Volume 6; Issue 2

Molecular Cancer Therapeutics

Volume 6; Issue 2

1

In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1

Lansing, T. J., McConnell, R. T., Duckett, D. R., Spehar, G. M., Knick, V. B., Hassler, D. F., Noro, N., Furuta, M., Emmitte, K. A., Gilmer, T. M., Mook, R. A., Cheung, M.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 445 KB

english, 2007

2

Effect of frequently used chemotherapeutic drugs on the cytotoxic activity of human natural killer cells

Markasz, L., Stuber, G., Vanherberghen, B., Flaberg, E., Olah, E., Carbone, E., Eksborg, S., Klein, E., Skribek, H., Szekely, L.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 409 KB

english, 2007

3

Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications

Chattopadhyay, S., Moran, R. G., Goldman, I. D.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 396 KB

english, 2007

4

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

Mitchell, C., Park, M. A., Zhang, G., Han, S. I., Harada, H., Franklin, R. A., Yacoub, A., Li, P.-L., Hylemon, P. B., Grant, S., Dent, P.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 712 KB

english, 2007

5

Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade

Wu, W., Onn, A., Isobe, T., Itasaka, S., Langley, R. R., Shitani, T., Shibuya, K., Komaki, R., Ryan, A. J., Fidler, I. J., Herbst, R. S., O'Reilly, M. S.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 1.33 MB

english, 2007

6

Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose

Maher, J. C., Wangpaichitr, M., Savaraj, N., Kurtoglu, M., Lampidis, T. J.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 696 KB

english, 2007

7

HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells

Mani, K., Sandgren, S., Lilja, J., Cheng, F., Svensson, K., Persson, L., Belting, M.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 300 KB

english, 2007

8

Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2

Mhaidat, N. M., Wang, Y., Kiejda, K. A., Zhang, X. D., Hersey, P.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 551 KB

english, 2007

9

A novel three-dimensional model to quantify metastatic melanoma invasion

Ghajar, C. M., Suresh, V., Peyton, S. R., Raub, C. B., Meyskens, F. L., George, S. C., Putnam, A. J.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 516 KB

english, 2007

10

Optimizing the development of targeted agents in pancreatic cancer: tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays

Rubio-Viqueira, B., Mezzadra, H., Nielsen, M. E., Jimeno, A., Zhang, X., Iacobuzio-Donahue, C., Maitra, A., Hidalgo, M., Altiok, S.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 529 KB

english, 2007

11

Interleukin-18 directly activates T-bet expression and function via p38 mitogen-activated protein kinase and nuclear factor- B in acute myeloid leukemia-derived predendritic KG-1 cells

Bachmann, M., Dragoi, C., Poleganov, M. A., Pfeilschifter, J., Muhl, H.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 359 KB

english, 2007

12

Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit

Williams, K. J., Telfer, B. A., Shannon, A. M., Babur, M., Stratford, I. J., Wedge, S. R.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 472 KB

english, 2007

13

Why should we still care about oncogenes?

Diehl, K. M., Keller, E. T., Woods Ignatoski, K. M.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 235 KB

english, 2007

14

The NC1 domain of type XIX collagen inhibits in vivo melanoma growth

Ramont, L., Brassart-Pasco, S., Thevenard, J., Deshorgue, A., Venteo, L., Laronze, J. Y., Pluot, M., Monboisse, J.-C., Maquart, F.-X.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 667 KB

english, 2007

15

Inhibition of p38 mitogen-activated protein kinase unmasks a CD30-triggered apoptotic pathway in anaplastic large cell lymphoma cells

Krysov, S. V., Rowley, T. F., Al-Shamkhani, A.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 361 KB

english, 2007

16

Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions

Rosato, R. R., Almenara, J. A., Kolla, S. S., Maggio, S. C., Coe, S., Gimenez, M. S., Dent, P., Grant, S.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 704 KB

english, 2007

17

Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition

Buck, E., Eyzaguirre, A., Barr, S., Thompson, S., Sennello, R., Young, D., Iwata, K. K., Gibson, N. W., Cagnoni, P., Haley, J. D.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 792 KB

english, 2007

18

Disrupting Skp2-cyclin A interaction with a blocking peptide induces selective cancer cell killing

Ji, P., Sun, D., Wang, H., Bauzon, F., Zhu, L.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 612 KB

english, 2007

19

Functional evaluation of novel soluble insulin-like growth factor (IGF)-II-specific ligand traps based on modified domain 11 of the human IGF2 receptor

Prince, S. N., Foulstone, E. J., Zaccheo, O. J., Williams, C., Hassan, A. B.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 519 KB

english, 2007

20

The application of cassette dosing for pharmacokinetic screening in small-molecule cancer drug discovery

