Volume 6; Issue 4

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MedChemComm
Volume 6; Issue 4

MedChemComm

Volume 6; Issue 4

1

3-(2,6-Dichloro-benzyloxy)-11-oxo-olean-12-ene-29-oic acid, a semisynthetic derivative of glycyrrhetic acid: synthesis, antiproliferative, apoptotic and anti-angiogenesis activity

Sharma, Rajni, Guru, Santosh K., Jain, Shreyans K., Pathania, Anup Singh, Vishwakarma, Ram A., Bhushan, Shashi, Bharate, Sandip B.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.38 MB

english, 2015

2

Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents

Chau, Bich Anh, Drummond, Grant, Jackson, W. Roy, Jarrott, Bevyn, Miller, Alyson A., Subasinghe, Kamani R., Tan, Christina Y. R., White, Paul J., Wright, Christine E., Ziogas, James

Journal:

Year:

2015

Language:

english

File:

PDF, 700 KB

english, 2015

3

Non-nucleoside anti-HBV agents: advances in structural optimization and mechanism of action investigations

Liu, Na, Zhao, Fabao, Jia, Haiyong, Rai, Diwakar, Zhan, Peng, Jiang, Xuemei, Liu, Xinyong

Journal:

Year:

2015

Language:

english

File:

PDF, 2.65 MB

english, 2015

4

Synthesis of 17-membered azalides from a 16-membered macrolide utilizing amide-selective silane reduction

Seki, Atsushi, Mori, Toshihiro, Sasaki, Kouji, Takahashi, Yoshiaki, Miyake, Toshiaki, Akamatsu, Yuzuru

Journal:

Year:

2015

Language:

english

File:

PDF, 1.14 MB

english, 2015

5

Identification of tris-(phenylalkyl)amines as new selective h5-HT 2B receptor antagonists

Ponnala, Shashikanth, Kapadia, Nirav, Harding, Wayne Wesley

Journal:

Year:

2015

Language:

english

File:

PDF, 778 KB

english, 2015

6

Inhibition of influenza H5N1 invasion by modified heparin derivatives

Skidmore, Mark A., Kajaste-Rudnitski, Anna, Wells, Nicola M., Guimond, Scott E., Rudd, Timothy R., Yates, Edwin A., Vicenzi, Elisa

Journal:

Year:

2015

Language:

english

File:

PDF, 964 KB

english, 2015

7

A solid- and solution-phase-based library of 2β-methyl substituted penicillin derivatives and their effects on growth inhibition of tumor cell lines

Boggián, Dora B., Cornier, Patricia G., Mata, Ernesto G., Blank, Viviana C., Cárdenas, Mariano G., Roguin, Leonor P.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.86 MB

english, 2015

8

Discovery of highly potent triazole antifungal agents with piperidine-oxadiazole side chains

He, Xiaomeng, Jiang, Yan, Zhang, Yongqiang, Wu, Shanchao, Dong, Guoqiang, Liu, Na, Liu, Yang, Yao, Jianzhong, Miao, Zhenyuan, Wang, Yan, Zhang, Wannian, Sheng, Chunquan

Journal:

Year:

2015

Language:

english

File:

PDF, 1.25 MB

english, 2015

9

Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α 1 and 5-HT 1A receptor ligand: an in vitro and computational study

Franchini, Silvia, Baraldi, Annamaria, Sorbi, Claudia, Pellati, Federica, Cichero, Elena, Battisti, Umberto M., Angeli, Piero, Cilia, Antonio, Brasili, Livio

Journal:

Year:

2015

Language:

english

File:

PDF, 2.30 MB

english, 2015

10

Synthesis and evaluation of 6-methylcoumarin derivatives as potent and selective monoamine oxidase B inhibitors

Lan, Jin-Shuai, Pan, Long-Fei, Xie, Sai-Sai, Wang, Xiao-Bing, Kong, Ling-Yi

Journal:

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

11

Cytotoxic potential of dispirooxindolo/acenaphthoquino andrographolide derivatives against MCF-7 cell line

Chakraborty, Debanjana, Maity, Arindam, Jain, Chetan K., Hazra, Abhijit, Bharitkar, Yogesh P., Jha, Tarun, Majumder, Hemanta K., Roychoudhury, Susanta, Mondal, Nirup B.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.09 MB

english, 2015

12

Activity-based probes as molecular tools for biomarker discovery

Carvalho, L. A. R., Ruivo, E. F. P., Lucas, S. D., Moreira, R.

Journal:

Year:

2015

Language:

english

File:

PDF, 996 KB

english, 2015

13

Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group

Li, Youxuan, Woster, Patrick M.

Journal:

Year:

2015

Language:

english

File:

PDF, 3.32 MB

english, 2015

14

Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells

Rodriguez, Veronica, Valente, Sergio, Rovida, Stefano, Rotili, Dante, Stazi, Giulia, Lucidi, Alessia, Ciossani, Giuseppe, Mattevi, Andrea, Botrugno, Oronza A., Dessanti, Paola, Mercurio, Ciro, Vianell

Journal:

Year:

2015

Language:

english

File:

PDF, 957 KB

english, 2015

15

Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus

Zhao, Xin, Zhang, Zhen-Wei, Cui, Wei, Chen, Shengwei, Zhou, Yang, Dong, Jianghong, Jie, Yanling, Wan, Junting, Xu, Yong, Hu, Wenhui

Journal:

Year:

2015

Language:

english

File:

PDF, 845 KB

english, 2015

16

Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors

Yang, Liuqing, Liu, Wei, Mei, Hanbing, Zhang, Yuan, Yu, Xiaojuan, Xu, Yufang, Li, Honglin, Huang, Jin, Zhao, Zhenjiang

