Volume 9; Issue 5

Molecular Cancer Therapeutics

Volume 9; Issue 5

1

A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

Harikumar, K. B., Kunnumakkara, A. B., Ochi, N., Tong, Z., Deorukhkar, A., Sung, B., Kelland, L., Jamieson, S., Sutherland, R., Raynham, T.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 724 KB

english, 2010

2

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

Ben Sahra, I., Le Marchand-Brustel, Y., Tanti, J.-F., Bost, F.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 303 KB

english, 2010

3

S110, a 5-Aza-2'-Deoxycytidine-Containing Dinucleotide, Is an Effective DNA Methylation Inhibitor In vivo and Can Reduce Tumor Growth

Chuang, J. C., Warner, S. L., Vollmer, D., Vankayalapati, H., Redkar, S., Bearss, D. J., Qiu, X., Yoo, C. B., Jones, P. A.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 337 KB

english, 2010

4

Delivery of 5-Azacytidine to Human Cancer Cells by Elaidic Acid Esterification Increases Therapeutic Drug Efficacy

Brueckner, B., Rius, M., Markelova, M. R., Fichtner, I., Hals, P.-A., Sandvold, M. L., Lyko, F.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 416 KB

english, 2010

5

Inhibition of Mer and Axl Receptor Tyrosine Kinases in Astrocytoma Cells Leads to Increased Apoptosis and Improved Chemosensitivity

Keating, A. K., Kim, G. K., Jones, A. E., Donson, A. M., Ware, K., Mulcahy, J. M., Salzberg, D. B., Foreman, N. K., Liang, X., Thorburn, A., Graham, D. K.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 394 KB

english, 2010

6

A Bead-Based Activity Screen for Small-Molecule Inhibitors of Signal Transduction in Chronic Myelogenous Leukemia Cells

Sylvester, J. E., Kron, S. J.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 502 KB

english, 2010

7

SKI-606 (Bosutinib) Blocks Prostate Cancer Invasion, Growth, and Metastasis In vitro and In vivo through Regulation of Genes Involved in Cancer Growth and Skeletal Metastasis

Rabbani, S. A., Valentino, M.-L., Arakelian, A., Ali, S., Boschelli, F.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 543 KB

english, 2010

8

Dasatinib Is Preclinically Active against Src-Overexpressing Human Transitional Cell Carcinoma of the Urothelium with Activated Src Signaling

Levitt, J. M., Yamashita, H., Jian, W., Lerner, S. P., Sonpavde, G.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 329 KB

english, 2010

9

Identification of c-Src as a Potential Therapeutic Target for Gastric Cancer and of MET Activation as a Cause of Resistance to c-Src Inhibition

Okamoto, W., Okamoto, I., Yoshida, T., Okamoto, K., Takezawa, K., Hatashita, E., Yamada, Y., Kuwata, K., Arao, T., Yanagihara, K., Fukuoka, M., Nishio, K., Nakagawa, K.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.22 MB

english, 2010

10

Anticancer Efficacy of a Difluorodiarylidenyl Piperidone (HO-3867) in Human Ovarian Cancer Cells and Tumor Xenografts

Selvendiran, K., Tong, L., Bratasz, A., Kuppusamy, M. L., Ahmed, S., Ravi, Y., Trigg, N. J., Rivera, B. K., Kalai, T., Hideg, K., Kuppusamy, P.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 469 KB

english, 2010

11

Effects of Thymoquinone in the Expression of Mucin 4 in Pancreatic Cancer Cells: Implications for the Development of Novel Cancer Therapies

Torres, M. P., Ponnusamy, M. P., Chakraborty, S., Smith, L. M., Das, S., Arafat, H. A., Batra, S. K.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 937 KB

english, 2010

12

Targeting p70S6K Prevented Lung Metastasis in a Breast Cancer Xenograft Model

Akar, U., Ozpolat, B., Mehta, K., Lopez-Berestein, G., Zhang, D., Ueno, N. T., Hortobagyi, G. N., Arun, B.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 694 KB

english, 2010

13

Sunitinib Malate and Figitumumab in Solitary Fibrous Tumor: Patterns and Molecular Bases of Tumor Response

Stacchiotti, S., Negri, T., Palassini, E., Conca, E., Gronchi, A., Morosi, C., Messina, A., Pastorino, U., Pierotti, M. A., Casali, P. G., Pilotti, S.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 606 KB

english, 2010

14

Activity of the Aurora Kinase Inhibitor VX-680 against Bcr/Abl-Positive Acute Lymphoblastic Leukemias

