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Volume 23; Issue 6

Medicinal Chemistry Research

Volume 23; Issue 6

1

Synthesis, characterization, and antibacterial activities of some novelN,N′-disubstituted thiourea, 2-amino thiazole, and imidazole-2-thione derivatives

Kalhor, Mehdi, Salehifar, Mina, Nikokar, Iraj

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 346 KB

english, 2014

2

Vanillin derivatives as the selective small molecule inhibitors of FtsZ

Sun, Juan, Li, Ming-Hui, Wang, Xin-Yi, Zhang, Yang, Yuan, Rong-Ju, Liu, Han-Yu, Zhu, Hai-Liang

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 485 KB

english, 2014

3

Synthesis and biological evaluation of 1-cyano-2-amino-benzimidazole derivatives as a novel class of antitumor agents

Hu, Zhang, Ou, Lili, Li, Sidong, Yang, Lei

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 919 KB

english, 2014

4

Synthesis and pharmacological evaluation of novel thienopyrimidine and triazolothienopyrimidine derivatives

Mulla, Jameel Ahmed S., Khazi, Mohammed Iqbal A., Panchamukhi, Shridhar I., Gong, Young-Dae, Khazi, Imtiyaz Ahmed M.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 351 KB

english, 2014

5

Synthesis, structure, and in vitro anticancer activity of new polycyclic 1,2-diazines

Mantu, Dorina, Maftei, Dan, Iurea, Dorina, Ursu, Cornelia, Bejan, Vasilichia

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 519 KB

english, 2014

6

QSAR study of mGlu5 inhibitors by genetic algorithm-multiple linear regressions

Pourbasheer, Eslam, Aalizadeh, Reza, Ganjali, Mohammad Reza, Norouzi, Parviz, Banaei, Alireza

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 448 KB

english, 2014

7

Effect of two series of isoindolines over HDAC8 activity and expression

Trejo Muñoz, Cynthia R., Jiménez, Elvia Mera, Pinto-Almazán, Rodolfo, Gandarilla, José Alfredo Díaz, Correa-Basurto, José, Trujillo-Ferrara, José G., Guerra-Araiza, Christian, Rohana, Patricia Talamás

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 494 KB

english, 2014

8

Synthesis, in vitro anticancer activity and in silico study of new disubstituted thiazolidinedione derivatives

Rêgo, Moacyr Jesus Barreto de Melo, Galdino-Pitta, Marina Rocha, Pereira, Daniel Tarciso Martins, da Silva, Juliana Cruz, Rabello, Marcelo Montenegro, Alves de Lima, Maria do Carmo, Hernandes, Marcelo

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 518 KB

english, 2014

9

Synthesis of 1-benzhydryl piperazine derivatives and evaluation of their ACE inhibition and antimicrobial activities

Santhoshi, Amlipur, Kumar, Singam Naveen, Sujitha, Pombala, Poornachandra, Yedla, Sadhu, Partha Sarathi, Kumar, C. Ganesh, Rao, Vaidya Jayathirtha

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

10

Molecular docking studies onN-hydroxyindole derivatives as potent inhibitors of human lactate dehydrogenase isoform 5 against cancer cell proliferation

Choudhury, Manisha

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 555 KB

english, 2014

11

Studies on the synthesis, in vitro antitumor activity of 4H-benzo[h]chromene, 7H-benzo[h]chromene[2,3-d]pyrimidine derivatives and structure–activity relationships of the 2-,3- and 2,3-positions

El-Agrody, Ahmed M., Fouda, Ahmed M., Al-Dies, Al-Anood M.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 621 KB

english, 2014

12

Synthesis, in vitro and in vivo giardicidal activity, and pharmacokinetic profile of a new nitazoxanide analog

Valladares-Méndez, Adriana, Hernández-Núñez, Emanuel, Cedillo-Rivera, Roberto, Moo-Puc, Rosa, Barbosa-Cabrera, Elizabeth, Orozco-Castellanos, Luis M., Rivera-Leyva, Julio C., Navarrete-Vázquez, Gabrie

