Volume 12; Issue 10

Molecular Cancer Therapeutics

Volume 12; Issue 10

1

Chemotherapy Counteracts Metastatic Dissemination Induced by Antiangiogenic Treatment in Mice

Rovida, A., Castiglioni, V., Decio, A., Scarlato, V., Scanziani, E., Giavazzi, R., Cesca, M.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 859 KB

english, 2013

2

Overcoming Platinum Resistance in Preclinical Models of Ovarian Cancer Using the Neddylation Inhibitor MLN4924

Jazaeri, A. A., Shibata, E., Park, J., Bryant, J. L., Conaway, M. R., Modesitt, S. C., Smith, P. G., Milhollen, M. A., Berger, A. J., Dutta, A.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 828 KB

english, 2013

3

The Dual Pathway Inhibitor Rigosertib Is Effective in Direct Patient Tumor Xenografts of Head and Neck Squamous Cell Carcinomas

Anderson, R. T., Keysar, S. B., Bowles, D. W., Glogowska, M. J., Astling, D. P., Morton, J. J., Le, P., Umpierrez, A., Eagles-Soukup, J., Gan, G. N., Vogler, B. W., Sehrt, D., Takimoto, S. M., Aisner,

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1020 KB

english, 2013

4

Novel Inhibitors of Cyclin-Dependent Kinases Combat Hepatocellular Carcinoma without Inducing Chemoresistance

Haider, C., Grubinger, M., Reznickova, E., Weiss, T. S., Rotheneder, H., Miklos, W., Berger, W., Jorda, R., Zatloukal, M., Gucky, T., Strnad, M., Krystof, V., Mikulits, W.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.53 MB

english, 2013

5

Receptor-Directed Chimeric Toxins Created by Sortase-Mediated Protein Fusion

McCluskey, A. J., Collier, R. J.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1004 KB

english, 2013

6

EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas

Basu, D., Bewley, A. F., Sperry, S. M., Montone, K. T., Gimotty, P. A., Rasanen, K., Facompre, N. D., Weinstein, G. S., Nakagawa, H., Diehl, J. A., Rustgi, A. K., Herlyn, M.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 2.48 MB

english, 2013

7

Sorafenib Overcomes Irinotecan Resistance in Colorectal Cancer by Inhibiting the ABCG2 Drug-Efflux Pump

Mazard, T., Causse, A., Simony, J., Leconet, W., Vezzio-Vie, N., Torro, A., Jarlier, M., Evrard, A., Del Rio, M., Assenat, E., Martineau, P., Ychou, M., Robert, B., Gongora, C.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 840 KB

english, 2013

8

Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

Thurn, K. T., Thomas, S., Raha, P., Qureshi, I., Munster, P. N.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.41 MB

english, 2013

9

Histone Deacetylase Inhibition Overcomes Drug Resistance through a miRNA-Dependent Mechanism

Murray-Stewart, T., Hanigan, C. L., Woster, P. M., Marton, L. J., Casero, R. A.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 611 KB

english, 2013

10

Synthetic Lethal Targeting of PTEN-Deficient Cancer Cells Using Selective Disruption of Polynucleotide Kinase/Phosphatase

Mereniuk, T. R., El Gendy, M. A. M., Mendes-Pereira, A. M., Lord, C. J., Ghosh, S., Foley, E., Ashworth, A., Weinfeld, M.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.04 MB

english, 2013

11

RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis

Bid, H. K., Roberts, R. D., Manchanda, P. K., Houghton, P. J.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 843 KB

english, 2013

12

Glycolysis Inhibition Sensitizes Non-Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation

Kim, S. M., Yun, M. R., Hong, Y. K., Solca, F., Kim, J.-H., Kim, H.-J., Cho, B. C.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.58 MB

english, 2013

13

Combination Drug Scheduling Defines a "Window of Opportunity" for Chemopotentiation of Gemcitabine by an Orally Bioavailable, Selective ChK1 Inhibitor, GNE-900

Blackwood, E., Epler, J., Yen, I., Flagella, M., O'Brien, T., Evangelista, M., Schmidt, S., Xiao, Y., Choi, J., Kowanetz, K., Ramiscal, J., Wong, K., Jakubiak, D., Yee, S., Cain, G., Gazzard, L., Will

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.92 MB

english, 2013

14

A Urokinase Receptor-Derived Peptide Inhibiting VEGF-Dependent Directional Migration and Vascular Sprouting

Bifulco, K., Longanesi-Cattani, I., Liguori, E., Arra, C., Rea, D., Masucci, M. T., De Rosa, M., Pavone, V., Stoppelli, M. P., Carriero, M. V.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.92 MB

english, 2013

15

Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2'-Deoxycytidine in Solid Tumor Cells

Venturelli, S., Berger, A., Weiland, T., Essmann, F., Waibel, M., Nuebling, T., Hacker, S., Schenk, M., Schulze-Osthoff, K., Salih, H. R., Fulda, S., Sipos, B., Johnstone, R. W., Lauer, U. M., Bitzer,

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.76 MB

english, 2013

16

Combining Erlotinib and Cetuximab Is Associated with Activity in Patients with Non-Small Cell Lung Cancer (Including Squamous Cell Carcinomas) and Wild-Type EGFR or Resistant Mutations

Wheler, J. J., Tsimberidou, A. M., Falchook, G. S., Zinner, R. G., Hong, D. S., Fok, J. Y., Fu, S., Piha-Paul, S. A., Naing, A., Kurzrock, R.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 527 KB

english, 2013

17

Catalase Abrogates -Lapachone-Induced PARP1 Hyperactivation-Directed Programmed Necrosis in NQO1-Positive Breast Cancers

