Volume 4; Issue 2

ACS Medicinal Chemistry Letters

Volume 4; Issue 2

1

Synthesis of 8-Hydroxyquinoline Derivatives as Novel Antitumor Agents

Chan, Sau Hing, Chui, Chung Hin, Chan, Shun Wan, Kok, Stanton Hon Lun, Chan, Dessy, Tsoi, Miriam Yuen Tung, Leung, Polly Hang Mei, Lam, Alfred King Yin, Chan, Albert Sun Chi, Lam, Kim Hung, Tang, John

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

2

Structure-Based Approach for the Discovery of Pyrrolo[3,2- d ]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors

Sogabe, Satoshi, Kawakita, Youichi, Igaki, Shigeru, Iwata, Hidehisa, Miki, Hiroshi, Cary, Douglas R., Takagi, Terufumi, Takagi, Shinji, Ohta, Yoshikazu, Ishikawa, Tomoyasu

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.42 MB

english, 2013

3

Synthesis and Antimycobacterial Activity of 2,1′-Dihydropyridomycins

Horlacher, Oliver P., Hartkoorn, Ruben C., Cole, Stewart T., Altmann, Karl-Heinz

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 474 KB

english, 2013

4

Synthesis and Antimalarial Activity of 3,3-Spiroanellated 5,6-Disubstituted 1,2,4-Trioxanes

Maurya, Ranjani, Soni, Awakash, Anand, Devireddy, Ravi, Makthala, Raju, Kanumuri S. R., Taneja, Isha, Naikade, Niraj K., Puri, S. K., Wahajuddin,, Kanojiya, Sanjeev, Yadav, Prem P.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 592 KB

english, 2013

5

A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer’s and Prion Diseases

Staderini, Matteo, Aulić, Suzana, Bartolini, Manuela, Tran, Hoang Ngoc Ai, González-Ruiz, Víctor, Pérez, Daniel I., Cabezas, Nieves, Martínez, Ana, Martín, M. Antonia, Andrisano, Vincenza, Legname, Gi

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013

6

Metal Impurities Cause False Positives in High-Throughput Screening Campaigns

Hermann, Johannes C., Chen, Yingsi, Wartchow, Charles, Menke, John, Gao, Lin, Gleason, Shelley K., Haynes, Nancy-Ellen, Scott, Nathan, Petersen, Ann, Gabriel, Stephen, Vu, Binh, George, Kelly M., Nara

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 301 KB

english, 2013

7

Pharmaceutical Profiling Case Study in Disruption

Kerns, Edward H.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 423 KB

english, 2013

8

Discovery of a Series of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion

Zheng, Shilong, Zhong, Qiu, Jiang, Quan, Mottamal, Madhusoodanan, Zhang, Qiang, Zhu, Naijue, Burow, Matthew E., Worthylake, Rebecca A., Wang, Guangdi

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 680 KB

english, 2013

9

[3 a ,4]-Dihydropyrazolo[1,5 a ]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase β Inhibitors

Yu, Hongyi, Moore, Michael L., Erhard, Karl, Hardwicke, Mary Ann, Lin, Hong, Luengo, Juan I., McSurdy-Freed, Jeanelle, Plant, Ramona, Qu, Junya, Raha, Kaushik, Rominger, Cynthia M., Schaber, Michael D

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 292 KB

english, 2013

10

Probing the Binding Site of Abl Tyrosine Kinase Using in Situ Click Chemistry

Peruzzotti, Cristina, Borrelli, Stella, Ventura, Micol, Pantano, Rebecca, Fumagalli, Gaia, Christodoulou, Michael S., Monticelli, Damiano, Luzzani, Marcello, Fallacara, Anna Lucia, Tintori, Cristina,

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 243 KB

english, 2013

11

Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195

Tong, Yunsong, Stewart, Kent D., Florjancic, Alan S., Harlan, John E., Merta, Philip J., Przytulinska, Magdalena, Soni, Nirupama, Swinger, Kerren K., Zhu, Haizhong, Johnson, Eric F., Shoemaker, Alexan

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 327 KB

english, 2013

12

Discovery of a Highly Potent, Orally Active Mitosis/Angiogenesis Inhibitor R1530 for the Treatment of Solid Tumors

Liu, Jin-Jun, Higgins, Brian, Ju, Grace, Kolinsky, Kenneth, Luk, Kin-Chun, Packman, Kathryn, Pizzolato, Giacomo, Ren, Yi, Thakkar, Kshitij, Tovar, Christian, Zhang, Zhuming, Wovkulich, Peter M.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 305 KB

english, 2013

13

Discovery of a Novel Broad-Spectrum Antifungal Agent Derived from Albaconazole

Guillon, Rémi, Pagniez, Fabrice, Picot, Carine, Hédou, Damien, Tonnerre, Alain, Chosson, Elizabeth, Duflos, Muriel, Besson, Thierry, Logé, Cédric, Le Pape, Patrice

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 283 KB

english, 2013

14

Discovery of O -Alkylamino-Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents

Chen, Haijun, Yang, Zhengduo, Ding, Chunyong, Chu, Lili, Zhang, Yusong, Terry, Kristin, Liu, Huiling, Shen, Qiang, Zhou, Jia

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 369 KB

english, 2013

15

Nanomaterials for (Nano)medicine

Marchesan, Silvia, Prato, Maurizio

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 484 KB

english, 2013

16

The Role of the Acidity of N-Heteroaryl Sulfonamides as Inhibitors of Bcl-2 Family Protein–Protein Interactions

Touré, B. Barry, Miller-Moslin, Karen, Yusuff, Naeem, Perez, Lawrence, Doré, Michael, Joud, Carol, Michael, Walter, DiPietro, Lucian, van der Plas, Simon, McEwan, Michael, Lenoir, Francois, Hoe, Madel

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.01 MB

english, 2013

17

Toll-Like Receptor Agonists for Treatment of Viral Infections

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 224 KB

english, 2013

18

TRPV4 Antagonists: Potential Treatment for Congestive Heart Failure, Bladder Dysfunctions, and Pain

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 182 KB

english, 2013

19

Inhibition of Ebola Virus Infection: Identification of Niemann-Pick C1 as the Target by Optimization of a Chemical Probe

Lee, Kyungae, Ren, Tao, Côté, Marceline, Gholamreza, Berahman, Misasi, John, Bruchez, Anna, Cunningham, James

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 273 KB

english, 2013

20

Novel Hybrid-Type Antimicrobial Agents Targeting the Switch Region of Bacterial RNA Polymerase

Yakushiji, Fumika, Miyamoto, Yuko, Kunoh, Yuki, Okamoto, Reiko, Nakaminami, Hidemasa, Yamazaki, Yuri, Noguchi, Norihisa, Hayashi, Yoshio

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.93 MB

english, 2013

21

Antimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase

Xue, Jian, Diao, Jiasheng, Cai, Guobin, Deng, Lisheng, Zheng, Baisong, Yao, Yuan, Song, Yongcheng

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 996 KB

english, 2013

22

Discovery of Novel N -Substituted Oxindoles as Selective M 1 and M 4 Muscarinic Acetylcholine Receptors Partial Agonists

Sumiyoshi, Takaaki, Enomoto, Takeshi, Takai, Kentaro, Takahashi, Yoko, Konishi, Yasuko, Uruno, Yoshiharu, Tojo, Kengo, Suwa, Atsushi, Matsuda, Harumi, Nakako, Tomokazu, Sakai, Mutsuko, Kitamura, Atsus

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 744 KB

english, 2013

23

l -Aminoacyl-triazine Derivatives Are Isoform-Selective PI3Kβ Inhibitors That Target Nonconserved Asp862 of PI3Kβ

