, Günther, Eckhard G., Amon, Peter, Ivanov, Igor, Müller, Klaus

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.01 MB

english, 2011

16

Structure-Based Design of Potent Aromatase Inhibitors by High-Throughput Docking

Caporuscio, Fabiana, Rastelli, Giulio, Imbriano, Carol, Del Rio, Alberto

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.56 MB

english, 2011

17

Irreversible Nek2 Kinase Inhibitors with Cellular Activity

Henise, Jeffrey C., Taunton, Jack

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.98 MB

english, 2011

18

An Electroneutral Macrocyclic Iron(II) Complex That Enhances MRI Contrast in Vivo

Touti, Fayçal, Singh, Akhilesh Kumar, Maurin, Philippe, Canaple, Laurence, Beuf, Olivier, Samarut, Jacques, Hasserodt, Jens

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.99 MB

english, 2011

19

How Well Can Fragments Explore Accessed Chemical Space? A Case Study from Heat Shock Protein 90

Roughley, Stephen D., Hubbard, Roderick E.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 7.08 MB

english, 2011

20

Pyrimidine Nucleotides with 4-Alkyloxyimino and Terminal Tetraphosphate δ-Ester Modifications as Selective Agonists of the P2Y 4 Receptor

Maruoka, Hiroshi, Jayasekara, M. P. Suresh, Barrett, Matthew O., Franklin, Derek A., de Castro, Sonia, Kim, Nathaniel, Costanzi, Stefano, Harden, T. Kendall, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.74 MB

english, 2011

21

Design, Synthesis, and Cytotoxic Evaluation of Acyl Derivatives of 3-Aminonaphtho[2,3- b ]thiophene-4,9-dione, a Quinone-Based System

Gomez-Monterrey, Isabel, Campiglia, Pietro, Aquino, Claudio, Bertamino, Alessia, Granata, Ilaria, Carotenuto, Alfonso, Brancaccio, Diego, Stiuso, Paola, Scognamiglio, Ilaria, Rusciano, M. Rosaria, Mai

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.67 MB

english, 2011

22

Discovery of a Series of Imidazo[4,5- b ]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ

Casimiro-Garcia, Agustin, Filzen, Gary F., Flynn, Declan, Bigge, Christopher F., Chen, Jing, Davis, Jo Ann, Dudley, Danette A., Edmunds, Jeremy J., Esmaeil, Nadia, Geyer, Andrew, Heemstra, Ronald J.,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.52 MB

english, 2011

23

Book Review of Catalytic Asymmetric Synthesis. Third Edition Catalytic Asymmetric Synthesis. Third Edition . Edited by Iwao Ojima . Wiley , Hoboken, NJ . 2010 . xvii + 998 pp. 16 × 24 cm. ISBN 978-0-470-17577-4 . $175.00.

Friestad, Gregory K.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 618 KB

english, 2011

24

Book Review of Chemical Library Design Chemical Library Design . Edited by Joe Zhongxiang Zhou . Humana Press , New York, NY . 2011 . x + 362 pp. 18.5 × 26 cm. ISBN 9781607619307 . $209.00.

Roman, David L.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 623 KB

english, 2011

25

Correction to Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1 H -1,2,3-triazoles

Bakunov, Stanislav A., Bakunova, Svetlana M., Wenzler, Tanja, Ghebru, Maedot, Werbovetz, Karl A., Brun, Reto, Tidwell, Richard R.

Journal:

Journal of Medicinal Chemistry

Year:

2011

File:

PDF, 605 KB

2011

26

Structure–Activity Relationship Studies To Probe the Phosphoprotein Binding Site on the Carboxy Terminal Domains of the Breast Cancer Susceptibility Gene 1

Yuan, Ziyan, Kumar, Eric A., Kizhake, Smitha, Natarajan, Amarnath

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.82 MB

english, 2011

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