Journal:

Year:

2015

Language:

english

File:

PDF, 1.11 MB

english, 2015

17

Design, synthesis and biological activity of 4′-[(benzimidazol-1-yl)methyl]biphenyl-2-sulphonamides as dual angiotensin II and endothelin A receptor antagonists

Hao, Li-Ping, Xue, Wei-Zhe, Han, Xiao-Feng, He, Xing, Zhang, Jun, Zhou, Zhi-Ming

Journal:

Year:

2015

Language:

english

File:

PDF, 1.25 MB

english, 2015

18

The chemistry and pharmacology of privileged pyrroloquinazolines

Chao, Bo, Li, Bingbing X., Xiao, Xiangshu

Journal:

Year:

2015

Language:

english

File:

PDF, 1022 KB

english, 2015

19

Structure-based design, synthesis by click chemistry and in vivo activity of highly selective A 3 adenosine receptor agonists

Tosh, Dilip K., Paoletta, Silvia, Chen, Zhoumou, Crane, Steven, Lloyd, John, Gao, Zhan-Guo, Gizewski, Elizabeth T., Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.

Journal:

Year:

2015

Language:

english

File:

PDF, 5.44 MB

english, 2015

20

O-Benzoyl pyridine aldoxime and amidoxime derivatives: novel efficient DNA photo-cleavage agents

Karamtzioti, Paraskevi, Papastergiou, Asterios, Stefanakis, John G., Koumbis, Alexandros E., Anastasiou, Ioanna, Koffa, Maria, Fylaktakidou, Konstantina C.

Journal:

Year:

2015

Language:

english

File:

PDF, 578 KB

english, 2015

21

Dimethylaminoethyl methacrylate copolymer-siRNA nanoparticles for silencing a therapeutically relevant gene in macrophages

Jain, Ratnesh, Dandekar, Prajakta, Loretz, Brigitta, Koch, Marcus, Lehr, Claus-Michael

Journal:

Year:

2015

Language:

english

File:

PDF, 2.73 MB

english, 2015

22

The natural product brartemicin is a high affinity ligand for the carbohydrate-recognition domain of the macrophage receptor mincle

Jacobsen, Kristian M., Keiding, Ulrik B., Clement, Lise L., Schaffert, Eva S., Rambaruth, Neela D. S., Johannsen, Mogens, Drickamer, Kurt, Poulsen, Thomas B.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.82 MB

english, 2015

23

Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides

Klečka, Martin, Slavětínská, Lenka Poštová, Tloušťová, Eva, Džubák, Petr, Hajdúch, Marián, Hocek, Michal

Journal:

Year:

2015

Language:

english

File:

PDF, 900 KB

english, 2015

24

Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands

Rossi, Daniela, Talman, Virpi, Gennäs, Gustav Boije Af, Marra, Annamaria, Picconi, Pietro, Nasti, Rita, Serra, Massimo, Ann, Jihyae, Amadio, Marialaura, Pascale, Alessia, Tuominen, Raimo K., Yli-Kauha

Journal:

Year:

2015

Language:

english

File:

PDF, 3.53 MB

english, 2015

25

Relating Caco-2 permeability to molecular properties using block relevance analysis

Potter, T., Ermondi, G., Newbury, G., Caron, G.

Journal:

Year:

2015

Language:

english

File:

PDF, 1022 KB

english, 2015

26

Enhancement of exon skipping in mdx52 mice by 2′-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides

Masaki, Yoshiaki, Inde, Takeshi, Nagata, Tetsuya, Tanihata, Jun, Kanamori, Takashi, Seio, Kohji, Takeda, Shin'ichi, Sekine, Mitsuo

Journal:

Year:

2015

Language:

english

File:

PDF, 746 KB

english, 2015

27

Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats

Olberg, Dag Erlend, Hausner, Sven H., Bauer, Nadine, Klaveness, Jo, Indrevoll, Bård, Andressen, Kjetil Wessel, Dahl, Marie, Levy, Finn Olav, Sutcliffe, Julie L., Haraldsen, Ira

Journal:

Year:

2015

Language:

english

File:

PDF, 1.86 MB

english, 2015

28

Correction: Identification of tris-(phenylalkyl)amines as new selective h5-HT 2B receptor antagonists

Ponnala, Shashikanth, Kapadia, Nirav, Harding, Wayne Wesley

Journal:

Year:

2015

Language:

english

File:

PDF, 121 KB

english, 2015

29

Back cover

Journal:

Year:

2015

File:

PDF, 3.69 MB

2015

30

Synthesis and relationship of stability and biological activity of new DSS and TMP conjugates

Sun, Yewei, Tan, Zicheng, Liang, Zhibin, Wang, Liang, Shan, Luchen, Yu, Pei, Lee, Simon MingYuen, Wang, Yuqiang

Journal:

Year:

2015

Language:

english

File:

PDF, 1.36 MB

english, 2015

31

Front cover

Journal:

Year:

2015

File:

PDF, 965 KB

2015

32

Interactive articles in MedChemComm – connecting readers to a wealth of data and information

Journal:

Year:

2015

Language:

english

File:

PDF, 1.40 MB

english, 2015

33

Tantalising technology

Journal:

Year:

2015

Language:

english

File:

PDF, 116 KB

english, 2015

34

Inside front cover

Journal:

Year:

2015

File:

PDF, 947 KB

2015

35

Contents list

Journal:

Year:

2015

Language:

english

File:

PDF, 5.24 MB

english, 2015