Volume 8; Issue 11

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ACS Chemical Biology
Volume 8; Issue 11

ACS Chemical Biology

Volume 8; Issue 11

1

Murgocil is a Highly Bioactive Staphylococcal-Specific Inhibitor of the Peptidoglycan Glycosyltransferase Enzyme MurG

Mann, Paul A., Müller, Anna, Xiao, Li, Pereira, Pedro M., Yang, Christine, Ho Lee, Sang, Wang, Hao, Trzeciak, Joanna, Schneeweis, Jonathan, dos Santos, Margarida Moreira, Murgolo, Nicholas, She, Xinwe

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.28 MB

english, 2013

2

Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

Bauman, Joseph D., Patel, Disha, Baker, Steven F., Vijayan, R. S. K., Xiang, Amy, Parhi, Ajit K., Martínez-Sobrido, Luis, LaVoie, Edmond J., Das, Kalyan, Arnold, Eddy

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.49 MB

english, 2013

3

Change in Heat Capacity for Enzyme Catalysis Determines Temperature Dependence of Enzyme Catalyzed Rates

Hobbs, Joanne K., Jiao, Wanting, Easter, Ashley D., Parker, Emily J., Schipper, Louis A., Arcus, Vickery L.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 615 KB

english, 2013

4

Photoreactive “Nanorulers” Detect a Novel Conformation of Full Length HDAC3-SMRT Complex in Solution

Abdelkarim, Hazem, Brunsteiner, Michael, Neelarapu, Raghupathi, Bai, He, Madriaga, Antonett, van Breemen, Richard B., Blond, Sylvie Y., Gaponenko, Vadim, Petukhov, Pavel A.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.61 MB

english, 2013

5

Chemoenzymatic Synthesis of Novel C-Ribosylated Naphthoquinones

Blauenburg, Bastian, Oja, Terhi, Klika, Karel D., Metsä-Ketelä, Mikko

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 496 KB

english, 2013

6

Reducing Levels of Toxic RNA with Small Molecules

Coonrod, Leslie A., Nakamori, Masayuki, Wang, Wenli, Carrell, Samuel, Hilton, Cameron L., Bodner, Micah J., Siboni, Ruth B., Docter, Aaron G., Haley, Michael M., Thornton, Charles A., Berglund, J. And

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.55 MB

english, 2013

7

Structure-Guided Discovery of a Novel Aminoglycoside Conjugate Targeting HIV-1 RNA Viral Genome

Ennifar, Eric, Aslam, Muhammad Waqar, Strasser, Perrine, Hoffmann, Guillaume, Dumas, Philippe, van Delft, Floris L.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.47 MB

english, 2013

8

Conformationally Constrained Lipid A Mimetics for Exploration of Structural Basis of TLR4/MD-2 Activation by Lipopolysaccharide

Artner, Daniel, Oblak, Alja, Ittig, Simon, Garate, Jose Antonio, Horvat, Simon, Arrieumerlou, Cécile, Hofinger, Andreas, Oostenbrink, Chris, Jerala, Roman, Kosma, Paul, Zamyatina, Alla

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.10 MB

english, 2013

9

Selectively Targeting Prostate Cancer with Antiandrogen Equipped Histone Deacetylase Inhibitors

Gryder, Berkley E., Akbashev, Michelle J., Rood, Michael K., Raftery, Eric D., Meyers, Warren M., Dillard, Paulette, Khan, Shafiq, Oyelere, Adegboyega K.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.49 MB

english, 2013

10

Small Molecule Probe Suitable for In Situ Profiling and Inhibition of Protein Disulfide Isomerase

Ge, Jingyan, Zhang, Chong-Jing, Li, Lin, Chong, Li Min, Wu, Xiaoyuan, Hao, Piliang, Sze, Siu Kwan, Yao, Shao Q.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.17 MB

english, 2013

11

Cytochrome P450 sky Interacts Directly with the Nonribosomal Peptide Synthetase to Generate Three Amino Acid Precursors in Skyllamycin Biosynthesis

Uhlmann, Stefanie, Süssmuth, Roderich D., Cryle, Max J.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.53 MB

english, 2013

12

Modulation of Aldose Reductase Inhibition by Halogen Bond Tuning

Fanfrlík, Jindřich, Kolář, Michal, Kamlar, Martin, Hurný, David, Ruiz, Francesc X., Cousido-Siah, Alexandra, Mitschler, André, Řezáč, Jan, Munusamy, Elango, Lepšík, Martin, Matějíček, Pavel, Veselý, J

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.51 MB

english, 2013

13

Exploring Binding and Effector Functions of Natural Human Antibodies Using Synthetic Immunomodulators

Jakobsche, Charles E., Parker, Christopher G., Tao, Ran N., Kolesnikova, Mariya D., Douglass, Eugene F., Spiegel, David A.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.66 MB

english, 2013

14

Development and Characterization of a Non-natural Nucleoside that Displays Anticancer Activity Against Solid Tumors