Pinson, Jo-Anne, Zheng, Zhaohua, Miller, Michelle S., Chalmers, David K., Jennings, Ian G., Thompson, Philip E.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.49 MB

english, 2013

24

Modulation of TRPV1 Receptor for Treatment of Pain and Other Disorders

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 157 KB

english, 2013

25

Development of N -Hydroxycinnamamide-Based Histone Deacetylase Inhibitors with an Indole-Containing Cap Group

Zhang, Yingjie, Yang, Penghui, Chou, C. James, Liu, Chunxi, Wang, Xuejian, Xu, Wenfang

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

26

PDE10 Inhibitors as Potential Treatment for Schizophrenia

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 217 KB

english, 2013

27

Gadolinium Complex of 125 I/ 127 I-RGD-DOTA Conjugate as a Tumor-Targeting SPECT/MR Bimodal Imaging Probe

Park, Ji-Ae, Kim, Jung Young, Lee, Yong Jin, Lee, Wonho, Lim, Sang Moo, Kim, Tae-Jeong, Yoo, Jeongsoo, Chang, Yongmin, Kim, Kyeong Min

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 269 KB

english, 2013

28

Irreversible Inhibitors of Cysteine Proteases

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 264 KB

english, 2013

29

Aldosterone Synthase Inhibitors: Targeting Chronic Kidney Disease and Diabetic Nephropathy

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 211 KB

english, 2013

30

Bodilisant—A Novel Fluorescent, Highly Affine Histamine H 3 Receptor Ligand

Tomasch, Miriam, Schwed, J. Stephan, Paulke, Alexander, Stark, Holger

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.49 MB

english, 2013

31

High-Throughput Selectivity Assays for Small-Molecule Inhibitors of β-Catenin/T-Cell Factor Protein–Protein Interactions

Zhang, Min, Catrow, J. Leon, Ji, Haitao

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

32

Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors

Minegishi, Hidemitsu, Fukashiro, Shinji, Ban, Hyun Seung, Nakamura, Hiroyuki

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.27 MB

english, 2013

33

C-Terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences upon the Catalytic Cleft

Šilhár, Peter, Lardy, Matthew A., Hixon, Mark S., Shoemaker, Charles B., Barbieri, Joseph T., Struss, Anjali K., Lively, Jenny M., Javor, Sacha, Janda, Kim D.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.44 MB

english, 2013

34

Immune-Stimulatory Dinucleotide at the 5′-End of Oligodeoxynucleotides Is Critical for TLR9-Mediated Immune Responses

Putta, Mallikarjuna R., Bhagat, Lakshmi, Wang, Daqing, Zhu, Fu-Gang, Kandimalla, Ekambar R., Agrawal, Sudhir

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 537 KB

english, 2013

35

Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema

Hilfiker, Mark A., Hoang, Tram H., Cornil, Johan, Eidam, Hilary S., Matasic, Daniel S., Roethke, Theresa J., Klein, Michael, Thorneloe, Kevin S., Cheung, Mui

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 391 KB

english, 2013

36

Interrogation of the Active Sites of Protein Arginine Deiminases (PAD1, -2, and -4) Using Designer Probes

Bello, Angelica M., Wasilewski, Ewa, Wei, Lianhu, Moscarello, Mario A., Kotra, Lakshmi P.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.39 MB

english, 2013

37

In This Issue, Volume 4, Issue 2

Silverman, Janice Elaine Y.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 577 KB

english, 2013

38

Improving the Affinity of SL0101 for RSK Using Structure-Based Design

Mrozowski, Roman M., Vemula, Rajender, Wu, Bulan, Zhang, Qi, Schroeder, Benjamin R., Hilinski, Michael K., Clark, David E., Hecht, Sidney M., O’Doherty, George A., Lannigan, Deborah A.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.07 MB

english, 2013

39

Synthesis of Novel Analogs of Cabergoline: Improving Cardiovascular Safety by Removing 5-HT 2B Receptor Agonism

Dosa, Peter I., Ward, Tim, Walters, Michael A., Kim, Suck Won

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 434 KB

english, 2013

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Tor version

Z-Library

Z-Library Since 2009 support@z-lib.do

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски