Volume 4; Issue 10

ACS Medicinal Chemistry Letters

Volume 4; Issue 10

1

A Structurally Simplified Analogue of Geldanamycin Exhibits Neuroprotective Activity

Madathil, Manikandadas M., Khdour, Omar M., Jaruvangsanti, Jennifer, Hecht, Sidney M.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.63 MB

english, 2013

2

Effectively Delivering a Unique Hsp90 Inhibitor Using Star Polymers

Kim, Seong Jong, Ramsey, Deborah M., Boyer, Cyrille, Davis, Thomas P., McAlpine, Shelli R.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 359 KB

english, 2013

3

Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR

Wu, Jianwei, Chen, Wenteng, Xia, Guangxin, Zhang, Jing, Shao, Jiaan, Tan, Biqin, Zhang, Chunchun, Yu, Wanwan, Weng, Qinjie, Liu, Haiyan, Hu, Miao, Deng, Hailin, Hao, Yu, Shen, Jingkang, Yu, Yongping

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 312 KB

english, 2013

4

Synthesis and Evaluation of Quinazolone Derivatives as a New Class of c - KIT G-Quadruplex Binding Ligands

Wang, Xiaoxiao, Zhou, Chen-Xi, Yan, Jin-Wu, Hou, Jin-Qiang, Chen, Shuo-Bin, Ou, Tian-Miao, Gu, Lian-Quan, Huang, Zhi-Shu, Tan, Jia-Heng

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 593 KB

english, 2013

5

Arylthioamides as H 2 S Donors: l -Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

Martelli, Alma, Testai, Lara, Citi, Valentina, Marino, Alice, Pugliesi, Isabella, Barresi, Elisabetta, Nesi, Giulia, Rapposelli, Simona, Taliani, Sabrina, Da Settimo, Federico, Breschi, Maria C., Cald

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 512 KB

english, 2013

6

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

Axten, Jeffrey M., Romeril, Stuart P., Shu, Arthur, Ralph, Jeffrey, Medina, Jesús R., Feng, Yanhong, Li, William Hoi Hong, Grant, Seth W., Heerding, Dirk A., Minthorn, Elisabeth, Mencken, Thomas, Gaul

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 314 KB

english, 2013

7

Design and Synthesis of 4-(4-Benzoylaminophenoxy)phenol Derivatives As Androgen Receptor Antagonists

Yamada, Ayumi, Fujii, Shinya, Mori, Shuichi, Kagechika, Hiroyuki

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 599 KB

english, 2013

8

Design, Synthesis, and Antileukemic Activity of Stereochemically Defined Constrained Analogues of FTY720 (Gilenya)

Fransson, Rebecca, McCracken, Alison N., Chen, Bin, McMonigle, Ryan J., Edinger, Aimee L., Hanessian, Stephen

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 702 KB

english, 2013

9

Identification of 1-[4-Benzyloxyphenyl)-but-3-enyl]-1 H -azoles as New Class of Antitubercular and Antimicrobial Agents

Anand, Namrata, Ramakrishna, K. K. G., Gupt, Munna P., Chaturvedi, Vinita, Singh, Shubhra, Srivastava, Kishore K., Sharma, Prapunjika, Rai, Niyati, Ramachandran, Ravishankar, Dwivedi, A. K., Gupta, Va

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 704 KB

english, 2013

10

Discovery of Clinical Candidate GSK1842799 As a Selective S1P 1 Receptor Agonist (Prodrug) for Multiple Sclerosis

Deng, Hongfeng, Bernier, Sylvie G., Doyle, Elisabeth, Lorusso, Jeanine, Morgan, Barry A., Westlin, William F., Evindar, Ghotas

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 352 KB

english, 2013

11

Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy

Alder, Catherine M., Ambler, Martin, Campbell, Amanda J., Champigny, Aurelie C., Deakin, Angela M., Harling, John D., Harris, Carol A., Longstaff, Tim, Lynn, Sean, Maxwell, Aoife C., Mooney, Chris J.,

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.30 MB

english, 2013

12

Pharmacokinetics, Metabolism, and in Vivo Efficacy of the Antimalarial Natural Product Bromophycolide A

