Volume 9; Issue 11

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ACS Chemical Biology
Volume 9; Issue 11

ACS Chemical Biology

Volume 9; Issue 11

1

Small-Molecule Inhibitors of SETD8 with Cellular Activity

Blum, Gil, Ibáñez, Glorymar, Rao, Xiangjun, Shum, David, Radu, Constantin, Djaballah, Hakim, Rice, Judd C., Luo, Minkui

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 3.23 MB

english, 2014

2

Aldehyde Recognition and Discrimination by Mammalian Odorant Receptors via Functional Group-Specific Hydration Chemistry

Li, Yadi, Peterlin, Zita, Ho, Jianghai, Yarnitzky, Tali, Liu, Min Ting, Fichman, Merav, Niv, Masha Y., Matsunami, Hiroaki, Firestein, Stuart, Ryan, Kevin

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 2.80 MB

english, 2014

3

The Renaissance of Ras

Milroy, Lech-Gustav, Ottmann, Christian

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 3.98 MB

english, 2014

4

Boronic Acids as Probes for Investigation of Allosteric Modulation of the Chemokine Receptor CXCR3

Bernat, Viachaslau, Admas, Tizita Haimanot, Brox, Regine, Heinemann, Frank W., Tschammer, Nuska

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.75 MB

english, 2014

5

Novel Imidazoline Antimicrobial Scaffold That Inhibits DNA Replication with Activity against Mycobacteria and Drug Resistant Gram-Positive Cocci

Harris, Kendra K., Fay, Allison, Yan, Han-Guang, Kunwar, Pratima, Socci, Nicholas D., Pottabathini, Narender, Juventhala, Ramakrishna R., Djaballah, Hakim, Glickman, Michael S.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 6.12 MB

english, 2014

6

Identification of Small Molecule Modulators of Gene Transcription with Anticancer Activity

Tran, Tram Anh, Wichterman-Kouznetsova, Jennifer, Varghese, Diana, Huang, Ruili, Huang, Wenwei, Becker, Matthias, Austin, Christopher P., Inglese, James, Johnson, Ronald L., Martinez, Elisabeth D.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 651 KB

english, 2014

7

Hydrogen/Deuterium Exchange-Protected Oligomers Populated during Aβ Fibril Formation Correlate with Neuronal Cell Death

Serra-Vidal, Bernat, Pujadas, Lluís, Rossi, Daniela, Soriano, Eduardo, Madurga, Sergio, Carulla, Natàlia

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 4.00 MB

english, 2014

8

Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket

Leu, Julia I-Ju, Zhang, Pingfeng, Murphy, Maureen E., Marmorstein, Ronen, George, Donna L.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 6.51 MB

english, 2014

9

Uncovering Caffeine’s Adenosine A 2A Receptor Inverse Agonism in Experimental Parkinsonism

Fernández-Dueñas, Víctor, Gómez-Soler, Maricel, López-Cano, Marc, Taura, Jaume J., Ledent, Catherine, Watanabe, Masahiko, Jacobson, Kenneth A., Vilardaga, Jean-Pierre, Ciruela, Francisco

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 946 KB

english, 2014

10

Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease

Soumana, Djadé I., Ali, Akbar, Schiffer, Celia A.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 6.03 MB

english, 2014

11

General Platform for Systematic Quantitative Evaluation of Small-Molecule Permeability in Bacteria

Davis, Tony D., Gerry, Christopher J., Tan, Derek S.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 2.27 MB

english, 2014

12

Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome

Washington, Arren Z., Benicewicz, Derek B., Canzoneri, Joshua C., Fagan, Crystal E., Mwakwari, Sandra C., Maehigashi, Tatsuya, Dunham, Christine M., Oyelere, Adegboyega K.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 6.36 MB

english, 2014

13

Characterization of Two Distinct Modes of Drug Binding to Human Intestinal Fatty Acid Binding Protein

Patil, Rahul, Laguerre, Aisha, Wielens, Jerome, Headey, Stephen J., Williams, Martin L., Hughes, Maria L. R., Mohanty, Biswaranjan, Porter, Christopher J. H., Scanlon, Martin J.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 2.97 MB

english, 2014

14

Conditional and Target-Specific Transgene Induction through RNA Replacement Using an Allosteric Trans-Splicing Ribozyme

Kim, Juhyun, Jeong, Seonyeong, Kertsburg, Alexis, Soukup, Garrett A., Lee, Seong-Wook

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.30 MB

english, 2014

15

Insights into Substrate and Metal Binding from the Crystal Structure of Cyanobacterial Aldehyde Deformylating Oxygenase with Substrate Bound

Buer, Benjamin C., Paul, Bishwajit, Das, Debasis, Stuckey, Jeanne A., Marsh, E. Neil G.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 5.18 MB

english, 2014

16

Designed Phosphoprotein Recognition in Escherichia coli

Sawyer, Nicholas, Gassaway, Brandon M., Haimovich, Adrian D., Isaacs, Farren J., Rinehart, Jesse, Regan, Lynne

