Volume 13; Issue 5

Molecular Cancer Therapeutics

Volume 13; Issue 5

1

Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors

Dienstmann, R., Rodon, J., Serra, V., Tabernero, J.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 664 KB

english, 2014

2

Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer

Marin-Aguilera, M., Codony-Servat, J., Reig, O., Lozano, J. J., Fernandez, P. L., Pereira, M. V., Jimenez, N., Donovan, M., Puig, P., Mengual, L., Bermudo, R., Font, A., Gallardo, E., Ribal, M. J., Al

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.26 MB

english, 2014

3

Preclinical Pharmacological Evaluation of a Novel Multiple Kinase Inhibitor, ON123300, in Brain Tumor Models

Zhang, X., Lv, H., Zhou, Q., Elkholi, R., Chipuk, J. E., Reddy, M. V. R., Reddy, E. P., Gallo, J. M.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 977 KB

english, 2014

4

UPARANT: A Urokinase Receptor-Derived Peptide Inhibitor of VEGF-Driven Angiogenesis with Enhanced Stability and In Vitro and In Vivo Potency

Carriero, M. V., Bifulco, K., Minopoli, M., Lista, L., Maglio, O., Mele, L., Di Carluccio, G., De Rosa, M., Pavone, V.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.01 MB

english, 2014

5

Preclinical Evaluation of the Supercritical Extract of Azadirachta Indica (Neem) Leaves In Vitro and In Vivo on Inhibition of Prostate Cancer Tumor Growth

Wu, Q., Kohli, M., Bergen, H. R., Cheville, J. C., Karnes, R. J., Cao, H., Young, C. Y. F., Tindall, D. J., McNiven, M. A., Donkena, K. V.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.35 MB

english, 2014

6

Combination of Imatinib with CXCR4 Antagonist BKT140 Overcomes the Protective Effect of Stroma and Targets CML In Vitro and In Vivo

Beider, K., Darash-Yahana, M., Blaier, O., Koren-Michowitz, M., Abraham, M., Wald, H., Wald, O., Galun, E., Eizenberg, O., Peled, A., Nagler, A.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.22 MB

english, 2014

7

Metallothionein 1G and Zinc Sensitize Human Colorectal Cancer Cells to Chemotherapy

Arriaga, J. M., Greco, A., Mordoh, J., Bianchini, M.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.50 MB

english, 2014

8

PIM Kinases Are Essential for Chronic Lymphocytic Leukemia Cell Survival (PIM2/3) and CXCR4-Mediated Microenvironmental Interactions (PIM1)

Decker, S., Finter, J., Forde, A. J., Kissel, S., Schwaller, J., Mack, T. S., Kuhn, A., Gray, N., Follo, M., Jumaa, H., Burger, M., Zirlik, K., Pfeifer, D., Miduturu, C. V., Eibel, H., Veelken, H., Di

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.34 MB

english, 2014

9

A Novel Temozolomide-Perillyl Alcohol Conjugate Exhibits Superior Activity against Breast Cancer Cells In Vitro and Intracranial Triple-Negative Tumor Growth In Vivo

Chen, T. C., Cho, H.-Y., Wang, W., Barath, M., Sharma, N., Hofman, F. M., Schonthal, A. H.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

10

Protein Kinase D as a Potential Chemotherapeutic Target for Colorectal Cancer

Wei, N., Chu, E., Wipf, P., Schmitz, J. C.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.11 MB

english, 2014

11

The Use of Olaparib (AZD2281) Potentiates SN-38 Cytotoxicity in Colon Cancer Cells by Indirect Inhibition of Rad51-Mediated Repair of DNA Double-Strand Breaks

Tahara, M., Inoue, T., Sato, F., Miyakura, Y., Horie, H., Yasuda, Y., Fujii, H., Kotake, K., Sugano, K.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.45 MB

english, 2014

12

Embelin Reduces Colitis-Associated Tumorigenesis through Limiting IL-6/STAT3 Signaling

Dai, Y., Jiao, H., Teng, G., Wang, W., Zhang, R., Wang, Y., Hebbard, L., George, J., Qiao, L.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.73 MB

english, 2014

13

Nuclear Epidermal Growth Factor Receptor Is a Functional Molecular Target in Triple-Negative Breast Cancer

Brand, T. M., Iida, M., Dunn, E. F., Luthar, N., Kostopoulos, K. T., Corrigan, K. L., Wleklinski, M. J., Yang, D., Wisinski, K. B., Salgia, R., Wheeler, D. L.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.94 MB

english, 2014

14

Aurora Kinase Inhibition Induces PUMA via NF- B to Kill Colon Cancer Cells

Sun, J., Knickelbein, K., He, K., Chen, D., Dudgeon, C., Shu, Y., Yu, J., Zhang, L.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.10 MB

english, 2014

15

Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells

Fiskus, W., Sharma, S., Qi, J., Valenta, J. A., Schaub, L. J., Shah, B., Peth, K., Portier, B. P., Rodriguez, M., Devaraj, S. G. T., Zhan, M., Sheng, J., Iyer, S. P., Bradner, J. E., Bhalla, K. N.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.31 MB

english, 2014

16

ERBB3/HER2 Signaling Promotes Resistance to EGFR Blockade in Head and Neck and Colorectal Cancer Models