Bey, E. A., Reinicke, K. E., Srougi, M. C., Varnes, M., Anderson, V. E., Pink, J. J., Li, L. S., Patel, M., Cao, L., Moore, Z., Rommel, A., Boatman, M., Lewis, C., Euhus, D. M., Bornmann, W. G., Buchs

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.66 MB

english, 2013

18

Novel Treatment for Mantle Cell Lymphoma Including Therapy-Resistant Tumor by NF- B and mTOR Dual-Targeting Approach

Chaturvedi, N. K., Rajule, R. N., Shukla, A., Radhakrishnan, P., Todd, G. L., Natarajan, A., Vose, J. M., Joshi, S. S.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 2.01 MB

english, 2013

19

Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non-Small Cell Lung Cancer

Li, R., Hu, Z., Sun, S.-Y., Chen, Z. G., Owonikoko, T. K., Sica, G. L., Ramalingam, S. S., Curran, W. J., Khuri, F. R., Deng, X.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 2.00 MB

english, 2013

20

Subtype-Specific MEK-PI3 Kinase Feedback as a Therapeutic Target in Pancreatic Adenocarcinoma

Mirzoeva, O. K., Collisson, E. A., Schaefer, P. M., Hann, B., Hom, Y. K., Ko, A. H., Korn, W. M.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 2.11 MB

english, 2013

21

Preclinical Activity of the Type II CD20 Antibody GA101 (Obinutuzumab) Compared with Rituximab and Ofatumumab In Vitro and in Xenograft Models

Herter, S., Herting, F., Mundigl, O., Waldhauer, I., Weinzierl, T., Fauti, T., Muth, G., Ziegler-Landesberger, D., Van Puijenbroek, E., Lang, S., Duong, M. N., Reslan, L., Gerdes, C. A., Friess, T., B

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

22

Prognostic Role of Lemur Tyrosine Kinase-3 Germline Polymorphisms in Adjuvant Gastric Cancer in Japan and the United States

Wakatsuki, T., LaBonte, M. J., Bohanes, P. O., Zhang, W., Yang, D., Azuma, M., Barzi, A., Ning, Y., Loupakis, F., Saadat, S., Volz, N., Stintzing, S., El-Khoueiry, R., Koizumi, W., Watanabe, M., Shah,

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.00 MB

english, 2013

23

Overexpression of Asparagine Synthetase and Matrix Metalloproteinase 19 Confers Cisplatin Sensitivity in Nasopharyngeal Carcinoma Cells

Liu, R.-Y., Dong, Z., Liu, J., Zhou, L., Huang, W., Khoo, S. K., Zhang, Z., Petillo, D., Teh, B. T., Qian, C.-N., Zhang, J.-T.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 996 KB

english, 2013

24

Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II

Meng, Z., Li, T., Ma, X., Wang, X., Van Ness, C., Gan, Y., Zhou, H., Tang, J., Lou, G., Wang, Y., Wu, J., Yen, Y., Xu, R., Huang, W.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 2.30 MB

english, 2013

25

PI3K Stimulates DNA Synthesis and Cell-Cycle Progression via Its p55PIK Regulatory Subunit Interaction with PCNA

Wang, G., Cao, X., Lai, S., Luo, X., Feng, Y., Xia, X., Yen, P. M., Gong, J., Hu, J.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 931 KB

english, 2013

26

The Functionalized Human Serine Protease Granzyme B/VEGF121 Targets Tumor Vasculature and Ablates Tumor Growth

Mohamedali, K. A., Cao, Y., Cheung, L. H., Hittelman, W. N., Rosenblum, M. G.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.81 MB

english, 2013

27

Sunitinib and SU11652 Inhibit Acid Sphingomyelinase, Destabilize Lysosomes, and Inhibit Multidrug Resistance

Ellegaard, A.-M., Groth-Pedersen, L., Oorschot, V., Klumperman, J., Kirkegaard, T., Nylandsted, J., Jaattela, M.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 2.34 MB

english, 2013

28

Targeting Aberrant Sialylation in Cancer Cells Using a Fluorinated Sialic Acid Analog Impairs Adhesion, Migration, and In Vivo Tumor Growth

Bull, C., Boltje, T. J., Wassink, M., de Graaf, A. M. A., van Delft, F. L., den Brok, M. H., Adema, G. J.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 2.31 MB

english, 2013

29

Targeting Aberrant DNA Double-Strand Break Repair in Triple-Negative Breast Cancer with Alpha-Particle Emitter Radiolabeled Anti-EGFR Antibody

Song, H., Hedayati, M., Hobbs, R. F., Shao, C., Bruchertseifer, F., Morgenstern, A., DeWeese, T. L., Sgouros, G.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.38 MB

english, 2013

30

Cetuximab Reverses the Warburg Effect by Inhibiting HIF-1-Regulated LDH-A

Lu, H., Li, X., Luo, Z., Liu, J., Fan, Z.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 2.72 MB

english, 2013

31

Correction: Inhibition of Monocarboxylate Transporter 2 Induces Senescence-Associated Mitochondrial Dysfunction and Suppresses Progression of Colorectal Malignancies In Vivo

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 282 KB

english, 2013

32

Uracil-DNA Glycosylase Expression Determines Human Lung Cancer Cell Sensitivity to Pemetrexed

Weeks, L. D., Fu, P., Gerson, S. L.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.31 MB

english, 2013