Volume 7; Issue 1

Molecular Neurodegeneration

Volume 7; Issue 1

1

A molecular signature in blood identifies early Parkinson’s disease

Molochnikov, Leonid, Rabey, Jose M, Dobronevsky, Evgenya, Bonucelli, Ubaldo, Ceravolo, Roberto, Frosini, Daniela, Grünblatt, Edna, Riederer, Peter, Jacob, Christian, Aharon-Peretz, Judith, Bashenko, Y

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.49 MB

english, 2012

2

Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in aDrosophilamodel of Fus-mediated ALS

Ruohan Xia, Yajuan Liu, Liuqing Yang, Jozsef Gal, Haining Zhu, Jianhang Jia

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.68 MB

english, 2012

3

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

Jin Chu, Phillip F Giannopoulos, Carolina Ceballos-Diaz, Todd E Golde, Domenico Pratico

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 742 KB

english, 2012

4

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

Youren Tong, Emilie Giaime, Hiroo Yamaguchi, Takaharu Ichimura, Yumin Liu, Huiqing Si, Huaibin Cai, Joseph V Bonventre, Jie Shen

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 2.10 MB

english, 2012

5

Both common variations and rare non-synonymous substitutions and small insertion/deletions inCLUare associated with increased Alzheimer risk

Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Jean-Charles Lambert, Ekaterina Rogaeva, Rik Vandenberghe, Nathalie Le Bastard, Florence Pasquier, Steven Vermeulen, Jasper Van Dongen, Mar

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 452 KB

english, 2012

6

WldSbut not Nmnat1 protects dopaminergic neurites from MPP+neurotoxicity

Jo Ann V Antenor-Dorsey, Karen L O’Malley

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 885 KB

english, 2012

7

Spinal cord trauma and the molecular point of no return

Ping K Yip, Andrea Malaspina

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 751 KB

english, 2012

8

Rapid glutamate receptor 2 trafficking during retinal degeneration

Yanhua Lin, Bryan W Jones, Aihua Liu, Félix R Vazquéz-Chona, J Scott Lauritzen, W Drew Ferrell, Robert E Marc

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 4.94 MB

english, 2012

9

Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells

Slowik, Alexander, Merres, Julika, Elfgen, Anne, Jansen, Sandra, Mohr, Fabian, Wruck, Christoph J, Pufe, Thomas, Brandenburg, Lars-Ove

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 4.42 MB

english, 2012

10

Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome

Xu, Zhao-Hui, Yang, Qi, Feng, Bin, Liu, Shui-bing, Zhang, Nan, Xing, Jiang-hao, Li, Xiao-Qiang, Wu, Yu-mei, Gao, Guo-Dong, Zhao, Ming-Gao

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.94 MB

english, 2012

11

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

Kathryn Rogers, Kevin M Felsenstein, Lori Hrdlicka…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.09 MB

english, 2012

12

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection

Robert Tamayev, Nsikan Akpan, Ottavio Arancio, Carol M Troy…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 577 KB

english, 2012

13

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

Manuel Torres, Sebastian Jimenez, Raquel Sanchez-Varo…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.35 MB

english, 2012

14

The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease

Hannah Brautigam, John W Steele, David Westaway…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 261 KB

english, 2012

15

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity inCaenorhabditis elegansfor drug screening for Alzheimer’s disease

Gawain McColl, Blaine R Roberts, Tara L Pukala…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 615 KB

english, 2012

16

Regulated protein aggregation: stress granules and neurodegeneration

Benjamin Wolozin

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 596 KB

english, 2012

17

Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP

Anaïs Aulas, Stéphanie Stabile, Christine Vande Velde

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.93 MB

english, 2012

18

Expression ofFused in sarcomamutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis

Christophe Verbeeck, Qiudong Deng, Mariely DeJesus-Hernandez…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 3.00 MB

english, 2012

19

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

Linda Chami, Frédéric Checler

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 503 KB

english, 2012

20

Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons

Carolina Franco, Silvia Fernández, Ignacio Torres-Alemán

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 296 KB

english, 2012

21

Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease

Yuhki Saito, Tsuyoshi Inoue, Gang Zhu, Naoki Kimura…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 2.07 MB

english, 2012

22

Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

Paula Desplats, Pruthul Patel, Kori Kosberg, Michael Mante…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 576 KB

english, 2012

23

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

Keiichi Inoue, Joanne Rispoli, Hanoch Kaphzan, Eric Klann…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 997 KB

english, 2012

24

IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery

Hong Lian, David J Shim, Samson SK Gaddam…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.10 MB

english, 2012

25

Identification of BACE2 as an avid ß-amyloid-degrading protease

Samer O Abdul-Hay, Tomoko Sahara, Melinda McBride…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 720 KB

english, 2012

26

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

Terina N Martinez, Xi Chen, Sibali Bandyopadhyay…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 466 KB

