Volume 7; Issue 5

Molecular Cancer Therapeutics

Volume 7; Issue 5

1

Comparison of antitumor effects of multitargeted tyrosine kinase inhibitors in acute myelogenous leukemia

Niu, H., Minkin, P., Orwick, S., Shimada, A., Inaba, H., Dahl, G. V.H., Rubnitz, J., Baker, S. D., Hu, S.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 394 KB

english, 2008

2

Relevance of the Fanconi anemia pathway in the response of human cells to trabectedin

Casado, J. A., Rio, P., Marco, E., Garcia-Hernandez, V., Domingo, A., Perez, L., Tercero, J. C., Vaquero, J. J., Albella, B., Gago, F., Bueren, J. A.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 567 KB

english, 2008

3

Improved grading and survival prediction of human astrocytic brain tumors by artificial neural network analysis of gene expression microarray data

Petalidis, L. P., Oulas, A., Backlund, M., Wayland, M. T., Liu, L., Plant, K., Happerfield, L., Freeman, T. C., Poirazi, P., Collins, V. P.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 656 KB

english, 2008

4

Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells

Zhu, N., Gu, L., Li, F., Zhou, M.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 404 KB

english, 2008

5

Nucleolus and c-Myc: potential targets of cardenolide-mediated antitumor activity

Mijatovic, T., De Neve, N., Gailly, P., Mathieu, V., Haibe-Kains, B., Bontempi, G., Lapeira, J., Decaestecker, C., Facchini, V., Kiss, R.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 1021 KB

english, 2008

6

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells

Samudio, I., Kurinna, S., Ruvolo, P., Korchin, B., Kantarjian, H., Beran, M., Dunner, K., Kondo, S., Andreeff, M., Konopleva, M.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 485 KB

english, 2008

7

Competitive or noncompetitive, that's the question: research toward histone deacetylase inhibitors

Su, H., Altucci, L., You, Q.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 173 KB

english, 2008

8

Combi-targeting concept: an optimized single-molecule dual-targeting model for the treatment of chronic myelogenous leukemia

Katsoulas, A., Rachid, Z., McNamee, J. P., Williams, C., Jean-Claude, B. J.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 1.09 MB

english, 2008

9

Ethnic disparities in Americans of European descent versus Americans of African descent related to polymorphic ERCC1, ERCC2, XRCC1, and PARP1

Gao, R., Price, D. K., Sissung, T., Reed, E., Figg, W. D.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 143 KB

english, 2008

10

Requirement of hypoxia-inducible factor-1 down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab

Li, X., Lu, Y., Liang, K., Pan, T., Mendelsohn, J., Fan, Z.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 504 KB

english, 2008

11

Human papillomavirus type 16 L1E7 chimeric capsomeres have prophylactic and therapeutic efficacy against papillomavirus in mice

Bian, T., Wang, Y., Lu, Z., Ye, Z., Zhao, L., Ren, J., Zhang, H., Ruan, L., Tian, H.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 286 KB

english, 2008

12

PBISe, a novel selenium-containing drug for the treatment of malignant melanoma

Madhunapantula, S. V., Desai, D., Sharma, A., Huh, S. J., Amin, S., Robertson, G. P.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 355 KB

english, 2008

13

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo

Hassig, C. A., Symons, K. T., Guo, X., Nguyen, P.-M., Annable, T., Wash, P. L., Payne, J. E., Jenkins, D. A., Bonnefous, C., Trotter, C., Wang, Y., Anzola, J. V., Milkova, E. L., Hoffman, T. Z., Dozie

