Volume 2; Issue 7

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MedChemComm
Volume 2; Issue 7

MedChemComm

Volume 2; Issue 7

1

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

Alex, Alexander, Millan, David S., Perez, Manuel, Wakenhut, Florian, Whitlock, Gavin A.

Journal:

Year:

2011

Language:

english

File:

PDF, 310 KB

english, 2011

2

Identification of target family directed bioisosteric replacements

Wassermann, Anne Mai, Bajorath, Jürgen

Journal:

Year:

2011

Language:

english

File:

PDF, 394 KB

english, 2011

3

Antimycobacterial activity of spirooxindolo-pyrrolidine, pyrrolizine and pyrrolothiazole hybrids obtained by a three-component regio- and stereoselective 1,3-dipolar cycloaddition

Rajesh, Stephen Michael, Perumal, Subbu, Menéndez, J. Carlos, Yogeeswari, Perumal, Sriram, Dharmarajan

Journal:

Year:

2011

Language:

english

File:

PDF, 322 KB

english, 2011

4

Carbocyclic 5′-nor “reverse” fleximers. Design, synthesis, and preliminary biological activity

Zimmermann, Sarah C., Sadler, Joshua M., Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, Seley-Radtke, Katherine L.

Journal:

Year:

2011

Language:

english

File:

PDF, 165 KB

english, 2011

5

Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

Shnyder, Steve D., Fu, Ying, Habtemariam, Abraha, van Rijt, Sabine H., Cooper, Patricia A., Loadman, Paul M., Sadler, Peter J.

Journal:

Year:

2011

Language:

english

File:

PDF, 131 KB

english, 2011

6

Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities

Marti, Francesc, Chadwick, James, Amewu, Richard K., Burrell-Saward, Hollie, Srivastava, Abhishek, Ward, Stephen A., Sharma, Raman, Berry, Neil, O'Neill, Paul M.

Journal:

Year:

2011

Language:

english

File:

PDF, 180 KB

english, 2011

7

Temocene: the porphycene analogue of temoporfin (Foscan®)

García-Díaz, María, Sánchez-García, David, Soriano, Jorge, Sagristà, M. Lluïsa, Mora, Margarita, Villanueva, Ángeles, Stockert, Juan C., Cañete, Magdalena, Nonell, Santi

Journal:

Year:

2011

Language:

english

File:

PDF, 230 KB

english, 2011

8

Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development

Kellett, Andrew, O'Connor, Mark, McCann, Malachy, Howe, Orla, Casey, Alan, McCarron, Pauraic, Kavanagh, Kevin, McNamara, Mary, Kennedy, Sean, May, Donald D., Skell, Philip S., O'Shea, Denis, Devereux,

Journal:

Year:

2011

Language:

english

File:

PDF, 602 KB

english, 2011

9

Front cover

Journal:

Year:

2011

Language:

english

File:

PDF, 723 KB

english, 2011

10

RCAI-39, 41, 53, 100, 127 and 128, the analogues of KRN7000, activate mouse natural killer T cells to produce Th2-biased cytokines by their administration as liposomal particles

Tashiro, Takuya, Ishii, Yasuyuki, Shigeura, Tomokuni, Nakagawa, Ryusuke, Watarai, Hiroshi, Taniguchi, Masaru, Mori, Kenji

Journal:

Year:

2011

Language:

english

File:

PDF, 157 KB

english, 2011

11

Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors

de Kloe, Gerdien E., Kool, Jeroen, van Elk, Rene, van Muijlwijk-Koezen, Jacqueline E., Smit, August B., Lingeman, Henk, Irth, Hubertus, Niessen, Wilfried M. A., de Esch, Iwan J. P.

Journal:

Year:

2011

Language:

english

File:

PDF, 431 KB

english, 2011

12

Back cover

Journal:

Year:

2011

Language:

english

File:

PDF, 723 KB

english, 2011

13

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

Granchi, Carlotta, Roy, Sarabindu, Del Fiandra, Claudia, Tuccinardi, Tiziano, Lanza, Mario, Betti, Laura, Giannaccini, Gino, Lucacchini, Antonio, Martinelli, Adriano, Macchia, Marco, Minutolo, Filippo

Journal:

Year:

2011

Language:

english

File:

PDF, 562 KB

english, 2011

14

Synthesis and biological evaluation of novel 1-aryl, 5-(phenoxy-substituted)aryl-1,4-pentadien-3-one derivatives

Yuan, Kai, Song, Baoan, Jin, Linhong, Xu, Shuai, Hu, Deyu, Xu, Xiaoqing, Yang, Song

Journal:

Year:

2011

Language:

english

File:

PDF, 365 KB

english, 2011

15

Quantification of the orientations of pyrrolidine-based oxypeptide nucleic acid–DNA hybrid duplexes

Kitamatsu, Mizuki, Sisido, Masahiko

Journal:

Year:

2011

Language:

english

File:

PDF, 182 KB

english, 2011

16

Contents list

Journal:

Year:

2011

Language:

english

File:

PDF, 2.22 MB

english, 2011

17

Binding of 9-O-(ω-amino) alkyl ether analogues of the plant alkaloid berberine to poly(A): insights into self-structure induction

Islam, Md. Maidul, Basu, Anirban, Suresh Kumar, Gopinatha

Journal:

Year:

2011

Language:

english

File:

PDF, 210 KB

english, 2011

18

N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases

Medda, Federico, Joseph, Thomas L., Pirrie, Lisa, Higgins, Maureen, Slawin, Alexandra M. Z., Lain, Sonia, Verma, Chandra, Westwood, Nicholas J.

Journal:

Year:

2011

Language:

english

File:

PDF, 312 KB

english, 2011

19

Phenyldiazenyl benzothiazole derivatives as probes for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains

Matsumura, Kenji, Ono, Masahiro, Hayashi, Shun, Kimura, Hiroyuki, Okamoto, Yoko, Ihara, Masafumi, Takahashi, Ryosuke, Mori, Hiroshi, Saji, Hideo

Journal:

Year:

2011

Language:

english

File:

PDF, 229 KB

english, 2011

20

Structure–activity relationships of gramicidin S analogs containing (β-3-pyridyl)-α,β-dehydroalanine residues on membrane permeability

Yamada, Keiichi, Kodaira, Makoto, Shinoda, Shun-suke, Komagoe, Keiko, Oku, Hiroyuki, Katakai, Ryoichi, Katsu, Takashi, Matsuo, Ichiro

Journal:

Year:

2011

Language:

english

File:

PDF, 245 KB

english, 2011

21

Discovery of novel selective Sigma-1 ligands as cognitive enhancers

Valade, Anne, Cross, Sophie Binet, Brown, Claire, Detrait, Eric, Ene, Doina, Gillard, Michel, Guyaux, Michel, Lamberty, Yves, Maguire, Martin, Namdev, Nivedita, Provins, Laurent, Schwartz, Eric, Verme

Journal:

Year:

2011

Language:

english

File:

PDF, 224 KB

english, 2011

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