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 367 KB

english, 2014

13

Synthesis and structure–activity relationship of nuciferine derivatives as potential acetylcholinesterase inhibitors

Yang, Zhongduo, Song, Zhuwen, Xue, Weiwei, Sheng, Jie, Shu, Zongmei, Shi, Yin, Liang, Jibei, Yao, Xiaojun

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 632 KB

english, 2014

14

Synthesis of progesterone derivatives and evaluation of their efficiency as pneumococcal vaccines

Mohareb, Rafat M., Al Farouk, Fatma O., Sherif, Sherif M., Karaghiosoff, Konstantin

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 406 KB

english, 2014

15

Microwave-assisted synthesis of some hybrid molecules containing penicillanic acid or cephalosporanic acid moieties and investigation of their biological activities

Basoglu, Serap, Ulker, Serdar, Alpay-Karaoglu, Sengul, Demirbas, Neslihan

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 433 KB

english, 2014

16

Synthesis of 5-arylidine amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamides endowed with potent antioxidants and anticancer activity induces growth inhibition in HEK293, BT474 and NCI-H226 cells

Chhajed, Mahavir, Shrivastava, Anil Kumar, Taile, Vijay

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 451 KB

english, 2014

17

Development of amino acid conjugated sulfonamides as potent antiulcer agent

Sahoo, Shakti Prasanna, Subudhi, Bharat Bhusan

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 582 KB

english, 2014

18

New 6-bromoimidazo[1,2-a]pyridine-2-carbohydrazide derivatives: synthesis and anticonvulsant studies

Ulloora, Shrikanth, Shabaraya, Ramakrishna, Adhikari, Airody Vasudeva

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 314 KB

english, 2014

19

Microwave-assisted synthesis of novel 1,2,3-triazole derivatives and their antimicrobial activity

Ashok, D., Mohan Gandhi, D., Srinivas, G., Vikas Kumar, A.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 401 KB

english, 2014

20

Synthesis of azabicyclo[4.2.0]octa-1,3,5-trien-8-one analogues of 1H-imidazo[4,5-c]quinoline and evaluation of their antimicrobial and anticancer activities

Kayarmar, Reshma, Nagaraja, G. K., Bhat, Manjunath, Naik, Prashantha, Rajesh, K. P., Shetty, Suchetha, Arulmoli, T.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 491 KB

english, 2014

21

Synthesis, characterization of 4,6-disubstituted aminopyrimidines and their sulphonamide derivatives as anti-amoebic agents

Siddiqui, Shadab Miyan, Azam, Amir

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 422 KB

english, 2014

22

3D QSAR study of 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives as potential anti-mycobacterial agents

Patel, Paresh, Chintha, Chetan, Ghate, Manjunath, Bhatt, Hardik, Vyas, Vivek K.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 651 KB

english, 2014

23

Synthesis, molecular docking and antiviral screening of novelN′-substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazides

Aslam, Sana, Ahmad, Matloob, Athar, Muhammad Makshoof, Ashfaq, Usman Ali, Gardiner, John M., Montero, Catherine, Detorio, Mervi, Parvez, Masood, Schinazi, Raymond F.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 714 KB

english, 2014

24

Synthesis and antioxidant activity of amido-linked benzoxazolyl/benzothiazolyl/benzimidazolyl-pyrroles and pyrazoles

Durgamma, Suram, Muralikrishna, Akkarapalli, Padmavathi, Venkatapuram, Padmaja, Adivireddy

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 516 KB

english, 2014

25

Synthesis and antimicrobial screening of some novel chalcones and flavanones substituted with higher alkyl chains

Mallavadhani, Uppuluri Venkata, Sahoo, Laxmidhar, Kumar, Koochana Pranay, Murty, Upadyayula Suryanarayana

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 550 KB

english, 2014

26

Homology modeling of lanosterol 14α-demethylase ofCandida albicansand insights into azole binding

Iman, Maryam, Davood, Asghar

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 1012 KB

english, 2014

27

Synthesis and in vitro cytotoxicity study of 3-(1H-indol-3-yl)-1,3-diphenylpropan-1-ones

Masagalli, Jagadeesh N., Mahadevan, Kittappa M., Jayadevappa, Honnali, Harishkumar, Hosanagara N., Ganalu, Rajesha, Nagaraja, Prashantha

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 632 KB

english, 2014

28

Synthesis, anti-inflammatory and analgesic activities of arylidene-2-(3-chloroanilino)nicotinic acid hydrazides

Navidpour, Latifeh, Shafaroodi, Hamed, Saeedi-Motahar, Ghazaleh, Shafiee, Abbas

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 460 KB

english, 2014

29

Identification of neuraminidase inhibitors by structure-based screening: promising new leads for influenza

Bhakat, Soumendranath, Shaikh, Faraz, Yadav, Siddharth, Rawal, Rakesh M.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 686 KB

english, 2014

30

Synthesis and anticonvulsant evaluation of some new 1,3,4,5-tetrahydro-6-alkoxy-2H-1-benzazepin-2-one derivatives

Han, Rong-Bi, Shao, Yun-Peng, Wu, Hui-Fan, Zhang, Duo, Piao, Feng-Yu

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 482 KB

english, 2014

31

Synthesis, anti-inflammatory evaluation, and docking studies of some new thiazole derivatives

Deb, Pran Kishore, Kaur, Rajwinder, Chandrasekaran, Balakumar, Bala, Madhu, Gill, Dilshad, Kaki, Venkat Rao, Akkinepalli, Raghuram Rao, Mailavaram, Raghuprasad

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 977 KB

english, 2014

32

In vitro cytotoxicity, α-glucosidase inhibition, antioxidant, and free radical scavenging activities ofIllicium griffithiiHook. f. & Thoms fruits

Vijayakumar, A., Jeyaraj, B., Karunai Raj, M., Nimal Christhudas, I. V. S., Balachandran, C., Agastian, P., Ignacimuthu, S.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 700 KB

english, 2014

33

Predictive 3D-QSAR and HQSAR model generation of isocitrate lyase (ICL) inhibitors by various alignment methods combined with docking study

Gupta, Nirzari, Vyas, Vivek K., Patel, Bhumika, Ghate, Manjunath

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 788 KB

english, 2014

34

Prediction of glucagon receptor antagonist activities of some substituted imidazoles using combined radial basis function neural network and density functional theory

Shahlaei, Mohsen, Nazari, Zohreh

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 640 KB

english, 2014

35

Synthesis and antiseizure evaluation of isoindoline-1,3-dione derivatives in mice

Aliabadi, Alireza, Gholamine, Babak, Karimi, Tahereh

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 329 KB

english, 2014

36

Synthesis, molecular docking studies, and in vitro screening of barbiturates/thiobarbiturates as antibacterial and cholinesterase inhibitors

Mumtaz, Saira, Hussain, Rashad, Rauf, Abdul, Fatmi, M. Q., Bokhari, H., Oelgemöller, M., Qureshi, A. M.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 1.02 MB

english, 2014

37

Facile synthesis of novel quinoline derivatives as anticancer agents

Marganakop, Sheetal Babu, Kamble, Ravindra Ramappa, Hoskeri, Joy, Prasad, D. Jagadish, Meti, Gangadhar Yamanappa

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 526 KB

english, 2014

38

In silico accounting of novel pyridazine analogues as h-PTP 1B inhibitors: pharmacophore modelling, atom-based 3D QSAR and docking studies

