Volume 327; Issue 3

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Journal of Pharmacology and Experimental Therapeutics
Volume 327; Issue 3

Journal of Pharmacology and Experimental Therapeutics

Volume 327; Issue 3

1

Comparison of the Novel Subtype-Selective GABAA Receptor-Positive Allosteric Modulator NS11394 [3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with Diazepam, Zolpidem, Bretazenil, and Gaboxadol in Rat Models of Inflammatory and Neuropathic Pain

Munro, G., Lopez-Garcia, J. A., Rivera-Arconada, I., Erichsen, H. K., Nielsen, E. O., Larsen, J. S., Ahring, P. K., Mirza, N. R.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 480 KB

english, 2008

2

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

Iglarz, M., Binkert, C., Morrison, K., Fischli, W., Gatfield, J., Treiber, A., Weller, T., Bolli, M. H., Boss, C., Buchmann, S., Capeleto, B., Hess, P., Qiu, C., Clozel, M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 255 KB

english, 2008

3

Characterization of N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 Antagonist in Animal Models of Pain and Inflammation

Broom, D. C., Matson, D. J., Bradshaw, E., Buck, M. E., Meade, R., Coombs, S., Matchett, M., Ford, K. K., Yu, W., Yuan, J., Sun, S. H., Ochoa, R., Krause, J. E., Wustrow, D. J., Cortright, D. N.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 800 KB

english, 2008

4

Identification and Characterization of Novel Small-Molecule Protease-Activated Receptor 2 Agonists

Gardell, L. R., Ma, J.-N., Seitzberg, J. G., Knapp, A. E., Schiffer, H. H., Tabatabaei, A., Davis, C. N., Owens, M., Clemons, B., Wong, K. K., Lund, B., Nash, N. R., Gao, Y., Lameh, J., Schmelzer, K.,

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 297 KB

english, 2008

5

Dehydroalanine Analog of Glutathione: An Electrophilic Busulfan Metabolite That Binds to Human Glutathione S-Transferase A1-1

Younis, I. R., Elliott, M., Peer, C. J., Cooper, A. J. L., Pinto, J. T., Konat, G. W., Kraszpulski, M., Petros, W. P., Callery, P. S.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 254 KB

english, 2008

6

Novel Peroxisome Proliferator-Activated Receptor Agonists Lower Low-Density Lipoprotein and Triglycerides, Raise High-Density Lipoprotein, and Synergistically Increase Cholesterol Excretion with a Liver X Receptor Agonist

Mukherjee, R., Locke, K. T., Miao, B., Meyers, D., Monshizadegan, H., Zhang, R., Search, D., Grimm, D., Flynn, M., O'Malley, K. M., Zhang, L., Li, J., Shi, Y., Kennedy, L. J., Blanar, M., Cheng, P. T.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 306 KB

english, 2008

7

Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats

Brady, A. E., Jones, C. K., Bridges, T. M., Kennedy, J. P., Thompson, A. D., Heiman, J. U., Breininger, M. L., Gentry, P. R., Yin, H., Jadhav, S. B., Shirey, J. K., Conn, P. J., Lindsley, C. W.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 644 KB

english, 2008

8

Antidepressants Targeting the Serotonin Reuptake Transporter Act via a Competitive Mechanism

Apparsundaram, S., Stockdale, D. J., Henningsen, R. A., Milla, M. E., Martin, R. S.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 264 KB

english, 2008

9

Kinetic and Thermodynamic Assessment of Binding of Serotonin Transporter Inhibitors

Martin, R. S., Henningsen, R. A., Suen, A., Apparsundaram, S., Leung, B., Jia, Z., Kondru, R. K., Milla, M. E.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 483 KB

english, 2008

10

Impact of High and Low Folate Diets on Tissue Folate Receptor Levels and Antitumor Responses Toward Folate-Drug Conjugates

Leamon, C. P., Reddy, J. A., Dorton, R., Bloomfield, A., Emsweller, K., Parker, N., Westrick, E.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 313 KB

english, 2008

11

New Insights into Metabolic Signaling and Cell Survival: The Role of -O-Linkage of N-Acetylglucosamine

Ngoh, G. A., Jones, S. P.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 280 KB

english, 2008

12

Pamapimod, a Novel p38 Mitogen-Activated Protein Kinase Inhibitor: Preclinical Analysis of Efficacy and Selectivity

Hill, R. J., Dabbagh, K., Phippard, D., Li, C., Suttmann, R. T., Welch, M., Papp, E., Song, K. W., Chang, K.-c., Leaffer, D., Kim, Y.-N., Roberts, R. T., Zabka, T. S., Aud, D., Porto, J. D., Manning,

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 474 KB

english, 2008

13

NIM811 (N-Methyl-4-isoleucine Cyclosporine), a Mitochondrial Permeability Transition Inhibitor, Attenuates Cholestatic Liver Injury but Not Fibrosis in Mice

