Volume 13; Issue 2

Molecular Cancer Therapeutics

Volume 13; Issue 2

1

MiR-134/487b/655 Cluster Regulates TGF- -Induced Epithelial-Mesenchymal Transition and Drug Resistance to Gefitinib by Targeting MAGI2 in Lung Adenocarcinoma Cells

Kitamura, K., Seike, M., Okano, T., Matsuda, K., Miyanaga, A., Mizutani, H., Noro, R., Minegishi, Y., Kubota, K., Gemma, A.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 695 KB

english, 2014

2

Increasing the Antitumor Effect of an EpCAM-Targeting Fusion Toxin by Facile Click PEGylation

Simon, M., Stefan, N., Borsig, L., Pluckthun, A., Zangemeister-Wittke, U.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.09 MB

english, 2014

3

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

Murai, J., Huang, S.-Y. N., Renaud, A., Zhang, Y., Ji, J., Takeda, S., Morris, J., Teicher, B., Doroshow, J. H., Pommier, Y.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.26 MB

english, 2014

4

Targeting Microtubules by Natural Agents for Cancer Therapy

Mukhtar, E., Adhami, V. M., Mukhtar, H.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 620 KB

english, 2014

5

Novel Neutralizing Hedgehog Antibody MEDI-5304 Exhibits Antitumor Activity by Inhibiting Paracrine Hedgehog Signaling

Michaud, N. R., Wang, Y., McEachern, K. A., Jordan, J. J., Mazzola, A. M., Hernandez, A., Jalla, S., Chesebrough, J. W., Hynes, M. J., Belmonte, M. A., Wang, L., Kang, J. S., Jovanovic, J., Laing, N.,

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 520 KB

english, 2014

6

Characterization of LY2228820 Dimesylate, a Potent and Selective Inhibitor of p38 MAPK with Antitumor Activity

Campbell, R. M., Anderson, B. D., Brooks, N. A., Brooks, H. B., Chan, E. M., De Dios, A., Gilmour, R., Graff, J. R., Jambrina, E., Mader, M., McCann, D., Na, S., Parsons, S. H., Pratt, S. E., Shih, C.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 833 KB

english, 2014

7

GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling

Duffy, D. J., Krstic, A., Schwarzl, T., Higgins, D. G., Kolch, W.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.65 MB

english, 2014

8

Inhibition of GSK-3 Induces Differentiation and Impaired Glucose Metabolism in Renal Cancer

Pal, K., Cao, Y., Gaisina, I. N., Bhattacharya, S., Dutta, S. K., Wang, E., Gunosewoyo, H., Kozikowski, A. P., Billadeau, D. D., Mukhopadhyay, D.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.58 MB

english, 2014

9

Acquired Resistance to Dasatinib in Lung Cancer Cell Lines Conferred by DDR2 Gatekeeper Mutation and NF1 Loss

Beauchamp, E. M., Woods, B. A., Dulak, A. M., Tan, L., Xu, C., Gray, N. S., Bass, A. J., Wong, K.-k., Meyerson, M., Hammerman, P. S.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 517 KB

english, 2014

10

Inhibition of Insulin-like Growth Factor-Binding Protein-3 Signaling through Sphingosine Kinase-1 Sensitizes Triple-Negative Breast Cancer Cells to EGF Receptor Blockade

Martin, J. L., de Silva, H. C., Lin, M. Z., Scott, C. D., Baxter, R. C.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.47 MB

english, 2014

11

Blocking SDF-1 /CXCR4 Downregulates PDGF-B and Inhibits Bone Marrow-Derived Pericyte Differentiation and Tumor Vascular Expansion in Ewing Tumors

Hamdan, R., Zhou, Z., Kleinerman, E. S.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 848 KB

english, 2014

12

Pharmacodynamic and Antineoplastic Activity of BI 836845, a Fully Human IGF Ligand-Neutralizing Antibody, and Mechanistic Rationale for Combination with Rapamycin

Friedbichler, K., Hofmann, M. H., Kroez, M., Ostermann, E., Lamche, H. R., Koessl, C., Borges, E., Pollak, M. N., Adolf, G., Adam, P. J.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.53 MB

english, 2014

13

Bisphosphonamidate Clodronate Prodrug Exhibits Selective Cytotoxic Activity against Melanoma Cell Lines

Webster, M. R., Kamat, C., Connis, N., Zhao, M., Weeraratna, A. T., Rudek, M. A., Hann, C. L., Freel Meyers, C. L.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.09 MB

english, 2014

14

Nonclinical Evaluation of the Serum Pharmacodynamic Biomarkers HGF and Shed MET following Dosing with the Anti-MET Monovalent Monoclonal Antibody Onartuzumab

