Volume 9; Issue 10

Molecular Cancer Therapeutics

Volume 9; Issue 10

1

Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules

Lopus, M., Oroudjev, E., Wilson, L., Wilhelm, S., Widdison, W., Chari, R., Jordan, M. A.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 488 KB

english, 2010

2

Curcumin Enhances the Effect of Cisplatin in Suppression of Head and Neck Squamous Cell Carcinoma via Inhibition of IKK Protein of the NF B Pathway

Duarte, V. M., Han, E., Veena, M. S., Salvado, A., Suh, J. D., Liang, L.-J., Faull, K. F., Srivatsan, E. S., Wang, M. B.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

3

Rapamycin Regulates Stearoyl CoA Desaturase 1 Expression in Breast Cancer

Luyimbazi, D., Akcakanat, A., McAuliffe, P. F., Zhang, L., Singh, G., Gonzalez-Angulo, A. M., Chen, H., Do, K.-A., Zheng, Y., Hung, M.-C., Mills, G. B., Meric-Bernstam, F.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 690 KB

english, 2010

4

Renal Cancer Resistance to Antiangiogenic Therapy Is Delayed by Restoration of Angiostatic Signaling

Bhatt, R. S., Wang, X., Zhang, L., Collins, M. P., Signoretti, S., Alsop, D. C., Goldberg, S. N., Atkins, M. B., Mier, J. W.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.26 MB

english, 2010

5

Association of Human Cytochrome P450 1A1 (CYP1A1) and Sulfotransferase 1A1 (SULT1A1) Polymorphisms with Differential Metabolism and Cytotoxicity of Aminoflavone

Zheng, Q., Sha, X., Liu, J., Heath, E., LoRusso, P., Li, J.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 395 KB

english, 2010

6

The Use of One-Bead One-Compound Combinatorial Library Technology to Discover High-Affinity v 3 Integrin and Cancer Targeting Arginine-Glycine-Aspartic Acid Ligands with a Built-in Handle

Xiao, W., Wang, Y., Lau, E. Y., Luo, J., Yao, N., Shi, C., Meza, L., Tseng, H., Maeda, Y., Kumaresan, P., Liu, R., Lightstone, F. C., Takada, Y., Lam, K. S.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 781 KB

english, 2010

7

Pharmacologic Inactivation of Kinase Suppressor of Ras1 Sensitizes Epidermal Growth Factor Receptor and Oncogenic Ras-Dependent Tumors to Ionizing Radiation Treatment

Xiao, H., Zhang, Q., Shen, J., Bindokas, V., Xing, H. R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 510 KB

english, 2010

8

Phase I Safety, Pharmacokinetic, and Biomarker Study of BIBF 1120, an Oral Triple Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors

Okamoto, I., Kaneda, H., Satoh, T., Okamoto, W., Miyazaki, M., Morinaga, R., Ueda, S., Terashima, M., Tsuya, A., Sarashina, A., Konishi, K., Arao, T., Nishio, K., Kaiser, R., Nakagawa, K.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 353 KB

english, 2010

9

Monitoring Molecular-Specific Pharmacodynamics of Rapamycin In vivo with Inducible Gal4->Fluc Transgenic Reporter Mice

Pan, M.-H., Lin, J., Prior, J. L., Piwnica-Worms, D.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 521 KB

english, 2010

10

Small Interfering RNA Targeting 14-3-3 Increases Efficacy of Chemotherapeutic Agents in Head and Neck Cancer Cells

Matta, A., DeSouza, L. V., Ralhan, R., Siu, K. W. M.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.47 MB

english, 2010

11

A Better TRAIL Variant for Tumor Cell-Specific Targeting? - Response

Spitzer, D., Goedegebuure, P., Hawkins, W. G.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 106 KB

english, 2010

12

Maytansinoid-Antibody Conjugates Induce Mitotic Arrest by Suppressing Microtubule Dynamic Instability

Oroudjev, E., Lopus, M., Wilson, L., Audette, C., Provenzano, C., Erickson, H., Kovtun, Y., Chari, R., Jordan, M. A.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 644 KB

english, 2010

13

Correction: Serine Proteases in Histone Deacetylase Inhibitor-Induced Apoptosis Still an Unresolved Question - Response

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 94 KB

english, 2010

14

Efficacy of the Multi-Kinase Inhibitor Enzastaurin Is Dependent on Cellular Signaling Context

Kuo, W.-L., Liu, J., Mauceri, H., Vokes, E. E., Weichselbaum, R., Rosner, M. R., Cohen, E. E. W.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 617 KB

english, 2010

15

TAK-701, a Humanized Monoclonal Antibody to Hepatocyte Growth Factor, Reverses Gefitinib Resistance Induced by Tumor-Derived HGF in Non-Small Cell Lung Cancer with an EGFR Mutation

Okamoto, W., Okamoto, I., Tanaka, K., Hatashita, E., Yamada, Y., Kuwata, K., Yamaguchi, H., Arao, T., Nishio, K., Fukuoka, M., Janne, P. A., Nakagawa, K.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 373 KB

english, 2010

16

A Better TRAIL Variant for Tumor Cell-Specific Targeting? - Letter

Bremer, E., Helfrich, W.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 99 KB

english, 2010

17

Phase I Study of the Selective Aurora A Kinase Inhibitor MLN8054 in Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, and Pharmacodynamics

Macarulla, T., Cervantes, A., Elez, E., Rodriguez-Braun, E., Baselga, J., Rosello, S., Sala, G., Blasco, I., Danaee, H., Lee, Y., Ecsedy, J., Shinde, V., Chakravarty, A., Bowman, D., Liu, H., Eton, O.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 408 KB

english, 2010

18

Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer

Buck, E., Gokhale, P. C., Koujak, S., Brown, E., Eyzaguirre, A., Tao, N., Rosenfeld-Franklin, M., Lerner, L., Chiu, M. I., Wild, R., Epstein, D., Pachter, J. A., Miglarese, M. R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 932 KB

english, 2010

19

Aflibercept Exerts Antivascular Effects and Enhances Levels of Anthracycline Chemotherapy In vivo in Human Acute Myeloid Leukemia Models

Lal, D., Park, J. A., Demock, K., Marinaro, J., Perez, A. M., Lin, M.-H., Tian, L., Mashtare, T. J., Murphy, M., Prey, J., Wetzler, M., Fetterly, G. J., Wang, E. S.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.36 MB

english, 2010

20

Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2-Neutralizing Peptibody

Coxon, A., Bready, J., Min, H., Kaufman, S., Leal, J., Yu, D., Lee, T. A., Sun, J.-R., Estrada, J., Bolon, B., McCabe, J., Wang, L., Rex, K., Caenepeel, S., Hughes, P., Cordover, D., Kim, H., Han, S.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 489 KB

english, 2010

21

Correction: Serine Proteases in Histone Deacetylase Inhibitor-Induced Apoptosis - Letter

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 94 KB

english, 2010

22

Genetically Engineered Oncolytic Newcastle Disease Virus Effectively Induces Sustained Remission of Malignant Pleural Mesothelioma

Silberhumer, G. R., Brader, P., Wong, J., Serganova, I. S., Gonen, M., Gonzalez, S. J., Blasberg, R., Zamarin, D., Fong, Y.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 400 KB

english, 2010

23

Multigene Expression-Based Predictors for Sensitivity to Vorinostat and Velcade in Non-Small Cell Lung Cancer

Nagji, A. S., Cho, S.-H., Liu, Y., Lee, J. K., Jones, D. R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 670 KB

english, 2010