Volume 9; Issue 6

Molecular Cancer Therapeutics

Volume 9; Issue 6

1

Bortezomib Sensitizes Human Esophageal Squamous Cell Carcinoma Cells to TRAIL-Mediated Apoptosis via Activation of Both Extrinsic and Intrinsic Apoptosis Pathways

Seki, N., Toh, U., Sayers, T. J., Fujii, T., Miyagi, M., Akagi, Y., Kusukawa, J., Kage, M., Shirouzu, K., Yamana, H.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 743 KB

english, 2010

2

Decitabine Maintains Hematopoietic Precursor Self-Renewal by Preventing Repression of Stem Cell Genes by a Differentiation-Inducing Stimulus

Hu, Z., Negrotto, S., Gu, X., Mahfouz, R., Ng, K. P., Ebrahem, Q., Copelan, E., Singh, H., Maciejewski, J. P., Saunthararajah, Y.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 529 KB

english, 2010

3

BNC105: A Novel Tubulin Polymerization Inhibitor That Selectively Disrupts Tumor Vasculature and Displays Single-Agent Antitumor Efficacy

Kremmidiotis, G., Leske, A. F., Lavranos, T. C., Beaumont, D., Gasic, J., Hall, A., O'Callaghan, M., Matthews, C. A., Flynn, B.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 672 KB

english, 2010

4

Butein Sensitizes Human Hepatoma Cells to TRAIL-Induced Apoptosis via Extracellular Signal-Regulated Kinase/Sp1-Dependent DR5 Upregulation and NF- B Inactivation

Moon, D.-O., Kim, M.-O., Choi, Y. H., Kim, G.-Y.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 670 KB

english, 2010

5

Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice

Fritz, V., Benfodda, Z., Rodier, G., Henriquet, C., Iborra, F., Avances, C., Allory, Y., de la Taille, A., Culine, S., Blancou, H., Cristol, J. P., Michel, F., Sardet, C., Fajas, L.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 667 KB

english, 2010

6

Improved Antitumor Activity and Tumor Targeting of NH2-Terminal-Specific PEGylated Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

Chae, S. Y., Kim, T. H., Park, K., Jin, C.-H., Son, S., Lee, S., Youn, Y. S., Kim, K., Jo, D.-G., Kwon, I. C., Chen, X., Lee, K. C.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 382 KB

english, 2010

7

A Novel Plant Homeodomain Finger 10-Mediated Antiapoptotic Mechanism Involving Repression of Caspase-3 in Gastric Cancer Cells

Wei, M., Liu, B., Su, L., Li, J., Zhang, J., Yu, Y., Yan, M., Yang, Z., Chen, X., Liu, J., Lv, X., Nie, H., Zhang, Q., Zheng, Z., Yu, B., Ji, J., Zhang, J., Zhu, Z., Gu, Q.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 690 KB

english, 2010

8

Bioengineering a Unique Deimmunized Bispecific Targeted Toxin That Simultaneously Recognizes Human CD22 and CD19 Receptors in a Mouse Model of B-Cell Metastases

Vallera, D. A., Oh, S., Chen, H., Shu, Y., Frankel, A. E.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 693 KB

english, 2010

9

BMS-777607, a Small-Molecule Met Kinase Inhibitor, Suppresses Hepatocyte Growth Factor-Stimulated Prostate Cancer Metastatic Phenotype In vitro

Dai, Y., Siemann, D. W.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 376 KB

english, 2010

10

Oligodeoxyribozymes That Cleave -Catenin Messenger RNA Inhibit Growth of Colon Cancer Cells via Reduction of -Catenin Response Transcription

Choi, B.-R., Gwak, J., Kwon, H.-M., Oh, S., Kim, K. P., Choi, W.-H., Cho, Y.-H., Kim, D.-E.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 376 KB

english, 2010

11

Evaluation of Selective -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

Wei, P., Walls, M., Qiu, M., Ding, R., Denlinger, R. H., Wong, A., Tsaparikos, K., Jani, J. P., Hosea, N., Sands, M., Randolph, S., Smeal, T.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.11 MB

english, 2010

12

ErbB-Inhibitory Protein: A Modified Ectodomain of Epidermal Growth Factor Receptor Synergizes with Dasatinib to Inhibit Growth of Breast Cancer Cells

Nautiyal, J., Yu, Y., Aboukameel, A., Kanwar, S. S., Das, J. K., Du, J., Patel, B. B., Sarkar, F. H., Rishi, A. K., Mohammad, R. M., Majumdar, A. P. N.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 692 KB

english, 2010

13

Sensitization to Radiation and Alkylating Agents by Inhibitors of Poly(ADP-ribose) Polymerase Is Enhanced in Cells Deficient in DNA Double-Strand Break Repair

Loser, D. A., Shibata, A., Shibata, A. K., Woodbine, L. J., Jeggo, P. A., Chalmers, A. J.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 527 KB

english, 2010

14

Global Targeting of Subcellular Heat Shock Protein-90 Networks for Therapy of Glioblastoma

