Volume 24; Issue 4

Medicinal Chemistry Research

Volume 24; Issue 4

1

Synthesis and antitumor activity of 4-cyclohexyl/aryl-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones

Bhat, Mashooq Ahmad, Al-Omar, Mohamed A., Naglah, Ahmed M., Abdulla, Mohamed M., Fun, Hoong-Kun

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 586 KB

english, 2015

2

Prospective study directed to the synthesis of unsymmetrical linked bis-5-arylidene rhodanine derivatives via “one-pot two steps” reactions under microwave irradiation with their antitumor activity

Coulibaly, Wacothon Karime, Paquin, Ludovic, Bénie, Anoubilé, Békro, Yves-Alain, Le Guével, Rémy, Ravache, Myriam, Corlu, Anne, Bazureau, Jean Pierre

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 481 KB

english, 2015

3

Synthesis, characterization, and POM analysis of novel bioactive imidazolium-based ionic liquids

Messali, Mouslim, Aouad, Mohamed R., Ali, Adeeb A.-S., Rezki, Nadjet, Ben Hadda, Taibi, Hammouti, Belkheir

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 832 KB

english, 2015

4

QSAR and docking studies of some 1,2,3,4-tetrahydropyrimidines: evaluation of gp41 as possible target for anti-HIV-1 activity

Sepehri, Saghi, Gharagani, Sajjad, Saghaie, Lotfollah, Aghasadeghi, Mohammad R., Fassihi, Afshin

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 1.69 MB

english, 2015

5

Triterpenic and monoterpenic esters from stems ofIchnocarpus frutescensand their drug likeness potential

Aggarwal, Babita, Singla, Rajeev K., Ali, Mohd., Singh, Vijender, Igoli, John O., Gundamaraju, Rohit, Kim, Kah Hwi

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 943 KB

english, 2015

6

Evaluation of newly synthesized quinazolinone derivatives of hydrazones as potent anti-inflammatory and antibacterial agents

Kandpal, Bhavna, Meshram, Jyotsna, Mohanram, Ipsita, Shaikh, Ambareen

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 302 KB

english, 2015

7

LC-MS guided isolation of antibacterial and cytotoxic constituents fromClausena anisata

Tatsimo, Simplice Joel Ndendoung, Tamokou, Jean-De-Dieu, Lamshöft, Marc, Mouafo, Ferdinand Talontsi, Lannang, Alain Meli, Sarkar, Prodipta, Bag, Prasanta Kumar, Spiteller, Michael

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 463 KB

english, 2015

8

Modification of 3,5-bis(arylidene)-4-piperidone pharmacophore by phosphonate group using 1,2,3-triazole cycle as a linker for the synthesis of new cytostatics

Makarov, Mikhail V., Rybalkina, Ekaterina Yu., Khrustalev, Victor N., Röschenthaler, Gerd-Volker

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 390 KB

english, 2015

9

Triarylimidazoles-synthesis of 3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives as potent α-glucosidase inhibitors

Naureen, Sadia, Noreen, Shazia, Nazeer, Areesha, Ashraf, Muhammad, Alam, Umber, Munawar, Munawar Ali, Khan, Misbahul Ain

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 556 KB

english, 2015

10

Synthesis, X-ray characterization and biological evaluation of some new 2-(4-methy-2-oxo-2H-chromen-7yloxy) acetamide derivatives

Diwakar, Bhagavathula S., Govindh, B., Nagendra Sastry, Y., Kaladhar, D. S. V. G. K., Murthy, Y. L. N.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 962 KB

english, 2015

11

Protective effect ofPelargonium graveolensagainst carbon tetrachloride-induced hepatotoxicity in mice and characterization of its bioactive constituents by HPLC–PDA–ESI–MS/MS analysis

Al-Sayed, Eman, Martiskainen, Olli, Seif el-Din, Sayed H., Sabra, Abdel-Nasser A., Hammam, Olfat A., El-Lakkany, Naglaa M.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

12

Synthesis, spectroscopic characterization, analgesic, and antimicrobial activities of Co(II), Ni(II), and Cu(II) complexes of 2-[N,N-bis-(3,5-dimethyl-pyrazolyl-1- methyl)]aminothiazole

Kalanithi, M., Rajarajan, M., Tharmaraj, P., Johnson Raja, S.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 369 KB

english, 2015

13

An efficient synthesis and antimicrobial screening of new hybrid molecules containing coumarin and indenopyridine moiety

Brahmbhatt, Dinkar I., Patel, Chirag V., Bhila, Varun G., Patel, Niraj H., Patel, Apoorva A.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 404 KB

english, 2015

14

Synthesis and anti-proliferative activity evaluation of sorafenib derivatives with a 3-arylacryloyl hydrazide unit

Zhang, Lijing, Li, Yan, Wang, Ke, Qin, Aifang, Chen, Xiaoguang, Feng, Zhiqiang

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 550 KB

english, 2015

15

Microwave-assisted synthesis of substituted 4-chloro-8-methyl-2-phenyl-1,5-dioxa-2H-phenanthren-6-ones and their antimicrobial activity

Ashok, D., Vijaya Lakshmi, B., Ravi, S., Ganesh, A.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 765 KB

english, 2015

16

Synthesis and biological evaluation of novel indolo[2,3-c]isoquinoline derivatives

Saundane, Anand R., Kalpana, R.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 501 KB

english, 2015

17

Two- and three-dimensional quantitative structure–permeability relationship of flavonoids in Caco-2 cells using stepwise multiple linear regression (SMLR), partial least squares regression (PLSR), and pharmacophore (GALAHAD)-based comparative molecular similarity index analysis (COMSIA)

Gonzales, Gerard Bryan, Van Camp, John, Zotti, Moises, Kobayashi, Vladimer, Grootaert, Charlotte, Raes, Katleen, Smagghe, Guy

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 995 KB

english, 2015

18

Design, synthesis and antidepressant activities of some novel fatty acid analogues

Jubie, Selvaraj, Dhanabal, Palaniswamy, Azam, Mohammed Afzal, Kumar, Natarajan Satish, Ambhore, Nilesh, Kalirajan, Rajagopal

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 677 KB

english, 2015

19

Antimalarial activity of novel imidazoisoquinolinone derivatives correlates with heme binding affinity

Bollini, Mariela, Casal, Juan J., Asís, Silvia E., Leal, Emilse S., Bruno, Ana M.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 1.07 MB

english, 2015

20

Antibacterial potential of selected 4-phenyl hydroxycoumarins: integrated in vitro and molecular docking studies

Veselinović, Jovana B., Veselinović, Aleksandar M., Nikolić, Goran M., Pešić, Srđan Z., Stojanović, Dušica B., Matejić, Jelena S., Mihajilov-Krstev, Tatjana M.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 1.48 MB

english, 2015

21

Amino- and fluoro-substituted quinoline-4-carboxylic acid derivatives: MWI synthesis, cytotoxic activity, apoptotic DNA fragmentation and molecular docking studies

Bhatt, Hardik G., Agrawal, Yadvendra K., Patel, Manish J.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 677 KB

english, 2015

22

The SAR studies on FAP inhibitors as tumor-targeted agents

Xu, Jun, Huang, Sichao, Zhang, Tiantian, Wu, Nong, Kang, Hongjun, Cai, Shaohui, Shen, Weizai

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 1.86 MB

english, 2015

23

Synthesis of quinoline/naphthalene-containing azaphenothiazines and their potent in vitro antioxidant properties

Jeleń, Małgorzata, Bavavea, Eugenia I., Pappa, Maria, Kourounakis, Angeliki P., Morak-Młodawska, Beata, Pluta, Krystian

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 628 KB

english, 2015

24

Hybrid pharmacophore-based drug design, synthesis, and antiproliferative activity of 1,4-dihydropyridines-linked alkylating anticancer agents

Singh, Rajesh K., Prasad, D. N., Bhardwaj, T. R.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 491 KB

english, 2015

25

Synthesis and selected immunological properties of 10-substituted 1,8-diazaphenothiazines

Morak-Młodawska, Beata, Pluta, Krystian, Zimecki, Michał, Jeleń, Małgorzata, Artym, Jolanta, Kocięba, Maja

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 669 KB

english, 2015

26

Moisture stable heteroleptic titanium (IV) complexes derived from 8-hydroxyquinoline: synthesis, antibacterial, and antifungal studies

Samuel, Blassan, Ethiraj, K. R., Pathak, Madhvesh

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 768 KB

english, 2015

27

Molecular modeling and correlation of PFI1625c-peptide models of bioactive peptides with antimalarial properties

Lhouvum, Kimjolly, Bhuyar, Kshitij Shekhar, Trivedi, Vishal

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 700 KB

english, 2015

28

Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Chung, Po-Yee, Gambari, Roberto, Chen, Yi-Xin, Cheng, Chor-Hing, Bian, Zhao-Xiang, Chan, Albert Sun-Chi, Tang, Johnny Cheuk-On, Leung, Polly Hang-Mei, Chui, Chung-Hin, Lam, Kim-Hung

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 1021 KB

english, 2015

29

Indolyl linkedmeta-substituted benzylidene-based novel PPAR ligands: synthetic and docking studies

Verma, Raman K., Mall, Rajiv, Singh, Amanjot

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 1.06 MB

english, 2015

30

Computational identification of JAK2 inhibitors: a combined pharmacophore mapping and molecular docking approach

Sathe, Rohit Y., Kulkarni, Seema A., Sella, Raja Natesan, Madhavan, Thirumurthy

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 2.26 MB

english, 2015

31

Combination therapy with p53–MDM2 binding inhibitors for malignancies

Jin, Zegao, Shen, Jianfeng, He, Jingyao, Hu, Chunqi

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 657 KB

english, 2015

32

A review of new approaches in Her-2 targeting and1H MRI application

Bartusik, Dorota, Aebisher, David, Tomanek, Boguslaw

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 203 KB

english, 2015

33

Design, synthesis, and evaluation of dihydropyrimidinone (DHPM) based muscarinic receptor antagonist

Acharya, Badri N., Rao, G. B. Dharma, Kumar, Deo, Kumar, Pravin, Kaushik, Mahabir P.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 2.85 MB

english, 2015

34

Biological evaluation of synthetic chalcone and flavone derivatives as anti-inflammatory agents

Mateeva, Nelly, Gangapuram, Madhavi, Mazzio, Elizabeth, Eyunni, Suresh, Soliman, Karam F. A., Redda, Kinfe K.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 1.48 MB

english, 2015

35

Anticancer activity of some newly synthesized pyrano[2,3-d][1,2,3]triazine derivatives using 1-(7-hydroxy-2,2-dimethylchroman-6-yl)ethanone as synthon

Ouf, Nabil H., Amr, Abd El-Galil E., Sakran, Mohamed I.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 424 KB

english, 2015

36

Synthesis and evaluation of mefway analogs as ligands for serotonin 5HT1Areceptors

Thio, Joanne P., Liang, Christopher, Bajwa, Alisha K., Wooten, Dustin W., Christian, Bradley T., Mukherjee, Jogeshwar

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 358 KB

english, 2015

37

A new open source data analysis python script for QSAR study and its validation

Kurdekar, Vadiraj, Jadhav, Hemant R.

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 748 KB

english, 2015

38

Antiproliferative and apoptosis inducing effect of essential oil extracted fromCyrtomium fortumei(J.) Smith leaves

Yang, Shengjie, Liu, Mingchuan, Zhao, Qi, Zhao, Hongju, Xue, Wei, Yang, Song

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 3.04 MB

english, 2015

39

Design, synthesis, and Gaussia luciferase Assay of triorganotin(IV)-based HCV inhibitors

Shah, Farooq Ali, Fatima, Kaneez, Sabir, Shaista, Ali, Saqib, Fischer, Andreas, Qadri, Mohammad Ishtiaq

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 1.23 MB

english, 2015

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