Volume 8; Issue 6

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ACS Chemical Biology
Volume 8; Issue 6

ACS Chemical Biology

Volume 8; Issue 6

1

Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qβ Capsids

Yin, Zhaojun, Comellas-Aragones, Marta, Chowdhury, Sudipa, Bentley, Philip, Kaczanowska, Katarzyna, BenMohamed, Lbachir, Gildersleeve, Jeffrey C., Finn, M. G., Huang, Xuefei

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 906 KB

english, 2013

2

In Vitro Selection of Multiple Libraries Created by Genetic Code Reprogramming To Discover Macrocyclic Peptides That Antagonize VEGFR2 Activity in Living Cells

Kawakami, Takashi, Ishizawa, Takahiro, Fujino, Tomoshige, Reid, Patrick C., Suga, Hiroaki, Murakami, Hiroshi

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.09 MB

english, 2013

3

Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease

Tiefenbrunn, Theresa, Forli, Stefano, Baksh, Michael M., Chang, Max W., Happer, Meaghan, Lin, Ying-Chuan, Perryman, Alexander L., Rhee, Jin-Kyu, Torbett, Bruce E., Olson, Arthur J., Elder, John H., Fi

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 503 KB

english, 2013

4

Facilitating Cytokine-Mediated Cancer Cell Death by Proteobacterial N -Acylhomoserine Lactones

Kravchenko, Vladimir, Garner, Amanda L., Mathison, John, Seit-Nebi, Alim, Yu, Jing, Gileva, Irina P., Ulevitch, Richard, Janda, Kim D.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 272 KB

english, 2013

5

Enhanced Chemical Stability of AdoMet Analogues for Improved Methyltransferase-Directed Labeling of DNA

Lukinavičius, Gražvydas, Tomkuvienė, Miglė, Masevičius, Viktoras, Klimašauskas, Saulius

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 609 KB

english, 2013

6

Design, Synthesis, and Kinetic Characterization of Protein N-Terminal Acetyltransferase Inhibitors

Foyn, Håvard, Jones, Justin E., Lewallen, Dan, Narawane, Rashmi, Varhaug, Jan Erik, Thompson, Paul R., Arnesen, Thomas

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.06 MB

english, 2013

7

Structure, Dynamics, and Activity of Xylanase Solvated in Binary Mixtures of Ionic Liquid and Water

Jaeger, Vance W., Pfaendtner, Jim

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 444 KB

english, 2013

8

Controllable Hydrogen Sulfide Donors and Their Activity against Myocardial Ischemia-Reperfusion Injury

Zhao, Yu, Bhushan, Shashi, Yang, Chuntao, Otsuka, Hiroyuki, Stein, Jason D., Pacheco, Armando, Peng, Bo, Devarie-Baez, Nelmi O., Aguilar, Hector C., Lefer, David J., Xian, Ming

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.12 MB

english, 2013

9

Using Sequence-Specific Oligonucleotides To Inhibit Bacterial rRNA

Trylska, Joanna, Thoduka, Sapna G., Dąbrowska, Zofia

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 9.72 MB

english, 2013

10

Carbofluoresceins and Carborhodamines as Scaffolds for High-Contrast Fluorogenic Probes

Grimm, Jonathan B., Sung, Andrew J., Legant, Wesley R., Hulamm, Phuson, Matlosz, Sylwia M., Betzig, Eric, Lavis, Luke D.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.51 MB

english, 2013

11

Probing p300/CBP Associated Factor (PCAF)-Dependent Pathways with a Small Molecule Inhibitor

Modak, Rahul, Basha, Jeelan, Bharathy, Narendra, Maity, Koustav, Mizar, Pushpak, Bhat, Akshay V., Vasudevan, Madavan, Rao, Vinay Kumar, Kok, Wai Kay, Natesh, Nagashayana, Taneja, Reshma, Kundu, Tapas

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.85 MB

english, 2013

12

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

Konze, Kyle D., Ma, Anqi, Li, Fengling, Barsyte-Lovejoy, Dalia, Parton, Trevor, MacNevin, Christopher J., Liu, Feng, Gao, Cen, Huang, Xi-Ping, Kuznetsova, Ekaterina, Rougie, Marie, Jiang, Alice, Patte

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 4.35 MB

english, 2013

13

The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules

Zheng, Jianting, Fage, Christopher D., Demeler, Borries, Hoffman, David W., Keatinge-Clay, Adrian T.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.38 MB

english, 2013

14

Persulfide Reactivity in the Detection of Protein S -Sulfhydration

Pan, Jia, Carroll, Kate S.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 423 KB

english, 2013

15

Design of a Cyclotide Antagonist of Neuropilin-1 and -2 That Potently Inhibits Endothelial Cell Migration