Siegelin, M. D., Plescia, J., Raskett, C. M., Gilbert, C. A., Ross, A. H., Altieri, D. C.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 757 KB

english, 2010

15

Distinct Roles of Cytochrome P450 Reductase in Mitomycin c Redox Cycling and Cytotoxicity

Wang, Y., Gray, J. P., Mishin, V., Heck, D. E., Laskin, D. L., Laskin, J. D.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 428 KB

english, 2010

16

Role of the 18:1 Lysophosphatidic Acid-Ovarian Cancer Immunoreactive Antigen Domain Containing 1 (OCIAD1)-Integrin Axis in Generating Late-Stage Ovarian Cancer

Wang, C., Michener, C. M., Belinson, J. L., Vaziri, S., Ganapathi, R., Sengupta, S.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 455 KB

english, 2010

17

Docetaxel-Resistant Prostate Cancer Cells Remain Sensitive to S-Trityl-L-Cysteine-Mediated Eg5 Inhibition

Wiltshire, C., Singh, B. L., Stockley, J., Fleming, J., Doyle, B., Barnetson, R., Robson, C. N., Kozielski, F., Leung, H. Y.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 954 KB

english, 2010

18

ARC Synergizes with ABT-737 to Induce Apoptosis in Human Cancer Cells

Bhat, U. G., Pandit, B., Gartel, A. L.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 591 KB

english, 2010

19

Enhanced Anticancer Effect of the Combination of BIBW2992 and Thymidylate Synthase-Targeted Agents in Non-Small Cell Lung Cancer with the T790M Mutation of Epidermal Growth Factor Receptor

Takezawa, K., Okamoto, I., Tanizaki, J., Kuwata, K., Yamaguchi, H., Fukuoka, M., Nishio, K., Nakagawa, K.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 571 KB

english, 2010

20

Effect of Pazopanib on Tumor Microenvironment and Liposome Delivery

Tailor, T. D., Hanna, G., Yarmolenko, P. S., Dreher, M. R., Betof, A. S., Nixon, A. B., Spasojevic, I., Dewhirst, M. W.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 543 KB

english, 2010

21

Antitumor Activity and Immune Response Induction of a Dual Agonist of Toll-Like Receptors 7 and 8

Wang, D., Precopio, M., Lan, T., Yu, D., Tang, J. X., Kandimalla, E. R., Agrawal, S.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 708 KB

english, 2010

22

A Preclinical Study on the Rescue of Normal Tissue by Nicotinic Acid in High-Dose Treatment with APO866, a Specific Nicotinamide Phosphoribosyltransferase Inhibitor

Olesen, U. H., Thougaard, A. V., Jensen, P. B., Sehested, M.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 369 KB

english, 2010

23

ARQ 197, a Novel and Selective Inhibitor of the Human c-Met Receptor Tyrosine Kinase with Antitumor Activity

Munshi, N., Jeay, S., Li, Y., Chen, C.-R., France, D. S., Ashwell, M. A., Hill, J., Moussa, M. M., Leggett, D. S., Li, C. J.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 686 KB

english, 2010

24

High-Content Phenotypic Profiling of Drug Response Signatures across Distinct Cancer Cells

Caie, P. D., Walls, R. E., Ingleston-Orme, A., Daya, S., Houslay, T., Eagle, R., Roberts, M. E., Carragher, N. O.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.38 MB

english, 2010

25

Correction: Analysis of Food and Drug Administration-Approved Anticancer Agents in the NCI60 Panel of Human Tumor Cell Lines

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 94 KB

english, 2010

26

Na,K-ATPase Subunits as Markers for Epithelial-Mesenchymal Transition in Cancer and Fibrosis

Rajasekaran, S. A., Huynh, T. P., Wolle, D. G., Espineda, C. E., Inge, L. J., Skay, A., Lassman, C., Nicholas, S. B., Harper, J. F., Reeves, A. E., Ahmed, M. M., Leatherman, J. M., Mullin, J. M., Raja

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 654 KB

english, 2010

27

A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo

Dransfield, D. T., Cohen, E. H., Chang, Q., Sparrow, L. G., Bentley, J. D., Dolezal, O., Xiao, X., Peat, T. S., Newman, J., Pilling, P. A., Phan, T., Priebe, I., Brierley, G. V., Kastrapeli, N., Kopac

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 897 KB

english, 2010

28

Benzyl Isothiocyanate-Mediated Inhibition of Histone Deacetylase Leads to NF- B Turnoff in Human Pancreatic Carcinoma Cells

Batra, S., Sahu, R. P., Kandala, P. K., Srivastava, S. K.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 621 KB

english, 2010

29

Structural Basis on the Dityrosyl-Diiron Radical Cluster and the Functional Differences of Human Ribonucleotide Reductase Small Subunits hp53R2 and hRRM2

