Volume 7; Issue 10

Molecular Cancer Therapeutics

Volume 7; Issue 10

1

Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines

Galmarini, C. M., Warren, G., Kohli, E., Zeman, A., Mitin, A., Vinogradov, S. V.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 206 KB

english, 2008

2

Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3'-indoly)-1-(p-substituted phenyl)methanes

Lei, P., Abdelrahim, M., Cho, S. D., Liu, X., Safe, S.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 777 KB

english, 2008

3

Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma

Payne, C. A., Maleki, S., Messina, M., O'Sullivan, M. G., Stone, G., Hall, N. R., Parkinson, J. F., Wheeler, H. R., Cook, R. J., Biggs, M. T., Little, N. S., Teo, C., Robinson, B. G., McDonald, K. L.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 329 KB

english, 2008

4

Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition

Fischer, H., Taylor, N., Allerstorfer, S., Grusch, M., Sonvilla, G., Holzmann, K., Setinek, U., Elbling, L., Cantonati, H., Grasl-Kraupp, B., Gauglhofer, C., Marian, B., Micksche, M., Berger, W.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 707 KB

english, 2008

5

Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

Wilhelm, S. M., Adnane, L., Newell, P., Villanueva, A., Llovet, J. M., Lynch, M.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 932 KB

english, 2008

6

Bone marrow and tumor cell colony-forming units and human tumor xenograft efficacy of noncamptothecin and camptothecin topoisomerase I inhibitors

Kurtzberg, L. S., Battle, T., Rouleau, C., Bagley, R. G., Agata, N., Yao, M., Schmid, S., Roth, S., Crawford, J., Krumbholz, R., Ewesuedo, R., Yu, X.-J., Wang, F., LaVoie, E. J., Teicher, B. A.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 357 KB

english, 2008

7

Treatment of hepatocellular carcinoma in mice with PE38KDEL type I mutant-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with humanized SM5-1 F(ab') fragments

Gao, J., Kou, G., Chen, H., Wang, H., Li, B., Lu, Y., Zhang, D., Wang, S., Hou, S., Qian, W., Dai, J., Zhao, J., Zhong, Y., Guo, Y.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 323 KB

english, 2008

8

Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells

Gu, H., Wang, X., Rao, S., Wang, J., Zhao, J., Ren, F. L., Mu, R., Yang, Y., Qi, Q., Liu, W., Lu, N., Ling, H., You, Q., Guo, Q.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 402 KB

english, 2008

9

Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function

Basak, S., Pookot, D., Noonan, E. J., Dahiya, R.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 371 KB

english, 2008

10

15-deoxy- 12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription

Su, R.-Y., Chi, K.-H., Huang, D.-Y., Tai, M.-H., Lin, W.-W.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 667 KB

english, 2008

11

Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin

Peklak-Scott, C., Smitherman, P. K., Townsend, A. J., Morrow, C. S.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 550 KB

english, 2008

12

Class I -tubulin mutations in 2-methoxyestradiol-resistant acute lymphoblastic leukemia cells: implications for drug-target interactions

Liaw, T. Y.E., Salam, N. K., McKay, M. J., Cunningham, A. M., Hibbs, D. E., Kavallaris, M.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 537 KB

english, 2008

13

Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor

Hodgson, M. C., Shen, H. C., Hollenberg, A. N., Balk, S. P.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 438 KB

english, 2008

14

A genomic approach to identify molecular pathways associated with chemotherapy resistance

Riedel, R. F., Porrello, A., Pontzer, E., Chenette, E. J., Hsu, D. S., Balakumaran, B., Potti, A., Nevins, J., Febbo, P. G.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 703 KB

english, 2008

15

Cisplatin abrogates the geldanamycin-induced heat shock response

McCollum, A. K., Lukasiewicz, K. B., TenEyck, C. J., Lingle, W. L., Toft, D. O., Erlichman, C.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 387 KB

english, 2008

16

Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition

Yagi, H., Yotsumoto, F., Miyamoto, S.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 813 KB

english, 2008

17

Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor- B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis

Kunnumakkara, A. B., Ichikawa, H., Anand, P., Mohankumar, C. J., Hema, P. S., Nair, M. S., Aggarwal, B. B.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 666 KB

english, 2008

18

Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance

Bewry, N. N., Nair, R. R., Emmons, M. F., Boulware, D., Pinilla-Ibarz, J., Hazlehurst, L. A.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 366 KB

english, 2008

19

Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism

Priego, S., Feddi, F., Ferrer, P., Mena, S., Benlloch, M., Ortega, A., Carretero, J., Obrador, E., Asensi, M., Estrela, J. M.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 383 KB

english, 2008

20

Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion

Saunders, L. P., Ouellette, A., Bandle, R., Chang, W. C., Zhou, H., Misra, R. N., De La Cruz, E. M., Braddock, D. T.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 563 KB

english, 2008

21

Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines

Lorenzi, P. L., Llamas, J., Gunsior, M., Ozbun, L., Reinhold, W. C., Varma, S., Ji, H., Kim, H., Hutchinson, A. A., Kohn, E. C., Goldsmith, P. K., Birrer, M. J., Weinstein, J. N.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 357 KB

english, 2008

22

Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions

Rosato, R. R., Almenara, J. A., Maggio, S. C., Coe, S., Atadja, P., Dent, P., Grant, S.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 736 KB

english, 2008

23

FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells

Fernandez de Mattos, S., Villalonga, P., Clardy, J., Lam, E. W-F.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 378 KB

english, 2008

24

Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts

Sarup, J., Jin, P., Turin, L., Bai, X., Beryt, M., Brdlik, C., Higaki, J. N., Jorgensen, B., Lau, F. W., Lindley, P., Liu, J., Ni, I., Rozzelle, J., Kumari, R., Watson, S. A., Zhang, J., Shepard, H. M

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 409 KB

english, 2008

25

Long-term progression and therapeutic response of visceral metastatic disease non-invasively monitored in mouse urine using -human choriogonadotropin secreting tumor cell lines

Francia, G., Emmenegger, U., Lee, C. R., Shaked, Y., Folkins, C., Mossoba, M., Medin, J. A., Man, S., Zhu, Z., Witte, L., Kerbel, R. S.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 578 KB

english, 2008

26

ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo

Ackler, S., Xiao, Y., Mitten, M. J., Foster, K., Oleksijew, A., Refici, M., Schlessinger, S., Wang, B., Chemburkar, S. R., Bauch, J., Tse, C., Frost, D. J., Fesik, S. W., Rosenberg, S. H., Elmore, S.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 584 KB

english, 2008

27

Identification and characterization of small-molecule inhibitors of hepsin

Chevillet, J. R., Park, G. J., Bedalov, A., Simon, J. A., Vasioukhin, V. I.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 336 KB

english, 2008

28

Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer

Song, D., Chaerkady, R., Tan, A. C., Garcia-Garcia, E., Nalli, A., Suarez-Gauthier, A., Lopez-Rios, F., Zhang, X. F., Solomon, A., Tong, J., Read, M., Fritz, C., Jimeno, A., Pandey, A., Hidalgo, M.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 785 KB

english, 2008

29

EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance

Zhang, Y., Linn, D., Liu, Z., Melamed, J., Tavora, F., Young, C. Y., Burger, A. M., Hamburger, A. W.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 866 KB

english, 2008

30

Curcumin suppresses constitutive activation of nuclear factor- B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines

Hussain, A. R., Ahmed, M., Al-Jomah, N. A., Khan, A. S., Manogaran, P., Sultana, M., Abubaker, J., Platanias, L. C., Al-Kuraya, K. S., Uddin, S.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 529 KB

english, 2008

31

Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3 phosphorylation

Lu, Y., Nie, D., Witt, W. T., Chen, Q., Shen, M., Xie, H., Lai, L., Dai, Y., Zhang, J.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 515 KB

english, 2008

32

Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway

Co, N. N., Tsang, W. P., Wong, T. W.L., Cheung, H. H., Tsang, T. Y., Kong, S. K., Kwok, T. T.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 1.14 MB

english, 2008

33

Distribution and bioactivity of the Ret-specific D4 aptamer in three-dimensional collagen gel cultures

Vento, M. T., Iuorio, M., Netti, P. A., Duconge, F., Tavitian, B., Franciscis, V., Cerchia, L.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 600 KB

english, 2008

34

Therapeutic efficacy of soluble receptor activator of nuclear factor- B-Fc delivered by nonviral gene transfer in a mouse model of osteolytic osteosarcoma

Lamoureux, F., Picarda, G., Rousseau, J., Gourden, C., Battaglia, S., Charrier, C., Pitard, B., Heymann, D., Redini, F.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 792 KB

english, 2008