Volume 8; Issue 6

Molecular Cancer Therapeutics

Volume 8; Issue 6

1

Epigenetics in cancer: Targeting chromatin modifications

Ellis, L., Atadja, P. W., Johnstone, R. W.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 329 KB

english, 2009

2

Luteinizing hormone-releasing hormone receptor-targeted deslorelin-docetaxel conjugate enhances efficacy of docetaxel in prostate cancer therapy

Sundaram, S., Durairaj, C., Kadam, R., Kompella, U. B.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 583 KB

english, 2009

3

Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells

Beharry, Z., Zemskova, M., Mahajan, S., Zhang, F., Ma, J., Xia, Z., Lilly, M., Smith, C. D., Kraft, A. S.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 496 KB

english, 2009

4

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

Miranda, T. B., Cortez, C. C., Yoo, C. B., Liang, G., Abe, M., Kelly, T. K., Marquez, V. E., Jones, P. A.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 458 KB

english, 2009

5

Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts

Baschnagel, A., Russo, A., Burgan, W. E., Carter, D., Beam, K., Palmieri, D., Steeg, P. S., Tofilon, P., Camphausen, K.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 404 KB

english, 2009

6

SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor- B activation, c-Fos/c-Jun expression, and cellular apoptosis

Farhana, L., Dawson, M. I., Xu, L., Dannenberg, J.-H., Fontana, J. A.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 539 KB

english, 2009

7

Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice

Li, H., Wang, D., Zhang, H., Kirmani, K., Zhao, Z., Steinmetz, R., Xu, Y.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 514 KB

english, 2009

8

Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice

Shankar, S., Davis, R., Singh, K. P., Kurzrock, R., Ross, D. D., Srivastava, R. K.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 774 KB

english, 2009

9

Expression levels of p18INK4C modify the cellular efficacy of cyclin-dependent kinase inhibitors via regulation of Mcl-1 expression in tumor cell lines

Eguchi, T., Itadani, H., Shimomura, T., Kawanishi, N., Hirai, H., Kotani, H.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 830 KB

english, 2009

10

Angiotensin-(1-7) inhibits tumor angiogenesis in human lung cancer xenografts with a reduction in vascular endothelial growth factor

Soto-Pantoja, D. R., Menon, J., Gallagher, P. E., Tallant, E. A.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 359 KB

english, 2009

11

Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer

Yuen, J. S.P., Akkaya, E., Wang, Y., Takiguchi, M., Peak, S., Sullivan, M., Protheroe, A. S., Macaulay, V. M.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 737 KB

english, 2009

12

Induction of programmed cell death in ErbB2/HER2-expressing cancer cells by targeted delivery of apoptosis-inducing factor

Mahmud, H., Dalken, B., Wels, W. S.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 458 KB

english, 2009

13

Mutation-associated fusion cancer genes in solid tumors

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 297 KB

english, 2009

14

Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit

Bekier, M. E., Fischbach, R., Lee, J., Taylor, W. R.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 659 KB

english, 2009

15

Inflexinol inhibits colon cancer cell growth through inhibition of nuclear factor- B activity via direct interaction with p50

Ban, J. O., Oh, J. H., Hwang, B. Y., Moon, D. C., Jeong, H.-S., Lee, S., Kim, S., Lee, H., Kim, K.-B., Han, S. B., Hong, J. T.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 1.24 MB

english, 2009

16

Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A

Gu, Y., Patterson, A. V., Atwell, G. J., Chernikova, S. B., Brown, J. M., Thompson, L. H., Wilson, W. R.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 506 KB

english, 2009

17

Orally active -tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer

Hahn, T., Fried, K., Hurley, L. H., Akporiaye, E. T.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 534 KB

english, 2009

18

Demonstration of the equivalent pharmacokinetic/pharmacodynamic dosing strategy in a multiple-dose study of gefitinib

Wang, S., Zhou, Q., Gallo, J. M.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 211 KB

english, 2009

19

Silibinin inhibits translation initiation: implications for anticancer therapy

Lin, C.-J., Sukarieh, R., Pelletier, J.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 514 KB

english, 2009

20

Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cells

Herberger, B., Berger, W., Puhalla, H., Schmid, K., Novak, S., Brandstetter, A., Pirker, C., Gruenberger, T., Filipits, M.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 495 KB

english, 2009

21

Regulated cell death pathways: New twists in modulation of BCL2 family function

Sasi, N., Hwang, M., Jaboin, J., Csiki, I., Lu, B.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 302 KB

english, 2009

22

The Pyk2 FERM domain as a target to inhibit glioma migration

Loftus, J. C., Yang, Z., Tran, N. L., Kloss, J., Viso, C., Berens, M. E., Lipinski, C. A.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 374 KB

english, 2009

23

Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts

Messersmith, W. A., Rajeshkumar, N.V., Tan, A. C., Wang, X. F., Diesl, V., Choe, S. E., Follettie, M., Coughlin, C., Boschelli, F., Garcia-Garcia, E., Lopez-Rios, F., Jimeno, A., Hidalgo, M.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 732 KB

english, 2009

24

Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells

Rozanov, D. V., Savinov, A. Y., Golubkov, V. S., Rozanova, O. L., Postnova, T. I., Sergienko, E. A., Vasile, S., Aleshin, A. E., Rega, M. F., Pellecchia, M., Strongin, A. Y.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

25

The antiproliferative cytostatic effects of a self-activating viridin prodrug

Smith, A., Blois, J., Yuan, H., Aikawa, E., Ellson, C., Figueiredo, J.-L., Weissleder, R., Kohler, R., Yaffe, M. B., Cantley, L. C., Josephson, L.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 593 KB

english, 2009

26

Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors

Baird, R. D., Kitzen, J., Clarke, P. A., Planting, A., Reade, S., Reid, A., Welsh, L., Lopez Lazaro, L., de las Heras, B., Judson, I. R., Kaye, S. B., Eskens, F., Workman, P., deBono, J. S., Verweij,

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 154 KB

english, 2009

27

Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin

Zhou, Q., Yan, B., Hu, X., Li, X.-B., Zhang, J., Fang, J.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 608 KB

english, 2009

28

Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1

Sullivan, R., Graham, C. H.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 1.44 MB

english, 2009

29

Consensus transcriptome signature of perineural invasion in pancreatic carcinoma

Abiatari, I., DeOliveira, T., Kerkadze, V., Schwager, C., Esposito, I., Giese, N. A., Huber, P., Bergman, F., Abdollahi, A., Friess, H., Kleeff, J.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 809 KB

english, 2009

30

IKK -mediated nuclear factor- B activation attenuates smac mimetic-induced apoptosis in cancer cells

Bai, L., Chen, W., Chen, W., Wang, X., Tang, H., Lin, Y.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 480 KB

english, 2009

31

Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer

Dokmanovic, M., Hirsch, D. S., Shen, Y., Wu, W. J.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 948 KB

english, 2009

32

Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor

Freeman, D. J., Bush, T., Ogbagabriel, S., Belmontes, B., Juan, T., Plewa, C., Van, G., Johnson, C., Radinsky, R.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 1.00 MB

english, 2009

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