Fei, F., Stoddart, S., Groffen, J., Heisterkamp, N.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 953 KB

english, 2010

15

Driven to Death: Inhibition of Farnesylation Increases Ras Activity and Promotes Growth Arrest and Cell Death

Geryk-Hall, M., Yang, Y., Hughes, D. P. M.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 405 KB

english, 2010

16

Inhibition of Histone Deacetylase Attenuates Hypoxia-Induced Migration and Invasion of Cancer Cells via the Restoration of RECK Expression

Jeon, H. W., Lee, Y. M.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 489 KB

english, 2010

17

Synergistic Antitumor Effect of S-1 and HER2-Targeting Agents in Gastric Cancer with HER2 Amplification

Tanizaki, J., Okamoto, I., Takezawa, K., Tsukioka, S., Uchida, J., Kiniwa, M., Fukuoka, M., Nakagawa, K.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 658 KB

english, 2010

18

Minimally Cytotoxic Doses of Temozolomide Produce Radiosensitization in Human Glioblastoma Cells Regardless of MGMT Expression

Bobola, M. S., Kolstoe, D. D., Blank, A., Silber, J. R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 352 KB

english, 2010

19

mRNA and microRNA Expression Profiles of the NCI-60 Integrated with Drug Activities

Liu, H., D'Andrade, P., Fulmer-Smentek, S., Lorenzi, P., Kohn, K. W., Weinstein, J. N., Pommier, Y., Reinhold, W. C.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.66 MB

english, 2010

20

17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species

Walker, T., Mitchell, C., Park, M. A., Yacoub, A., Rahmani, M., Haussinger, D., Reinehr, R., Voelkel-Johnson, C., Fisher, P. B., Grant, S., Dent, P.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 713 KB

english, 2010

21

Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma

Uddin, S., Hussain, A. R., Ahmed, M., Bu, R., Ahmed, S. O., Ajarim, D., Al-Dayel, F., Bavi, P., Al-Kuraya, K. S.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 553 KB

english, 2010

22

Epithelial-to-Mesenchymal Transition and Oncogenic Ras Expression in Resistance to the Protein Kinase C Inhibitor Enzastaurin in Colon Cancer Cells

Serova, M., Astorgues-Xerri, L., Bieche, I., Albert, S., Vidaud, M., Benhadji, K. A., Emami, S., Vidaud, D., Hammel, P., Theou-Anton, N., Gespach, C., Faivre, S., Raymond, E.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 855 KB

english, 2010

23

Microtubule Dynamics, Mitotic Arrest, and Apoptosis: Drug-Induced Differential Effects of III-Tubulin

Gan, P. P., McCarroll, J. A., Po'uha, S. T., Kamath, K., Jordan, M. A., Kavallaris, M.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 391 KB

english, 2010

24

Targeting the HGF/c-Met Axis: State of Play

Yap, T. A., de Bono, J. S.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 133 KB

english, 2010

25

Correction: Tautomycetin and Tautomycin Suppress the Growth of Medullary Thyroid Cancer Cells via Inhibition of Glycogen Synthase Kinase-3

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 127 KB

english, 2010

26

Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD-Dependent Manner

Turbyville, T. J., Gursel, D. B., Tuskan, R. G., Walrath, J. C., Lipschultz, C. A., Lockett, S. J., Wiemer, D. F., Beutler, J. A., Reilly, K. M.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 483 KB

english, 2010

27

Expression of Oncogenic Kinase Bcr-Abl Impairs Mitotic Checkpoint and Promotes Aberrant Divisions and Resistance to Microtubule-Targeting Agents

Wolanin, K., Magalska, A., Kusio-Kobialka, M., Podszywalow-Bartnicka, P., Vejda, S., McKenna, S. L., Mosieniak, G., Sikora, E., Piwocka, K.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 467 KB

english, 2010

28

Inhibition of the Insulin-Like Growth Factor I Receptor by Epigallocatechin Gallate Blocks Proliferation and Induces the Death of Ewing Tumor Cells

Kang, H.-G., Jenabi, J. M., Liu, X. F., Reynolds, C. P., Triche, T. J., Sorensen, P. H. B.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 712 KB

english, 2010

29

Mechanistic Evaluation of the Novel HSP90 Inhibitor NVP-AUY922 in Adult and Pediatric Glioblastoma

