Volume 6; Issue 1

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MedChemComm
Volume 6; Issue 1

MedChemComm

Volume 6; Issue 1

1

Design, synthesis, and biological and docking studies of novel epipodophyllotoxin–chalcone hybrids as potential anticancer agents

Banday, Abid Hussain, Kulkarni, Vinod V., Hruby, Victor J.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.13 MB

english, 2015

2

Polypharmacology modelling using proteochemometrics (PCM): recent methodological developments, applications to target families, and future prospects

Cortés-Ciriano, Isidro, Ain, Qurrat Ul, Subramanian, Vigneshwari, Lenselink, Eelke B., Méndez-Lucio, Oscar, IJzerman, Adriaan P., Wohlfahrt, Gerd, Prusis, Peteris, Malliavin, Thérèse E., van Westen, G

Journal:

Year:

2015

Language:

english

File:

PDF, 4.59 MB

english, 2015

3

Synthesis and biological evaluation of a new class of quinazolinoneazoles as potential antimicrobial agents and their interactions with calf thymus DNA and human serum albumin

Peng, Li-Ping, Nagarajan, Sangaraiah, Rasheed, Syed, Zhou, Cheng-He

Journal:

Year:

2015

Language:

english

File:

PDF, 776 KB

english, 2015

4

A step forward in the sigma enigma: a role for chirality in the sigma1 receptor–ligand interaction?

Rossi, Daniela, Marra, Annamaria, Rui, Marta, Laurini, Erik, Fermeglia, Maurizio, Pricl, Sabrina, Schepmann, Dirk, Wuensch, Bernhard, Peviani, Marco, Curti, Daniela, Collina, Simona

Journal:

Year:

2015

Language:

english

File:

PDF, 1.13 MB

english, 2015

5

The status of the lysophosphatidic acid receptor type 1 (LPA 1 R)

González-Gil, Inés, Zian, Debora, Vázquez-Villa, Henar, Ortega-Gutiérrez, Silvia, López-Rodríguez, María L.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.71 MB

english, 2015

6

Rational design of protein–protein interaction inhibitors

Journal:

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

7

Synthesis of tetrazole compounds as a novel type of potential antimicrobial agents and their synergistic effects with clinical drugs and interactions with calf thymus DNA

Dai, Ling-Ling, Zhang, Hui-Zhen, Nagarajan, Sangaraiah, Rasheed, Syed, Zhou, Cheng-He

Journal:

Year:

2015

Language:

english

File:

PDF, 832 KB

english, 2015

8

Tetrazole regioisomers in the development of nitro group-containing antitubercular agents

Karabanovich, Galina, Roh, Jaroslav, Soukup, Ondřej, Pávková, Ivona, Pasdiorová, Markéta, Tambor, Vojtěch, Stolaříková, Jiřina, Vejsová, Marcela, Vávrová, Kateřina, Klimešová, Věra, Hrabálek, Alexandr

Journal:

Year:

2015

Language:

english

File:

PDF, 269 KB

english, 2015

9

Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitors

Chini, Maria Giovanna, Ferroni, Claudia, Cantone, Vincenza, Dambruoso, Paolo, Varchi, Greta, Pepe, Antonella, Fischer, Katrin, Pergola, Carlo, Werz, Oliver, Bruno, Ines, Riccio, Raffaele, Bifulco, Giu

Journal:

Year:

2015

Language:

english

File:

PDF, 3.60 MB

english, 2015

10

Computationally motivated synthesis and enzyme kinetic evaluation of N-(β- d -glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors

Begum, Jaida, Varga, Gergely, Docsa, Tibor, Gergely, Pál, Hayes, Joseph M., Juhász, László, Somsák, László

Journal:

Year:

2015

Language:

english

File:

PDF, 661 KB

english, 2015

11

Synthesis, structure–activity relationship, and mechanistic investigation of lithocholic acidamphiphiles for colon cancer therapy

Singh, Manish, Bansal, Sandhya, Kundu, Somanath, Bhargava, Priyanshu, Singh, Ashima, Motiani, Rajender K., Shyam, Radhey, Sreekanth, Vedagopuram, Sengupta, Sagar, Bajaj, Avinash

Journal:

Year:

2015

Language:

english

File:

PDF, 1.51 MB

english, 2015

12

Probing cytochrome P450-mediated activation with a truncated azinomycin analogue

Vinader, Victoria, Sadiq, Maria, Sutherland, Mark, Huang, Mengying, Loadman, Paul M., Elsalem, Lina, Shnyder, Steven D., Cui, Hongjuan, Afarinkia, Kamyar, Searcey, Mark, Patterson, Laurence H., Pors,

Journal:

Year:

2015

Language:

english

File:

PDF, 689 KB

english, 2015

13

Design, synthesis and biological evaluation of novel 1,2,4-triazolo and 1,2,4-triazino[4,3-a]quinoxalines as potential anticancer and antimicrobial agents

Issa, Doaa A. E., Habib, Nargues S., Abdel Wahab, Abeer E.

