Volume 5; Issue 10

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MedChemComm
Volume 5; Issue 10

MedChemComm

Volume 5; Issue 10

1

N-Arylalkylbenzo[d]thiazole-2-carboxamides as anti-mycobacterial agents: design, new methods of synthesis and biological evaluation

Shah, Parth, Dhameliya, Tejas M., Bansal, Rohit, Nautiyal, Manesh, Kommi, Damodara N., Jadhavar, Pradeep S., Sridevi, Jonnalagadda Padma, Yogeeswari, Perumal, Sriram, Dharmarajan, Chakraborti, Asit K.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.15 MB

english, 2014

2

Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: reversing the resistance against frontline antibacterial drugs

Joshi, Prashant, Singh, Samsher, Wani, Abubakar, Sharma, Sadhana, Jain, Shreyans K., Singh, Baljinder, Gupta, Bishan D., Satti, Naresh K., Koul, Surrinder, Khan, Inshad A., Kumar, Ajay, Bharate, Sandi

Journal:

Year:

2014

Language:

english

File:

PDF, 1.63 MB

english, 2014

3

Peptide HIV fusion inhibitors: modifications and conjugations

Liu, Wei, Tan, Jianjun, Mehryar, Mohammadreza Mohammadzad, Teng, Zhiping, Zeng, Yi

Journal:

Year:

2014

Language:

english

File:

PDF, 564 KB

english, 2014

4

A double effect molecular switch leads to a novel potent negative allosteric modulator of metabotropic glutamate receptor 5

Gómez-Santacana, X., Rovira, X., Dalton, J. A., Goudet, C., Pin, J. P., Gorostiza, P., Giraldo, J., Llebaria, A.

Journal:

Year:

2014

Language:

english

File:

PDF, 433 KB

english, 2014

5

Antisense oligonucleotides: modifications and clinical trials

Sharma, Vivek K., Sharma, Raman K., Singh, Sunil K.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.08 MB

english, 2014

6

Gold compounds as aquaporin inhibitors: new opportunities for therapy and imaging

de Almeida, Andreia, Soveral, Graça, Casini, Angela

Journal:

Year:

2014

Language:

english

File:

PDF, 866 KB

english, 2014

7

Design, synthesis and molecular docking of novel bipyrazolyl thiazolone scaffold as a new class of antibacterial agents

Kalaria, Piyush N., Makawana, Jigar A., Satasia, Shailesh P., Raval, Dipak K., Zhu, Hai-Liang

Journal:

Year:

2014

Language:

english

File:

PDF, 513 KB

english, 2014

8

Identification of tanshinone IIA as a natural monoacylglycerol lipase inhibitor by combined in silico and in vitro approach

Yang, Ruolin, Lu, Yang, Liu, Jianhua

Journal:

Year:

2014

Language:

english

File:

PDF, 468 KB

english, 2014

9

Front cover

Journal:

Year:

2014

File:

PDF, 381 KB

2014

10

MedChemWatch Issue 21 and Back cover

Journal:

Year:

2014

Language:

english

File:

PDF, 9.03 MB

english, 2014

11

Diversity-oriented synthesis for novel, selective and drug-like inhibitors for a phosphatase from Mycobacterium tuberculosis

He, Rongjun, Bai, Yunpeng, Yu, Zhi-Hong, Wu, Li, Gunawan, Andrea Michelle, Zhang, Zhong-Yin

Journal:

Year:

2014

Language:

english

File:

PDF, 289 KB

english, 2014

12

Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity

McCoull, William, Hennessy, Edward J., Blades, Kevin, Box, Matthew R., Chuaqui, Claudio, Dowling, James E., Davies, Christopher D., Ferguson, Andrew D., Goldberg, Frederick W., Howe, Nicholas J., Kemm

Journal:

Year:

2014

Language:

english

File:

PDF, 527 KB

english, 2014

13

Discovery of novel guanidinophenylpyrazole human acrosin inhibitors by molecular hybridization

Zhao, Juntao, Sun, Nannan, Gao, Yue, Lv, Diya, Liu, Yang, Jiang, Yan, Dong, Guoqiang, Chen, Qianqian, Li, Wei, Zhou, Youjun, Zhu, Ju, Sheng, Chunquan, Lv, Jiaguo

