Volume 4; Issue 6

ACS Medicinal Chemistry Letters

Volume 4; Issue 6

1

Metabolically Stable tert -Butyl Replacement

Barnes-Seeman, David, Jain, Monish, Bell, Leslie, Ferreira, Suzie, Cohen, Scott, Chen, Xiao-Hui, Amin, Jakal, Snodgrass, Brad, Hatsis, Panos

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 387 KB

english, 2013

2

Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase

Zheng, Baisong, Yao, Yuan, Liu, Zhen, Deng, Lisheng, Anglin, Justin L., Jiang, Hong, Prasad, B. V. Venkataram, Song, Yongcheng

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 279 KB

english, 2013

3

New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi

Friggeri, Laura, Scipione, Luigi, Costi, Roberta, Kaiser, Marcel, Moraca, Francesca, Zamperini, Claudio, Botta, Bruno, Di Santo, Roberto, De Vita, Daniela, Brun, Reto, Tortorella, Silvano

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 256 KB

english, 2013

4

Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4

Albohy, Amgad, Zhang, Yi, Smutova, Victoria, Pshezhetsky, Alexey V., Cairo, Christopher W.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.61 MB

english, 2013

5

Development of Unsymmetrical Dyads As Potent Noncarbohydrate-Based Inhibitors against Human β- N -Acetyl- d -hexosaminidase

Guo, Peng, Chen, Qi, Liu, Tian, Xu, Lin, Yang, Qing, Qian, Xuhong

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.75 MB

english, 2013

6

Enzymatic Stability and Immunoregulatory Efficacy of a Synthetic Indolicidin Analogue with Regular Enantiomeric Sequence

Chang, Ching-Yun, Lin, Chih-Wei, Chiang, Sheng-Kuo, Chen, Po-Ling, Huang, Chiung-Yi, Liu, Shih-Jen, Chong, Pele, Huang, Ming-Hsi

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.25 MB

english, 2013

7

Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 217 KB

english, 2013

8

3-Hydroxyquinolin-2(1 H )-ones As Inhibitors of Influenza A Endonuclease

Sagong, Hye Yeon, Parhi, Ajit, Bauman, Joseph D., Patel, Disha, Vijayan, R. S. K., Das, Kalyan, Arnold, Eddy, LaVoie, Edmond J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.12 MB

english, 2013

9

New Peptide-Based Antimicrobials for Tackling Drug Resistance in Bacteria: Single-Cell Fluorescence Imaging

Pagès, Jean-Marie, Kascàkovà, Slavka, Maigre, Laure, Allam, Anas, Alimi, Mickael, Chevalier, Jacqueline, Galardon, Erwan, Réfrégiers, Matthieu, Artaud, Isabelle

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 643 KB

english, 2013

10

Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold

Mori, Mattia, Massaro, Assunta, Calderone, Vito, Fragai, Marco, Luchinat, Claudio, Mordini, Alessandro

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.45 MB

english, 2013

11

Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles

Wang, Yingcai, Liu, Jiwen (Jim), Dransfield, Paul J., Zhu, Liusheng, Wang, Zhongyu, Du, Xiaohui, Jiao, Xianyun, Su, Yongli, Li, An-rong, Brown, Sean P., Kasparian, Annie, Vimolratana, Marc, Yu, Ming,

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.21 MB

english, 2013

12

Discovery of a Potent, Dual Serotonin and Norepinephrine Reuptake Inhibitor

Dreyfus, Nicolas, Myers, Jason K., Badescu, Valentina O., de Frutos, Oscar, de la Puente, Maria Luz, Ding, Chunjin, Filla, Sandra A., Fynboe, Karsten, Gernert, Douglas L., Heinz, Beverly A., Hemrick-L

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 886 KB

english, 2013

13

Imidazopyrazine Derivatives As Inhibitors of mTOR

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 253 KB

english, 2013

14

SAR-Based Optimization of a 4-Quinoline Carboxylic Acid Analogue with Potent Antiviral Activity

Das, Priyabrata, Deng, Xiaoyi, Zhang, Liang, Roth, Michael G., Fontoura, Beatriz M. A., Phillips, Margaret A., De Brabander, Jef K.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 283 KB

english, 2013

15

Tricyclic Pyrimidines As Inhibitors of DYRK1A/DYRK1B As Potential Treatment for Down’s Syndrome or Alzheimer’s Disease

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 414 KB

english, 2013

16

Identification of New Nonsteroidal RORα Ligands; Related Structure–Activity Relationships and Docking Studies

Dubernet, Mathieu, Duguet, Nicolas, Colliandre, Lionel, Berini, Christophe, Helleboid, Stéphane, Bourotte, Marilyne, Daillet, Matthieu, Maingot, Lucie, Daix, Sébastien, Delhomel, Jean-François, Morin-

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.46 MB

english, 2013

17

Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase

Liu, Ping, Hamill, Terence G., Chioda, Marc, Chobanian, Harry, Fung, Selena, Guo, Yan, Chang, Linda, Bakshi, Raman, Hong, Qingmei, Dellureficio, James, Lin, Linus S., Abbadie, Catherine, Alexander, Je

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.16 MB

english, 2013

18

In This Issue, Volume 4, Issue 6

Silverman, Janice Elaine Y.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 792 KB

english, 2013

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