Golden, Jackelyn, Motea, Edward, Zhang, Xuemei, Choi, Jung-Suk, Feng, Ye, Xu, Yan, Lee, Irene, Berdis, Anthony J.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 4.75 MB

english, 2013

15

Novel Cleavage of Reductively Aminated Glycan-Tags by N -Bromosuccinimide to Regenerate Free, Reducing Glycans

Song, Xuezheng, Johns, Brian A., Ju, Hong, Lasanajak, Yi, Zhao, Chunmei, Smith, David F., Cummings, Richard D.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.09 MB

english, 2013

16

Immunogenicity and Diagnostic Potential of Synthetic Antigenic Cell Surface Glycans of Leishmania

Anish, Chakkumkal, Martin, Christopher E., Wahlbrink, Annette, Bogdan, Christian, Ntais, Pantelis, Antoniou, Maria, Seeberger, Peter H.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.31 MB

english, 2013

17

Molecular Insight into Substrate Recognition and Catalysis of Baeyer–Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin

Bosserman, Mary A., Downey, Theresa, Noinaj, Nicholas, Buchanan, Susan K., Rohr, Jürgen

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.97 MB

english, 2013

18

Computational Approaches to Predicting the Impact of Novel Bases on RNA Structure and Stability

Harrison, Jason G., Zheng, Yvonne B., Beal, Peter A., Tantillo, Dean J.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.10 MB

english, 2013

19

Engineering the Polyproline II Propensity of a Class II Major Histocompatibility Complex Ligand Peptide

Unudurthi, Sathya Dev, Hotta, Kinya, Kim, Chu-Young

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 838 KB

english, 2013

20

Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains

Martin, Mathew P., Olesen, Sanne H., Georg, Gunda I., Schönbrunn, Ernst

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1020 KB

english, 2013

21

Introducing Our Authors

Powell, Rachelle

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.32 MB

english, 2013

22

Testing the Substrate-Envelope Hypothesis with Designed Pairs of Compounds

Shen, Yang, Altman, Michael D., Ali, Akbar, Nalam, Madhavi N. L., Cao, Hong, Rana, Tariq M., Schiffer, Celia A., Tidor, Bruce

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 5.18 MB

english, 2013

23

Fine Spatiotemporal Control of Nitric Oxide Release by Infrared Pulse-Laser Irradiation of a Photolabile Donor

Nakagawa, Hidehiko, Hishikawa, Kazuhiro, Eto, Kei, Ieda, Naoya, Namikawa, Tomotaka, Kamada, Kenji, Suzuki, Takayoshi, Miyata, Naoki, Nabekura, Jun-ichi

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.38 MB

english, 2013

24

Engineering V-Type Nerve Agents Detoxifying Enzymes Using Computationally Focused Libraries

Cherny, Izhack, Greisen, Per, Ashani, Yacov, Khare, Sagar D., Oberdorfer, Gustav, Leader, Haim, Baker, David, Tawfik, Dan S.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 4.21 MB

english, 2013

25

Tyrosine Phosphorylation of Mig6 Reduces Its Inhibition of the Epidermal Growth Factor Receptor

Wang, Zhihong, Raines, Lily L., Hooy, Richard M., Roberson, Heather, Leahy, Daniel J., Cole, Philip A.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.19 MB

english, 2013

26

In This Issue

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.99 MB

english, 2013

27

Immunoactivity of Protein Conjugates of Carba Analogues from Neisseria meningitidis A Capsular Polysaccharide

Gao, Qi, Tontini, Marta, Brogioni, Giulia, Nilo, Alberto, Filippini, Sara, Harfouche, Carole, Polito, Laura, Romano, Maria R., Costantino, Paolo, Berti, Francesco, Adamo, Roberto, Lay, Luigi

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

28

Direct Comparison of a Genetically Encoded Sensor and Small Molecule Indicator: Implications for Quantification of Cytosolic Zn 2+

Qin, Yan, Miranda, Jose G., Stoddard, Caitlin I., Dean, Kevin M., Galati, Domenico F., Palmer, Amy E.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.89 MB

english, 2013

29

Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

Cukier, Cyprian D., Hope, Anthony G., Elamin, Ayssar A., Moynie, Lucile, Schnell, Robert, Schach, Susanne, Kneuper, Holger, Singh, Mahavir, Naismith, James H., Lindqvist, Ylva, Gray, David W., Schneid

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.53 MB

english, 2013

30

Endogenous Ethanol Affects Biopolyester Molecular Weight in Recombinant Escherichia coli

Hiroe, Ayaka, Hyakutake, Manami, Thomson, Nicholas M., Sivaniah, Easan, Tsuge, Takeharu

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.79 MB

english, 2013

31

Spotlight

Gordon, Eva J., Underwood, Jason G., Webb, Sarah A.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.61 MB

english, 2013

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