Volume 3; Issue 11

ACS Medicinal Chemistry Letters

Volume 3; Issue 11

1

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Stamford, Andrew W., Scott, Jack D., Li, Sarah W., Babu, Suresh, Tadesse, Dawit, Hunter, Rachael, Wu, Yusheng, Misiaszek, Jeffrey, Cumming, Jared N., Gilbert, Eric J., Huang, Chunli, McKittrick, Brian

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.14 MB

english, 2012

2

Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer

Darras, Fouad H., Kling, Beata, Heilmann, Jörg, Decker, Michael

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 455 KB

english, 2012

3

Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside

Fuller, Nathan O., Hubbs, Jed L., Austin, Wesley F., Creaser, Steffen P., McKee, Timothy D., Loureiro, Robyn M. B., Tate, Barbara, Xia, Weiming, Ives, Jeffrey L., Findeis, Mark A., Bronk, Brian S.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 415 KB

english, 2012

4

Bivalent Ligands Targeting Multiple Pathological Factors Involved in Alzheimer's Disease

Liu, Kai, Gandhi, Ronak, Chen, Jiangmin, Zhang, Shijun

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.82 MB

english, 2012

5

Identification of Aminopyridazine-Derived Antineuroinflammatory Agents Effective in an Alzheimer's Mouse Model

Zhou, Wei, Zhong, Guifa, Rao, Xiurong, Xie, Hui, Zeng, Shaogao, Chi, Tianyan, Zou, Libo, Wu, Donghai, Hu, Wenhui

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.60 MB

english, 2012

6

Novel Indolethylbenzamides for the Treatment of Tauopathies

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 225 KB

english, 2012

7

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Wu, Wen-Lian, Domalski, Martin, Burnett, Duane A., Josien, Hubert, Bara, Thomas, Rajagopalan, Murali, Xu, Ruo, Clader, John, Greenlee, William J., Brunskill, Andrew, Hyde, Lynn A., Del Vecchio, Robert

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 315 KB

english, 2012

8

Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators

Dang, Zhao, Jung, Kathy, Qian, Keduo, Lee, Kuo-Hsiung, Huang, Li, Chen, Chin-Ho

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 302 KB

english, 2012

9

Compounds and Their Use as BACE Inhibitors

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 216 KB

english, 2012

10

Approaches Toward New Alzheimer's Treatments

Vacca, Joseph P.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 126 KB

english, 2012

11

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

Huang, Xianhai, Zhou, Wei, Liu, Xiaoxiang, Li, Hongmei, Sun, George, Mandal, Mihirbaran, Vicarel, Monica, Zhu, Xiaohong, Bennett, Chad, McCraken, Troy, Pissarnitski, Dmitri, Zhao, Zhiqiang, Cole, Davi

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 596 KB

english, 2012

12

5-Amino-oxazepine and 5-Amino-thiazepine Compounds as β-Secretase Antagonists and Methods of Use

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 243 KB

english, 2012

13

Novel Benzoisoxazole as Partial Agonist of the 5-HT4 Receptor

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 163 KB

english, 2012

14

Novel and Selective Inhibitors of Histone Deacetylase

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 229 KB

english, 2012

15

BACE Inhibitors: Potential Treatment of Alzheimer's Disease, Dementia, and Related Neurodegenerative Disorders (B): 3-Amino-4-fluoro-1 H -isoindol Derivatives

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 193 KB

english, 2012

16

Evaluation of [ 11 C] N -Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles

Shao, Xia, Carpenter, Garrett M., Desmond, Timothy J., Sherman, Phillip, Quesada, Carole A., Fawaz, Maria, Brooks, Allen F., Kilbourn, Michael R., Albin, Roger L., Frey, Kirk A., Scott, Peter J. H.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 3.90 MB

english, 2012

17

Benzenesulfonyl and Benzenesulfonamide as Modulators of the 5-HT 6 Receptor

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 204 KB

english, 2012

18

BACE Inhibitors: Potential Treatment of Alzheimer's Disease, Dementia, and Related Neurodegenerative Disorders (A): 5,6-Dihydroimidazo[1,2- a ]pyrazin-8-yl-amine Derivatives

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 193 KB

english, 2012

19

Novel Quinolinones as Activators of AMP Activated Protein Kinase

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 183 KB

english, 2012

20

In This Issue, Vol. 3, Issue 11

Silverman, Janice Elaine Y.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 384 KB

english, 2012

21

Nonpeptidic Lysosomal Modulators Derived from Z-Phe-Ala-Diazomethylketone for Treating Protein Accumulation Diseases

Viswanathan, Kishore, Hoover, Dennis J., Hwang, Jeannie, Wisniewski, Meagan L., Ikonne, Uzoma S., Bahr, Ben A., Wright, Dennis L.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.23 MB

english, 2012

22

A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase

Kaller, Matthew R., Harried, Scott S., Albrecht, Brian, Amarante, Patricia, Babu-Khan, Safura, Bartberger, Michael D., Brown, James, Brown, Ryan, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Micha

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.61 MB

english, 2012

23

“It Ain’t Over ’til It’s Over” a —The Search for Treatments and Cures for Alzheimer’s Disease

Hargreaves, Richard J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 178 KB

english, 2012

24

BACE-Inhibitors: Potential Treatment of Alzheimer Disease, Dementia, and Related Neurodegenerative Diseases. C. Spiro-Heterocyclic Derivatives

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 172 KB

english, 2012

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