Volume 13; Issue 7

Molecular Cancer Therapeutics

Volume 13; Issue 7

1

A Meta-analysis of Somatic Mutations from Next Generation Sequencing of 241 Melanomas: A Road Map for the Study of Genes with Potential Clinical Relevance

Xia, J., Jia, P., Hutchinson, K. E., Dahlman, K. B., Johnson, D., Sosman, J., Pao, W., Zhao, Z.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 5.62 MB

english, 2014

2

Combination of Conventional Chemotherapeutics with Redox-Active Cerium Oxide Nanoparticles--A Novel Aspect in Cancer Therapy

Sack, M., Alili, L., Karaman, E., Das, S., Gupta, A., Seal, S., Brenneisen, P.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 681 KB

english, 2014

3

Phosphoproteomics of MAPK Inhibition in BRAF-Mutated Cells and a Role for the Lethal Synergism of Dual BRAF and CK2 Inhibition

Parker, R., Clifton-Bligh, R., Molloy, M. P.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.47 MB

english, 2014

4

Targeting Multiple Key Signaling Pathways in Melanoma Using Leelamine

Gowda, R., Madhunapantula, S. V., Kuzu, O. F., Sharma, A., Robertson, G. P.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 905 KB

english, 2014

5

Leelamine Mediates Cancer Cell Death through Inhibition of Intracellular Cholesterol Transport

Kuzu, O. F., Gowda, R., Sharma, A., Robertson, G. P.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.42 MB

english, 2014

6

Inhibition of SIRT1 Signaling Sensitizes the Antitumor Activity of Silybin against Human Lung Adenocarcinoma Cells In Vitro and In Vivo

Liang, Z., Yang, Y., Wang, H., Yi, W., Yan, X., Yan, J., Li, Y., Feng, Y., Yu, S., Yang, J., Jin, Z., Duan, W., Chen, W.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 690 KB

english, 2014

7

PIK3R3 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Colorectal Cancer

Wang, G., Yang, X., Li, C., Cao, X., Luo, X., Hu, J.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.96 MB

english, 2014

8

Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

Zerbini, L. F., Bhasin, M. K., de Vasconcellos, J. F., Paccez, J. D., Gu, X., Kung, A. L., Libermann, T. A.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 8.83 MB

english, 2014

9

Combination of Anti-HER3 Antibody MM-121/SAR256212 and Cetuximab Inhibits Tumor Growth in Preclinical Models of Head and Neck Squamous Cell Carcinoma

Jiang, N., Wang, D., Hu, Z., Shin, H. J. C., Qian, G., Rahman, M. A., Zhang, H., Amin, A. R. M. R., Nannapaneni, S., Wang, X., Chen, Z., Garcia, G., MacBeath, G., Shin, D. M., Khuri, F. R., Ma, J., Ch

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.01 MB

english, 2014

10

Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling

Balic, A., Sorensen, M. D., Trabulo, S. M., Sainz, B., Cioffi, M., Vieira, C. R., Miranda-Lorenzo, I., Hidalgo, M., Kleeff, J., Erkan, M., Heeschen, C.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.67 MB

english, 2014

11

Geranylgeranylacetone Blocks Doxorubicin-Induced Cardiac Toxicity and Reduces Cancer Cell Growth and Invasion through RHO Pathway Inhibition

Sysa-Shah, P., Xu, Y., Guo, X., Pin, S., Bedja, D., Bartock, R., Tsao, A., Hsieh, A., Wolin, M. S., Moens, A., Raman, V., Orita, H., Gabrielson, K. L.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.48 MB

english, 2014

12

Evaluation of Apoptosis Induction by Concomitant Inhibition of MEK, mTOR, and Bcl-2 in Human Acute Myelogenous Leukemia Cells

Zhang, W., Ruvolo, V. R., Gao, C., Zhou, L., Bornmann, W., Tsao, T., Schober, W. D., Smith, P., Guichard, S., Konopleva, M., Andreeff, M.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.96 MB

english, 2014

13

Anti-miR182 Reduces Ovarian Cancer Burden, Invasion, and Metastasis: An In Vivo Study in Orthotopic Xenografts of Nude Mice

Xu, X., Ayub, B., Liu, Z., Serna, V. A., Qiang, W., Liu, Y., Hernando, E., Zabludoff, S., Kurita, T., Kong, B., Wei, J.-J.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.24 MB

english, 2014

14

Preferential Estrogen Receptor Ligands Reduce Bcl-2 Expression in Hormone-Resistant Breast Cancer Cells to Increase Autophagy

