Volume 7; Issue 3

Molecular Cancer Therapeutics

Volume 7; Issue 3

1

Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase

Okabe, T., Okamoto, I., Tsukioka, S., Uchida, J., Iwasa, T., Yoshida, T., Hatashita, E., Yamada, Y., Satoh, T., Tamura, K., Fukuoka, M., Nakagawa, K.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 680 KB

english, 2008

2

Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells

Sun, M., Estrov, Z., Ji, Y., Coombes, K. R., Harris, D. H., Kurzrock, R.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 738 KB

english, 2008

3

Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells

Kim, H.-P., Han, S.-W., Kim, S.-H., Im, S.-A., Oh, D.-Y., Bang, Y.-J., Kim, T.-Y.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 691 KB

english, 2008

4

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

Hamed, H., Hawkins, W., Mitchell, C., Gilfor, D., Zhang, G., Pei, X.-Y., Dai, Y., Hagan, M. P., Roberts, J. D., Yacoub, A., Grant, S., Dent, P.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 749 KB

english, 2008

5

Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L-like proteases in tumor microenvironment

Burden, R. E., Snoddy, P., Buick, R. J., Johnston, J. A., Walker, B., Scott, C. J.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 729 KB

english, 2008

6

Modulation of drug resistance by artificial transcription factors

Blancafort, P., Tschan, M. P., Bergquist, S., Guthy, D., Brachat, A., Sheeter, D. A., Torbett, B. E., Erdmann, D., Barbas, C. F.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 515 KB

english, 2008

7

Antitumor effect of dsRNA-induced p21WAF1/CIP1 gene activation in human bladder cancer cells

Chen, Z., Place, R. F., Jia, Z.-J., Pookot, D., Dahiya, R., Li, L.-C.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 428 KB

english, 2008

8

Level of HER-2/neu protein expression in breast cancer may affect the development of endogenous HER-2/neu-specific immunity

Goodell, V., Waisman, J., Salazar, L. G., dela Rosa, C., Link, J., Coveler, A. L., Childs, J. S., Fintak, P. A., Higgins, D. M., Disis, M. L.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 157 KB

english, 2008

9

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

Cummings, J., Hodgkinson, C., Odedra, R., Sini, P., Heaton, S. P., Mundt, K. E., Ward, T. H., Wilkinson, R. W., Growcott, J., Hughes, A., Dive, C.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 859 KB

english, 2008

10

A small-molecule inhibitor of Tcf/ -catenin signaling down-regulates PPAR and PPAR activities

Handeli, S., Simon, J. A.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 442 KB

english, 2008

11

Effects of sustained and intermittent paclitaxel therapy on tumor repopulation in ovarian cancer

Vassileva, V., Allen, C. J., Piquette-Miller, M.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 597 KB

english, 2008

12

Dicoumarol down-regulates human PTTG1/Securin mRNA expression through inhibition of Hsp90

Hernandez, A., Lopez-Lluch, G., Bernal, J. A., Navas, P., Pintor-Toro, J. A.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 459 KB

english, 2008

13

Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

Ding, Y., Boguslawski, E. A., Berghuis, B. D., Young, J. J., Zhang, Z., Hardy, K., Furge, K., Kort, E., Frankel, A. E., Hay, R. V., Resau, J. H., Duesbery, N. S.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 676 KB

english, 2008

14

p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR

Gong, M., Meng, L., Jiang, B., Zhang, J., Yang, H., Wu, J., Shou, C.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 420 KB

english, 2008

15

Modulation of survival pathways in ovarian carcinoma cell lines resistant to platinum compounds

Benedetti, V., Perego, P., Luca Beretta, G., Corna, E., Tinelli, S., Righetti, S. C., Leone, R., Apostoli, P., Lanzi, C., Zunino, F.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 408 KB

english, 2008

16

A chaperone protein-enriched tumor cell lysate vaccine generates protective humoral immunity in a mouse breast cancer model

