Volume 32; Issue 1

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Nature Genetics
Volume 32; Issue 1

Nature Genetics

Volume 32; Issue 1

1

Erratum: Digenic inheritance of severe insulin resistance in a human pedigree

Journal:

Nature Genetics

Year:

2002

File:

PDF, 29 KB

2002

2

Growing pains

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 56 KB

english, 2002

3

Paths to the pancreas

Bort, Roque, Zaret, Ken

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 65 KB

english, 2002

4

ATM heterozygosity and cancer risk

Concannon, Patrick

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 266 KB

english, 2002

5

Immortalizing the immortal

Cooke, Howard J.

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 107 KB

english, 2002

6

TOUCHINGbase

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 179 KB

english, 2002

7

A window into the past

Relethford, John H.

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 187 KB

english, 2002

8

Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae

Ottenhoff, Tom H.M., Verreck, Frank A.W., Lichtenauer-Kaligis, Elgin G.R., Hoeve, Marieke A., Sanal, Ozden, van Dissel, Jaap T.

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 207 KB

english, 2002

9

Acknowledgments

Journal:

Nature Genetics

Year:

2002

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english

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PDF, 39 KB

english, 2002

10

Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation

Lee, Jeannie T.

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 1016 KB

english, 2002

11

Distinct in vivo requirements for establishment versus maintenance of transcriptional repression

Wheeler, John C., VanderZwan, Christine, Xu, Xiaoti, Swantek, Deborah, Tracey, W. Daniel, Gergen, J. Peter

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 323 KB

english, 2002

12

Stopping transcription in its tracks

Jennings, Barbara

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 66 KB

english, 2002

13

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

Lewis, David L., Hagstrom, James E., Loomis, Aaron G., Wolff, Jon A., Herweijer, Hans

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 310 KB

english, 2002

14

Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication

Kitami, Toshimori, Nadeau, Joseph H.

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 129 KB

english, 2002

15

Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts

Hess, Patricia, Pihan, German, Sawyers, Charles L., Flavell, Richard A., Davis, Roger J.

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 1.26 MB

english, 2002

16

Human genome sequence variation and the influence of gene history, mutation and recombination

Reich, David E., Schaffner, Stephen F., Daly, Mark J., McVean, Gil, Mullikin, James C., Higgins, John M., Richter, Daniel J., Lander, Eric S., Altshuler, David

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 224 KB

english, 2002

17

Mutant deoxynucleotide carrier is associated with congenital microcephaly

Rosenberg, Marjorie J., Agarwala, Richa, Bouffard, Gerard, Davis, Joie, Fiermonte, Giuseppe, Hilliard, Mark S., Koch, Thorsten, Kalikin, Linda M., Makalowska, Izabela, Morton, D. Holmes

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 116 KB

english, 2002

18

New genes involved in cancer identified by retroviral tagging

Suzuki, Takeshi, Shen, Haifa, Akagi, Keiko, Morse, Herbert C, Malley, James D, Naiman, Daniel Q, Jenkins, Nancy A, Copeland, Neal G

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 299 KB

english, 2002

19

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer

Mikkers, Harald, Allen, John, Knipscheer, Puck, Romeyn, Lieke, Hart, Augustinus, Vink, Edwin, Berns, Anton

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 477 KB

english, 2002

20

The transcriptional program of meiosis and sporulation in fission yeast

Mata, Juan, Lyne, Rachel, Burns, Gavin, Bähler, Jürg

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 561 KB

english, 2002

21

Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret

Batourina, Ekatherina, Choi, Christopher, Paragas, Neal, Bello, Natalie, Hensle, Terry, Costantini, Frank D., Schuchardt, Anita, Bacallao, Robert L., Mendelsohn, Cathy L.

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 1007 KB

english, 2002

22

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair

Hartman, Anne-Renee, Ford, James M.

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 533 KB

english, 2002

23

Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice

Hoogenraad, Casper C., Koekkoek, Bas, Akhmanova, Anna, Krugers, Harm, Dortland, Bjorn, Miedema, Marja, van Alphen, Arjan, Kistler, Werner M., Jaegle, Martine, Koutsourakis, Manoussos

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 1.60 MB

english, 2002

24

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

Wechsler, Joshua, Greene, Marianne, McDevitt, Michael A., Anastasi, John, Karp, Judith E., Le Beau, Michelle M., Crispino, John D.

