Volume 13; Issue 2

Organic Process Research & Development

Volume 13; Issue 2

1

A Practical Method for Functionalized Peptide or Amide Bond Formation in Aqueous−Ethanol Media with EDC as Activator†

Pu, Yangwei John, Vaid, Radhe K., Boini, Sathish K., Towsley, Robert W., Doecke, Christopher W., Mitchell, David

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 113 KB

english, 2009

2

Heavy-Metal-Free Reduction Methodology for Large-Scale Synthesis Applicable to Heterocyclic and Arylhydrazines†

Norris, Timothy, Bezze, Chiara, Franz, Samuela Zambelli, Stivanello, Mariano

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 80 KB

english, 2009

3

Preparation, Use, and Safety of O-Mesitylenesulfonylhydroxylamine

Mendiola, Javier, Rincón, Juan A., Mateos, Carlos, Soriano, José Francisco, de Frutos, Óscar, Niemeier, Jeffry K., Davis, Edward M.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 1.60 MB

english, 2009

4

Crystallization Process Development for a Stable Polymorph of Treprostinil Diethanolamine (UT-15C) by Seeding

Batra, Hitesh, Penmasta, Raju, Phares, Kenneth, Staszewski, James, Tuladhar, Sudersan M., Walsh, David A.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 2.49 MB

english, 2009

5

Optimization of Organolithium Reactions

Rathman, Terry ‘Li’, Bailey, William F.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 198 KB

english, 2009

6

Practical Synthesis of Chiral 2-Morpholine: (4-Benzylmorpholin-2-( S )-yl)-(tetrahydropyran-4-yl)methanone Mesylate, a Useful Pharmaceutical Intermediate

Kopach, Michael E., Singh, Utpal K., Kobierski, Michael E., Trankle, William G., Murray, Michael M., Pietz, Mark A., Forst, Mindy B., Stephenson, Gregory A., Mancuso, Vincent, Giard, Thierry, Vanmarse

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 417 KB

english, 2009

7

Synthesis of 2-Methyl-2,5-diazabicyclo[2.2.1]heptane, Side Chain to Danofloxacin(1)

Braish, Tamim F.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 166 KB

english, 2009

8

Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB 1 Antagonist for the Treatment of Obesity

Ragan, John A., Bourassa, Dennis E., Blunt, Jon, Breen, Darragh, Busch, Frank R., Cordi, Eric M., Damon, David B., Do, Nga, Engtrakul, Alanya, Lynch, Denis, McDermott, Ruth E., Mongillo, Joseph A., O’

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 1007 KB

english, 2009

9

Improved Synthesis of 1-(Azidomethyl)-3,5-bis-(trifluoromethyl)benzene: Development of Batch and Microflow Azide Processes

Kopach, Michael E., Murray, Michael M., Braden, Timothy M., Kobierski, Michael E., Williams, Otis L.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 280 KB

english, 2009

10

Process Development and Scale-Up of a PPARγ Agonist: Selection of the Manufacture Route

Bullock, Kae M., Burton, Delphilia, Corona, John, Diederich, Ann, Glover, Bobby, Harvey, Kim, Mitchell, Mark B., Trone, Mark D., Yule, Robert, Zhang, Yong, Toczko, Jennifer F.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 152 KB

english, 2009

11

Enzymatic Resolution of N -Substituted-β-prolines

Mendiola, Javier, García-Cerrada, Susana, de Frutos, Óscar, de la Puente, María Luz, Gu, Rui Lin, Khau, Vien V.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 114 KB

english, 2009

12

Large-Scale Preparation of (+)- p -Menth-2-ene-1,8-diol, a Key Intermediate in the Synthesis of Δ-9-Tetrahydrocannabinol

Cabaj, John E., Lukesh, Julie M., Pariza, Richard J., Zizelman, Paul M.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 135 KB

english, 2009

13

Impact of Entropic Effects in the Classical Resolution of a 2-Arylpyrrolidine †

Barnes, David M., Barkalow, Jufang, Chen, Yong, Gupta, Ashok, Haight, Anthony R., Hengeveld, John E., Kerdesky, Francis A. J., Kotecki, Brian J., Macri, Bryan, Pal, Agnes

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 214 KB

english, 2009

14

Development of a Practical Synthesis of a p38 MAP Kinase Inhibitor

Thiel, Oliver R., Achmatowicz, Michal, Bernard, Charles, Wheeler, Philip, Savarin, Cecile, Correll, Tiffany L., Kasparian, Annie, Allgeier, Alan, Bartberger, Michael D., Tan, Helming, Larsen, Robert D

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 1.19 MB

english, 2009

15

Process Development for Sodelglitazar: A PPAR Panagonist

Brown, Andrew D., Davis, Roman D., Fitzgerald, Russ N., Glover, Bobby N., Harvey, Kim A., Jones, Lynda A., Liu, Bing, Patterson, Daniel E., Sharp, Matthew J.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 131 KB

english, 2009

16

Syntheses of a Selective Peroxisome Proliferator Activated Receptor Modulator and Practical New Preparations of 2-(4-Alkoxyphenyl)ethylamines †

Magnus, Nicholas A., Astleford, Bret A., Brennan, John, Stout, James R., Tharp-Taylor, Roger W.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 120 KB

english, 2009

17

Approaches to Assessment, Testing Decisions, and Analytical Determination of Genotoxic Impurities in Drug Substances

Pierson, Duane A., Olsen, Bernard A., Robbins, David K., DeVries, Keith M., Varie, David L.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 124 KB

english, 2009

18

Microwave-Irradiated Synthesis of Nitrophen Using PEG 400 as Phase Transfer Catalyst and Solvent

Yadav, Ganapati D., Motirale, Bhavana G.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 164 KB

english, 2009

19

Book Review of Good Manufacturing Practices for Pharmaceuticals Good Manufacturing Practices for Pharmaceuticals (Drugs and the Pharmaceutical Sciences, 6th ed., Vol. 169). Edited by Joseph D. Nally. Informa Healthcare: New York. 2007. 398 pp. $249.95, £125.00 (Hardcover). ISBN 978-0-8493-3972-1 .

Robinson, Derek

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 36 KB

english, 2009

20

An Efficient Synthesis of a Multipotent Eicosanoid Pathway Modulator †

Yates, Matthew H., Koenig, Thomas M., Kallman, Neil J., Ley, Christopher P., Mitchell, David

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 869 KB

english, 2009

21

Global Green Chemistry Metrics Analysis Algorithm and Spreadsheets: Evaluation of the Material Efficiency Performances of Synthesis Plans for Oseltamivir Phosphate (Tamiflu) as a Test Case

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 3.18 MB

english, 2009

22

Development of a Practical Synthesis of an Aminoindanol-Derived M1 Agonist †

Hansen, Marvin M., Borders, