Volume 9; Issue 12

Molecular Cancer Therapeutics

Volume 9; Issue 12

1

Resistance May Not Be Futile: microRNA Biomarkers for Chemoresistance and Potential Therapeutics

Allen, K. E., Weiss, G. J.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 751 KB

english, 2010

2

Cytochrome P450 1B1 Gene Polymorphisms as Predictors of Anticancer Drug Activity: Studies with In vitro Models

Laroche-Clary, A., Morvan, V. L., Yamori, T., Robert, J.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 315 KB

english, 2010

3

MS-275 Sensitizes TRAIL-Resistant Breast Cancer Cells, Inhibits Angiogenesis and Metastasis, and Reverses Epithelial-Mesenchymal Transition In vivo

Srivastava, R. K., Kurzrock, R., Shankar, S.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

4

Combined Inhibition of Notch Signaling and Bcl-2/Bcl-xL Results in Synergistic Antimyeloma Effect

Li, M., Chen, F., Clifton, N., Sullivan, D. M., Dalton, W. S., Gabrilovich, D. I., Nefedova, Y.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

5

AZ960, a Novel Jak2 Inhibitor, Induces Growth Arrest and Apoptosis in Adult T-Cell Leukemia Cells

Yang, J., Ikezoe, T., Nishioka, C., Furihata, M., Yokoyama, A.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 714 KB

english, 2010

6

A Synergistic Interaction between Lapatinib and Chemotherapy Agents in a Panel of Cell Lines Is Due to the Inhibition of the Efflux Pump BCRP

Perry, J., Ghazaly, E., Kitromilidou, C., McGrowder, E. H., Joel, S., Powles, T.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 447 KB

english, 2010

7

The Quassinoid Derivative NBT-272 Targets Both the AKT and ERK Signaling Pathways in Embryonal Tumors

Castelletti, D., Fiaschetti, G., Di Dato, V., Ziegler, U., Kumps, C., De Preter, K., Zollo, M., Speleman, F., Shalaby, T., De Martino, D., Berg, T., Eggert, A., Arcaro, A., Grotzer, M. A.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.80 MB

english, 2010

8

Inhibition of Constitutive Activation of STAT3 by Curcurbitacin-I (JSI-124) Sensitized Human B-Leukemia Cells to Apoptosis

Ishdorj, G., Johnston, J. B., Gibson, S. B.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

9

Specific Alterations of MicroRNA Transcriptome and Global Network Structure in Colorectal Carcinoma after Cetuximab Treatment

Ragusa, M., Majorana, A., Statello, L., Maugeri, M., Salito, L., Barbagallo, D., Guglielmino, M. R., Duro, L. R., Angelica, R., Caltabiano, R., Biondi, A., Di Vita, M., Privitera, G., Scalia, M., Capp

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.15 MB

english, 2010

10

Nakiterpiosin Targets Tubulin and Triggers Mitotic Catastrophe in Human Cancer Cells

Wei, J.-H., Seemann, J.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.52 MB

english, 2010

11

Genome-Wide mRNA and microRNA Profiling of the NCI 60 Cell-Line Screen and Comparison of FdUMP[10] with Fluorouracil, Floxuridine, and Topoisomerase 1 Poisons

Gmeiner, W. H., Reinhold, W. C., Pommier, Y.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.12 MB

english, 2010

12

Proof of Concept: Network and Systems Biology Approaches Aid in the Discovery of Potent Anticancer Drug Combinations

Azmi, A. S., Wang, Z., Philip, P. A., Mohammad, R. M., Sarkar, F. H.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.06 MB

english, 2010

13

Peroxisome Proliferator-Activated Receptor- Activation Inhibits Tumor Metastasis by Antagonizing Smad3-Mediated Epithelial-Mesenchymal Transition

Reka, A. K., Kurapati, H., Narala, V. R., Bommer, G., Chen, J., Standiford, T. J., Keshamouni, V. G.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.50 MB

english, 2010

14

Combination of Vorinostat and Flavopiridol Is Selectively Cytotoxic to Multidrug-Resistant Neuroblastoma Cell Lines with Mutant TP53

Huang, J.-M., Sheard, M. A., Ji, L., Sposto, R., Keshelava, N.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.35 MB

english, 2010

15

Monensin Is a Potent Inducer of Oxidative Stress and Inhibitor of Androgen Signaling Leading to Apoptosis in Prostate Cancer Cells

Ketola, K., Vainio, P., Fey, V., Kallioniemi, O., Iljin, K.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 974 KB

english, 2010

16

Chemoprevention of Chemically Induced Skin Tumorigenesis by Ligand Activation of Peroxisome Proliferator-Activated Receptor- / and Inhibition of Cyclooxygenase 2