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 434 KB

english, 2002

25

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer

Spring, Kevin, Ahangari, Farida, Scott, Shaun P., Waring, Paul, Purdie, David M., Chen, Philip C., Hourigan, Kevin, Ramsay, Jonathan, McKinnon, Peter J., Swift, Michael

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 580 KB

english, 2002

26

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

Kawaguchi, Yoshiya, Cooper, Bonnie, Gannon, Maureen, Ray, Michael, MacDonald, Raymond J., Wright, Christopher V.E.

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 804 KB

english, 2002

27

A leukemogenic twist for GATA1

Look, A. Thomas

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 277 KB

english, 2002

28

Spreading the word

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 47 KB

english, 2002

29

Power to the people

Baxevanis, Andreas D., Collins, Francis S.

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 28 KB

english, 2002

30

Genomic empowerment: the importance of public databases

Journal:

Nature Genetics

Year:

2002

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english

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PDF, 32 KB

english, 2002

31

A user's guide to the human genome

Wolfsberg, Tyra G., Wetterstrand, Kris A., Guyer, Mark S., Collins, Francis S., Baxevanis, Andreas D.

Journal:

Nature Genetics

Year:

2002

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english

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PDF, 33 KB

english, 2002

32

Introduction: putting it together

Journal:

Nature Genetics

Year:

2002

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english

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PDF, 56 KB

english, 2002

33

Question 1 How does one find a gene of interest and determine that gene's structure? Once the gene has been located on the map, how does one easily examine other genes in that same region?

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 2.25 MB

english, 2002

34

Question 2 How can sequence-tagged sites within a DNA sequence be identified?

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 1.76 MB

english, 2002

35

Question 3 During a positional cloning project aimed at finding a human disease gene, linkage data have been obtained suggesting that the gene of interest lies between two sequence-tagged site markers. How can all the known and predicted candidate genes in this interval be identified? What BAC clones cover that particular region?

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 1.91 MB

english, 2002

36

Question 4 A user wishes to find all the single nucleotide polymorphisms that lie between two sequence-tagged sites. Do any of these single nucleotide polymorphisms fall within the coding region of a gene? Where can any additional information about the function of these genes be found?

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 754 KB

english, 2002

37

Question 5 Given a fragment of mRNA sequence, how would one find where that piece of DNA mapped in the human genome? Once its position has been determined, how would one find alternatively spliced transcripts?

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 2.02 MB

english, 2002

38

Question 7 How would an investigator easily find compiled information describing the structure of a gene of interest? Is it possible to obtain the sequence of any putative promoter regions?

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 832 KB

english, 2002

39

Question 8 How can one find all the members of a human gene family?

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 1002 KB

english, 2002

40

Question 9 Are there ways to customize displays and designate preferences? Can tracks or features be added to displays by users on the basis of their own research?

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 852 KB

english, 2002

41

Question 10 For a given protein, how can one determine whether it contains any functional domains of interest? What other proteins contain the same functional domains as this protein? How can one determine whether there is a similarity to other proteins, not only at the sequence level, but also at the structural level?

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 1.26 MB

english, 2002

42

Question 11 An investigator has identified and cloned a human gene, but no corresponding mouse ortholog has yet been identified. How can a mouse genomic sequence with similarity to the human gene sequence be retrieved?

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 949 KB

english, 2002

43

Question 12 How does a user find characterized mouse mutants corresponding to human genes?

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 1.05 MB

english, 2002

44

Question 13 A user has identified an interesting phenotype in a mouse model and has been able to narrow down the critical region for the responsible gene to approximately 0.5 cM. How does one find the mouse genes in this region?

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 1.01 MB

english, 2002

45

Commentary: keeping biology in mind

Journal:

Nature Genetics

Year:

2002

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english

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PDF, 48 KB

english, 2002

46

Web resources: Internet resources featured in this guide

Journal:

Nature Genetics

Year:

2002

Language:

english

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PDF, 44 KB

english, 2002

47

Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice

Lund, Anders H., Turner, Geoffrey, Trubetskoy, Alla, Verhoeven, Els, Wientjens, Ellen, Hulsman, Danielle, Russell, Robert, DePinho, Ronald A., Lenz, Jack, van Lohuizen, Maarten

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 406 KB

english, 2002

48

Question 6 How would one retrieve the sequence of a gene, along with all annotated exons and introns, as well as a certain number of flanking bases for use in primer design?

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 983 KB

english, 2002