Volume 5; Issue 12

ACS Medicinal Chemistry Letters

Volume 5; Issue 12

1

Crystal Structure of Sphingosine Kinase 1 with PF-543

Wang, Jing, Knapp, Stefan, Pyne, Nigel J., Pyne, Susan, Elkins, Jonathan M.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 3.68 MB

english, 2014

2

Direct Arginine Modification in Native Peptides and Application to Chemical Probe Development

Grundler, Verena, Gademann, Karl

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.74 MB

english, 2014

3

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor

Buzard, Daniel J., Kim, Sun Hee, Lopez, Luis, Kawasaki, Andrew, Zhu, Xiuwen, Moody, Jeanne, Thoresen, Lars, Calderon, Imelda, Ullman, Brett, Han, Sangdon, Lehmann, Juerg, Gharbaoui, Tawfik, Sengupta,

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1010 KB

english, 2014

4

Exploration and Pharmacokinetic Profiling of Phenylalanine Based Carbamates as Novel Substance P 1–7 Analogues

Fransson, Rebecca, Nordvall, Gunnar, Bylund, Johan, Carlsson-Jonsson, Anna, Kratz, Jadel M., Svensson, Richard, Artursson, Per, Hallberg, Mathias, Sandström, Anja

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 621 KB

english, 2014

5

Biological and Structural Characterization of Rotamers of C–C Chemokine Receptor Type 5 (CCR5) Inhibitor GSK214096

Kazmierski, Wieslaw M., Danehower, Susan, Duan, Maosheng, Ferris, Robert G., Elitzin, Vassil, Minick, Douglas, Sharp, Matthew, Stewart, Eugene, Villeneuve, Manon

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 720 KB

english, 2014

6

Optimization of Drug-Like Properties of Nonsteroidal Glucocorticoid Mimetics and Identification of a Clinical Candidate

Harcken, Christian, Riether, Doris, Liu, Pingrong, Razavi, Hossein, Patel, Usha, Lee, Thomas, Bosanac, Todd, Ward, Yancey, Ralph, Mark, Chen, Zhidong, Souza, Donald, Nelson, Richard M., Kukulka, Aliso

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 474 KB

english, 2014

7

Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator

Stoyanovsky, Detcho A., Jiang, Jianfei, Murphy, Michael P., Epperly, Michael, Zhang, Xiaolan, Li, Song, Greenberger, Joel, Kagan, Valerian, Bayır, Hülya

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 910 KB

english, 2014

8

Synthesis and Characterization of a “Turn-On” photoCORM for Trackable CO Delivery to Biological Targets

Carrington, Samantha J., Chakraborty, Indranil, Bernard, Jenna M. L., Mascharak, Pradip K.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.30 MB

english, 2014

9

Correction to Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors

Subramanian, Sharadha, Costales, Abran, Williams, Teresa E., Levine, Barry, McBride, Christopher M., Poon, Daniel, Amiri, Payman, Renhowe, Paul A., Shafer, Cynthia M., Stuart, Darrin, Verhagen, Joelle

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

File:

PDF, 114 KB

2014

10

Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)

Fang, Chao, D’Souza, Brendan, Thompson, Christopher F., Clifton, Matthew C., Fairman, James W., Fulroth, Ben, Leed, Alison, McCarren, Patrick, Wang, Lili, Wang, Yikai, Feau, Clementine, Kaushik, Viren

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.41 MB

english, 2014

11

β- and γ-Amino Acids at α-Helical Interfaces: Toward the Formation of Highly Stable Foldameric Coiled Coils

Nyakatura, Elisabeth K., Mortier, Jérémie, Radtke, Vanessa S., Wieczorek, Sebastian, Rezaei Araghi, Raheleh, Baldauf, Carsten, Wolber, Gerhard, Koksch, Beate

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.19 MB

english, 2014

12

Maturing From Embryonic to Adult Policy on Stem Cell Therapeutics

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 303 KB

english, 2014

13

In This Issue, Volume 5, Issue 12

Silverman, Janice Elaine Y.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 426 KB

english, 2014

14

(7-Benzyloxy-2,3-dihydro- 1H -pyrrolo[1,2- a ]indol-1-yl)acetic Acids as S1P 1 Functional Antagonists

Buzard, Daniel J., Lopez, Luis, Moody, Jeanne, Kawasaki, Andrew, Schrader, Thomas O., Kasem, Michelle, Johnson, Ben, Zhu, Xiuwen, Thoresen, Lars, Kim, Sun Hee, Gharbaoui, Tawfik, Sengupta, Dipanjan, C

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 393 KB

english, 2014

15

GnRH Antagonists: The Promise of Treating Sex-Hormone-Related Diseases

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 312 KB

english, 2014

16

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

Flaherty, Daniel P., Miller, Justin R., Garshott, Danielle M., Hedrick, Michael, Gosalia, Palak, Li, Yujie, Milewski, Monika, Sugarman, Eliot, Vasile, Stefan, Salaniwal, Sumeet, Su, Ying, Smith, Layto

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 519 KB

english, 2014

17

Inhibition of O -GlcNAcase (OGA): A Potential Therapeutic Target to Treat Alzheimer’s Disease

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 240 KB

english, 2014

18

Electronic Notebooks in the Post-America Invents Act World

Palovich, Tracy U.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 137 KB

english, 2014

19

C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators

Du, Xiaohui, Hinklin, Ronald J., Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J., Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Venian

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 809 KB

english, 2014