Volume 3; Issue 10

ACS Medicinal Chemistry Letters

Volume 3; Issue 10

1

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies

Dockendorff, Chris, Nagiec, Marek M., Weïwer, Michel, Buhrlage, Sara, Ting, Amal, Nag, Partha P., Germain, Andrew, Kim, Han-Je, Youngsaye, Willmen, Scherer, Christina, Bennion, Melissa, Xue, Linlong,

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

2

Structure–Activity Relationships for Side Chain Oxysterol Agonists of the Hedgehog Signaling Pathway

Corman, Audrey, DeBerardinis, Albert M., Hadden, M. Kyle

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 372 KB

english, 2012

3

Discovery of a Novel Chemotype of Tyrosine Kinase Inhibitors by Fragment-Based Docking and Molecular Dynamics

Zhao, Hongtao, Dong, Jing, Lafleur, Karine, Nevado, Cristina, Caflisch, Amedeo

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 335 KB

english, 2012

4

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo

Popovici-Muller, Janeta, Saunders, Jeffrey O., Salituro, Francesco G., Travins, Jeremy M., Yan, Shunqi, Zhao, Fang, Gross, Stefan, Dang, Lenny, Yen, Katharine E., Yang, Hua, Straley, Kimberly S., Jin,

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 982 KB

english, 2012

5

Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

Yu, Jianxin, Liu, Haiyan, Xia, Guangxin, Liu, Lin, Xu, Zhenmin, Chen, Qian, Ma, Chen, Sun, Xing, Xu, Jiajun, Li, Hua, Li, Ping, Shi, Yufang, Xiong, Bing, Liu, Xuejun, Shen, Jingkang

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 618 KB

english, 2012

6

Use of Bupropion in the Treatment of Sexual Dysfunction

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 131 KB

english, 2012

7

The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol

Kim, Michelle B., O'Brien, Terrence E., Moore, Jared T., Anderson, David E., Foss, Marie H., Weibel, Douglas B., Ames, James B., Shaw, Jared T.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 571 KB

english, 2012

8

Syntheses of Siderophore–Drug Conjugates Using a Convergent Thiol–Maleimide System

Juárez-Hernández, Raúl E., Miller, Patricia A., Miller, Marvin J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 660 KB

english, 2012

9

Synthesis of [ 11 C]Am80 via Novel Pd(0)-Mediated Rapid [ 11 C]Carbonylation Using Arylboronate and [ 11 C]Carbon Monoxide

Takashima-Hirano, Misato, Ishii, Hideki, Suzuki, Masaaki

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 220 KB

english, 2012

10

Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47

Weinstock, Joseph, Wu, Jian, Cao, Ping, Kingsbury, William D., McDermott, Jeffrey L., Kodrasov, Matthew P., McKelvey, Devin M., Suresh Kumar, K. G., Goldenberg, Seth J., Mattern, Michael R., Nicholson

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 677 KB

english, 2012

11

Antifungal Spectrum, In Vivo Efficacy, and Structure–Activity Relationship of Ilicicolin H

Singh, Sheo B., Liu, Weiguo, Li, Xiaohua, Chen, Tom, Shafiee, Ali, Card, Deborah, Abruzzo, George, Flattery, Amy, Gill, Charles, Thompson, John R., Rosenbach, Mark, Dreikorn, Sarah, Hornak, Viktor, Me

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 844 KB

english, 2012

12

Kinetic Profile of Amyloid Formation in the Presence of an Aromatic Inhibitor by Nuclear Magnetic Resonance

Liu, Gai, Gaines, Jennifer C., Robbins, Kevin J., Lazo, Noel D.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 438 KB

english, 2012

13

Combatting Drug-Resistant Bacteria with Gyrase and Topoisomerase IV Inhibitors

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 191 KB

english, 2012

14

Factor D Inhibitors for the Treatment of AMD

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 216 KB

english, 2012

15

Synthesis and SAR of 1-Hydroxy-1 H -benzo[ d ]imidazol-2(3 H )-ones as Inhibitors of d -Amino Acid Oxidase

Berry, James F., Ferraris, Dana V., Duvall, Bridget, Hin, Niyada, Rais, Rana, Alt, Jesse, Thomas, Ajit G., Rojas, Camilo, Hashimoto, Kenji, Slusher, Barbara S., Tsukamoto, Takashi

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 721 KB

english, 2012

16

Novel Use of Leflunomide and Malononitrilamides

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 156 KB

english, 2012

17

Imidazotriazinone Compounds

Rotella, David P.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 150 KB

english, 2012

18

In This Issue, Vol. 3, Issue 10

Silverman, Janice Elaine Y.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 664 KB

english, 2012

19

Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate

Keith, John M., Apodaca, Rich, Tichenor, Mark, Xiao, Wei, Jones, William, Pierce, Joan, Seierstad, Mark, Palmer, James, Webb, Michael, Karbarz, Mark, Scott, Brian, Wilson, Sandy, Luo, Lin, Wennerholm,

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 288 KB

english, 2012

20

Identification of the Significant Involvement and Mechanistic Role of CYP3A4/5 in Clopidogrel Bioactivation

Zhu, Yaoqiu, Zhou, Jiang

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

21

Novel Compounds for the Treatment of Neurodegenerative Diseases

Rotella, David P.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 180 KB

english, 2012