Gaspar, N., Sharp, S. Y., Eccles, S. A., Gowan, S., Popov, S., Jones, C., Pearson, A., Vassal, G., Workman, P.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 682 KB

english, 2010

30

ENMD-1198, a New Analogue of 2-Methoxyestradiol, Displays Both Antiangiogenic and Vascular-Disrupting Properties

Pasquier, E., Sinnappan, S., Munoz, M. A., Kavallaris, M.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 472 KB

english, 2010

31

AT7867 Is a Potent and Oral Inhibitor of AKT and p70 S6 Kinase That Induces Pharmacodynamic Changes and Inhibits Human Tumor Xenograft Growth

Grimshaw, K. M., Hunter, L.-J. K., Yap, T. A., Heaton, S. P., Walton, M. I., Woodhead, S. J., Fazal, L., Reule, M., Davies, T. G., Seavers, L. C., Lock, V., Lyons, J. F., Thompson, N. T., Workman, P.,

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 705 KB

english, 2010

32

Development of Candidate Genomic Markers to Select Breast Cancer Patients for Dasatinib Therapy

Moulder, S., Yan, K., Huang, F., Hess, K. R., Liedtke, C., Lin, F., Hatzis, C., Hortobagyi, G. N., Symmans, W. F., Pusztai, L.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 286 KB

english, 2010

33

Transcriptional Analysis of an E2F Gene Signature as a Biomarker of Activity of the Cyclin-Dependent Kinase Inhibitor PHA-793887 in Tumor and Skin Biopsies from a Phase I Clinical Study

Locatelli, G., Bosotti, R., Ciomei, M., Brasca, M. G., Calogero, R., Mercurio, C., Fiorentini, F., Bertolotti, M., Scacheri, E., Scaburri, A., Galvani, A., Pesenti, E., De Baere, T., Soria, J.-C., Laz

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 542 KB

english, 2010

34

IFN Restores Breast Cancer Sensitivity to Fulvestrant by Regulating STAT1, IFN Regulatory Factor 1, NF- B, BCL2 Family Members, and Signaling to Caspase-Dependent Apoptosis

Ning, Y., Riggins, R. B., Mulla, J. E., Chung, H., Zwart, A., Clarke, R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 597 KB

english, 2010

35

X-Linked Inhibitor of Apoptosis Protein Inhibits Apoptosis in Inflammatory Breast Cancer Cells with Acquired Resistance to an ErbB1/2 Tyrosine Kinase Inhibitor

Aird, K. M., Ghanayem, R. B., Peplinski, S., Lyerly, H. K., Devi, G. R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 919 KB

english, 2010

36

Analysis of Food and Drug Administration-Approved Anticancer Agents in the NCI60 Panel of Human Tumor Cell Lines

Holbeck, S. L., Collins, J. M., Doroshow, J. H.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 687 KB

english, 2010

37

Preclinical Evaluation of Nilotinib Efficacy in an Imatinib-Resistant KIT-Driven Tumor Model

Cullinane, C., Natoli, A., Hui, Y., Conus, N., Jackson, S., Bruggen, J., Manley, P. W., McArthur, G. A.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 393 KB

english, 2010

38

The Histone Deacetylase Inhibitor MGCD0103 Induces Apoptosis in B-Cell Chronic Lymphocytic Leukemia Cells through a Mitochondria-Mediated Caspase Activation Cascade

El-Khoury, V., Moussay, E., Janji, B., Palissot, V., Aouali, N., Brons, N. H. C., Van Moer, K., Pierson, S., Van Dyck, E., Berchem, G.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 496 KB

english, 2010

39

1,25-Dihydroxyvitamin D3 Enhances the Apoptotic Activity of MDM2 Antagonist Nutlin-3a in Acute Myeloid Leukemia Cells Expressing Wild-type p53

Thompson, T., Andreeff, M., Studzinski, G. P., Vassilev, L. T.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 381 KB

english, 2010

40

Effects of Short-term Celecoxib Treatment in Patients with Invasive Transitional Cell Carcinoma of the Urinary Bladder

Dhawan, D., Craig, B. A., Cheng, L., Snyder, P. W., Mohammed, S. I., Stewart, J. C., Zheng, R., Loman, R. A., Foster, R. S., Knapp, D. W.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 288 KB

english, 2010