english, 2012

27

Neuromuscular effects of G93A-SOD1 expression in zebrafish

Stacey A Sakowski, J Simon Lunn, Angela S Busta, Sang Su Oh…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 862 KB

english, 2012

28

ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT

Peter O Bauer, Roman Hudec, Anand Goswami, Masaru Kurosawa…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.76 MB

english, 2012

29

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Karin M Danzer, Lisa R Kranich, Wolfgang P Ruf…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 483 KB

english, 2012

30

Mass spectrometry quantification of clusterin in the human brain

Junjun Chen, Meiyao Wang, Illarion V Turko

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 292 KB

english, 2012

31

L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL

Haigang Ren, Kai Fu, Chenchen Mu, Xuechu Zhen, Guanghui Wang

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 637 KB

english, 2012

32

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

Pritam Das, Christophe Verbeeck, Lisa Minter…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 748 KB

english, 2012

33

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

Masatoshi Konno, Takafumi Hasegawa, Toru Baba, Emiko Miura…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 937 KB

english, 2012

34

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

Suhail Rasool, Ricardo Albay III, Hilda Martinez-Coria…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 965 KB

english, 2012

35

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition

Paramita Chakrabarty, Li Tianbai, Amanda Herring…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1001 KB

english, 2012

36

Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

Georg Nübling, Benedikt Bader, Johannes Levin…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.04 MB

english, 2012

37

Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system

Victor Tulio Ribeiro-Resende, Alvaro Carrier-Ruiz…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 2.86 MB

english, 2012

38

Progranulin regulates neuronal outgrowth independent of Sortilin

Jennifer Gass, Wing C Lee, Casey Cook, Nicole Finch…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 426 KB

english, 2012

39

Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach

Carole J Proctor, Ilse Sanet Pienaar, Joanna L Elson…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 2.39 MB

english, 2012

40

LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease

Julie Brodeur, Caroline Thériault, Mélissa Lessard-Beaudoin…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.52 MB

english, 2012

41

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

Yonghao Zhao, Yunshu Wang, Jiaye Yang, Xin Wang…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 907 KB

english, 2012

42

Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases

Cheng Fang, Dennis Bourdette, Gary Banker

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.25 MB

english, 2012

43

Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult

Shaefali P Rodgers, Heather A Born, Pritam Das…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.29 MB

english, 2012

44

Does a loss of TDP-43 function cause neurodegeneration?

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 373 KB

english, 2012

45

LRRK2knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

Kelly M Hinkle, Mei Yue, Bahareh Behrouz, Justus C Dächsel…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

46

Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+in cognitively intact aged individuals with Alzheimer’s disease neuropathology

Nicole L Bjorklund, Lindsay C Reese, V-M Sadagoparamanujam…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 574 KB

english, 2012

47

Regulation of mitochondrial permeability transition pore by PINK1

Clement A Gautier, Emilie Giaime, Erica Caballero…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.65 MB

english, 2012

48

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

Jiankun Cui, Shanyan Chen, Chunyang Zhang, Fanjun Meng…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.54 MB

english, 2012

49

Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington’s disease

Keizo Sugaya, Shiro Matsubara

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.54 MB

english, 2012

50

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia

Robert Tamayev, Luciano D’Adamio

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 412 KB

english, 2012

51

Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPreslevel disparity

Victoria Lewis, Cathryn L Haigh, Colin L Masters…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

52

Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia

Yanyan Sun, Yu Zhang, Xiaoyang Wang, Klas Blomgren…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 760 KB

english, 2012

53

Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects

Saori Hata, Miyako Taniguchi, Yi Piao, Takeshi Ikeuchi…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 564 KB

english, 2012

54

The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities

Tatsunori Maekawa, Sayuri Mori, Yui Sasaki, Takashi Miyajima…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 708 KB

english, 2012

55

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

Jacob M Basak, Jungsu Kim, Yuriy Pyatkivskyy…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 402 KB

english, 2012

56

Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

Mariet Allen, Fanggeng Zou, High Seng Chai, Curtis S Younkin…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 253 KB

english, 2012

57

Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

Miriam A Hickey, Chunni Zhu, Vera Medvedeva, Renata P Lerner…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 776 KB

english, 2012

58

Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease

Carolina Cabeza, Alicia Figueroa, Oscar M Lazo…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 923 KB

english, 2012

59

FE65 as a link between VLDLR and APP to regulate their trafficking and processing

Sonya B Dumanis, Kelly A Chamberlain, Yoo Jin Sohn…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

60

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

Katherine L Youmans, Leon M Tai, Takahisa Kanekiyo…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 736 KB

english, 2012

61

Nurr1regulatesTop IIβand functions in axon genesis of mesencephalic dopaminergic neurons

Xin Heng, Gang Jin, Xin Zhang, Dehuang Yang, Mingzhe Zhu…

Journal:

Molecular Neurodegeneration

Year:

2012

Language:

english

File:

PDF, 1.44 MB

english, 2012

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