Volume 3; Issue 9

ACS Medicinal Chemistry Letters

Volume 3; Issue 9

1

Four Lessons from Global Health Drug Discovery: Medicine for an Ailing Industry?

Elliott, Richard L.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 181 KB

english, 2012

2

Quinolinyl Pyrimidines: Potent Inhibitors of NDH-2 as a Novel Class of Anti-TB Agents

Shirude, Pravin S., Paul, Beena, Roy Choudhury, Nilanjana, Kedari, Chaitanya, Bandodkar, Balachandra, Ugarkar, Bheemarao G.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 674 KB

english, 2012

3

Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor

Haynes, Nancy-Ellen, Scott, Nathan R., Chen, Li C., Janson, Cheryl A., Li, Jia Kui, Lukacs, Christine M., Railkar, Aruna, Tozzo, Effie, Whittard, Toni, Brown, Nicholas F., Cheung, Adrian Wai-Hing

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.81 MB

english, 2012

4

Structure–Activity Relationships and Molecular Modeling of 1,2,4-Triazoles as Adenosine Receptor Antagonists

Carlsson, Jens, Tosh, Dilip K., Phan, Khai, Gao, Zhan-Guo, Jacobson, Kenneth A.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 340 KB

english, 2012

5

Design, Synthesis, and Testing of a Molecular Truck for Colonic Delivery of 5-Aminosalicylic Acid

Navath, Suryakiran, Rao, Venkataramanarao, Woodford, Rita-Marie T., Midura-Kiela, Monica T., Ahad, Ali M., Alleti, Ramesh, Kiela, Pawel R., Mash, Eugene A.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.39 MB

english, 2012

6

Discovery of Disubstituted Imidazo[4,5- b ]pyridines and Purines as Potent TrkA Inhibitors

Wang, Tao, Lamb, Michelle L., Block, Michael H., Davies, Audrey Molina, Han, Yongxin, Hoffmann, Ethan, Ioannidis, Stephanos, Josey, John A., Liu, Zhong-Ying, Lyne, Paul D., MacIntyre, Terry, Mohr, Pet

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.33 MB

english, 2012

7

Crystal Structure and Specific Binding Mode of Sisomicin to the Bacterial Ribosomal Decoding Site

Kondo, Jiro, Koganei, Mai, Kasahara, Tomoko

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.71 MB

english, 2012

8

Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor

Nakamura, Yuji, Fujimoto, Teppei, Ogawa, Yasuyuki, Sugita, Chie, Miyazaki, Shojiro, Tamaki, Kazuhiko, Takahashi, Mizuki, Matsui, Yumi, Nagayama, Takahiro, Manabe, Kenichi, Mizuno, Makoto, Masubuchi, N

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.29 MB

english, 2012

9

Bromodomains: Are Readers Right for Epigenetic Therapy?

Conway, Stuart J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

10

Macrocyclic Peptoid–Peptide Hybrids as Inhibitors of Class I Histone Deacetylases

Olsen, Christian A., Montero, Ana, Leman, Luke J., Ghadiri, M. Reza

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.45 MB

english, 2012

11

Hepatitis C Virus Protease Inhibitors

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 243 KB

english, 2012

12

Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes

Windsor, Matthew A., Hermanson, Daniel J., Kingsley, Philip J., Xu, Shu, Crews, Brenda C., Ho, Winnie, Keenan, Catherine M., Banerjee, Surajit, Sharkey, Keith A., Marnett, Lawrence J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.29 MB

english, 2012

13

Substituted Pyridines as Sodium Channel Blockers

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 250 KB

english, 2012

14

Fluorescent Human EP 3 Receptor Antagonists

Tomasch, Miriam, Schwed, J. Stephan, Kuczka, Karina, Meyer dos Santos, Sascha, Harder, Sebastian, Nüsing, Rolf M., Paulke, Alexander, Stark, Holger

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 4.92 MB

english, 2012

15

Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist

Brown, Sean P., Dransfield, Paul J., Vimolratana, Marc, Jiao, XianYun, Zhu, Liusheng, Pattaropong, Vatee, Sun, Ying, Liu, Jinqian, Luo, Jian, Zhang, Jane, Wong, Simon, Zhuang, Run, Guo, Qi, Li, Frank,

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 635 KB

english, 2012

16

From in Silico Discovery to Intracellular Activity: Targeting JNK–Protein Interactions with Small Molecules

Kaoud, Tamer S., Yan, Chunli, Mitra, Shreya, Tseng, Chun-Chia, Jose, Jiney, Taliaferro, Juliana M., Tuohetahuntila, Maidina, Devkota, Ashwini, Sammons, Rachel, Park, Jihyun, Park, Heekwang, Shi, Yue,

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.99 MB

english, 2012

17

Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease

Prime, Michael E., Brookfield, Frederick A., Courtney, Stephen M., Gaines, Simon, Marston, Richard W., Ichihara, Osamu, Li, Marie, Vaidya, Darshan, Williams, Helen, Pedret-Dunn, Anna, Reed, Laura, Sch

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.34 MB

english, 2012

18

Synthesis and Biological Evaluation of a Biotinylated Paclitaxel with an Extra-Long Chain Spacer Arm

Lis, Lev. G., Smart, Mary A., Luchniak, Anna, Gupta, Mohan L., Gurvich, Vadim J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.23 MB

english, 2012

19

Cyclopropyl- spiro -piperidines Useful as Sodium Channel Blockers

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 228 KB

english, 2012

20

Prostaglandin E 2 Synthase-1 Inhibitors as Potential Treatment for Osteoarthritis

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 207 KB

english, 2012

21

Symmetric Kv1.5 Blockers Discovered by Focused Screening

Boström, Jonas

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.28 MB

english, 2012

22

In This Issue, Vol. 3, Issue 9

Silverman, Janice Elaine Y.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

23

Inhibitors of LRRK2 as Treatment for Parkinson's Disease

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 159 KB

english, 2012