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 538 KB

english, 2008

14

Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib

Hong, D., Ye, L., Gagel, R., Chintala, L., El Naggar, A. K., Wright, J., Kurzrock, R.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 405 KB

english, 2008

15

Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor

Beltran, A. S., Sun, X., Lizardi, P. M., Blancafort, P.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 668 KB

english, 2008

16

Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78

Kotecha, M., Kluza, J., Wells, G., O'Hare, C. C., Forni, C., Mantovani, R., Howard, P. W., Morris, P., Thurston, D. E., Hartley, J. A., Hochhauser, D.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 520 KB

english, 2008

17

The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis

Liby, K., Black, C. C., Royce, D. B., Williams, C. R., Risingsong, R., Yore, M. M., Liu, X., Honda, T., Gribble, G. W., Lamph, W. W., Sporn, T. A., Dmitrovsky, E., Sporn, M. B.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 496 KB

english, 2008

18

Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57

Lu, L., Qiu, J., Liu, S., Luo, W.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 366 KB

english, 2008

19

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells

Vultur, A., Buettner, R., Kowolik, C., Liang, W., Smith, D., Boschelli, F., Jove, R.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 559 KB

english, 2008

20

Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells

D'Alise, A. M., Amabile, G., Iovino, M., Di Giorgio, F. P., Bartiromo, M., Sessa, F., Villa, F., Musacchio, A., Cortese, R.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 707 KB

english, 2008

21

p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis

Schiappacassi, M., Lovat, F., Canzonieri, V., Belletti, B., Berton, S., Di Stefano, D., Vecchione, A., Colombatti, A., Baldassarre, G.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 741 KB

english, 2008

22

Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9

Lin, C.-W., Shen, S.-C., Hou, W.-C., Yang, L.-Y., Chen, Y.-C.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 672 KB

english, 2008

23

Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis

So, P.-L., Fujimoto, M. A., Epstein, E. H.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 578 KB

english, 2008

24

Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice

Raina, K., Rajamanickam, S., Deep, G., Singh, M., Agarwal, R., Agarwal, C.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 689 KB

english, 2008

25

Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin

Newbold, A., Lindemann, R. K., Cluse, L. A., Whitecross, K. F., Dear, A. E., Johnstone, R. W.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 823 KB

english, 2008

26

An experimental and theoretical evaluation of the influence of pretargeting antibody on the tumor accumulation of effector

Liu, G., Dou, S., Rusckowski, M., Hnatowich, D. J.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 211 KB

english, 2008

27

LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells

Lipka, D. B., Hoffmann, L. S., Heidel, F., Markova, B., Blum, M.-C., Breitenbuecher, F., Kasper, S., Kindler, T., Levine, R. L., Huber, C., Fischer, T.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 600 KB

english, 2008

28

Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells

Weisberg, E., Wright, R. D., McMillin, D. W., Mitsiades, C., Ray, A., Barrett, R., Adamia, S., Stone, R., Galinsky, I., Kung, A. L., Griffin, J. D.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 729 KB

english, 2008

29

Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors

Johansson, G., Mahller, Y. Y., Collins, M. H., Kim, M.-O., Nobukuni, T., Perentesis, J., Cripe, T. P., Lane, H. A., Kozma, S. C., Thomas, G., Ratner, N.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 462 KB

english, 2008

30

Plasminogen activator inhibitor-1 inhibits prostate tumor growth through endothelial apoptosis

Chen, S.-C., Henry, D. O., Reczek, P. R., Wong, M. K.K.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 508 KB

english, 2008

31

Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells

Alfano, R. W., Leppla, S. H., Liu, S., Bugge, T. H., Herlyn, M., Smalley, K. S., Bromberg-White, J. L., Duesbery, N. S., Frankel, A. E.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 535 KB

english, 2008

32

Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein

Wang, H., Chen, K., Cai, W., Li, Z., He, L., Kashefi, A., Chen, X.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 680 KB

english, 2008

33

Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells

Wang, X., Chen, W., Zeng, W., Bai, L., Tesfaigzi, Y., Belinsky, S. A., Lin, Y.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 359 KB

english, 2008

34

Proteasome inhibitor PS-341 (VELCADE) induces stabilization of the TRAIL receptor DR5 mRNA through the 3'-untranslated region

Kandasamy, K., Kraft, A. S.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 701 KB

english, 2008

35

MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer

Oguri, T., Ozasa, H., Uemura, T., Bessho, Y., Miyazaki, M., Maeno, K., Maeda, H., Sato, S., Ueda, R.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 327 KB

english, 2008