Volume 8; Issue 9

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ACS Chemical Biology
Volume 8; Issue 9

ACS Chemical Biology

Volume 8; Issue 9

1

Integrated Metabolomics Approach Facilitates Discovery of an Unpredicted Natural Product Suite from Streptomyces coelicolor M145

Sidebottom, Ashley M., Johnson, Andrew R., Karty, Jonathan A., Trader, Darci J., Carlson, Erin E.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.10 MB

english, 2013

2

Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers

Molzan, Manuela, Kasper, Stefan, Röglin, Lars, Skwarczynska, Malgorzata, Sassa, Takeshi, Inoue, Takatsugu, Breitenbuecher, Frank, Ohkanda, Junko, Kato, Nobuo, Schuler, Martin, Ottmann, Christian

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.41 MB

english, 2013

3

Engineering Unnatural Variants of Plantazolicin through Codon Reprogramming

Deane, Caitlin D., Melby, Joel O., Molohon, Katie J., Susarrey, Aziz R., Mitchell, Douglas A.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.07 MB

english, 2013

4

Reduction of Human Defensin 5 Affords a High-Affinity Zinc-Chelating Peptide

Zhang, Yunfei, Cougnon, Fabien B. L., Wanniarachchi, Yoshitha A., Hayden, Joshua A., Nolan, Elizabeth M.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 686 KB

english, 2013

5

Reduction of Lectin Valency Drastically Changes Glycolipid Dynamics in Membranes but Not Surface Avidity

Arnaud, Julie, Claudinon, Julie, Tröndle, Kevin, Trovaslet, Marie, Larson, Göran, Thomas, Aline, Varrot, Annabelle, Römer, Winfried, Imberty, Anne, Audfray, Aymeric

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1015 KB

english, 2013

6

Profiling Targets of the Irreversible Palmitoylation Inhibitor 2-Bromopalmitate

Davda, Dahvid, El Azzouny, Mahmoud A., Tom, Christopher T.M.B., Hernandez, Jeannie L., Majmudar, Jaimeen D., Kennedy, Robert T., Martin, Brent R.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.13 MB

english, 2013

7

Avidity Modulation of Folate-Targeted Multivalent Dendrimers for Evaluating Biophysical Models of Cancer Targeting Nanoparticles

Silpe, Justin E., Sumit, Madhuresh, Thomas, Thommey P., Huang, Baohua, Kotlyar, Alina, van Dongen, Mallory A., Banaszak Holl, Mark M., Orr, Bradford G., Choi, Seok Ki

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.72 MB

english, 2013

8

Orthoformimycin, a Selective Inhibitor of Bacterial Translation Elongation from Streptomyces Containing an Unusual Orthoformate

Maffioli, Sonia I., Fabbretti, Attilio, Brandi, Letizia, Savelsbergh, Andreas, Monciardini, Paolo, Abbondi, Monica, Rossi, Rossana, Donadio, Stefano, Gualerzi, Claudio O.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.40 MB

english, 2013

9

High-Titer Heterologous Production in E. coli of Lyngbyatoxin, a Protein Kinase C Activator from an Uncultured Marine Cyanobacterium

Ongley, Sarah E., Bian, Xiaoying, Zhang, Youming, Chau, Rocky, Gerwick, William H., Müller, Rolf, Neilan, Brett A.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.57 MB

english, 2013

10

Inhibitors of Bacterial Transcription Initiation Complex Formation

Ma, Cong, Yang, Xiao, Kandemir, Hakan, Mielczarek, Marcin, Johnston, Elecia B, Griffith, Renate, Kumar, Naresh, Lewis, Peter J.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

11

New Fluorescent Substrate Enables Quantitative and High-Throughput Examination of Vesicular Monoamine Transporter 2 (VMAT2)

Hu, Gang, Henke, Adam, Karpowicz, Richard J., Sonders, Mark S., Farrimond, Frances, Edwards, Robert, Sulzer, David, Sames, Dalibor

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 430 KB

english, 2013

12

Lipo-chitooligosaccharidic Symbiotic Signals Are Recognized by LysM Receptor-Like Kinase LYR3 in the Legume Medicago truncatula

Fliegmann, Judith, Canova, Sophie, Lachaud, Christophe, Uhlenbroich, Sandra, Gasciolli, Virginie, Pichereaux, Carole, Rossignol, Michel, Rosenberg, Charles, Cumener, Marie, Pitorre, Delphine, Lefebvre

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 451 KB

english, 2013

13

Synthetic Inhibitors of Bacterial Cell Division Targeting the GTP-Binding Site of FtsZ

Ruiz-Avila, Laura B., Huecas, Sonia, Artola, Marta, Vergoñós, Albert, Ramírez-Aportela, Erney, Cercenado, Emilia, Barasoain, Isabel, Vázquez-Villa, Henar, Martín-Fontecha, Mar, Chacón, Pablo, López-Ro

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.47 MB

english, 2013

14

CH−π “T-Shape” Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa Lectin LecA

Kadam, Rameshwar U., Garg, Divita, Schwartz, Julian, Visini, Ricardo, Sattler, Michael, Stocker, Achim, Darbre, Tamis, Reymond, Jean-Louis

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.21 MB

english, 2013

15

Curvature Engineering: Positive Membrane Curvature Induced by Epsin N-Terminal Peptide Boosts Internalization of Octaarginine