Teasdale, Margaret E., Prudhomme, Jacques, Torres, Manuel, Braley, Matthew, Cervantes, Serena, Bhatia, Shanti C., La Clair, James J., Le Roch, Karine, Kubanek, Julia

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 418 KB

english, 2013

13

Discovery of DF-461, a Potent Squalene Synthase Inhibitor

Ichikawa, Masanori, Ohtsuka, Masami, Ohki, Hitoshi, Ota, Masahiro, Haginoya, Noriyasu, Itoh, Masao, Shibata, Yoshihiro, Sugita, Kazuyuki, Ishigai, Yutaka, Terayama, Koji, Kanda, Akira, Usui, Hiroyuki

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 613 KB

english, 2013

14

Potent Vinblastine C20′ Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line

Barker, Timothy J., Duncan, Katharine K., Otrubova, Katerina, Boger, Dale L.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 240 KB

english, 2013

15

Nexus Between Protein–Ligand Affinity Rank-Ordering, Biophysical Approaches, and Drug Discovery

Spies, M. Ashley

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 702 KB

english, 2013

16

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K., Gawron, Sylwia, Sassano, Maria F., Kahsai, Alem W., Wingler, Laura M., Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnar

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 438 KB

english, 2013

17

Non-Cross-Bridged Tetraazamacrocyclic Chelator for Stable 64 Cu-Based Radiopharmaceuticals

Dale, Ajit V., Pandya, Darpan N., Kim, Jung Young, Lee, Hochun, Ha, Yeong Su, Bhatt, Nikunj, Kim, Jonghee, Seo, Jeong Ju, Lee, Woonghee, Kim, Sung Hong, Yoon, Young-Ran, An, Gwang Il, Yoo, Jeongsoo

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.29 MB

english, 2013

18

Fused 3-Hydroxy-3-trifluoromethylpyrazoles Inhibit Mutant Huntingtin Toxicity

La Rosa, Salvatore, Benicchi, Tiziana, Bettinetti, Laura, Ceccarelli, Ilaria, Diodato, Enrica, Federico, Cesare, Fiengo, Pasquale, Franceschini, Davide, Gokce, Ozgun, Heitz, Freddy, Lazzeroni, Giulia,

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.82 MB

english, 2013

19

WalK, the Path towards New Antibacterials with Low Potential for Resistance Development

Velikova, Nadya, Bem, Agnieszka E., van Baarlen, Peter, Wells, Jerry M., Marina, Alberto

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.40 MB

english, 2013

20

Fighting Obesity and Metabolic Disorders with MGAT-2 Inhibitors

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 267 KB

english, 2013

21

Synthesis and Biological Evaluation of the First Example of NO-Donor Histone Deacetylase Inhibitor

Borretto, Emily, Lazzarato, Loretta, Spallotta, Francesco, Cencioni, Chiara, D’Alessandra, Yuri, Gaetano, Carlo, Fruttero, Roberta, Gasco, Alberto

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.86 MB

english, 2013

22

Largazole Arrests Cell Cycle at G1 Phase and Triggers Proteasomal Degradation of E2F1 in Lung Cancer Cells

Wu, Li-Chuan, Wen, Zhe-Sheng, Qiu, Ya-Tao, Chen, Xiao-Qin, Chen, Hao-Bin, Wei, Ming-Ming, Liu, Zi, Jiang, Sheng, Zhou, Guang-Biao

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.24 MB

english, 2013

23

Fighting Obesity and Metabolic Disorders with DGAT-1 Inhibitors

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 240 KB

english, 2013

24

Anabaseine Analogues as Modulators of Nicotinic Acetylcholine Receptor

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 237 KB

english, 2013

25

In This Issue, Volume 4, Issue 10

Silverman, Janice Elaine Y.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 642 KB

english, 2013

26

Effects of the Arg-Pro and Gly-Gly-Nle Moieties on Melanocortin-1 Receptor Binding Affinities of α-MSH Peptides

Yang, Jianquan, Liu, Liqin, Miao, Yubin

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 885 KB

english, 2013