Volume 13; Issue 1

Organic Process Research & Development

Volume 13; Issue 1

1

Identification and Suppression of a Dimer Impurity in the Development of Delafloxacin

Hanselmann, Roger, Johnson, Graham, Reeve, Maxwell M., Huang, Shu-Ting

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 439 KB

english, 2009

2

Response to Dancer’s Comments on Our Article “Substrate Modification Approach to Achieve Efficient Resolution: Didesmethylcitalopram: A Key Intermediate for Escitalopram” [ Org. Process Res. Dev. 2007 , 11 , 289−292]

Elati, Chandrashekar R., Kolla, Naveenkumar, Mathad, Vijayavitthal T.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 89 KB

english, 2009

3

Use of a Fiber-Optic Turbidity Probe to Monitor and Control Commercial-Scale Unseeded Batch Crystallizations

Harner, Richard S., Ressler, Roberta J., Briggs, Roger L., Hitt, James E., Larsen, Paul A., Frank, Timothy C.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 481 KB

english, 2009

4

N,N ′-Carbonyldiimidazole-Mediated Amide Coupling: Significant Rate Enhancement Achieved by Acid Catalysis with Imidazole·HCl

Woodman, Emily K., Chaffey, Julian G. K., Hopes, Philip A., Hose, David R. J., Gilday, John P.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 387 KB

english, 2009

5

An Improved Process for the Synthesis and Isolation of ( S )- N -(1-Phenylethyl)hydroxylamine

Patel, Ian, Smith, Neil A., Tyler, Simon N. G.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 132 KB

english, 2009

6

A Review of U.S. Patents in the Field of Organic Process Development Published During August and September 2008

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 303 KB

english, 2009

7

First Scale-Up Synthesis of WAY-262398, a Novel, Dual-Acting SSRI/5HT1a Antagonist

Nikitenko, Antonia, Alimardanov, Asaf, Afragola, Jay, Schmid, Jean, Kristofova, Livia, Evrard, Deborah, Hatzenbuhler, Nicole T., Marathias, Vasilios, Stack, Gary, Lenicek, Steve, Potoski, John

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 172 KB

english, 2009

8

An Improved and Scalable Process for Celecoxib: A Selective Cyclooxygenase-2 Inhibitor §

Reddy, Anumula Raghupathi, Sampath, Alla, Goverdhan, Gilla, Yakambaram, Bojja, Mukkanti, Kagga, Reddy, Padi Pratap

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 81 KB

english, 2009

9

Attempted Resolution of Citalopram Using (−)- O , O′ -Di- p -toluoyl-( R , R )-tartaric Acid, and Reflections on an Alkylation Reaction; Comment on an Article by Elati et al.

Dancer, Robert James, Lopez de Diego, Heidi

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 1.54 MB

english, 2009

10

Response to the Comments by Elati et al. in Response to Our Article Examining One of Their Previous Articles

Dancer, Robert James, Lopez De Diego, Heidi

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 79 KB

english, 2009

11

Optimization of Solvent Chasing in API Manufacturing Process: Constant Volume Distillation

Li, Yao-En, Yang, Yubo, Kalthod, Vikram, Tyler, Stephen M.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 244 KB

english, 2009

12

The Suzuki−Miyaura Reaction under Mechanochemical Conditions §

Schneider, Franziska, Stolle, Achim, Ondruschka, Bernd, Hopf, Henning

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 124 KB

english, 2009

13

Crystallisation Design Space: Avoiding a Hydrate in a Water-Based Process

Black, Simon N., Phillips, Andrew, Scott, Claire I.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 2.10 MB

english, 2009

14

New Efficient Asymmetric Synthesis of Taranabant, a CB1R Inverse Agonist for the Treatment of Obesity

Wallace, Debra J., Campos, Kevin R., Shultz, C. Scott, Klapars, Artis, Zewge, Daniel, Crump, Brian R., Phenix, Brian D., McWilliams, J. Christopher, Krska, Shane, Sun, Yongkui, Chen, Cheng-yi, Spindle

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 150 KB

english, 2009

15

Pilot-Plant Preparation of an α v β 3 Integrin Antagonist: Process Development of a Carbonyldiimidazole Peptide Coupling

Weisenburger, Gerald A., Anderson, D. Keith, Clark, Jerry D., Edney, Albert D., Karbin, Puneh S., Gallagher, Donald J., Knable, Carl M., Pietz, Mark A.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 97 KB

english, 2009

16

An Improved and Scalable Process for Zafirlukast: An Asthma Drug †

Goverdhan, Gilla, Reddy, Anumula Raghupathi, Sampath, Aalla, Srinivas, Kurella, Himabindu, Vurimidi, Reddy, Ghanta Mahesh

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 210 KB

english, 2009

17

Some Items of Interest to Process R&D Chemists and Engineers

McLaughlin, Mark, García, Silvina, Pfeiffer, Matthew, Tilstam, Ulf, Antunes, Octavio Augusto Ceva, Zlota, Andrei A., Laird, Trevor

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 261 KB

english, 2009

18

Scientific Disputes and How OPRD Handles Them

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 32 KB

english, 2009

19

Goals in Pharmaceutical Management

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 43 KB

english, 2009

20

High Conversion, Solvent Free, Continuous Synthesis of Imidazolium Ionic Liquids In Spinning Tube-in-Tube Reactors

Gonzalez, Michael A., Ciszewski, James T.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 241 KB

english, 2009

21

Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 3. Development of an Acid-Catalyzed Racemization Process for ( S )-2,8-(Dimethoxy)-5-{4-[2-(1-piperidinyl)ethoxy]phenyl}−11,12-dihydro- 5H -6,13-dioxabenzo[3,4]cyclohepta[1,2- a ]naphthalene

Li, Xun, Russell, Ronald K., Horváth, András, Jain, Nareshkumar, Depré, Dominique, Ormerod, Dominic, Aelterman, Wim, Sui, Zhihua

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 126 KB

english, 2009

22

Book Review of Clean-In-Place for Biopharmaceutical Processes Clean-In-Place for Biopharmaceutical Processes. Edited by Dale A. Seiberling. Informa Healthcare: New York. 2008. 391 pp. $229.95, £115.00 (Hardcover). ISBN: 10:0-8493-4069-1

Robinson, Derek

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 31 KB

english, 2009

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