Zhang, L., Castanaro, C., Luan, B., Yang, K., Fan, L., Fairhurst, J. L., Rafique, A., Potocky, T. B., Shan, J., Delfino, F. J., Shi, E., Huang, T., Martin, J. H., Chen, G., MacDonald, D., Rudge, J. S.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.17 MB

english, 2014

17

Concordance of Genomic Alterations between Primary and Recurrent Breast Cancer

Meric-Bernstam, F., Frampton, G. M., Ferrer-Lozano, J., Yelensky, R., Perez-Fidalgo, J. A., Wang, Y., Palmer, G. A., Ross, J. S., Miller, V. A., Su, X., Eroles, P., Barrera, J. A., Burgues, O., Lluch,

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 900 KB

english, 2014

18

Characterization of the Activity of the PI3K/mTOR Inhibitor XL765 (SAR245409) in Tumor Models with Diverse Genetic Alterations Affecting the PI3K Pathway

Yu, P., Laird, A. D., Du, X., Wu, J., Won, K.-A., Yamaguchi, K., Hsu, P. P., Qian, F., Jaeger, C. T., Zhang, W., Buhr, C. A., Shen, P., Abulafia, W., Chen, J., Young, J., Plonowski, A., Yakes, F. M.,

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.27 MB

english, 2014

19

Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma

Ng, K. T.-P., Lo, C. M., Guo, D. Y., Qi, X., Li, C. X., Geng, W., Liu, X. B., Ling, C. C., Ma, Y. Y., Yeung, W. H., Shao, Y., Poon, R. T.-P., Fan, S. T., Man, K.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.03 MB

english, 2014

20

The Role of Gene Body Cytosine Modifications in MGMT Expression and Sensitivity to Temozolomide

Moen, E. L., Stark, A. L., Zhang, W., Dolan, M. E., Godley, L. A.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.13 MB

english, 2014

21

Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

Campbell, V. T., Nadesan, P., Ali, S. A., Wang, C. Y. Y., Whetstone, H., Poon, R., Wei, Q., Keilty, J., Proctor, J., Wang, L. W., Apte, S. S., McGovern, K., Alman, B. A., Wunder, J. S.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 876 KB

english, 2014

22

Nuclear Translocation of Hand-1 Acts as a Molecular Switch to Regulate Vascular Radiosensitivity in Medulloblastoma Tumors: The Protein uPAR Is a Cytoplasmic Sequestration Factor for Hand-1

Asuthkar, S., Gogineni, V. R., Rao, J. S., Velpula, K. K.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 3.12 MB

english, 2014

23

Centmitor-1, a Novel Acridinyl-Acetohydrazide, Possesses Similar Molecular Interaction Field and Antimitotic Cellular Phenotype as Rigosertib, ON 01910.Na

Maki-Jouppila, J. H. E., Laine, L. J., Rehnberg, J., Narvi, E., Tiikkainen, P., Hukasova, E., Halonen, P., Lindqvist, A., Kallio, L., Poso, A., Kallio, M. J.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 3.20 MB

english, 2014

24

Targeting STAT5 in Hematologic Malignancies through Inhibition of the Bromodomain and Extra-Terminal (BET) Bromodomain Protein BRD2

Liu, S., Walker, S. R., Nelson, E. A., Cerulli, R., Xiang, M., Toniolo, P. A., Qi, J., Stone, R. M., Wadleigh, M., Bradner, J. E., Frank, D. A.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 802 KB

english, 2014

25

The G Protein-Coupled Receptor GALR2 Promotes Angiogenesis in Head and Neck Cancer

Banerjee, R., Van Tubergen, E. A., Scanlon, C. S., Vander Broek, R., Lints, J. P., Liu, M., Russo, N., Inglehart, R. C., Wang, Y., Polverini, P. J., Kirkwood, K. L., D'Silva, N. J.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.19 MB

english, 2014

26

Pharmacologic Suppression of JAK1/2 by JAK1/2 Inhibitor AZD1480 Potently Inhibits IL-6-Induced Experimental Prostate Cancer Metastases Formation

Gu, L., Talati, P., Vogiatzi, P., Romero-Weaver, A. L., Abdulghani, J., Liao, Z., Leiby, B., Hoang, D. T., Mirtti, T., Alanen, K., Zinda, M., Huszar, D., Nevalainen, M. T.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.10 MB

english, 2014

27

Enhancement of Nab-Paclitaxel Antitumor Activity through Addition of Multitargeting Antiangiogenic Agents in Experimental Pancreatic Cancer

Awasthi, N., Zhang, C., Schwarz, A. M., Hinz, S., Schwarz, M. A., Schwarz, R. E.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.41 MB

english, 2014

28

Ponatinib Induces Apoptosis in Imatinib-Resistant Human Mast Cells by Dephosphorylating Mutant D816V KIT and Silencing -Catenin Signaling

Jin, B., Ding, K., Pan, J.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 3.23 MB

english, 2014

29

Characterization of the Novel and Specific PI3K Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials

Fritsch, C., Huang, A., Chatenay-Rivauday, C., Schnell, C., Reddy, A., Liu, M., Kauffmann, A., Guthy, D., Erdmann, D., De Pover, A., Furet, P., Gao, H., Ferretti, S., Wang, Y., Trappe, J., Brachmann,

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1014 KB

english, 2014

30

The Phosphoinositide 3-Kinase Selective Inhibitor BYL719 Enhances the Effect of the Protein Kinase C Inhibitor AEB071 in GNAQ/GNA11-Mutant Uveal Melanoma Cells

Musi, E., Ambrosini, G., de Stanchina, E., Schwartz, G. K.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.14 MB

english, 2014