Volume 6; Issue 1

ACS Medicinal Chemistry Letters

Volume 6; Issue 1

1

Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase

Johnson, Christopher N., Adelinet, Christophe, Berdini, Valerio, Beke, Lijs, Bonnet, Pascal, Brehmer, Dirk, Calo, Frederick, Coyle, Joseph E., Day, Phillip J., Frederickson, Martyn, Freyne, Eddy J. E.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.99 MB

english, 2015

2

Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase

Johnson, Christopher N., Berdini, Valerio, Beke, Lijs, Bonnet, Pascal, Brehmer, Dirk, Coyle, Joseph E., Day, Phillip J., Frederickson, Martyn, Freyne, Eddy J. E., Gilissen, Ron A. H. J., Hamlett, Chri

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.31 MB

english, 2015

3

Discovery of N -[4-(1 H -Pyrazolo[3,4- b ]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors

Halland, Nis, Schmidt, Friedemann, Weiss, Tilo, Saas, Joachim, Li, Ziyu, Czech, Jörg, Dreyer, Matthias, Hofmeister, Armin, Mertsch, Katharina, Dietz, Uwe, Strübing, Carsten, Nazare, Marc

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.15 MB

english, 2015

4

Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine

Warthaka, Mangalika, Adelmann, Charles H., Kaoud, Tamer S., Edupuganti, Ramakrishna, Yan, Chunli, Johnson, William H., Ferguson, Scarlett, Tavares, Clint D., Pence, Lindy J., Anslyn, Eric V., Ren, Pen

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015

5

RET Kinase Inhibitors May Treat Cancer and Gastrointestinal Disorders

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 248 KB

english, 2015

6

Quinalozinones as Inhibitors of Class I PI3K Kinases

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 317 KB

english, 2015

7

Class II but Not Second Class—Prospects for the Development of Class II PI3K Inhibitors

Mountford, Simon J., Zheng, Zhaohua, Sundaram, Krithika, Jennings, Ian G., Hamilton, Justin R., Thompson, Philip E.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.35 MB

english, 2015

8

Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors

Barsanti, Paul A, Pan, Yue, Lu, Yipin, Jain, Rama, Cox, Matthew, Aversa, Robert J., Dillon, Michael P., Elling, Robert, Hu, Cheng, Jin, Xianming, Knapp, Mark, Lan, Jiong, Ramurthy, Savithri, Rudewicz,

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 451 KB

english, 2015

9

Combination of Novel Imidazopyridazine Mps-1 Kinase Inhibitors and Bcl-2 Family Protein Inhibitors

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 258 KB

english, 2015

10

Synthesis and Biological Evaluation of Pyrazolo[1,5- a ]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors

Xu, Yong, Brenning, Benjamin G., Kultgen, Steven G., Foulks, Jason M., Clifford, Adrianne, Lai, Shuping, Chan, Ashley, Merx, Shannon, McCullar, Michael V., Kanner, Steven B., Ho, Koc-Kan

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 467 KB

english, 2015

11

P21-Activated Kinase 4 (PAK4) Inhibitors as Potential Cancer Therapy

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 255 KB

english, 2015

12

Dual Leucine Zipper Kinase Inhibitors: Potential Treatments for Neurodegenerative Diseases

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 249 KB

english, 2015

13

Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5- a ]pyrazines as ATR Inhibitors

Barsanti, Paul A, Aversa, Robert J., Jin, Xianming, Pan, Yue, Lu, Yipin, Elling, Robert, Jain, Rama, Knapp, Mark, Lan, Jiong, Lin, Xiaodong, Rudewicz, Patrick, Sim, Janet, Taricani, Lorena, Thomas, Ge

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 466 KB

english, 2015

14

Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability

Harrington, Paul E., Biswas, Kaustav, Malwitz, David, Tasker, Andrew S., Mohr, Christopher, Andrews, Kristin L., Dellamaggiore, Ken, Kendall, Richard, Beckmann, Holger, Jaeckel, Peter, Materna-Reichel

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.65 MB

english, 2015

15

Novel Azaindazole Sulfonamides Inhibitors of Serum and Glucocorticoid Regulated Kinase

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 272 KB

english, 2015

16

Novel Disubstituted Pyrimidines as Inhibitors of Bruton’s Tyrosine Kinase

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 227 KB

english, 2015

17

Synthesis and Structure–Activity Relationship Study of 5a-Carbasugar Analogues of SL0101

Li, Mingzong, Li, Yu, Mrozowski, Roman M., Sandusky, Zachary M., Shan, Mingde, Song, Xiwen, Wu, Bulan, Zhang, Qi, Lannigan, Deborah A., O’Doherty, George A.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.79 MB

english, 2015

18

Pyrrolopyridines-quinazolines Inhibitors of PKR-Like ER Kinase

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 253 KB

english, 2015

19

Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation

Goodwin, Nicole C., Cianchetta, Giovanni, Burgoon, Hugh A., Healy, Jason, Mabon, Ross, Strobel, Eric D., Allen, Jason, Wang, Shuli, Hamman, Brian D., Rawlins, David B.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.47 MB

english, 2015

20

Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed by Biochemical Characterization

Okamoto, Kiyoshi, Ikemori-Kawada, Megumi, Jestel, Anja, von König, Konstanze, Funahashi, Yasuhiro, Matsushima, Tomohiro, Tsuruoka, Akihiko, Inoue, Atsushi, Matsui, Junji

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.96 MB

english, 2015

21

In This Issue, Volume 6, Issue 1

Silverman, Janice Elaine Y.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 644 KB

english, 2015

22

Pyrrolopyrimidine Analogues as MKNK Inhibitors

Brazeau, Jean-Francois, Rosse, Gerard

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 228 KB

english, 2015

23

Pyrimidine-Based Tricyclic Molecules as Potent and Orally Efficacious Inhibitors of Wee1 Kinase

Tong, Yunsong, Torrent, Maricel, Florjancic, Alan S., Bromberg, Kenneth D., Buchanan, Fritz G., Ferguson, Debra C., Johnson, Eric F., Lasko, Loren M., Maag, David, Merta, Philip J., Olson, Amanda M.,

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.07 MB

english, 2015

24

New Frontiers in Kinases: Second Generation Inhibitors–Going beyond Cancer

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 124 KB

english, 2015

25

Structural Analysis of the Binding of Type I, I 1/2 , and II Inhibitors to Eph Tyrosine Kinases

Dong, Jing, Zhao, Hongtao, Zhou, Ting, Spiliotopoulos, Dimitrios, Rajendran, Chitra, Li, Xiao-Dan, Huang, Danzhi, Caflisch, Amedeo

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.33 MB

english, 2015

26

Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma

Harrison, Bryce A., Almstead, Zheng Y., Burgoon, Hugh, Gardyan, Michael, Goodwin, Nicole C., Healy, Jason, Liu, Ying, Mabon, Ross, Marinelli, Brett, Samala, Lakshman, Zhang, Yulian, Stouch, Terry R.,

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 986 KB

english, 2015

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Tor version

Z-Library

Z-Library Since 2009 support@z-lib.do

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски