Volume 6; Issue 3

Molecular Cancer Therapeutics

Volume 6; Issue 3

1

Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study

Shankavaram, U. T., Reinhold, W. C., Nishizuka, S., Major, S., Morita, D., Chary, K. K., Reimers, M. A., Scherf, U., Kahn, A., Dolginow, D., Cossman, J., Kaldjian, E. P., Scudiero, D. A., Petricoin, E

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 941 KB

english, 2007

2

Radiation-induced cell signaling: inside-out and outside-in

Valerie, K., Yacoub, A., Hagan, M. P., Curiel, D. T., Fisher, P. B., Grant, S., Dent, P.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 542 KB

english, 2007

3

Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor- B signaling in in vivo SKH-1 hairless mice

Sharma, S. D., Meeran, S. M., Katiyar, S. K.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 542 KB

english, 2007

4

Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor- B and nuclear factor- B-regulated gene products in IFN- -sensitive and IFN- -resistant human bladder cancer cells

Kamat, A. M., Sethi, G., Aggarwal, B. B.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 577 KB

english, 2007

5

Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

Sarkaria, J. N., Yang, L., Grogan, P. T., Kitange, G. J., Carlson, B. L., Schroeder, M. A., Galanis, E., Giannini, C., Wu, W., Dinca, E. B., James, C. D.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 417 KB

english, 2007

6

p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3

Wong, R. P. C., Tsang, W. P., Chau, P. Y., Co, N. N., Tsang, T. Y., Kwok, T. T.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 476 KB

english, 2007

7

Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo

Mook, O. R., Baas, F., de Wissel, M. B., Fluiter, K.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 375 KB

english, 2007

8

Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines

Pledgie-Tracy, A., Sobolewski, M. D., Davidson, N. E.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 658 KB

english, 2007

9

The power and promise of "rewiring" the mitogen-activated protein kinase network in prostate cancer therapeutics

Papatsoris, A. G., Karamouzis, M. V., Papavassiliou, A. G.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 469 KB

english, 2007

10

Targeting BRAFV600E in thyroid carcinoma: therapeutic implications

Mitsiades, C. S., Negri, J., McMullan, C., McMillin, D. W., Sozopoulos, E., Fanourakis, G., Voutsinas, G., Tseleni-Balafouta, S., Poulaki, V., Batt, D., Mitsiades, N.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 405 KB

english, 2007

11

Macromolecular delivery of 5-aminolaevulinic acid for photodynamic therapy using dendrimer conjugates

Battah, S., Balaratnam, S., Casas, A., O'Neill, S., Edwards, C., Batlle, A., Dobbin, P., MacRobert, A. J.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 404 KB

english, 2007

12

High-resolution single-photon emission computed tomography and X-ray computed tomography imaging of Tc-99m-labeled anti-DR5 antibody in breast tumor xenografts

Kim, H., Chaudhuri, T. R., Buchsbaum, D. J., Wang, D., Zinn, K. R.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 640 KB

english, 2007

13

Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells

Mimeault, M., Johansson, S. L., Vankatraman, G., Moore, E., Henichart, J.-P., Depreux, P., Lin, M.-F., Batra, S. K.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 616 KB

english, 2007

14

Resistance to c-KIT kinase inhibitors conferred by V654A mutation

Roberts, K. G., Odell, A. F., Byrnes, E. M., Baleato, R. M., Griffith, R., Lyons, A. B., Ashman, L. K.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 253 KB

english, 2007

15

A novel class of pyranocoumarin anti-androgen receptor signaling compounds

Guo, J., Jiang, C., Wang, Z., Lee, H.-J., Hu, H., Malewicz, B., Lee, H.-J., Lee, J.-H., Baek, N.-I., Jeong, J.-H., Kim, D.-K., Kang, K.-S., Kim, S.-H., Lu, J.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 654 KB

english, 2007

16

Proapoptotic ability of oncogenic H-Ras to facilitate apoptosis induced by histone deacetylase inhibitors in human cancer cells

Choudhary, S., Wang, H.-C. R.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 490 KB

english, 2007

17

ClC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment

Weylandt, K. H., Nebrig, M., Jansen-Rosseck, N., Amey, J. S., Carmena, D., Wiedenmann, B., Higgins, C. F., Sardini, A.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 489 KB

english, 2007

18

Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells

Ahmad, K. A., Harris, N. H., Johnson, A. D., Lindvall, H. C.N., Wang, G., Ahmed, K.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 306 KB

english, 2007

19

Bortezomib, but not cisplatin, induces mitochondria-dependent apoptosis accompanied by up-regulation of noxa in the non-small cell lung cancer cell line NCI-H460

Voortman, J., Checinska, A., Giaccone, G., Rodriguez, J. A., Kruyt, F. A.E.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 581 KB

english, 2007

20

Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein

Karikari, C. A., Roy, I., Tryggestad, E., Feldmann, G., Pinilla, C., Welsh, K., Reed, J. C., Armour, E. P., Wong, J., Herman, J., Rakheja, D., Maitra, A.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 557 KB

english, 2007

21

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial

Thomas, H. D., Calabrese, C. R., Batey, M. A., Canan, S., Hostomsky, Z., Kyle, S., Maegley, K. A., Newell, D. R., Skalitzky, D., Wang, L.-Z., Webber, S. E., Curtin, N. J.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 605 KB

english, 2007

22

P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models

Joshi, K. S., Rathos, M. J., Mahajan, P., Wagh, V., Shenoy, S., Bhatia, D., Chile, S., Sivakumar, M., Maier, A., Fiebig, H.-H., Sharma, S.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 857 KB

english, 2007

23

Inactivation of glycogen synthase kinase-3 , a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells

Kunnimalaiyaan, M., Vaccaro, A. M., Ndiaye, M. A., Chen, H.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 388 KB

english, 2007

24

Blockade of the phosphatidylinositol-3-kinase-Akt signaling pathway enhances the induction of apoptosis by microtubule-destabilizing agents in tumor cells in which the pathway is constitutively activated

Fujiwara, Y., Hosokawa, Y., Watanabe, K., Tanimura, S., Ozaki, K.-i., Kohno, M.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 669 KB

english, 2007

25

Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor

Muto, A., Hori, M., Sasaki, Y., Saitoh, A., Yasuda, I., Maekawa, T., Uchida, T., Asakura, K., Nakazato, T., Kaneda, T., Kizaki, M., Ikeda, Y., Yoshida, T.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 256 KB

english, 2007

26

Modulation of cancer cell survival pathways using multivalent liposomal therapeutic antibody constructs

Chiu, G. N.C., Edwards, L. A., Kapanen, A. I., Malinen, M. M., Dragowska, W. H., Warburton, C., Chikh, G. G., Fang, K. Y.Y., Tan, S., Sy, J., Tucker, C., Waterhouse, D. N., Klasa, R., Bally, M. B.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 856 KB

english, 2007

27

Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer

Jimeno, A., Rubio-Viqueira, B., Amador, M. L., Grunwald, V., Maitra, A., Iacobuzio-Donahue, C., Hidalgo, M.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 391 KB

english, 2007

28

A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells

Ding, W.-X., Ni, H.-M., Chen, X., Yu, J., Zhang, L., Yin, X.-M.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 397 KB

english, 2007

29

Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis

Wang, J., Kuropatwinski, K., Hauser, J., Rossi, M. R., Zhou, Y., Conway, A., Kan, J. L.C., Gibson, N. W., Willson, J. K.V., Cowell, J. K., Brattain, M. G.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 510 KB

english, 2007

30

Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2

Carlessi, L., Buscemi, G., Larson, G., Hong, Z., Wu, J. Z., Delia, D.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 628 KB

english, 2007

31

Targeted therapeutics for multiple myeloma: The arrival of a risk-stratified approach

Fonseca, R., Stewart, A. K.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 194 KB

english, 2007

32

Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates

Li, S., Zhou, Y., Wang, R., Zhang, H., Dong, Y., Ip, C.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 546 KB

english, 2007

33

Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets

Chekhun, V. F., Lukyanova, N. Y., Kovalchuk, O., Tryndyak, V. P., Pogribny, I. P.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 446 KB

english, 2007

34

Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo

Lang, S. A., Klein, D., Moser, C., Gaumann, A., Glockzin, G., Dahlke, M. H., Dietmaier, W., Bolder, U., Schlitt, H. J., Geissler, E. K., Stoeltzing, O.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 394 KB

english, 2007

35

Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer

Hassouneh, B., Islam, M., Nagel, T., Pan, Q., Merajver, S. D., Teknos, T. N.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 325 KB

english, 2007

36

The glycotope-specific RAV12 monoclonal antibody induces oncosis in vitro and has antitumor activity against gastrointestinal adenocarcinoma tumor xenografts in vivo

Loo, D., Pryer, N., Young, P., Liang, T., Coberly, S., King, K. L., Kang, K., Roberts, P., Tsao, M., Xu, X., Potts, B., Mather, J. P.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 861 KB

english, 2007

37

In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00

Joshi, K. S., Rathos, M. J., Joshi, R. D., Sivakumar, M., Mascarenhas, M., Kamble, S., Lal, B., Sharma, S.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 357 KB

english, 2007

38

A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations

Frgala, T., Kalous, O., Proffitt, R. T., Reynolds, C. P.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 686 KB

english, 2007

39

In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors

Skobeleva, N., Menon, S., Weber, L., Golemis, E. A., Khazak, V.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 670 KB

english, 2007

40

A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation

Hardcastle, A., Tomlin, P., Norris, C., Richards, J., Cordwell, M., Boxall, K., Rowlands, M., Jones, K., Collins, I., McDonald, E., Workman, P., Aherne, W.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 413 KB

english, 2007