Zhou, B., Su, L., Yuan, Y.-C., Un, F., Wang, N., Patel, M., Xi, B., Hu, S., Yen, Y.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 486 KB

english, 2010

30

Activated Phosphoinositide 3-Kinase/AKT Signaling Confers Resistance to Trastuzumab but not Lapatinib

O'Brien, N. A., Browne, B. C., Chow, L., Wang, Y., Ginther, C., Arboleda, J., Duffy, M. J., Crown, J., O'Donovan, N., Slamon, D. J.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 2.33 MB

english, 2010

31

Preclinical Evaluation of Differentially Targeting Dual Virotherapy for Human Solid Cancer

Sakai, R., Kagawa, S., Yamasaki, Y., Kojima, T., Uno, F., Hashimoto, Y., Watanabe, Y., Urata, Y., Tanaka, N., Fujiwara, T.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 646 KB

english, 2010

32

Serum Signature of Hypoxia-Regulated Factors Is Associated with Progression after Induction Therapy in Head and Neck Squamous Cell Cancer

Byers, L. A., Holsinger, F. C., Kies, M. S., William, W. N., El-Naggar, A. K., Lee, J. J., Hu, J., Lopez, A., Tran, H. T., Yan, S., Du, Z., Ang, K. K., Glisson, B. S., Raso, M. G., Wistuba, I. I., Mye

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 428 KB

english, 2010

33

Successful Treatment of Castleman's Disease with Interleukin-1 Receptor Antagonist (Anakinra)

El-Osta, H., Janku, F., Kurzrock, R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 199 KB

english, 2010

34

Effect of the Specific Src Family Kinase Inhibitor Saracatinib on Osteolytic Lesions Using the PC-3 Bone Model

Yang, J. C., Bai, L., Yap, S., Gao, A. C., Kung, H.-J., Evans, C. P.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 491 KB

english, 2010

35

Oncogenic Functions of Secreted Frizzled-Related Protein 2 in Human Renal Cancer

Yamamura, S., Kawakami, K., Hirata, H., Ueno, K., Saini, S., Majid, S., Dahiya, R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 659 KB

english, 2010

36

The NF- B Inhibitor LC-1 Has Single Agent Activity in Multiple Myeloma Cells and Synergizes with Bortezomib

Walsby, E. J., Pratt, G., Hewamana, S., Crooks, P. A., Burnett, A. K., Fegan, C., Pepper, C.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 535 KB

english, 2010

37

Zinc Protoporphyrin IX Stimulates Tumor Immunity by Disrupting the Immunosuppressive Enzyme Indoleamine 2,3-Dioxygenase

Metz, R., DuHadaway, J. B., Rust, S., Munn, D. H., Muller, A. J., Mautino, M., Prendergast, G. C.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 234 KB

english, 2010

38

Continuous Docetaxel Chemotherapy Improves Therapeutic Efficacy in Murine Models of Ovarian Cancer

De Souza, R., Zahedi, P., Moriyama, E. H., Allen, C. J., Wilson, B. C., Piquette-Miller, M.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 450 KB

english, 2010

39

Blockade of Rac1 Activity Induces G1 Cell Cycle Arrest or Apoptosis in Breast Cancer Cells through Downregulation of Cyclin D1, Survivin, and X-Linked Inhibitor of Apoptosis Protein

Yoshida, T., Zhang, Y., Rivera Rosado, L. A., Chen, J., Khan, T., Moon, S. Y., Zhang, B.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 498 KB

english, 2010

40

Reversible Epithelial to Mesenchymal Transition and Acquired Resistance to Sunitinib in Patients with Renal Cell Carcinoma: Evidence from a Xenograft Study

Hammers, H. J., Verheul, H. M., Salumbides, B., Sharma, R., Rudek, M., Jaspers, J., Shah, P., Ellis, L., Shen, L., Paesante, S., Dykema, K., Furge, K., Teh, B. T., Netto, G., Pili, R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.04 MB

english, 2010

41

Endocytosis of PEGylated Agents Enhances Cancer Imaging and Anticancer Efficacy

Chuang, K.-H., Wang, H.-E., Chen, F.-M., Tzou, S.-C., Cheng, C.-M., Chang, Y.-C., Tseng, W.-L., Shiea, J., Lin, S.-R., Wang, J.-Y., Chen, B.-M., Roffler, S. R., Cheng, T.-L.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 648 KB

english, 2010

42

Induction of Clusterin by AKT--Role in Cytoprotection against Docetaxel in Prostate Tumor Cells

Zhong, B., Sallman, D. A., Gilvary, D. L., Pernazza, D., Sahakian, E., Fritz, D., Cheng, J. Q., Trougakos, I., Wei, S., Djeu, J. Y.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 459 KB

english, 2010

43

Artemin-Stimulated Progression of Human Non-Small Cell Lung Carcinoma Is Mediated by BCL2

Tang, J.-Z., Kong, X.-J., Kang, J., Fielder, G. C., Steiner, M., Perry, J. K., Wu, Z.-S., Yin, Z., Zhu, T., Liu, D.-X., Lobie, P. E.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.07 MB

english, 2010