Pujals, Sílvia, Miyamae, Hiroki, Afonin, Sergii, Murayama, Tomo, Hirose, Hisaaki, Nakase, Ikuhiko, Taniuchi, Kentaro, Umeda, Masato, Sakamoto, Kazutami, Ulrich, Anne S., Futaki, Shiroh

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.81 MB

english, 2013

16

Exhaustive Proteome Mining for Functional MHC-I Ligands

Koch, Christian P., Perna, Anna M., Weissmüller, Sabrina, Bauer, Stefanie, Pillong, Max, Baleeiro, Renato B., Reutlinger, Michael, Folkers, Gerd, Walden, Peter, Wrede, Paul, Hiss, Jan A., Waibler, Zoe

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.65 MB

english, 2013

17

Monitoring Translation with Modified mRNAs Strategically Labeled with Isomorphic Fluorescent Guanosine Mimetics

Liu, Wei, Shin, Dongwon, Tor, Yitzhak, Cooperman, Barry S.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 991 KB

english, 2013

18

The Stanford Institute for Chemical Biology

Chen, James K., Du Bois, Justin, Glenn, Jeffrey, Herschlag, Daniel, Khosla, Chaitan

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 158 KB

english, 2013

19

Structure-Guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase Technology

Zhang, Chao, Lopez, Michael S., Dar, Arvin C., LaDow, Eva, Finkbeiner, Steven, Yun, Cai-Hong, Eck, Michael J., Shokat, Kevan M.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 484 KB

english, 2013

20

FluoQ: A Tool for Rapid Analysis of Multiparameter Fluorescence Imaging Data Applied to Oscillatory Events

Stein, Frank, Kress, Manuel, Reither, Sabine, Piljić, Alen, Schultz, Carsten

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.17 MB

english, 2013

21

New Interfacial Microtubule Inhibitors of Marine Origin, PM050489/PM060184, with Potent Antitumor Activity and a Distinct Mechanism

Pera, Benet, Barasoain, Isabel, Pantazopoulou, Areti, Canales, Angeles, Matesanz, Ruth, Rodriguez-Salarichs, Javier, García-Fernandez, Luis F., Moneo, Victoria, Jiménez-Barbero, Jesús, Galmarini, Carl

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

22

Novel Modifications on C-terminal Domain of RNA Polymerase II Can Fine-tune the Phosphatase Activity of Ssu72

Luo, Yonghua, Yogesha, S. D., Cannon, Joe R., Yan, Wupeng, Ellington, Andrew D., Brodbelt, Jennifer S., Zhang, Yan

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.37 MB

english, 2013

23

Development of Potent Fluorescent Polyamine Toxins and Application in Labeling of Ionotropic Glutamate Receptors in Hippocampal Neurons

Nørager, Niels G., Jensen, Christel B., Rathje, Mette, Andersen, Jacob, Madsen, Kenneth L., Kristensen, Anders S., Strømgaard, Kristian

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.80 MB

english, 2013

24

In This Issue

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 504 KB

english, 2013

25

Siderocalin Outwits the Coordination Chemistry of Vibriobactin, a Siderophore of Vibrio cholerae

Allred, Benjamin E., Correnti, Colin, Clifton, Matthew C., Strong, Roland K., Raymond, Kenneth N.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.76 MB

english, 2013

26

Deconstruction of Stable Cross-Beta Fibrillar Structures into Toxic and Nontoxic Products Using a Mutated Archaeal Chaperonin

Kurouski, Dmitry, Luo, Haibin, Sereda, Valentin, Robb, Frank T., Lednev, Igor K.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.88 MB

english, 2013

27

Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry

Zheng, Jianting, Piasecki, Shawn K., Keatinge-Clay, Adrian T.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.14 MB

english, 2013

28

A Novel Allosteric Inhibitor of the Uridine Diphosphate N -Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei

Urbaniak, Michael D., Collie, Iain T., Fang, Wenxia, Aristotelous, Tonia, Eskilsson, Susanne, Raimi, Olawale G., Harrison, Justin, Navratilova, Iva Hopkins, Frearson, Julie A., van Aalten, Daan M. F.,

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.79 MB

english, 2013

29

Inhibitors of Difficult Protein–Protein Interactions Identified by High-Throughput Screening of Multiprotein Complexes

Cesa, Laura C., Patury, Srikanth, Komiyama, Tomoko, Ahmad, Atta, Zuiderweg, Erik R. P., Gestwicki, Jason E.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.25 MB

english, 2013

30

Spotlight

Gordon, Eva J., Underwood, Jason G., Webb, Sarah A.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.24 MB

english, 2013

31

Targeting the Arginine Phosphatase YwlE with a Catalytic Redox-Based Inhibitor

Fuhrmann, Jakob, Subramanian, Venkataraman, Thompson, Paul R.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.70 MB

english, 2013

32

Probing the Hexosamine Biosynthetic Pathway in Human Tumor Cells by Multitargeted Tandem Mass Spectrometry

Abdel Rahman, Anas M., Ryczko, Michael, Pawling, Judy, Dennis, James W.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.57 MB

english, 2013

33

Introducing Our Authors

Powell, Rachelle

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 563 KB

english, 2013

34

Sulfopeptide Probes of the CXCR4/CXCL12 Interface Reveal Oligomer-Specific Contacts and Chemokine Allostery

Ziarek, Joshua J., Getschman, Anthony E., Butler, Stephen J., Taleski, Deni, Stephens, Bryan, Kufareva, Irina, Handel, Tracy M., Payne, Richard J., Volkman, Brian F.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 4.74 MB

english, 2013

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