Molecular BioSystems

1

Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish

Zhong, Hanbing, Xin, Shengchang, Zhao, Yanqiu, Lu, Jing, Li, Song, Gong, Jianxian, Yang, Zhen, Lin, Shuo

Journal:

Year:

2010

Language:

english

File:

PDF, 1.23 MB

english, 2010

2

Proteomics as a tool for studying energy metabolism in lactic acid bacteria

Pessione, Alessandro, Lamberti, Cristina, Pessione, Enrica

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.50 MB

english, 2010

3

Swapping the chitin-binding domain in Bacillus chitinases improves the substrate binding affinity and conformational stability

Neeraja, Chilukoti, Subramanyam, Rajagopal, Moerschbacher, Bruno M., Podile, Appa Rao

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.44 MB

english, 2010

4

A chemical-genetic approach for precise spatio-temporal control of cellular signaling

Dong, Shuyun, Allen, John A., Farrell, Martilias, Roth, Bryan L.

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.24 MB

english, 2010

5

Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders

Digby, Gregory J., Shirey, Jana K., Conn, P. Jeffrey

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

6

3-Iodothyronamine (T1AM): a new chapter of thyroid hormone endocrinology?

Ianculescu, Alexandra G., Scanlan, Thomas S.

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 651 KB

english, 2010

7

Allosteric regulation of protease activity by small molecules

Shen, Aimee

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 2.18 MB

english, 2010

8

A diverse family of type III polyketide synthases in Eucalyptus species

Rubin-Pitel, Sheryl B., Luo, Yunzi, Lee, Jung-Kul, Zhao, Huimin

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

9

Small-molecule inhibitors of c-Myc transcriptional factor suppress proliferation and induce apoptosis of promyelocytic leukemia cell via cell cycle arrest

Jeong, Kyung-Chae, Ahn, Kyung-Ohk, Yang, Chul-Hak

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 720 KB

english, 2010

10

Chemistry and biology of orexin signaling

Kodadek, Thomas, Cai, Di

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.43 MB

english, 2010

11

Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo

Simon, Gabriel M., Cravatt, Benjamin F.

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.45 MB

english, 2010

12

Robustness and evolvability in natural chemical resistance: identification of novel systems properties, biochemical mechanisms and regulatory interactions

Venancio, Thiago M., Balaji, S., Geetha, S., Aravind, L.

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 2.25 MB

english, 2010

13

Slow activator degradation reduces the robustness of a coupled feedback loop oscillator

Sayut, Daniel J., Sun, Lianhong

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

14

Back matter

Journal:

Molecular BioSystems

Year:

2010

File:

PDF, 2.47 MB

2010

15

Immobilization of trypsin on water-soluble dendrimer-modified carbon nanotubes for on-plate proteolysis combined with MALDI-MS analysis

Zhang, Ying, Cao, Weiman, Liu, Minbo, Yang, Shiping, Wu, Huixia, Lu, Haojie, Yang, Pengyuan

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

16

Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine

Ianculescu, Alexandra G., Friesema, Edith C. H., Visser, Theo J., Giacomini, Kathleen M., Scanlan, Thomas S.

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 760 KB

english, 2010

17

Analysis of mouse brain peptides using mass spectrometry-based peptidomics: implications for novel functions ranging from non-classical neuropeptides to microproteins

Fricker, Lloyd D.

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.20 MB

english, 2010

18

Protein–protein interaction as a powering source of oxidoreductive reactivity

Lin, Tiao-Yin

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.45 MB

english, 2010

19

Synthesis and evaluation of indazole based analog sensitive Akt inhibitors

Okuzumi, Tatsuya, Ducker, Gregory S., Zhang, Chao, Aizenstein, Brian, Hoffman, Randy, Shokat, Kevan M.

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.33 MB

english, 2010

20

Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism

Karageorgos, Ioannis, Tyukhtenko, Sergiy, Zvonok, Nikolai, Janero, David R., Sallum, Christine, Makriyannis, Alexandros

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 1.16 MB

english, 2010

21

Front cover

Journal:

Molecular BioSystems

Year:

2010

File:

PDF, 359 KB

2010

22

The interface of chemical biology and the nervous system (related to the NIDA Chemical Genomics Symposium)

Cravatt, Benjamin F., Kodadek, Thomas

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 75 KB

english, 2010

23

Back cover

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 441 KB

english, 2010

24

Quantifying cross-tissue diversity in proteasome complexes by mass spectrometry

Pelletier, Sarah, Schuurman, Karianne G., Berkers, Celia R., Ovaa, Huib, Heck, Albert J. R., Raijmakers, Reinout

Journal:

Molecular BioSystems

Year:

2010

Language:

english

File:

PDF, 704 KB

english, 2010

25

Volume 6; Issue 8

Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish

Proteomics as a tool for studying energy metabolism in lactic acid bacteria

Swapping the chitin-binding domain in Bacillus chitinases improves the substrate binding affinity and conformational stability

A chemical-genetic approach for precise spatio-temporal control of cellular signaling

Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders

3-Iodothyronamine (T1AM): a new chapter of thyroid hormone endocrinology?

Allosteric regulation of protease activity by small molecules

A diverse family of type III polyketide synthases in Eucalyptus species

Small-molecule inhibitors of c-Myc transcriptional factor suppress proliferation and induce apoptosis of promyelocytic leukemia cell via cell cycle arrest

Chemistry and biology of orexin signaling

Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo

Robustness and evolvability in natural chemical resistance: identification of novel systems properties, biochemical mechanisms and regulatory interactions

Slow activator degradation reduces the robustness of a coupled feedback loop oscillator

Back matter

Immobilization of trypsin on water-soluble dendrimer-modified carbon nanotubes for on-plate proteolysis combined with MALDI-MS analysis

Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine

Analysis of mouse brain peptides using mass spectrometry-based peptidomics: implications for novel functions ranging from non-classical neuropeptides to microproteins

Protein–protein interaction as a powering source of oxidoreductive reactivity

Synthesis and evaluation of indazole based analog sensitive Akt inhibitors

Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism

Front cover

The interface of chemical biology and the nervous system (related to the NIDA Chemical Genomics Symposium)

Back cover

Quantifying cross-tissue diversity in proteasome complexes by mass spectrometry

Contents