Smith, N. F., Raynaud, F. I., Workman, P.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 384 KB

english, 2007

21

Gene expression analysis of gallium-resistant and gallium-sensitive lymphoma cells reveals a role for metal-responsive transcription factor-1, metallothionein-2A, and zinc transporter-1 in modulating the antineoplastic activity of gallium nitrate

Yang, M., Kroft, S. H., Chitambar, C. R.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 479 KB

english, 2007

22

Plasminogen Kringle 5 blocks tumor progression by antiangiogenic and proinflammatory pathways

Perri, S. R., Martineau, D., Francois, M., Lejeune, L., Bisson, L., Durocher, Y., Galipeau, J.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 552 KB

english, 2007

23

Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

Senkal, C. E., Ponnusamy, S., Rossi, M. J., Bialewski, J., Sinha, D., Jiang, J. C., Jazwinski, S. M., Hannun, Y. A., Ogretmen, B.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 960 KB

english, 2007

24

Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells

Failly, M., Korur, S., Egler, V., Boulay, J.-L., Lino, M. M., Imber, R., Merlo, A.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 405 KB

english, 2007

25

Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells

Monks, N. R., Liu, S., Xu, Y., Yu, H., Bendelow, A. S., Moscow, J. A.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 490 KB

english, 2007

26

Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor B

Son, D. J., Park, M. H., Chae, S. J., Moon, S. O., Lee, J. W., Song, H. S., Moon, D. C., Kang, S. S., Kwon, Y. E., Hong, J. T.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 795 KB

english, 2007

27

Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect

Sheffer, Y., Leon, O., Pinthus, J. H., Nagler, A., Mor, Y., Genin, O., Iluz, M., Kawada, N., Yoshizato, K., Pines, M.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 591 KB

english, 2007

28

Treatment of prostate cancer with Ad5/3 24hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo

Rajecki, M., Kanerva, A., Stenman, U.-H., Tenhunen, M., Kangasniemi, L., Sarkioja, M., Ala-Opas, M. Y., Alfthan, H., Sankila, A., Rintala, E., Desmond, R. A., Hakkarainen, T., Hemminki, A.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 773 KB

english, 2007

29

Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells

Reinhold, W. C., Reimers, M. A., Maunakea, A. K., Kim, S., Lababidi, S., Scherf, U., Shankavaram, U. T., Ziegler, M. S., Stewart, C., Kouros-Mehr, H., Cui, H., Dolginow, D., Scudiero, D. A., Pommier,

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 801 KB

english, 2007

30

Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts

Taylor, A. P., Goldenberg, D. M.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 391 KB

english, 2007

31

Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling

Nahta, R., Yuan, L. X.H., Du, Y., Esteva, F. J.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 594 KB

english, 2007

32

Target-specific cytotoxic activity of recombinant immunotoxin scFv(MUC1)-ETA on breast carcinoma cells and primary breast tumors

Singh, R., Samant, U., Hyland, S., Chaudhari, P. R., Wels, W. S., Bandyopadhyay, D.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 460 KB

english, 2007

33

The rGel/BLyS fusion toxin specifically targets malignant B cells expressing the BLyS receptors BAFF-R, TACI, and BCMA

Lyu, M.-A., Cheung, L. H., Hittelman, W. N., Marks, J. W., Aguiar, R. C.T., Rosenblum, M. G.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 693 KB

english, 2007

34

The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems

Goldsmith, M. E., Aguila, A., Steadman, K., Martinez, A., Steinberg, S. M., Alley, M. C., Waud, W. R., Bates, S. E., Fojo, T.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 410 KB

english, 2007

35

Novel compounds with antiproliferative activity against imatinib-resistant cell lines

Lerma, E. I., Nguyen, V.-A., Wang, T., Tipping, A., Melo, J. V., Kufe, D., Austin, D. J., Deisseroth, A.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 448 KB

english, 2007

36

R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II

Zhu, H., Huang, M., Yang, F., Chen, Y., Miao, Z.-H., Qian, X.-H., Xu, Y.-F., Qin, Y.-X., Luo, H.-B., Shen, X., Geng, M.-Y., Cai, Y.-J., Ding, J.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 616 KB

english, 2007

37

Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer

Suzuki, C., Takahashi, K., Hayama, S., Ishikawa, N., Kato, T., Ito, T., Tsuchiya, E., Nakamura, Y., Daigo, Y.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 578 KB

english, 2007

38

Prediction of drug combination chemosensitivity in human bladder cancer

Havaleshko, D. M., Cho, H., Conaway, M., Owens, C. R., Hampton, G., Lee, J. K., Theodorescu, D.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 391 KB

english, 2007

39

Sensitization of p53-mutated epithelial ovarian cancer to CD95-mediated apoptosis is synergistically induced by cisplatin pretreatment

Bagnoli, M., Balladore, E., Luison, E., Alberti, P., Raspagliesi, F., Marcomini, B., Canevari, S., Mezzanzanica, D.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 627 KB

english, 2007

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