Rehman, H., Ramshesh, V. K., Theruvath, T. P., Kim, I., Currin, R. T., Giri, S., Lemasters, J. J., Zhong, Z.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 504 KB

english, 2008

14

Involvement of ST1B Subfamily of Cytosolic Sulfotransferase in Kynurenine Metabolism to Form Natriuretic Xanthurenic Acid Sulfate

Senggunprai, L., Yoshinari, K., Shimada, M., Yamazoe, Y.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 484 KB

english, 2008

15

Comparison of Cigarette Smoke-Induced Acute Inflammation in Multiple Strains of Mice and the Effect of a Matrix Metalloproteinase Inhibitor on These Responses

Morris, A., Kinnear, G., Wan, W.-Y. H., Wyss, D., Bahra, P., Stevenson, C. S.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 461 KB

english, 2008

16

The Molecular Mechanism of "Ryegrass Staggers," a Neurological Disorder of K+ Channels

Imlach, W. L., Finch, S. C., Dunlop, J., Meredith, A. L., Aldrich, R. W., Dalziel, J. E.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 488 KB

english, 2008

17

Do Desipramine [10,11-Dihydro-5-[3-(methylamino) propyl]-5H-dibenz[b,f]azepine monohydrochloride] and Fluoxetine [N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine] Ameliorate the Extent of Colonic Damage Induced by Acetic Acid in Rats?

Guemei, A. A., El Din, N. M. N., Baraka, A. M., El Said Darwish, I.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 97 KB

english, 2008

18

A Novel CCR5-Specific Pharmacodynamic Assay in Whole Blood Using Phosphoflow Cytometry Highlights Different Ligand-Dependent Responses but Similar Properties of Antagonists in CD8+ and CD4+ T Lymphocytes

Dahl, M. E., Berson, A., Lora, J., Fuentes, M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 574 KB

english, 2008

19

ADX47273 [S-(4-Fluoro-phenyl)- -methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with Preclinical Antipsychotic-Like and Procognitive Activities

Liu, F., Grauer, S., Kelley, C., Navarra, R., Graf, R., Zhang, G., Atkinson, P. J., Popiolek, M., Wantuch, C., Khawaja, X., Smith, D., Olsen, M., Kouranova, E., Lai, M., Pruthi, F., Pulicicchio, C., D

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 626 KB

english, 2008

20

Gene Expression Profiles in Livers from Diclofenac-Treated Rats Reveal Intestinal Bacteria-Dependent and -Independent Pathways Associated with Liver Injury

Deng, X., Liguori, M. J., Sparkenbaugh, E. M., Waring, J. F., Blomme, E. A. G., Ganey, P. E., Roth, R. A.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 566 KB

english, 2008

21

Tumor-Penetrating Microparticles for Intraperitoneal Therapy of Ovarian Cancer

Lu, Z., Tsai, M., Lu, D., Wang, J., Wientjes, M. G., Au, J. L.-S.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 493 KB

english, 2008

22

The 5-Hydroxytryptamine2A Receptor Antagonist R-(+)- -(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) Attenuates Impulsivity after Both Drug-Induced Disruption (Dizocilpine) and Enhancement (Antidepressant Drugs) of Differential-Reinforcement-of-Low-Rate 72-s Behavior in the Rat

Ardayfio, P. A., Benvenga, M. J., Chaney, S. F., Love, P. L., Catlow, J., Swanson, S. P., Marek, G. J.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 246 KB

english, 2008

23

Nanomolar Concentrations of Pregnenolone Sulfate Enhance Striatal Dopamine Overflow in Vivo

Sadri-Vakili, G., Janis, G. C., Pierce, R. C., Gibbs, T. T., Farb, D. H.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 178 KB

english, 2008

24

10.1124/jpet.108.142703

Cheng, Q., Law, P. K., de Gasparo, M., Leung, P. S.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 667 KB

english, 2008

25

Chronic Benzodiazepine Administration Potentiates High Voltage-Activated Calcium Currents in Hippocampal CA1 Neurons

Xiang, K., Earl, D. E., Davis, K. M., Giovannucci, D. R., Greenfield, L. J., Tietz, E. I.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 292 KB

english, 2008

26

Niacin-induced "Flush" Involves Release of Prostaglandin D2 from Mast Cells and Serotonin from Platelets: Evidence from Human Cells in Vitro and an Animal Model

Papaliodis, D., Boucher, W., Kempuraj, D., Michaelian, M., Wolfberg, A., House, M., Theoharides, T. C.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 325 KB

english, 2008

27

A Cross-Link between Protein Kinase A and Rho-Family GTPases Signaling Mediates Cell-Cell Adhesion and Actin Cytoskeleton Organization in Epithelial Cancer Cells

Leve, F., de Souza, W., Morgado-Diaz, J. A.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 947 KB

english, 2008

28

Inactivation of the Maternal Fragile X Gene Results in Sensitization of GABAB Receptor Function in the Offspring