Mahapatra, Manoj Kumar, Kumar, Rajnish, Malla, Priyanka, Kumar, Manoj

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 741 KB

english, 2014

39

A new trypsin inhibitory phthalic acid ester fromHeliotropium strigosum

Shah, Syed Majid, Shah, Azhar-ul-Haq Ali, Ullah, Farhat, Hussain, Sajid, Khan, Sher Bahadar, Asiri, Abdullah M., Ahmad, Shabir, Khan, Hidayatullah, Farooq, Umar

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 239 KB

english, 2014

40

New azetidine-3-carbonyl-N-methyl-hydrazino derivatives of fluoroquinolones: synthesis and evaluation of antibacterial and anticancer properties

Rajulu, G. Govinda, Naik, Halehatty S. Bhojya, Kumar, G. Charan, Ramaraj, S., Sambasivam, Ganesh, Koppolu, Kesavan Poonimangadu

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 515 KB

english, 2014

41

A comparative molecular dynamics simulation study to assess the exclusion ability of novel GSK3β inhibitors

Hanumanthappa, Pradeep, Krishnamurthy, Rajanikant G.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 684 KB

english, 2014

42

Structural findings of quinolone carboxylic acids in cytotoxic, antiviral, and anti-HIV-1 integrase activity through validated comparative molecular modeling studies

Adhikari, Nilanjan, Halder, Amit Kumar, Mondal, Chanchal, Jha, Tarun

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 7.37 MB

english, 2014

43

Synthesis and biological evaluation of amino acid-linked 1,2,3-bistriazole conjugates as potential antimicrobial agents

Kaushik, C. P., Lal, Kashmiri, Kumar, Ashwani, Kumar, Sunil

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 757 KB

english, 2014

44

3D-QSAR study using CoMFA and CoMSIA methods for a series of histone H3 phosphorylation inhibitors

Rao, Guo-Wu, Hu, Cheng-Hai, Ni, Jia-Bin, Wang, Jian, Wang, Cui, Wang, Bing-Lan

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 876 KB

english, 2014

45

Type II diabetes-related enzyme inhibition and molecular modeling study of a novel series of pyrazolone derivatives

Shetty, Shobhitha, Kalluraya, Balakrishna, Nithinchandra,, Peethambar, S. K., Telkar, Sandeep B.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 858 KB

english, 2014

46

Pancreatic α-amylase inhibition and free radical scavenging activity of substituted pyranochromenone derivatives

Ashok Kumar, J., Tiwari, Ashok K., Saidachary, G., Kishor, Chandan, Kumar, D. Anand, Ali, Zehra, Sridhar, B., Addlagatta, Anthony, Raju, B. China

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 1.52 MB

english, 2014

47

Curcumin as inhibitor of mammalian Cathepsin B, Cathepsin H, acid phosphatase and alkaline phosphatase: a correlation with pharmacological activities

Ravish, Indu, Raghav, Neera

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 977 KB

english, 2014

48

Studies on the inhibitory models of pyrazoline derivatives as EGFR kinase inhibitors by 3D-QSAR and molecular docking

Li, Peizhen, Tian, Yueli, Zhai, Honglin, Deng, Fangfang, Xie, Meihong, Zhang, Xiaoyun

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 3.05 MB

english, 2014

49

Synthesis, antimicrobial, and antioxidant activity of benzofuran barbitone and benzofuran thiobarbitone derivatives

Kenchappa, R., Bodke, Yadav D., Asha, B., Telkar, Sandeep, Aruna Sindhe, M.

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 4.51 MB

english, 2014

50

Coumarin-containing aminophosphonates bridged with chiral side chain: synthesis and influence of chirality on cytotoxicity and DNA binding

Li, Ya-Jun, Ye, Man-Yi, Huang, Ri-Zhen, Yao, Gui-Yang, Pan, Ying-Ming, Liao, Zhi-Xin, Wang, Heng-Shan

Journal:

Medicinal Chemistry Research

Year:

2014

Language:

english

File:

PDF, 890 KB

english, 2014