Zhu, B., Bai, R., Kennett, M. J., Kang, B.-H., Gonzalez, F. J., Peters, J. M.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.24 MB

english, 2010

17

Combined Treatment with Silibinin and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Overcomes Drug Resistance Caused by T790M Mutation

Rho, J. K., Choi, Y. J., Jeon, B.-S., Choi, S. J., Cheon, G. J., Woo, S.-K., Kim, H.-R., Kim, C. H., Choi, C.-M., Lee, J. C.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.90 MB

english, 2010

18

Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras-Mutated Colorectal Cancer

Tentler, J. J., Nallapareddy, S., Tan, A. C., Spreafico, A., Pitts, T. M., Morelli, M. P., Selby, H. M., Kachaeva, M. I., Flanigan, S. A., Kulikowski, G. N., Leong, S., Arcaroli, J. J., Messersmith, W

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 791 KB

english, 2010

19

Rb-Raf-1 Interaction Disruptor RRD-251 Induces Apoptosis in Metastatic Melanoma Cells and Synergizes with Dacarbazine

Singh, S., Davis, R., Alamanda, V., Pireddu, R., Pernazza, D., Sebti, S., Lawrence, N., Chellappan, S.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 899 KB

english, 2010

20

Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer

Landen, C. N., Goodman, B., Katre, A. A., Steg, A. D., Nick, A. M., Stone, R. L., Miller, L. D., Mejia, P. V., Jennings, N. B., Gershenson, D. M., Bast, R. C., Coleman, R. L., Lopez-Berestein, G., Soo

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 2.50 MB

english, 2010

21

Phase I Clinical Trial of MPC-6827 (Azixa), a Microtubule Destabilizing Agent, in Patients with Advanced Cancer

Tsimberidou, A.-M., Akerley, W., Schabel, M. C., Hong, D. S., Uehara, C., Chhabra, A., Warren, T., Mather, G. G., Evans, B. A., Woodland, D. P., Swabb, E. A., Kurzrock, R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 459 KB

english, 2010

22

Cyclin G-Associated Kinase Is Necessary for Osteosarcoma Cell Proliferation and Receptor Trafficking

Susa, M., Choy, E., Liu, X., Schwab, J., Hornicek, F. J., Mankin, H., Duan, Z.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.07 MB

english, 2010

23

Breaking through a Plateau in Renal Cell Carcinoma Therapeutics: Development and Incorporation of Biomarkers

Pal, S. K., Kortylewski, M., Yu, H., Figlin, R. A.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 713 KB

english, 2010

24

Antagonism of Cytotoxic Chemotherapy in Neuroblastoma Cell Lines by 13-cis-Retinoic Acid Is Mediated by the Antiapoptotic Bcl-2 Family Proteins

Hadjidaniel, M. D., Reynolds, C. P.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 686 KB

english, 2010

25

Antiangiogenic Activity of a Neutralizing Human Single-Chain Antibody Fragment against Fibroblast Growth Factor Receptor 1

Ronca, R., Benzoni, P., Leali, D., Urbinati, C., Belleri, M., Corsini, M., Alessi, P., Coltrini, D., Calza, S., Presta, M., Dell'Era, P.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 648 KB

english, 2010

26

The Histone Deacetylase Inhibitor, Vorinostat, Reduces Tumor Growth at the Metastatic Bone Site and Associated Osteolysis, but Promotes Normal Bone Loss

Pratap, J., Akech, J., Wixted, J. J., Szabo, G., Hussain, S., McGee-Lawrence, M. E., Li, X., Bedard, K., Dhillon, R. J., van Wijnen, A. J., Stein, J. L., Stein, G. S., Westendorf, J. J., Lian, J. B.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 2.15 MB

english, 2010

27

Contrasting Effects of Nutlin-3 on TRAIL- and Docetaxel-Induced Apoptosis Due to Upregulation of TRAIL-R2 and Mcl-1 in Human Melanoma Cells

Tseng, H.-Y., Jiang, C. C., Croft, A., Tay, K. H., Thorne, R. F., Yang, F., Liu, H., Hersey, P., Zhang, X. D.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.11 MB

english, 2010

28

Detection of Tumor Response to a Vascular Disrupting Agent by Hyperpolarized 13C Magnetic Resonance Spectroscopy

Bohndiek, S. E., Kettunen, M. I., Hu, D.-e., Witney, T. H., Kennedy, B. W. C., Gallagher, F. A., Brindle, K. M.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.31 MB

english, 2010

29

Modulation of 4E-BP1 Function as a Critical Determinant of Enzastaurin-Induced Apoptosis

Dumstorf, C. A., Konicek, B. W., McNulty, A. M., Parsons, S. H., Furic, L., Sonenberg, N., Graff, J. R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 473 KB

english, 2010