Zupan, B., Toth, M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 246 KB

english, 2008

29

Distinct Interactions of Human 1- and 2-Adrenoceptors with Isoproterenol, Epinephrine, Norepinephrine, and Dopamine

Weitl, N., Seifert, R.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 252 KB

english, 2008

30

Identification and Characterization of NDT 9513727 [N,N-bis(1,3-Benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a Novel, Orally Bioavailable C5a Receptor Inverse Agonist

Brodbeck, R. M., Cortright, D. N., Kieltyka, A. P., Yu, J., Baltazar, C. O., Buck, M. E., Meade, R., Maynard, G. D., Thurkauf, A., Chien, D.-S., Hutchison, A. J., Krause, J. E.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 432 KB

english, 2008

31

Bortezomib-Induced Survival Signals and Genes in Human Proximal Tubular Cells

Sarkozi, R., Perco, P., Hochegger, K., Enrich, J., Wiesinger, M., Pirklbauer, M., Eder, S., Rudnicki, M., Rosenkranz, A. R., Mayer, B., Mayer, G., Schramek, H.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 612 KB

english, 2008

32

Chemotherapy-Induced CXC-Chemokine/CXC-Chemokine Receptor Signaling in Metastatic Prostate Cancer Cells Confers Resistance to Oxaliplatin through Potentiation of Nuclear Factor- B Transcription and Evasion of Apoptosis

Wilson, C., Purcell, C., Seaton, A., Oladipo, O., Maxwell, P. J., O'Sullivan, J. M., Wilson, R. H., Johnston, P. G., Waugh, D. J. J.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 870 KB

english, 2008

33

Improvement of Endothelial Function of the Corpus Cavernosum in Apolipoprotein E Knockout Mice Treated with Irbesartan

Baumhakel, M., Custodis, F., Schlimmer, N., Laufs, U., Bohm, M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 362 KB

english, 2008

34

Heme Oxygenase-1 Inhibits the Proliferation of Pancreatic Stellate Cells by Repression of the Extracellular Signal-Regulated Kinase1/2 Pathway

Schwer, C. I., Guerrero, A. M., Humar, M., Roesslein, M., Goebel, U., Stoll, P., Geiger, K. K., Pannen, B. H. J., Hoetzel, A., Schmidt, R.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 389 KB

english, 2008

35

S32826, A Nanomolar Inhibitor of Autotaxin: Discovery, Synthesis and Applications as a Pharmacological Tool

Ferry, G., Moulharat, N., Pradere, J.-P., Desos, P., Try, A., Genton, A., Giganti, A., Beucher-Gaudin, M., Lonchampt, M., Bertrand, M., Saulnier-Blache, J.-S., Tucker, G. C., Cordi, A., Boutin, J. A.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 467 KB

english, 2008

36

Inhibition of Soluble Epoxide Hydrolase Does Not Protect against Endotoxin-Mediated Hepatic Inflammation

Fife, K. L., Liu, Y., Schmelzer, K. R., Tsai, H.-J., Kim, I.-H., Morisseau, C., Hammock, B. D., Kroetz, D. L.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 460 KB

english, 2008

37

Radiodefluorination of 3-Fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a Radioligand for Imaging Brain Metabotropic Glutamate Subtype-5 Receptors with Positron Emission Tomography, Occurs by Glutathionylation in Rat Brain

Shetty, H. U., Zoghbi, S. S., Simeon, F. G., Liow, J.-S., Brown, A. K., Kannan, P., Innis, R. B., Pike, V. W.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 244 KB

english, 2008

38

Effect of Erythromycin on Biological Activities Induced by Clostridium perfringens -Toxin

Oda, M., Kihara, A., Yoshioka, H., Saito, Y., Watanabe, N., Uoo, K., Higashihara, M., Nagahama, M., Koide, N., Yokochi, T., Sakurai, J.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 372 KB

english, 2008

39

Inhibition of Native and Recombinant Nicotinic Acetylcholine Receptors by the Myristoylated Alanine-Rich C Kinase Substrate Peptide

Gay, E. A., Klein, R. C., Melton, M. A., Blackshear, P. J., Yakel, J. L.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 322 KB

english, 2008

40

Ethanol Decreases Purkinje Neuron Excitability by Increasing GABA Release in Rat Cerebellar Slices

Mameli, M., Botta, P., Zamudio, P. A., Zucca, S., Valenzuela, C. F.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 485 KB

english, 2008

41

NS11394 [3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a Unique Subtype-Selective GABAA Receptor Positive Allosteric Modulator: In Vitro Actions, Pharmacokinetic Properties and in Vivo Anxiolytic Efficacy

Mirza, N. R., Larsen, J. S., Mathiasen, C., Jacobsen, T. A., Munro, G., Erichsen, H. K., Nielsen, A. N., Troelsen, K. B., Nielsen, E. O., Ahring, P. K.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 677 KB

english, 2008