Ruddy, S. C., Lau, R., Cabrita, M. A., McGregor, C., McKay, B. C., Murphy, L. C., Wright, J. S., Durst, T., Pratt, M. A. C.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.29 MB

english, 2014

15

MicroRNA-26b Represses Colon Cancer Cell Proliferation by Inhibiting Lymphoid Enhancer Factor 1 Expression

Zhang, Z., Kim, K., Li, X., Moreno, M., Sharp, T., Goodheart, M. J., Safe, S., Dupuy, A. J., Amendt, B. A.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 978 KB

english, 2014

16

Regulation of SRC Kinases by microRNA-3607 Located in a Frequently Deleted Locus in Prostate Cancer

Saini, S., Majid, S., Shahryari, V., Tabatabai, Z. L., Arora, S., Yamamura, S., Tanaka, Y., Dahiya, R., Deng, G.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.21 MB

english, 2014

17

Targeted BikDD Expression Kills Androgen-Dependent and Castration-Resistant Prostate Cancer Cells

Xie, X., Kong, Y., Tang, H., Yang, L., Hsu, J. L., Hung, M.-C.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.30 MB

english, 2014

18

A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Kashif, M., Andersson, C., Aberg, M., Nygren, P., Sjoblom, T., Hammerling, U., Larsson, R., Gustafsson, M. G.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.39 MB

english, 2014

19

Ectodomain-Specific E-Cadherin Antibody Suppresses Skin SCC Growth and Reduces Tumor Grade: A Multitargeted Therapy Modulating RTKs and the PTEN-p53-MDM2 Axis

Brouxhon, S. M., Kyrkanides, S., Raja, V., Silberfeld, A., Teng, X., Trochesset, D., Cohen, J., Ma, L.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.89 MB

english, 2014

20

Antibody-Based Delivery of IL2 and Cytotoxics Eradicates Tumors in Immunocompetent Mice

Gutbrodt, K. L., Casi, G., Neri, D.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 522 KB

english, 2014

21

BET Bromodomain Inhibitors Block Growth of Pancreatic Cancer Cells in Three-Dimensional Collagen

Sahai, V., Kumar, K., Knab, L. M., Chow, C. R., Raza, S. S., Bentrem, D. J., Ebine, K., Munshi, H. G.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 4.10 MB

english, 2014

22

Preclinical Evaluation of Multistep Targeting of Diasialoganglioside GD2 Using an IgG-scFv Bispecific Antibody with High Affinity for GD2 and DOTA Metal Complex

Cheal, S. M., Xu, H., Guo, H.-f., Zanzonico, P. B., Larson, S. M., Cheung, N.-K.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 650 KB

english, 2014

23

EW-7197, a Novel ALK-5 Kinase Inhibitor, Potently Inhibits Breast to Lung Metastasis

Son, J. Y., Park, S.-Y., Kim, S.-J., Lee, S. J., Park, S.-A., Kim, M.-J., Kim, S. W., Kim, D.-K., Nam, J.-S., Sheen, Y. Y.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.99 MB

english, 2014

24

Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer

Gharpure, K. M., Chu, K. S., Bowerman, C. J., Miyake, T., Pradeep, S., Mangala, S. L., Han, H.-D., Rupaimoole, R., Armaiz-Pena, G. N., Rahhal, T. B., Wu, S. Y., Luft, J. C., Napier, M. E., Lopez-Beres

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.54 MB

english, 2014

25

Activation of Liver X Receptors Inhibits Hedgehog Signaling, Clonogenic Growth, and Self-Renewal in Multiple Myeloma

Agarwal, J. R., Wang, Q., Tanno, T., Rasheed, Z., Merchant, A., Ghosh, N., Borrello, I., Huff, C. A., Parhami, F., Matsui, W.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 374 KB

english, 2014

26

Generation of a Canine Anti-EGFR (ErbB-1) Antibody for Passive Immunotherapy in Dog Cancer Patients

Singer, J., Fazekas, J., Wang, W., Weichselbaumer, M., Matz, M., Mader, A., Steinfellner, W., Meitz, S., Mechtcheriakova, D., Sobanov, Y., Willmann, M., Stockner, T., Spillner, E., Kunert, R., Jensen-

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.61 MB

english, 2014

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