Mai, E., Zheng, Z., Chen, Y., Peng, J., Severin, C., Filvaroff, E., Romero, M., Mallet, W., Kaur, S., Gelzleichter, T., Nijem, I., Merchant, M., Young, J. C.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 574 KB

english, 2014

15

Overcoming Acquired BRAF Inhibitor Resistance in Melanoma via Targeted Inhibition of Hsp90 with Ganetespib

Acquaviva, J., Smith, D. L., Jimenez, J.-P., Zhang, C., Sequeira, M., He, S., Sang, J., Bates, R. C., Proia, D. A.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.32 MB

english, 2014

16

The Effect of Photoimmunotherapy Followed by Liposomal Daunorubicin in a Mixed Tumor Model: A Demonstration of the Super-Enhanced Permeability and Retention Effect after Photoimmunotherapy

Sano, K., Nakajima, T., Choyke, P. L., Kobayashi, H.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 883 KB

english, 2014

17

Plastin Polymorphisms Predict Gender- and Stage-Specific Colon Cancer Recurrence after Adjuvant Chemotherapy

Ning, Y., Gerger, A., Zhang, W., Hanna, D. L., Yang, D., Winder, T., Wakatsuki, T., Labonte, M. J., Stintzing, S., Volz, N., Sunakawa, Y., Stremitzer, S., El-Khoueiry, R., Lenz, H.-J.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 474 KB

english, 2014

18

OATP1A/1B Transporters Affect Irinotecan and SN-38 Pharmacokinetics and Carboxylesterase Expression in Knockout and Humanized Transgenic Mice

Iusuf, D., Ludwig, M., Elbatsh, A., van Esch, A., van de Steeg, E., Wagenaar, E., van der Valk, M., Lin, F., van Tellingen, O., Schinkel, A. H.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.58 MB

english, 2014

19

Genetic and Pharmacologic Evidence That mTOR Targeting Outweighs mTORC1 Inhibition as an Antimyeloma Strategy

Chen, X., Diaz-Rodriguez, E., Ocio, E. M., Paiva, B., Mortensen, D. S., Lopez-Girona, A., Chopra, R., Miguel, J. S., Pandiella, A.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.21 MB

english, 2014

20

A Naturally Derived Small Molecule Disrupts Ligand-Dependent and Ligand-Independent Androgen Receptor Signaling in Human Prostate Cancer Cells

Amin, K. S., Jagadeesh, S., Baishya, G., Rao, P. G., Barua, N. C., Bhattacharya, S., Banerjee, P. P.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.69 MB

english, 2014

21

Correction: Aerosol Delivery of Urocanic Acid-Modified Chitosan/Programmed Cell Death 4 Complex Regulated Apoptosis, Cell Cycle, and Angiogenesis in Lungs of K-ras Null Mice

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 149 KB

english, 2014

22

Therapeutic Inhibition of Jak Activity Inhibits Progression of Gastrointestinal Tumors in Mice

Stuart, E., Buchert, M., Putoczki, T., Thiem, S., Farid, R., Elzer, J., Huszar, D., Waring, P. M., Phesse, T. J., Ernst, M.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 740 KB

english, 2014

23

Activation of AR Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation

Wang, Y., Yu, Q., He, X., Romigh, T., Altemus, J., Eng, C.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.34 MB

english, 2014

24

The Selective Anaplastic Lymphoma Receptor Tyrosine Kinase Inhibitor ASP3026 Induces Tumor Regression and Prolongs Survival in Non-Small Cell Lung Cancer Model Mice

Mori, M., Ueno, Y., Konagai, S., Fushiki, H., Shimada, I., Kondoh, Y., Saito, R., Mori, K., Shindou, N., Soga, T., Sakagami, H., Furutani, T., Doihara, H., Kudoh, M., Kuromitsu, S.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 785 KB

english, 2014

25

MM-141, an IGF-IR- and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors

Fitzgerald, J. B., Johnson, B. W., Baum, J., Adams, S., Iadevaia, S., Tang, J., Rimkunas, V., Xu, L., Kohli, N., Rennard, R., Razlog, M., Jiao, Y., Harms, B. D., Olivier, K. J., Schoeberl, B., Nielsen

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.11 MB

english, 2014

26

Selective Inhibition of Pancreatic Ductal Adenocarcinoma Cell Growth by the Mitotic MPS1 Kinase Inhibitor NMS-P715

Slee, R. B., Grimes, B. R., Bansal, R., Gore, J., Blackburn, C., Brown, L., Gasaway, R., Jeong, J., Victorino, J., March, K. L., Colombo, R., Herbert, B.-S., Korc, M.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 852 KB

english, 2014

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