Volume 10; Issue 4

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ACS Chemical Biology
Volume 10; Issue 4

ACS Chemical Biology

Volume 10; Issue 4

1

Identification of Potent Phosphodiesterase Inhibitors that Demonstrate Cyclic Nucleotide-Dependent Functions in Apicomplexan Parasites

Howard, Brittany L., Harvey, Katherine L., Stewart, Rebecca J., Azevedo, Mauro F., Crabb, Brendan S., Jennings, Ian G., Sanders, Paul R., Manallack, David T., Thompson, Philip E., Tonkin, Christopher

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 3.30 MB

english, 2015

2

Family of Class I Lantibiotics from Actinomycetes and Improvement of Their Antibacterial Activities

Maffioli, Sonia I., Monciardini, Paolo, Catacchio, Bruno, Mazzetti, Carlo, Münch, Daniela, Brunati, Cristina, Sahl, Hans-Georg, Donadio, Stefano

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 654 KB

english, 2015

3

Chemical Cross-Linking/Mass Spectrometry Maps the Amyloid β Peptide Binding Region on Both Apolipoprotein E Domains

Deroo, Stéphanie, Stengel, Florian, Mohammadi, Azadeh, Henry, Nicolas, Hubin, Ellen, Krammer, Eva-Maria, Aebersold, Ruedi, Raussens, Vincent

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 971 KB

english, 2015

4

The Elastase-PK101 Structure: Mechanism of an Ultrasensitive Activity-based Probe Revealed

Lechtenberg, Bernhard C., Kasperkiewicz, Paulina, Robinson, Howard, Drag, Marcin, Riedl, Stefan J.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 20.19 MB

english, 2015

5

Ironing out Their Differences: Dissecting the Structural Determinants of a Phenylalanine Aminomutase and Ammonia Lyase

Heberling, Matthew M., Masman, Marcelo F., Bartsch, Sebastian, Wybenga, Gjalt G., Dijkstra, Bauke W., Marrink, Siewert J., Janssen, Dick B.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 4.50 MB

english, 2015

6

Synergistic Binding of the Leader and Core Peptides by the Lantibiotic Synthetase HalM2

Thibodeaux, Gabrielle N., McClerren, Amanda L., Ma, Yunli, Gancayco, Marc R., van der Donk, Wilfred A.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 770 KB

english, 2015

7

Stereospecific Phosphorylation by the Central Mitotic Kinase Cdk1-Cyclin B

Etzkorn, Felicia A., Zhao, Song

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.58 MB

english, 2015

8

Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation

Zhang, Yao, Bartz, René, Grigoryan, Gevorg, Bryant, Michael, Aaronson, Jeff, Beck, Stephen, Innocent, Nathalie, Klein, Lee, Procopio, William, Tucker, Tom, Jadhav, Vasant, Tellers, David M., DeGrado,

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 562 KB

english, 2015

9

Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

Hett, Erik C., Xu, Hua, Geoghegan, Kieran F., Gopalsamy, Ariamala, Kyne, Robert E., Menard, Carol A., Narayanan, Arjun, Parikh, Mihir D., Liu, Shenping, Roberts, Lee, Robinson, Ralph P., Tones, Michae

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.08 MB

english, 2015

10

Isofunctional Enzymes PAD1 and UbiX Catalyze Formation of a Novel Cofactor Required by Ferulic Acid Decarboxylase and 4-Hydroxy-3-polyprenylbenzoic Acid Decarboxylase

Lin, Fengming, Ferguson, Kyle L., Boyer, David R., Lin, Xiaoxia Nina, Marsh, E. Neil G.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.50 MB

english, 2015

11

Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design

Slade, Daniel J., Fang, Pengfei, Dreyton, Christina J., Zhang, Ying, Fuhrmann, Jakob, Rempel, Don, Bax, Benjamin D., Coonrod, Scott A., Lewis, Huw D., Guo, Min, Gross, Michael L., Thompson, Paul R.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 7.15 MB

english, 2015

12

Genetic Targeting of a Small Fluorescent Zinc Indicator to Cell Surface for Monitoring Zinc Secretion

Li, Daliang, Liu, Lin, Li, Wen-Hong

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 7.02 MB

english, 2015

13

Small Molecule Inhibitors of Disulfide Bond Formation by the Bacterial DsbA–DsbB Dual Enzyme System

Halili, Maria A., Bachu, Prabhakar, Lindahl, Fredrik, Bechara, Chérine, Mohanty, Biswaranjan, Reid, Robert C., Scanlon, Martin J., Robinson, Carol V., Fairlie, David P., Martin, Jennifer L.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.43 MB

english, 2015

14

Structural and Functional Analysis of the Loading Acyltransferase from Avermectin Modular Polyketide Synthase

Wang, Fen, Wang, Yanjie, Ji, Junjie, Zhou, Zhan, Yu, Jingkai, Zhu, Hua, Su, Zhiguo, Zhang, Lixin, Zheng, Jianting

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 4.88 MB

english, 2015

15

Modulation of Alternative Splicing with Chemical Compounds in New Therapeutics for Human Diseases

Ohe, Kenji, Hagiwara, Masatoshi

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 2.07 MB

english, 2015

16

Colloidal Aggregation and the in Vitro Activity of Traditional Chinese Medicines

Duan, Da, Doak, Allison K., Nedyalkova, Lyudmila, Shoichet, Brian K.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.77 MB

english, 2015

17

Visualizing Cell Proximity with Genetically Encoded Bioluminescent Reporters

Jones, Krysten A., Li, David J., Hui, Elliot, Sellmyer, Mark A., Prescher, Jennifer A.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.93 MB

english, 2015

18

Structure-Guided Design of a High Affinity Inhibitor to Human CtBP

Hilbert, Brendan J., Morris, Benjamin L., Ellis, Keith C., Paulsen, Janet L., Schiffer, Celia A., Grossman, Steven R., Royer, William E.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 6.11 MB

english, 2015

19

Structural Basis of a Temporin 1b Analogue Antimicrobial Activity against Gram Negative Bacteria Determined by CD and NMR Techniques in Cellular Environment

Malgieri, Gaetano, Avitabile, Concetta, Palmieri, Maddalena, D’Andrea, Luca Domenico, Isernia, Carla, Romanelli, Alessandra, Fattorusso, Roberto

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.51 MB

english, 2015

20

Synthesis, Stereochemical Analysis, and Derivatization of Myricanol Provide New Probes That Promote Autophagic Tau Clearance

Martin, Mackenzie D., Calcul, Laurent, Smith, Courtney, Jinwal, Umesh K., Fontaine, Sarah N., Darling, April, Seeley, Kent, Wojtas, Lukasz, Narayan, Malathi, Gestwicki, Jason E., Smith, Garry R., Reit

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 4.00 MB

english, 2015

21

Critical Evaluation and Rate Constants of Chemoselective Ligation Reactions for Stoichiometric Conjugations in Water

Saito, Fumito, Noda, Hidetoshi, Bode, Jeffrey W.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015

22

C 5 -Epimerase and 2- O -Sulfotransferase Associate in Vitro to Generate Contiguous Epimerized and 2- O -Sulfated Heparan Sulfate Domains

Préchoux, Aurélie, Halimi, Célia, Simorre, Jean-Pierre, Lortat-Jacob, Hugues, Laguri, Cédric

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.39 MB

english, 2015

23

Genetically Encoding Lysine Modifications on Histone H4

Wilkins, Bryan J., Hahn, Liljan E., Heitmüller, Svenja, Frauendorf, Holm, Valerius, Oliver, Braus, Gerhard H., Neumann, Heinz

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 2.19 MB

english, 2015

24

Saturation Mutagenesis of TsrA Ala4 Unveils a Highly Mutable Residue of Thiostrepton A

Zhang, Feifei, Kelly, Wendy L.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 3.83 MB

english, 2015

25

Structural Basis of New Allosteric Inhibition in Kinesin Spindle Protein Eg5

Yokoyama, Hideshi, Sawada, Jun-ichi, Katoh, Shiori, Matsuno, Kenji, Ogo, Naohisa, Ishikawa, Yoshinobu, Hashimoto, Hiroshi, Fujii, Satoshi, Asai, Akira

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 6.02 MB

english, 2015

26

Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1

Perfetti, Michael T., Baughman, Brandi M., Dickson, Bradley M., Mu, Yunxiang, Cui, Gaofeng, Mader, Pavel, Dong, Aiping, Norris, Jacqueline L., Rothbart, Scott B., Strahl, Brian D., Brown, Peter J., Ja

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 2.67 MB

english, 2015

27

Selective Inhibitor of Platelet-Activating Factor Acetylhydrolases 1b2 and 1b3 That Impairs Cancer Cell Survival

Chang, Jae Won, Zuhl, Andrea M., Speers, Anna E., Niessen, Sherry, Brown, Steven J., Mulvihill, Melinda M., Fan, Yi Chiao, Spicer, Timothy P., Southern, Mark, Scampavia, Louis, Fernandez-Vega, Virneli

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 2.64 MB

english, 2015

28

Genetically Enhanced Lysozyme Evades a Pathogen Derived Inhibitory Protein

Dostal, Sarah M., Fang, Yongliang, Guerrette, Jonathan C., Scanlon, Thomas C., Griswold, Karl E.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 2.30 MB

english, 2015

29

Spotlights

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 2.16 MB

english, 2015

30

Introducing Our Author

Powell, Rachelle

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 2.93 MB

english, 2015

31

In This Issue

Underwood, Jason G.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 625 KB

english, 2015

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