Volume 9

Molecular Therapy — Nucleic Acids

Volume 9

1

Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson’s Disease

Helmschrodt, Christin, Höbel, Sabrina, Schöniger, Sandra, Bauer, Anne, Bonicelli, Jana, Gringmuth, Marieke, Fietz, Simone A., Aigner, Achim, Richter, Angelika, Richter, Franziska

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 3.29 MB

english, 2017

2

Profiling the Mismatch Tolerance of Argonaute 2 through Deep Sequencing of Sliced Polymorphic Viral RNAs

Theotokis, Pantazis I., Usher, Louise, Kortschak, Christopher K., Schwalbe, Ed, Moschos, Sterghios A.

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

3

Efficacy and Safety of Pancreas-Targeted Hydrodynamic Gene Delivery in Rats

Ogawa, Kohei, Kamimura, Kenya, Kobayashi, Yuji, Abe, Hiroyuki, Yokoo, Takeshi, Sakai, Norihiro, Nagoya, Takuro, Sakamaki, Akira, Abe, Satoshi, Hayashi, Kazunao, Ikarashi, Satoshi, Kohisa, Junji, Tsuch

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.94 MB

english, 2017

4

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

Li, Xiao-yu, Wang, Shan-shan, Han, Zhe, Han, Fei, Chang, Yun-peng, Yang, Yang, Xue, Mei, Sun, Bei, Chen, Li-ming

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.98 MB

english, 2017

5

The lncRNA PDIA3P Interacts with miR-185-5p to Modulate Oral Squamous Cell Carcinoma Progression by Targeting Cyclin D2

Sun, Cheng-Cao, Zhang, Ling, Li, Guang, Li, Shu-Jun, Chen, Zhen-Long, Fu, Yun-Feng, Gong, Feng-Yun, Bai, Tao, Zhang, Ding-Yu, Wu, Qing-Ming, Li, De-Jia

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 2.71 MB

english, 2017

6

Assessment of the Drug Interaction Potential of Unconjugated and GalNAc 3 -Conjugated 2′-MOE-ASOs

Shemesh, Colby S., Yu, Rosie Z., Warren, Mark S., Liu, Michael, Jahic, Mirza, Nichols, Brandon, Post, Noah, Lin, Song, Norris, Daniel A., Hurh, Eunju, Huang, Jane, Watanabe, Tanya, Henry, Scott P., Wa

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.62 MB

english, 2017

7

Role of Cell-Penetrating Peptides in Intracellular Delivery of Peptide Nucleic Acids Targeting Hepadnaviral Replication

Ndeboko, Bénédicte, Ramamurthy, Narayan, Lemamy, Guy Joseph, Jamard, Catherine, Nielsen, Peter E., Cova, Lucyna

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 882 KB

english, 2017

8

AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome

Arif, Rawa, Zaradzki, Marcin, Remes, Anca, Seppelt, Philipp, Kunze, Reiner, Schröder, Hannes, Schwill, Simon, Ensminger, Stephan M., Robinson, Peter N., Karck, Matthias, Müller, Oliver J., Hecker, Mar

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 2.62 MB

english, 2017

9

In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells

Holmgaard, Andreas, Askou, Anne Louise, Benckendorff, Josephine Natalia Esther, Thomsen, Emil Aagaard, Cai, Yujia, Bek, Toke, Mikkelsen, Jacob Giehm, Corydon, Thomas J.

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.97 MB

english, 2017

10

Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor

Falkenhagen, Alexander, Singh, Jastaranpreet, Asad, Sabah, Leontyev, Danila, Read, Stanley, Zúñiga-Pflücker, Juan Carlos, Joshi, Sadhna

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 2.28 MB

english, 2017

11

Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy

Gupta, Anisha, Quijano, Elias, Liu, Yanfeng, Bahal, Raman, Scanlon, Susan E., Song, Eric, Hsieh, Wei-Che, Braddock, Demetrios E., Ly, Danith H., Saltzman, W. Mark, Glazer, Peter M.

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.86 MB

english, 2017

12

Rational Design of Short Locked Nucleic Acid-Modified 2′- O -Methyl Antisense Oligonucleotides for Efficient Exon-Skipping In Vitro

Le, Bao T., Adams, Abbie M., Fletcher, Susan, Wilton, Stephen D., Veedu, Rakesh N.

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.15 MB

english, 2017

13

Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes

Setoguchi, Kiyoko, Cui, Lin, Hachisuka, Nobutaka, Obchoei, Sumalee, Shinkai, Kentaro, Hyodo, Fuminori, Kato, Kiyoko, Wada, Fumito, Yamamoto, Tsuyoshi, Harada-Shiba, Mariko, Obika, Satoshi, Nakano, Ken

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 2.74 MB

english, 2017

14

miR-124 Inhibits Lung Tumorigenesis Induced by K-ras Mutation and NNK

Jin, Hua, Li, Qing, Cao, Fenghao, Wang, Shu-Nan, Wang, Ren-Tao, Wang, Yun, Tan, Qun-You, Li, Cheng-Run, Zou, Hua, Wang, Dong, Xu, Cheng-Xiong

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.54 MB

english, 2017

15

Tween 85-Modified Low Molecular Weight PEI Enhances Exon-Skipping of Antisense Morpholino Oligomer In Vitro and in mdx Mice

Wang, Mingxing, Wu, Bo, Tucker, Jason D., Shah, Sapana N., Lu, Peijuan, Bollinger, Lauren E., Lu, Qilong

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 3.38 MB

english, 2017

16

Distinct Expression Profiles and Novel Targets of MicroRNAs in Human Spermatogonia, Pachytene Spermatocytes, and Round Spermatids between OA Patients and NOA Patients

Yao, Chencheng, Yuan, Qingqing, Niu, Minghui, Fu, Hongyong, Zhou, Fan, Zhang, Wenhui, Wang, Hong, Wen, Liping, Wu, Ligang, Li, Zheng, He, Zuping

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 2.21 MB

english, 2017

17

Alleviation of Toxicity Caused by Overactivation of P parα through P parα -Inducible miR-181a2

Cheng, Yanjie, Wei, Zhuying, Xie, Shengsong, Peng, You, Yan, Yi, Qin, Dan, Liu, Shenghui, Xu, Yanling, Li, Guangpeng, Zhang, Lisheng

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 2.02 MB

english, 2017

18

The Bioactivity of D-/L-Isonucleoside- and 2′-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression

Fan, Xinmeng, Sun, Lidan, Li, Kunfeng, Yang, Xiantao, Cai, Baobin, Zhang, Yanfen, Zhu, Yuejie, Ma, Yuan, Guan, Zhu, Wu, Yun, Zhang, Lihe, Yang, Zhenjun

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.72 MB

english, 2017

19

A New Long Noncoding RNA ALB Regulates Autophagy by Enhancing the Transformation of LC3BI to LC3BII during Human Lens Development

Fu, Qiuli, Qin, Zhenwei, Zhang, Lifang, Lyu, Danni, Tang, Qiaomei, Yin, Houfa, Chen, Zhijian, Yao, Ke

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 2.61 MB

english, 2017

20

Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma

Lin, Jing, Lee, Jia Hui Jane, Paramasivam, Kathirvel, Pathak, Elina, Wang, Zhenxun, Pramono, Zacharias Aloysius Dwi, Lim, Bing, Wee, Keng Boon, Surana, Uttam

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.85 MB

english, 2017

21

Factor VII-Induced MicroRNA-135a Inhibits Autophagy and Is Associated with Poor Prognosis in Hepatocellular Carcinoma

Huang, Kuang-Tzu, Kuo, I-Ying, Tsai, Ming-Chao, Wu, Chun-Hsien, Hsu, Li-Wen, Chen, Li-Yu, Kung, Chao-Pin, Cheng, Yu-Fan, Goto, Shigeru, Chou, Yu-Wei, Chen, Chao-Long, Lin, Chih-Che, Chen, Kuang-Den

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.15 MB

english, 2017

22

Site-Specific Modification Using the 2′-Methoxyethyl Group Improves the Specificity and Activity of siRNAs

Song, Xinyun, Wang, Xiaoxia, Ma, Yuan, Liang, Zicai, Yang, Zhenjun, Cao, Huiqing

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.04 MB

english, 2017

23

Long Noncoding RNA HCAL Facilitates the Growth and Metastasis of Hepatocellular Carcinoma by Acting as a ceRNA of LAPTM4B

Xie, Cheng-Rong, Wang, Fei, Zhang, Sheng, Wang, Fu-Qiang, Zheng, Sen, Li, Zhao, Lv, Jie, Qi, He-Qiang, Fang, Qin-Liang, Wang, Xiao-Min, Yin, Zhen-Yu

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 3.06 MB

english, 2017

24

Shrimp miR-34 from Shrimp Stress Response to Virus Infection Suppresses Tumorigenesis of Breast Cancer

Cui, Yalei, Yang, Xiaoyuan, Zhang, Xiaobo

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 2.77 MB

english, 2017

25

miR-3174 Contributes to Apoptosis and Autophagic Cell Death Defects in Gastric Cancer Cells by Targeting ARHGAP10

Li, Bowen, Wang, Lu, Li, Zheng, Wang, Weizhi, Zhi, Xiaofei, Huang, Xiaoxu, Zhang, Qiang, Chen, Zheng, Zhang, Xuan, He, Zhongyuan, Xu, Jianghao, Zhang, Lu, Xu, Hao, Zhang, Diancai, Xu, Zekuan

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 8.90 MB

english, 2017

26

Skin Delivery of Clec4a Small Hairpin RNA Elicited an Effective Antitumor Response by Enhancing CD8 + Immunity In Vivo

Weng, Tzu-Yang, Li, Chia-Jung, Li, Chung-Yen, Hung, Yu-Hsuan, Yen, Meng-Chi, Chang, Yu-Wei, Chen, Yu-Hung, Chen, Yi-Ling, Hsu, Hui-Ping, Chang, Jang-Yang, Lai, Ming-Derg

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.75 MB

english, 2017

27

As Technologies for Nucleotide Therapeutics Mature, Products Emerge

Beierlein, Jennifer M., McNamee, Laura M., Ledley, Fred D.

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.12 MB

english, 2017

28

Blockade of Inflammation and Apoptosis Pathways by siRNA Prolongs Cold Preservation Time and Protects Donor Hearts in a Porcine Model

Wei, Jia, Chen, Shiyou, Xue, Song, Zhu, Qiangru, Liu, Sha, Cui, Li, Hua, Xiuguo, Wang, Yongyi

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 2.66 MB

english, 2017

29

Link between MHC Fiber Type and Restoration of Dystrophin Expression and Key Components of the DAPC by Tricyclo-DNA-Mediated Exon Skipping

Omairi, Saleh, Hau, Kwan-Leong, Collin-Hooper, Henry, Montanaro, Federica, Goyenvalle, Aurelie, Garcia, Luis, Patel, Ketan

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 2.88 MB

english, 2017

30

CRISPR/Cas9: A Potential Life-Saving Tool. What’s next?

Gulei, Diana, Berindan-Neagoe, Ioana

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.05 MB

english, 2017

31

Size, Shape, and Sequence-Dependent Immunogenicity of RNA Nanoparticles

Guo, Sijin, Li, Hui, Ma, Mengshi, Fu, Jian, Dong, Yizhou, Guo, Peixuan

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.86 MB

english, 2017

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