Volume 4; Issue 12

ACS Medicinal Chemistry Letters

Volume 4; Issue 12

1

Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation

Butini, Stefania, Brindisi, Margherita, Brogi, Simone, Maramai, Samuele, Guarino, Egeria, Panico, Alessandro, Saxena, Ashima, Chauhan, Ved, Colombo, Raffaella, Verga, Laura, De Lorenzi, Ersilia, Barto

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 964 KB

english, 2013

2

Discovery of Potent and Selective Inhibitors of Toxoplasma gondii Thymidylate Synthase for Opportunistic Infections

Zaware, Nilesh, Sharma, Hitesh, Yang, Jie, Devambatla, Ravi Kumar Vyas, Queener, Sherry F., Anderson, Karen S., Gangjee, Aleem

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 335 KB

english, 2013

3

Synthesis and in Vitro and in Vivo Pharmacological Evaluation of New 4-Aminoquinoline-Based Compounds

Tukulula, Matshawandile, Njoroge, Mathew, Abay, Efrem T., Mugumbate, Grace C., Wiesner, Lubbe, Taylor, Dale, Gibhard, Liezl, Norman, Jennifer, Swart, Kenneth J., Gut, Jiri, Rosenthal, Philip J., Barte

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.27 MB

english, 2013

4

Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase

Iyidogan, Pinar, Sullivan, Todd J., Chordia, Mahendra D., Frey, Kathleen M., Anderson, Karen S.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.77 MB

english, 2013

5

Fragment-Based Discovery of 6-Azaindazoles As Inhibitors of Bacterial DNA Ligase

Howard, Steven, Amin, Nader, Benowitz, Andrew B., Chiarparin, Elisabetta, Cui, Haifeng, Deng, Xiaodong, Heightman, Tom D., Holmes, David J., Hopkins, Anna, Huang, Jianzhong, Jin, Qi, Kreatsoulas, Cons

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.67 MB

english, 2013

6

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

Meredith, Erik L., Ksander, Gary, Monovich, Lauren G., Papillon, Julien P. N., Liu, Qian, Miranda, Karl, Morris, Patrick, Rao, Chang, Burgis, Robin, Capparelli, Michael, Hu, Qi-Ying, Singh, Alok, Rige

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 231 KB

english, 2013

7

Discovery of Novel Putative Inhibitors of UDP-GlcNAc 2-Epimerase as Potent Antibacterial Agents

Xu, Yong, Brenning, Benjamin, Clifford, Adrianne, Vollmer, David, Bearss, Jared, Jones, Carissa, McCarthy, Virgil, Shi, Chongtie, Wolfe, Bradley, Aavula, Bhasker, Warner, Steve, Bearss, David J., McCu

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.04 MB

english, 2013

8

Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases

Nathubhai, Amit, Wood, Pauline J., Lloyd, Matthew D., Thompson, Andrew S., Threadgill, Michael D.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 4.17 MB

english, 2013

9

Structure-Based Design of 2-Aminopyridine Oxazolidinones as Potent and Selective Tankyrase Inhibitors

Huang, Hongbing, Guzman-Perez, Angel, Acquaviva, Lisa, Berry, Virginia, Bregman, Howard, Dovey, Jennifer, Gunaydin, Hakan, Huang, Xin, Huang, Liyue, Saffran, Doug, Serafino, Randy, Schneider, Steve, W

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.28 MB

english, 2013

10

Design and Synthesis of Peptide YY Analogues with C-terminal Backbone Amide-to-Ester Modifications

Albertsen, Louise, Andersen, Julie J., Paulsson, Johan F., Thomsen, Jens K., Norrild, Jens C., Strømgaard, Kristian

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.01 MB

english, 2013

11

Antimalarial Drug Discovery: From Quinine to the Dream of Eradication

Renslo, Adam R.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 217 KB

english, 2013

12

Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation

Shi, Ce, Tiwari, Divya, Wilson, Daniel J., Seiler, Christopher L., Schnappinger, Dirk, Aldrich, Courtney C.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 771 KB

english, 2013

13

New Inhibitors of Cytomegalovirus DNA Polymerase

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 204 KB

english, 2013

14

Exploring the Chemical Space of Multitarget Ligands Using Aligned Self-Organizing Maps

