Volume 5; Issue 8

ACS Medicinal Chemistry Letters

Volume 5; Issue 8

1

Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry

Pala, Nicolino, Micheletto, Laura, Sechi, Mario, Aggarwal, Mayank, Carta, Fabrizio, McKenna, Robert, Supuran, Claudiu T.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.24 MB

english, 2014

2

Discovery of Imigliptin, a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

Shu, Chutian, Ge, Hu, Song, Michael, Chen, Jyun-hong, Zhou, Huimin, Qi, Qu, Wang, Feng, Ma, Xifeng, Yang, Xiaolei, Zhang, Genyan, Ding, Yanwei, Zhou, Dapeng, Peng, Peng, Shih, Cheng-kon, Xu, Jun, Wu,

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 786 KB

english, 2014

3

Identification of Novel Phenyl Butenonyl C -Glycosides with Ureidyl and Sulfonamidyl Moieties as Antimalarial Agents

Ramakrishna, K. Kumar G., Gunjan, Sarika, Shukla, Akhilesh Kumar, Pasam, Venkata Reddy, Balaramnavar, Vishal M., Sharma, Abhisheak, Jaiswal, Swati, Lal, Jawahar, Tripathi, Renu, Anubhooti,, Ramachand

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.17 MB

english, 2014

4

Synthesis and Pharmacology of a Novel κ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton

Hirayama, Shigeto, Wada, Naohisa, Nemoto, Toru, Iwai, Takashi, Fujii, Hideaki, Nagase, Hiroshi

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.02 MB

english, 2014

5

Stabilized Helical Peptides: A Strategy to Target Protein–Protein Interactions

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 145 KB

english, 2014

6

Lead Optimization of Imidazopyrazines: A New Class of Antimalarial with Activity on Plasmodium Liver Stages

Zou, Bin, Nagle, Advait, Chatterjee, Arnab K., Leong, Seh Yong, Tan, Liying Jocelyn, Sim, Wei Lin Sandra, Mishra, Pranab, Guntapalli, Prasuna, Tully, David C., Lakshminarayana, Suresh B., Lim, Chek Sh

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 543 KB

english, 2014

7

RORγt Modulators Are Potentially Useful for the Treatment of the Immune-Mediated Inflammatory Diseases

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 272 KB

english, 2014

8

Quantification of the Effects of Ionic Strength, Viscosity, and Hydrophobicity on Protein–Ligand Binding Affinity

Papaneophytou, Christos P., Grigoroudis, Asterios I., McInnes, Campbell, Kontopidis, George

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.72 MB

english, 2014

9

An Uncharged Oxetanyl Sulfoxide as a Covalent Modifier for Improving Aqueous Solubility

Skoda, Erin M., Sacher, Joshua R., Kazancioglu, Mustafa Z., Saha, Jaideep, Wipf, Peter

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 495 KB

english, 2014

10

In This Issue, Volume 5, Issue 8

Silverman, Janice Elaine Y.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 310 KB

english, 2014

11

Alkylidene Oxapenem β-Lactamase Inhibitors Revisited: Potent Broad Spectrum Activity but New Stability Challenges

Miller, Matthew D., Kale, Manoj, Reddy, Kishore, Tentarelli, Sharon, Zambrowski, Mark, Zhang, Minli, Palmer, Tiffany, Breen, John, Lahiri, Sushmita, Shirude, Pravin S., Verheijen, Jeroen C.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 507 KB

english, 2014

12

Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol

Schunk, Stefan, Linz, Klaus, Hinze, Claudia, Frormann, Sven, Oberbörsch, Stefan, Sundermann, Bernd, Zemolka, Saskia, Englberger, Werner, Germann, Tieno, Christoph, Thomas, Kögel, Babette-Y., Schröder,

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.15 MB

english, 2014

13

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2–p53 Interaction

Yu, Ming, Wang, Yingcai, Zhu, Jiang, Bartberger, Michael D., Canon, Jude, Chen, Ada, Chow, David, Eksterowicz, John, Fox, Brian, Fu, Jiasheng, Gribble, Michael, Huang, Xin, Li, Zhihong, Liu, Jiwen (Ji

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.75 MB

english, 2014

14

Optimization of Rutaecarpine as ABCA1 Up-Regulator for Treating Atherosclerosis

Li, Yongzhen, Feng, Tingting, Liu, Peng, Liu, Chang, Wang, Xiao, Li, Dongsheng, Li, Ni, Chen, Minghua, Xu, Yanni, Si, Shuyi

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 823 KB

english, 2014

15

Identification and Synthesis of Quinolizidines with Anti-Influenza A Virus Activity

Dang, Zhao, Jung, Katherine, Zhu, Lei, Lai, Weihong, Xie, Hua, Lee, Kuo-Hsiung, Huang, Li, Chen, Chin-Ho

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.41 MB

english, 2014

16

Repurposing Cryptosporidium Inosine 5′-Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents

Mandapati, Kavitha, Gorla, Suresh Kumar, House, Amanda L., McKenney, Elizabeth S., Zhang, Minjia, Rao, Suraj Nagendra, Gollapalli, Deviprasad R., Mann, Barbara J., Goldberg, Joanna B., Cuny, Gregory D

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.11 MB

english, 2014

17

Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor

Kobayashi, Takaaki, Suemasa, Akihiro, Igawa, Arisa, Ide, Soichiro, Fukuda, Hayato, Abe, Hiroshi, Arisawa, Mitsuhiro, Minami, Masabumi, Shuto, Satoshi

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 748 KB

english, 2014

18

Fluorescent Probes for Subcellular Localization during Osteclast Formation

Wu, Jing, Shen, Qi, Wang, Yue, Zhao, Dan, Peng, Chen, Li, Jian-Xin

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.44 MB

english, 2014

19

Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties

Salvador, Lilibeth A., Park, Heekwang, Al-Awadhi, Fatma H., Liu, Yanxia, Kim, Bumki, Zeller, Sabrina L., Chen, Qi-Yin, Hong, Jiyong, Luesch, Hendrik

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.15 MB

english, 2014

20

Antiparasitic Compounds May Potentially Treat Malaria and Other Parasitic Diseases

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 288 KB

english, 2014

21

Factors Influencing in Vivo Disposition of Polymeric Micelles on Multiple Administrations

Hara, Eri, Ueda, Motoki, Makino, Akira, Hara, Isao, Ozeki, Eiichi, Kimura, Shunsaku

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.21 MB

english, 2014

22

Discovery of Spiro[cyclohexane-dihydropyrano[3,4- b ]indole]-amines as Potent NOP and Opioid Receptor Agonists

Schunk, Stefan, Linz, Klaus, Frormann, Sven, Hinze, Claudia, Oberbörsch, Stefan, Sundermann, Bernd, Zemolka, Saskia, Englberger, Werner, Germann, Tieno, Christoph, Thomas, Kögel, Babette-Y., Schröder,

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 981 KB

english, 2014

23

Discovery and Structure-Based Optimization of Adenain Inhibitors

Mac Sweeney, Aengus, Grosche, Philipp, Ellis, David, Combrink, Keith, Erbel, Paul, Hughes, Nicola, Sirockin, Finton, Melkko, Samu, Bernardi, Anna, Ramage, Paul, Jarousse, Nadine, Altmann, Eva

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.49 MB

english, 2014

24

MoGAT-2 Inhibitors May Provide Effective Treatment for Hypertriglyceridemia

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 235 KB

english, 2014

25

Total Synthesis and Biological Studies of TMC-205 and Analogues as Anticancer Agents and Activators of SV40 Promoter

Gao, Yang, Osman, Sami, Koide, Kazunori

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.92 MB

english, 2014

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