Volume 5; Issue 6

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MedChemComm
Volume 5; Issue 6

MedChemComm

Volume 5; Issue 6

1

Combretastatin A-4 inspired novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines as tubulin polymerization inhibitors, antimitotic and anticancer agents

Sanghai, Nitesh, Jain, Vaibhav, Preet, Ranjan, Kandekar, Somnath, Das, Sarita, Trivedi, Neha, Mohapatra, Purusottam, Priyadarshani, Garima, Kashyap, Maneesh, Das, Dipon, Satapathy, Shakti Ranjan, Sidd

Journal:

Year:

2014

Language:

english

File:

PDF, 2.93 MB

english, 2014

2

The role of modern drug discovery in the fight against neglected and tropical diseases

Burrows, Jeremy N., Elliott, Richard L., Kaneko, Takushi, Mowbray, Charles E., Waterson, David

Journal:

Year:

2014

Language:

english

File:

PDF, 1.26 MB

english, 2014

3

The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)

Le Trionnaire, Sophie, Perry, Alexis, Szczesny, Bartosz, Szabo, Csaba, Winyard, Paul G., Whatmore, Jacqueline L., Wood, Mark E., Whiteman, Matthew

Journal:

Year:

2014

Language:

english

File:

PDF, 602 KB

english, 2014

4

Design, synthesis and biological evaluation of novel trimethylpyrazine-2-carbonyloxy-cinnamic acids as potent cardiovascular agents

Chen, Hongfei, Li, Guoning, Zhan, Peng, Li, Hong, Wang, Shouxun, Liu, Xinyong

Journal:

Year:

2014

Language:

english

File:

PDF, 348 KB

english, 2014

5

Conformational properties of cholic acid, a lead compound at the crossroads of bile acid inspired drug discovery

Gioiello, Antimo, Venturoni, Francesco, Tamimi, Sara, Custodi, Chiara, Pellicciari, Roberto, Macchiarulo, Antonio

Journal:

Year:

2014

Language:

english

File:

PDF, 517 KB

english, 2014

6

The antimalarial drug atovaquone binds to saposin B with comparable affinity to coenzyme Q10

Huta, B. P., Roberts, A. M., Waters, E. S., Yu, V. Y., Doyle, R. P., Mehlenbacher, M. R., Bou-Abdallah, F.

Journal:

Year:

2014

Language:

english

File:

PDF, 484 KB

english, 2014

7

Specific chemical changes leading to consistent potency increases in structurally diverse active compounds

Dimova, Dilyana, Stumpfe, Dagmar, Bajorath, Jürgen

Journal:

Year:

2014

Language:

english

File:

PDF, 789 KB

english, 2014

8

Contents list

Journal:

Year:

2014

Language:

english

File:

PDF, 1.81 MB

english, 2014

9

Introduction of polar groups on the naphthalene scaffold of molecular tongs inhibiting wild-type and mutated HIV-1 protease dimerization

Fanelli, R., Ressurreição, A. S., Dufau, L., Soulier, J.-L., Vidu, A., Tonali, N., Bernadat, G., Reboud-Ravaux, M., Ongeri, S.

Journal:

Year:

2014

Language:

english

File:

PDF, 580 KB

english, 2014

10

Back cover

Journal:

Year:

2014

Language:

english

File:

PDF, 988 KB

english, 2014

11

Discovery and SAR study of a sulfonamide hydroxamic acid inhibitor for the botulinum neurotoxin serotype A light chain

Burtea, Alexander, Salzameda, Nicholas T.

Journal:

Year:

2014

Language:

english

File:

PDF, 348 KB

english, 2014

12

Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17

Fang, Wei, Lin, Xiuping, Zhou, Xuefeng, Wan, Junting, Lu, Xin, Yang, Bin, Ai, Wen, Lin, Ji, Zhang, Tianyu, Tu, Zhengchao, Liu, Yonghong

Journal:

Year:

2014

Language:

english

File:

PDF, 736 KB

english, 2014

13

Novel phthalimide derivatives with TNF-α and IL-1β expression inhibitory and apoptotic inducing properties

Coêlho, Lucas Cunha Duarte, Cardoso, Marcos Veríssimo de Oliveira, Moreira, Diogo Rodrigo Magalhães, Gomes, Paulo André Teixeira de Moraes, Cavalcanti, Suellen Melo Tibúrcio, Oliveira, Arsenio Rodrigu

Journal:

Year:

2014

Language:

english

File:

PDF, 529 KB

english, 2014

14

Scaffold hopping of potential anti-tumor agents by WEGA: a shape-based approach

Ge, Hu, Wang, Yu, Zhao, Wenxia, Lin, Wei, Yan, Xin, Xu, Jun

Journal:

Year:

2014

Language:

english

File:

PDF, 467 KB

english, 2014

15

Selective inhibition of bacterial topoisomerase I by alkynyl-bisbenzimidazoles

Ranjan, Nihar, Fulcrand, Geraldine, King, Ada, Brown, Joseph, Jiang, Xiuping, Leng, Fenfei, Arya, Dev P.

Journal:

Year:

2014

Language:

english

File:

PDF, 534 KB

english, 2014

16

N1-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors

Journé, Anne-Sophie, Habib, Samy A. M., Dodda, Bala R., Morcos, Mina N. F., Sadek, Mirna S., Tadros, Sarah A. A., Witt-Enderby, Paula A., Jockers, Ralf, Zlotos, Darius P.

Journal:

Year:

2014

Language:

english

File:

PDF, 423 KB

english, 2014

17

Metabolism of a novel skepinone l-like p38 mitogen-activated protein kinase inhibitor

Storch, K., Gehringer, M., Baur, B., Laufer, S. A.

Journal:

Year:

2014

Language:

english

File:

PDF, 522 KB

english, 2014

18

Front cover

Journal:

Year:

2014

Language:

english

File:

PDF, 471 KB

english, 2014

19

Optimizing glucokinase activator binding kinetics to lower in vivo hypoglycemia risk

Borzilleri, Kris A., Pfefferkorn, Jeffrey A., Guzman-Perez, Angel, Liu, Shenping, Qiu, Xiayang, Chrunyk, Boris A., Song, Xi, Tu, Meihua, Filipski, Kevin J., Aiello, Robert, Derksen, David R., Bourbona

Journal:

Year:

2014

Language:

english

File:

PDF, 487 KB

english, 2014

20

Design, synthesis, and evaluation of 4- and 5-substituted o-(octanesulfonamido)benzoic acids as inhibitors of glycerol-3-phosphate acyltransferase

Outlaw, Victor K., Wydysh, Edward A., Vadlamudi, Aravinda, Medghalchi, Susan M., Townsend, Craig A.

Journal:

Year:

2014

Language:

english

File:

PDF, 411 KB

english, 2014

21

Discovery of small molecule inhibitors targeting the SUMO–SIM interaction using a protein interface consensus approach

Voet, Arnout R. D., Ito, Akihiro, Hirohama, Mikako, Matsuoka, Seiji, Tochio, Naoya, Kigawa, Takanori, Yoshida, Minoru, Zhang, Kam Y. J.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.44 MB

english, 2014

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