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

17

Toward Peptide Nucleic Acid (PNA) Directed Peptide Translation Using Ester Based Aminoacyl Transfer

Singhal, Abhishek, Bagnacani, Valentina, Corradini, Roberto, Nielsen, Peter E.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 2.38 MB

english, 2014

18

Loop Electrostatics Modulates the Intersubunit Interactions in Ferritin

Bernacchioni, Caterina, Ghini, Veronica, Pozzi, Cecilia, Di Pisa, Flavio, Theil, Elizabeth C., Turano, Paola

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 7.96 MB

english, 2014

19

High Divergence of the Precursor Peptides in Combinatorial Lanthipeptide Biosynthesis

Zhang, Qi, Yang, Xiao, Wang, Huan, van der Donk, Wilfred A.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 2.67 MB

english, 2014

20

4-Methylproline Guided Natural Product Discovery: Co-Occurrence of 4-Hydroxy- and 4-Methylprolines in Nostoweipeptins and Nostopeptolides

Liu, Liwei, Jokela, Jouni, Herfindal, Lars, Wahlsten, Matti, Sinkkonen, Jari, Permi, Perttu, Fewer, David P, Døskeland, Stein Ove, Sivonen, Kaarina

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 2.02 MB

english, 2014

21

Rapid Transfer of Transmembrane Proteins for Single Molecule Dimerization Assays in Polymer-Supported Membranes

Roder, Friedrich, Wilmes, Stephan, Richter, Christian P., Piehler, Jacob

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.34 MB

english, 2014

22

N-Terminal Phosphorylation of Parathyroid Hormone (PTH) Abolishes Its Receptor Activity

Kumar, Amit, Gopalswamy, Mohanraj, Wishart, Clare, Henze, Mathias, Eschen-Lippold, Lennart, Donnelly, Dan, Balbach, Jochen

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.04 MB

english, 2014

23

A Distinct MaoC-like Enoyl-CoA Hydratase Architecture Mediates Cholesterol Catabolism in Mycobacterium tuberculosis

Yang, Meng, Guja, Kip E., Thomas, Suzanne T., Garcia-Diaz, Miguel, Sampson, Nicole S.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 6.74 MB

english, 2014

24

pHLIP-FIRE, a Cell Insertion-Triggered Fluorescent Probe for Imaging Tumors Demonstrates Targeted Cargo Delivery In Vivo

Karabadzhak, Alexander G., An, Ming, Yao, Lan, Langenbacher, Rachel, Moshnikova, Anna, Adochite, Ramona-Cosmina, Andreev, Oleg A., Reshetnyak, Yana K., Engelman, Donald M.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 4.09 MB

english, 2014

25

In This Issue

Underwood, Jason G.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.09 MB

english, 2014

26

Modulation of Gephyrin-Glycine Receptor Affinity by Multivalency

Maric, Hans Michael, Kasaragod, Vikram Babu, Schindelin, Hermann

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 3.27 MB

english, 2014

27

Correction to Recent Mechanistic Insights on Glycoconjugate Vaccines and Future Perspectives

Berti, Francesco, Adamo, Roberto

Journal:

ACS Chemical Biology

Year:

2014

File:

PDF, 308 KB

2014

28

Genome Editing-Enabled HTS Assays Expand Drug Target Pathways for Charcot–Marie–Tooth Disease

Inglese, James, Dranchak, Patricia, Moran, John J., Jang, Sung-Wook, Srinivasan, Rajini, Santiago, Yolanda, Zhang, Lei, Guha, Rajarshi, Martinez, Natalia, MacArthur, Ryan, Cost, Gregory J., Svaren, Jo

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 2.01 MB

english, 2014

29

Reaction Coupling between Wild-Type and Disease-Associated Mutant EZH2

Swalm, Brooke M., Knutson, Sarah K., Warholic, Natalie M., Jin, Lei, Kuntz, Kevin W., Keilhack, Heike, Smith, Jesse J., Pollock, Roy M., Moyer, Mikel P., Scott, Margaret Porter, Copeland, Robert A., W

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.42 MB

english, 2014

30

Introducing Our Authors

Powell, Rachelle

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 4.29 MB

english, 2014

31

Binding Mode Characterization of Novel RNA Polymerase Inhibitors Using a Combined Biochemical and NMR Approach

Fruth, Martina, Plaza, Alberto, Hinsberger, Stefan, Sahner, Jan Henning, Haupenthal, Jörg, Bischoff, Markus, Jansen, Rolf, Müller, Rolf, Hartmann, Rolf W.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 4.67 MB

english, 2014

32

Spotlights

Dahlmann, Heidi A., Underwood, Jason G., Soares, Jitesh A.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 3.19 MB

english, 2014