Journal:

Year:

2015

Language:

english

File:

PDF, 618 KB

english, 2015

14

8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential

Song, Yu'ning, Xu, Hao, Chen, Wenmin, Zhan, Peng, Liu, Xinyong

Journal:

Year:

2015

Language:

english

File:

PDF, 3.45 MB

english, 2015

15

Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation

Robinson, Elizabeth, Leung, Euphemia, Matuszek, Anna M., Krogsgaard-Larsen, Niels, Furkert, Daniel P., Brimble, Margaret A., Richardson, Alan, Reynisson, Jóhannes

Journal:

Year:

2015

Language:

english

File:

PDF, 679 KB

english, 2015

16

Synthesis of new betulinic acid–peptide conjugates and in vivo and in silico studies of the influence of peptide moieties on the triterpenoid core activity

Govdi, Anastasiya I., Sokolova, Nadezda V., Sorokina, Irina V., Baev, Dmitry S., Tolstikova, Tatyana G., Mamatyuk, Victor I., Fadeev, Dmitry S., Vasilevsky, Sergey F., Nenajdenko, Valentine G.

Journal:

Year:

2015

Language:

english

File:

PDF, 402 KB

english, 2015

17

3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: a family of antiproliferative thiazolidines

Önen-Bayram, F. Esra, Buran, Kerem, Durmaz, Irem, Berk, Barkin, Cetin-Atalay, Rengul

Journal:

Year:

2015

Language:

english

File:

PDF, 310 KB

english, 2015

18

Towards understanding cell penetration by stapled peptides

Chu, Qian, Moellering, Raymond E., Hilinski, Gerard J., Kim, Young-Woo, Grossmann, Tom N., Yeh, Johannes T.-H., Verdine, Gregory L.

Journal:

Year:

2015

Language:

english

File:

PDF, 974 KB

english, 2015

19

Sustained anti-BCR-ABL activity with pH responsive imatinib mesylate loaded PCL nanoparticles in CML cells

Cortese, Barbara, D'Amone, Stefania, Gigli, Giuseppe, Palamà, Ilaria Elena

Journal:

Year:

2015

Language:

english

File:

PDF, 1.40 MB

english, 2015

20

Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells

Tomašič, Tihomir, Nabergoj, Dominik, Vrbek, Sanja, Zidar, Nace, Jakopin, Žiga, Žula, Aleš, Hodnik, Žiga, Jukič, Marko, Anderluh, Marko, Ilaš, Janez, Dolenc, Marija Sollner, Peluso, Jean, Ubeaud-Séquie

Journal:

Year:

2015

Language:

english

File:

PDF, 646 KB

english, 2015

21

Discovery of mitochondria-targeting berberine derivatives as the inhibitors of proliferation, invasion and migration against rat C6 and human U87 glioma cells

Fu, Shengnan, Xie, Yanqi, Tuo, Jue, Wang, Yalong, Zhu, Wenbo, Wu, Sihan, Yan, Guangmei, Hu, Haiyan

Journal:

Year:

2015

Language:

english

File:

PDF, 2.70 MB

english, 2015

22

CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics

Nardon, Chiara, Boscutti, Giulia, Dalla Via, Lisa, Ringhieri, Paola, Di Noto, Vito, Morelli, Giancarlo, Accardo, Antonella, Fregona, Dolores

Journal:

Year:

2015

Language:

english

File:

PDF, 1.07 MB

english, 2015

23

Poly-α,β-aspartyl-Arg-Gly-Asp-Phe: a novel polymeric nanomedicine

Chen, Shuangling, Wang, Yuji, Li, Shan, Wang, Yaonan, Zhao, Ming, Zhu, Haimei, Wu, Jianhui, Peng, Shiqi

Journal:

Year:

2015

Language:

english

File:

PDF, 758 KB

english, 2015

24

Chemical space is big. Really big

Journal:

Year:

2015

Language:

english

File:

PDF, 149 KB

english, 2015

25

Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

Jardim, Guilherme A. M., Guimarães, Tiago T., Pinto, Maria do Carmo F. R., Cavalcanti, Bruno C., de Farias, Kaio M., Pessoa, Claudia, Gatto, Claudia C., Nair, Divya K., Namboothiri, Irishi N. N., da S

Journal:

Year:

2015

Language:

english

File:

PDF, 740 KB

english, 2015

26

Front cover

Journal:

Year:

2015

File:

PDF, 310 KB

2015

27

Inside front cover

Journal:

Year:

2015

File:

PDF, 332 KB

2015

28

Contents list

Journal:

Year:

2015

Language:

english

File:

PDF, 2.46 MB

english, 2015

29

Correction: Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

Wu, Jiang, Shin, Julia, Williams, Cara M. M., Geoghegan, Kieran F., Wright, Stephen W., Limburg, David C., Sahasrabudhe, Parag, Bonin, Paul D., Lefker, Bruce A., Ramsey, Simeon J.

Journal:

Year:

2015

Language:

english

File:

PDF, 146 KB

english, 2015

30

MedChemWatch Issue 22 and Back cover

Journal:

Year:

2015

Language:

english

File:

PDF, 5.51 MB

english, 2015

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