Volume 12; Issue 3

Organic Process Research & Development

Volume 12; Issue 3

1

Large-Scale Synthesis of the Glucosylceramide Synthase Inhibitor N-[5-(Adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin

Wennekes, Tom, Lang, Bernhard, Leeman, Michel, Marel, Gijsbert A. van der, Smits, Elly, Weber, Matthias, Wiltenburg, Jim van, Wolberg, Michael, Aerts, Johannes M.F.G., Overkleeft, Herman S.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 181 KB

english, 2008

2

Practical Asymmetric Synthesis of Trifluoromethyl-Containing Aminoester Using a Modified Davis Protocol

Alimardanov, Asaf, Schmid, Jean, Afragola, Jay, Khafizova, Gulnaz

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 113 KB

english, 2008

3

A Facile Total Synthesis of Imatinib Base and Its Analogues

Liu, Yi-Feng, Wang, Cui-Ling, Bai, Ya-Jun, Han, Ning, Jiao, Jun-Ping, Qi, Xiao-Li

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 170 KB

english, 2008

4

Optimization and Scale-up of a Pd-Catalyzed Aromatic C−N Bond Formation: A Key Step in the Synthesis of a Novel 5-HT1B Receptor Antagonist

Federsel, Hans-Jürgen, Hedberg, Martin, Tian, Wei

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 263 KB

english, 2008

5

Development of a Chemoenzymatic Manufacturing Process for Pregabalin

Martinez, Carlos A., Hu, Shanghui, Dumond, Yves, Tao, Junhua, Kelleher, Patrick, Tully, Liam

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 330 KB

english, 2008

6

Route Scouting and Process Development of Lu AA26778

Dahl, Allan C., Mealy, Michael J., Nielsen, Martin A., Lyngsø, Lars O., Suteu, Cristina

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 299 KB

english, 2008

7

Streamlined Synthesis of the Bippyphos Family of Ligands and Cross-Coupling Applications

Withbroe, Gregory J., Singer, Robert A., Sieser, Janice E.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 236 KB

english, 2008

8

UnyLinker: An Efficient and Scaleable Synthesis of Oligonucleotides Utilizing a Universal Linker Molecule: A Novel Approach To Enhance the Purity of Drugs

Ravikumar, Vasulinga T., Kumar, R. Krishna, Olsen, Phil, Moore, Max N., Carty, Recaldo L., Andrade, Mark, Gorman, Dennis, Zhu, Xuefeng, Cedillo, Isaiah, Wang, Zhiwei, Mendez, Lucio, Scozzari, Anthony

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 415 KB

english, 2008

9

Development of a Mild and Robust Method for Large-Scale Palladium-Catalysed Cyanation of Aryl Bromides: Importance of the Order of Addition

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 77 KB

english, 2008

10

Development of One-Pot Synthesis of New Antiarthritic Drug Candidate S-2474 with High E -Selectivity

Oda, Katsuo, Hida, Takemasa, Sakata, Teruo, Nagai, Masahiko, Sugata, Yoshihide, Masui, Toshiaki, Nogusa, Hideo

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 394 KB

english, 2008

11

Modeling the Chemical Conversion of Organic Compounds in Sodium Borohydride Reduction Reactions

Tinnacher, Ruth M., Honeyman, Bruce D.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 271 KB

english, 2008

12

Modeling-Based Approach towards On-Scale Implementation of a Methanethiol-Emitting Reaction

Remy, Brenda, Brueggemeier, Shawn, Marchut, Alex, Lyngberg, Olav, Lin, Dong, Hobson, Lindsay

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 444 KB

english, 2008

13

Transition Metal-Catalyzed Carbon−Carbon Bond Formation Suzuki, Heck, and Sonogashira Reactions Using Microwave and Microtechnology

Singh, Brajendra K., Kaval, Nadya, Tomar, Shilpi, Eycken, Erik Van der, Parmar, Virinder S.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 1.29 MB

english, 2008

14

Ligandless Heck Coupling between a Halogenated Aniline and Acrylonitrile Catalyzed by Pd/C: Development and Optimization of an Industrial-Scale Heck Process for the Production of a Pharmaceutical Intermediate

Schils, Didier, Stappers, Fred, Solberghe, Geoffrey, van Heck, Richard, Coppens, Michelle, Van den Heuvel, Dirk, Van der Donck, Peter, Callewaert, Tom, Meeussen, Frank, Bie, Erika De, Eersels, Kristof