Journal:

Year:

2014

Language:

english

File:

PDF, 499 KB

english, 2014

14

Protein–protein interactions of ASPP2: an emerging therapeutic target

Iosub-Amir, Anat, Friedler, Assaf

Journal:

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

15

A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

Wakabayashi, Rie, Ishiyama, Ryutaro, Kamiya, Noriho, Goto, Masahiro

Journal:

Year:

2014

Language:

english

File:

PDF, 303 KB

english, 2014

16

Conformational analysis of peramivir reveals critical differences between free and enzyme-bound states

Richards, Michele R., Brant, Michael G., Boulanger, Martin J., Cairo, Christopher W., Wulff, Jeremy E.

Journal:

Year:

2014

Language:

english

File:

PDF, 978 KB

english, 2014

17

Inside front cover

Journal:

Year:

2014

File:

PDF, 295 KB

2014

18

Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies

Frett, Brendan, McConnell, Nick, Wang, Yuanxiang, Xu, Zhigang, Ambrose, Andrew, Li, Hong-yu

Journal:

Year:

2014

Language:

english

File:

PDF, 506 KB

english, 2014

19

Exploring the substrate promiscuity of an antibiotic inactivating enzyme

Agarwal, Vinayak, Vondenhoff, Gaston, Gadakh, Bharat, Severinov, Konstantin, Van Aerschot, Arthur, Nair, Satish K.

Journal:

Year:

2014

Language:

english

File:

PDF, 443 KB

english, 2014

20

Cytoprotective effects of hydrogen sulfide-releasing N-methyl- d -aspartate receptor antagonists mediated by intracellular sulfane sulfur

Marutani, Eizo, Sakaguchi, Masahiro, Chen, Wei, Sasakura, Kiyoshi, Liu, Jifeng, Xian, Ming, Hanaoka, Kenjiro, Nagano, Tetsuo, Ichinose, Fumito

Journal:

Year:

2014

Language:

english

File:

PDF, 612 KB

english, 2014

21

Correction: Synthesis, chiral resolution, absolute configuration assignment and pharmacological evaluation of a series of melatoninergic ligands

Ettaoussi, Mohamed, Pérès, Basile, Jarry, Christian, Pallage, Viviane, Nosjean, Olivier, Boutin, Jean A., Gohier, Arnaud, Mannoury la Cour, Clotilde, Caignard, Daniel-Henri, Delagrange, Philippe, Bert

Journal:

Year:

2014

Language:

english

File:

PDF, 150 KB

english, 2014

22

Contents list

Journal:

Year:

2014

Language:

english

File:

PDF, 2.07 MB

english, 2014

23

Synthesis of 1-O-acetylbritannilactone analogues from Inula britannica and in vitro evaluation of their anticancer potential

Tang, Jiang-Jiang, Dong, Shuai, Han, Yang-Yang, Lei, Ming, Gao, Jin-Ming

Journal:

Year:

2014

Language:

english

File:

PDF, 573 KB

english, 2014

24

Naphthalene and 2,3-dihydrobenzo[b][1,4]dioxine derivatives with extended side chains as new scaffolds of CB 2 -selective ligands

Osman, Noha A., Mahmoud, Amr H., Klein, Christian D., Allarà, Marco, Di Marzo, Vincenzo, Abouzid, Khaled M., Abadi, Ashraf H.

Journal:

Year:

2014

Language:

english

File:

PDF, 412 KB

english, 2014

25

Non-classical β-carbonic anhydrase inhibitors-towards novel anti-mycobacterials

von Gnielinski, Natascha, Nienaber, Lisa, Mason, Lyndel, Ellis, Samantha, Triccas, James A., Davis, Rohan A., Hofmann, Andreas

Journal:

Year:

2014

Language:

english

File:

PDF, 256 KB

english, 2014

26

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

Devine, Shane M., Lim, San Sui, Chandrashekaran, Indu R., MacRaild, Christopher A., Drew, Damien R., Debono, Cael O., Lam, Raymond, Anders, Robin F., Beeson, James G., Scanlon, Martin J., Scammells, P

Journal:

Year:

2014

Language:

english

File:

PDF, 520 KB

english, 2014