Achenbach, Janosch, Klingler, Franca-Maria, Blöcher, René, Moser, Daniel, Häfner, Ann-Kathrin, Rödl, Carmen B., Kretschmer, Simon, Krüger, Björn, Löhr, Frank, Stark, Holger, Hofmann, Bettina, Steinhil

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.44 MB

english, 2013

15

Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors

Burger, Matthew T., Han, Wooseok, Lan, Jiong, Nishiguchi, Gisele, Bellamacina, Cornelia, Lindval, Mika, Atallah, Gordana, Ding, Yu, Mathur, Michelle, McBride, Chris, Beans, Elizabeth L., Muller, Krist

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

16

Influenza RNA-Dependent RNA Polymerase (RdRp) Inhibitors: Potential New Therapy for Influenza Treatment

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 217 KB

english, 2013

17

Inhibition of CK2: An Attractive Therapeutic Target for Cancer Treatment

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 238 KB

english, 2013

18

Synthesis of C11-Desmethoxy Soraphen A 1α : A Natural Product Analogue That Inhibits Acetyl-CoA Carboxylase

Canterbury, Daniel P., Scott, Kristen E. N., Kubo, Ozora, Jansen, Rolf, Cleveland, John L., Micalizio, Glenn C.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.31 MB

english, 2013

19

Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer

Nesi, Giulia, Sestito, Simona, Mey, Valentina, Ricciardi, Simona, Falasca, Marco, Danesi, Romano, Lapucci, Annalina, Breschi, Maria C., Fogli, Stefano, Rapposelli, Simona

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 321 KB

english, 2013

20

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

Harris, Philip A., Bandyopadhyay, Deepak, Berger, Scott B., Campobasso, Nino, Capriotti, Carol A., Cox, Julie A., Dare, Lauren, Finger, Joshua N., Hoffman, Sandra J., Kahler, Kirsten M., Lehr, Ruth, L

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 897 KB

english, 2013

21

Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors

Goswami, Rajeev, Mukherjee, Subhendu, Wohlfahrt, Gerd, Ghadiyaram, Chakshusmathi, Nagaraj, Jwala, Chandra, Beeram Ravi, Sistla, Ramesh K., Satyam, Leena K., Samiulla, Dodheri S., Moilanen, Anu, Subram

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 4.50 MB

english, 2013

22

Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC 2 Agonism and Glucose-Dependent Insulin Secretion

Giordanetto, Fabrizio, Revell, Jefferson D., Knerr, Laurent, Hostettler, Marie, Paunovic, Amalia, Priest, Claire, Janefeldt, Annika, Gill, Adrian

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.01 MB

english, 2013

23

Diphenylpropane Derivatives as Agonist of PPAR Nuclear Receptors

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 370 KB

english, 2013

24

Metabolomics Reveal d -Alanine: d -Alanine Ligase As the Target of d -Cycloserine in Mycobacterium tuberculosis

Prosser, Gareth A., de Carvalho, Luiz P. S.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.28 MB

english, 2013

25

Correction to Rapid Determination of Ionization Constants (p K a ) by UV Spectroscopy Using 96-Well Microtiter Plates

Martínez, Carlos H. Ríos, Dardonville, Christophe

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 196 KB

english, 2013

26

In This Issue, Volume 4, Issue 12

Silverman, Janice Elaine Y.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.18 MB

english, 2013

27

Antitumor Potential of Conjugable Valinomycins Bearing Hydroxyl Sites: In Vitro Studies

Iacobazzi, Rosa M., Annese, Cosimo, Azzariti, Amalia, D’Accolti, Lucia, Franco, Massimo, Fusco, Caterina, La Piana, Gianluigi, Laquintana, Valentino, Denora, Nunzio

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.09 MB

english, 2013

28

Probing the Binding Site of Bile Acids in TGR5

Macchiarulo, Antonio, Gioiello, Antimo, Thomas, Charles, Pols, Thijs W. H., Nuti, Roberto, Ferrari, Cristina, Giacchè, Nicola, De Franco, Francesca, Pruzanski, Mark, Auwerx, Johan, Schoonjans, Kristin

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 311 KB

english, 2013

29

Truncated Orexin Peptides: Structure–Activity Relationship Studies

German, Nadezhda A., Decker, Ann M., Gilmour, Brian P., Thomas, Brian F., Zhang, Yanan

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 265 KB

english, 2013