Getz, Jennifer A., Cheneval, Olivier, Craik, David J., Daugherty, Patrick S.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.61 MB

english, 2013

16

Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis

Hearn, Jessica M., Romero-Canelón, Isolda, Qamar, Bushra, Liu, Zhe, Hands-Portman, Ian, Sadler, Peter J.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.29 MB

english, 2013

17

104th American Association For Cancer Research (AACR) Annual Meeting; Breakthroughs In Science And Technology Changing Cancer Care

Abaan, Ogan D., Bilke, Sven

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 144 KB

english, 2013

18

A Unique Small Molecule Inhibitor of Enolase Clarifies Its Role in Fundamental Biological Processes

Jung, Da-Woon, Kim, Woong-Hee, Park, Si-Hwan, Lee, Jinho, Kim, Jinmi, Su, Dongdong, Ha, Hyung-Ho, Chang, Young-Tae, Williams, Darren R.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.39 MB

english, 2013

19

Electrostatic Effect of the Ribosomal Surface on Nascent Polypeptide Dynamics

Knight, Anders M., Culviner, Peter H., Kurt-Yilmaz, Neşe, Zou, Taisong, Ozkan, S. Banu, Cavagnero, Silvia

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.21 MB

english, 2013

20

Launching Spiking Ligands into a Protein–Protein Interface: A Promising Strategy To Destabilize and Break Interface Formation in a tRNA Modifying Enzyme

Immekus, Florian, Barandun, Luzi Jakob, Betz, Michael, Debaene, François, Petiot, Stéphanie, Sanglier-Cianferani, Sarah, Reuter, Klaus, Diederich, François, Klebe, Gerhard

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.40 MB

english, 2013

21

Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor

Mohedas, Agustin H., Xing, Xuechao, Armstrong, Kelli A., Bullock, Alex N., Cuny, Gregory D., Yu, Paul B.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.95 MB

english, 2013

22

Synthesis and SAR of Lehualide B: A Marine-Derived Natural Product with Potent Anti-Multiple Myeloma Activity

Jeso, Valer, Yang, Chunying, Cameron, Michael D., Cleveland, John L., Micalizio, Glenn C.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 4.67 MB

english, 2013

23

2-Hydroxyisoquinoline-1,3(2 H ,4 H )-diones (HIDs), Novel Inhibitors of HIV Integrase with a High Barrier to Resistance

Desimmie, Belete A., Demeulemeester, Jonas, Suchaud, Virginie, Taltynov, Oliver, Billamboz, Muriel, Lion, Cedric, Bailly, Fabrice, Strelkov, Sergei V., Debyser, Zeger, Cotelle, Philippe, Christ, Frauk

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.74 MB

english, 2013

24

Introducing Our Authors

Powell, Rachelle

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.16 MB

english, 2013

25

Structure of Enterococcus faecium l , d -Transpeptidase Acylated by Ertapenem Provides Insight into the Inactivation Mechanism

Lecoq, Lauriane, Dubée, Vincent, Triboulet, Sébastien, Bougault, Catherine, Hugonnet, Jean-Emmanuel, Arthur, Michel, Simorre, Jean-Pierre

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.85 MB

english, 2013

26

Mammalian Neuronal Sodium Channel Blocker μ-Conotoxin BuIIIB Has a Structured N-Terminus That Influences Potency

Kuang, Zhihe, Zhang, Min-Min, Gupta, Kallol, Gajewiak, Joanna, Gulyas, Jozsef, Balaram, Padmanabhan, Rivier, Jean E., Olivera, Baldomero M., Yoshikami, Doju, Bulaj, Grzegorz, Norton, Raymond S.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.46 MB

english, 2013

27

Spotlight

Gordon, Eva J., Webb, Sarah A., Underwood, Jason G.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 4.26 MB

english, 2013

28

Exploiting the Unique ATP-Binding Pocket of Toxoplasma Calcium-Dependent Protein Kinase 1 To Identify Its Substrates

Lourido, Sebastian, Jeschke, Grace R., Turk, Benjamin E., Sibley, L. David

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.72 MB

english, 2013

29

Chemical Engineering and Structural and Pharmacological Characterization of the α-Scorpion Toxin OD1

Durek, Thomas, Vetter, Irina, Wang, Ching-I Anderson, Motin, Leonid, Knapp, Oliver, Adams, David J., Lewis, Richard J., Alewood, Paul F.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.10 MB

english, 2013

30

Structural Basis for Enzyme I Inhibition by α-Ketoglutarate

Venditti, Vincenzo, Ghirlando, Rodolfo, Clore, G. Marius

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.18 MB

english, 2013

31

In This Issue

Soares, Jitesh A.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.35 MB

english, 2013

32

Evidence for Age-Dependent in Vivo Conformational Rearrangement within Aβ Amyloid Deposits

Nyström, Sofie, Psonka-Antonczyk, Katarzyna M., Ellingsen, Pål Gunnar, Johansson, Leif B. G., Reitan, Nina, Handrick, Susann, Prokop, Stefan, Heppner, Frank L., Wegenast-Braun, Bettina M., Jucker, Mat

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 4.13 MB

english, 2013