Li, G., Andreansky, S., Helguera, G., Sepassi, M., Janikashvili, N., Cantrell, J., LaCasse, C. L., Larmonier, N., Penichet, M. L., Katsanis, E.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 558 KB

english, 2008

17

Mitochondrial regulation by c-Myc and hypoxia-inducible factor-1 controls sensitivity to econazole

Yu, Y., Niapour, M., Zhang, Y., Berger, S. A.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 517 KB

english, 2008

18

Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells

Hui, R. C-Y., Francis, R. E., Guest, S. K., Costa, J. R., Gomes, A. R., Myatt, S. S., Brosens, J. J., Lam, E. W-F.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 698 KB

english, 2008

19

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in ApcMin/+ mice

Alferez, D., Wilkinson, R. W., Watkins, J., Poulsom, R., Mandir, N., Wedge, S. R., Pyrah, I. T., Smith, N. R., Jackson, L., Ryan, A. J., Goodlad, R. A.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 631 KB

english, 2008

20

Preclinical modeling of cytosine arabinoside response in Mll-Enl translocator mouse leukemias

Cano, F., Pannel, R., Follows, G. A., Rabbitts, T. H.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 352 KB

english, 2008

21

Blockade of viral interleukin-6 expression of Kaposi's sarcoma-associated herpesvirus

Zhang, Y.-J., Bonaparte, R. S., Patel, D., Stein, D. A., Iversen, P. L.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 347 KB

english, 2008

22

Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model

Laquente, B., Lacasa, C., Ginesta, M. M., Casanovas, O., Figueras, A., Galan, M., Ribas, I. G., Germa, J. R., Capella, G., Vinals, F.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 615 KB

english, 2008

23

Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies

An, F., Drummond, D. C., Wilson, S., Kirpotin, D. B., Nishimura, S. L., Broaddus, V. C., Liu, B.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 586 KB

english, 2008

24

Agelastatin A: a novel inhibitor of osteopontin-mediated adhesion, invasion, and colony formation

Mason, C. K., McFarlane, S., Johnston, P. G., Crowe, P., Erwin, P. J., Domostoj, M. M., Campbell, F. C., Manaviazar, S., Hale, K. J., El-Tanani, M.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 327 KB

english, 2008

25

Turning the gene tap off; implications of regulating gene expression for cancer therapeutics

Curtin, J. F., Candolfi, M., Xiong, W., Lowenstein, P. R., Castro, M. G.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 517 KB

english, 2008

26

Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery

Lo, A., Lin, C.-T., Wu, H.-C.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 752 KB

english, 2008

27

Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation

Frigo, D. E., McDonnell, D. P.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 1.22 MB

english, 2008

28

Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo

Maksimovic-Ivanic, D., Mijatovic, S., Harhaji, L., Miljkovic, D., Dabideen, D., Fan Cheng, K., Mangano, K., Malaponte, G., Al-Abed, Y., Libra, M., Garotta, G., Nicoletti, F., Stosic-Grujicic, S.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 435 KB

english, 2008

29

Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice

Takei, Y., Saga, Y., Mizukami, H., Takayama, T., Ohwada, M., Ozawa, K., Suzuki, M.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 321 KB

english, 2008

30

A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker

Crawford, S., Belajic, D., Wei, J., Riley, J. P., Dunford, P. J., Bembenek, S., Fourie, A., Edwards, J. P., Karlsson, L., Brunmark, A., Wolin, R. L., Blevitt, J. M.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 416 KB

english, 2008

31

Tumor-targeting nanodelivery enhances the anticancer activity of a novel quinazolinone analogue

Hwang, S. H., Rait, A., Pirollo, K. F., Zhou, Q., Yenugonda, V. M., Chinigo, G. M., Brown, M. L., Chang, E. H.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 309 KB

english, 2008

32

Ellipticine derivative NSC 338258 represents a potential new antineoplastic agent for the treatment of multiple myeloma

Tian, E., Landowski, T. H., Stephens, O. W., Yaccoby, S., Barlogie, B., Shaughnessy, J. D.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 675 KB

english, 2008

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