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 708 KB

english, 2008

15

A Practical and Improved Copper-Catalyzed Synthesis of the Central Intermediate of Diafenthiuron and Related Products

Schareina, Thomas, Zapf, Alexander, Cotté, Alain, Müller, Nikolaus, Beller, Matthias

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 81 KB

english, 2008

16

SPECIAL FEATURE SECTION: Transition-Metal-Mediated C-C and C-N Bond Formation

Lennon, Ian C., Bhatia, Ashok V.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 30 KB

english, 2008

17

Efficient Large-Scale Synthesis of 9-Alkylfluorenyl Phosphines for Pd-Catalyzed Cross-Coupling Reactions

Fleckenstein, Christoph A., Kadyrov, Renat, Plenio, Herbert

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 116 KB

english, 2008

18

Commercialization and Late-Stage Development of a Semisynthetic Antifungal API: Anidulafungin/ d -Fructose (Eraxis)

Norris, Timothy, VanAlsten, John, Hubbs, Stephen, Ewing, Marcus, Cai, Weiling, Jorgensen, Matthew L., Bordner, Jon, Jensen, Grace O.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 1.26 MB

english, 2008

19

Pharmaceutical Substances, Syntheses, Patents, Applications. By A. Kleeman, J. Engel, B. Kutscher and D. Reichert. Online version 3.0. Price on application.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 42 KB

english, 2008

20

Development of an Enantioselective, Kilogram-Scale, Rhodium-Catalysed 1,4-Addition

Brock, Sally, Hose, David R. J., Moseley, Jonathan D., Parker, Alexandra J., Patel, Ian, Williams, Andrew J.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 486 KB

english, 2008

21

Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials. Edited by R. A. Potyrailo and W. F. Maier. CRC Press, Taylor and Francis Group: Boca Raton, FL, U.S.A. 2007 . £115 (hard back). 467 pp. ISBN 978-0-8493-3669-0 .

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 42 KB

english, 2008

22

Regioselective Addition of Mesitol to a 2,4-Dichloropyridine

Ruggeri, Sally Gut, Vanderplas, Brian C., Anderson, Bruce G., Breitenbach, Ralph, Urban, Frank J., Stewart, III, A. Morgan, Young, Gregory R.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 81 KB

english, 2008

23

Microwaves in Organic Synthesis, Volumes 1 and 2. Edited by André Loupy. Wiley-VCH, Verlag GmbH and Co. KGaA: Weinheim. 2006. $375. Vol 1, 517 pp, Vol 2, 466 pp. Hard back. ISBN 978-3-527-31452-2 .

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 42 KB

english, 2008

24

A Concise Synthesis of Racemic 1-(6,7-Dimethoxy-2-naphthyl)-1-(1 H -imidazol-4-yl)-2-methylpropan-1-ol for a Potent C 17 , 20 -Lyase Inhibitor

Kawakami, Jun-ichi, Kimura, Kazuhiro, Yamaoka, Masayoshi

Journal:

Organic Process Research & Development

Year:

2008

File:

PDF, 27 KB

2008

25

In Praise of Heterocyclic Chemistry and Academic Research

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 43 KB

english, 2008

26

Some Items of Interest to Process R&D Chemists and Engineers

McLaughlin, Mark, García, Silvina, Pfeiffer, Matthew, Tilstam, Ulf, Mathen, Joseph Swaroop, Antunes, Octavio Augusto Ceva, Laird, Trevor

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 299 KB

english, 2008

27

Using Potassium Carbonate to Scavenge Hydrogen Fluoride: A Scale-Up Process for Quantitative Production of (1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinolinecarboxylato-κO3)difluoro−Boron

Li, Xun, Russell, Ronald K.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 89 KB

english, 2008

28

A Review of U.S. Patents in the Field of Organic Process Development Published During December 2007 and January 2008

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 291 KB

english, 2008

29

Cu-Catalyzed Formation of Triazole-Linked Glycoamino Acids and Application in Chemoenzymatic Peptide Synthesis

Kuijpers, Brian H. M., Groothuys, Stan, Hawner, Christine, Dam, Jeroen ten, Quaedflieg, Peter J. L. M., Schoemaker, Hans E., Delft, Floris L. van, Rutjes, Floris P. J. T.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 378 KB

english, 2008

30

A Highly Practical and General Route for α-Arylations of Ketones Using Bis-phosphinoferrocene-Based Palladium Catalysts

Grasa, Gabriela A., Colacot, Thomas J.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 413 KB

english, 2008

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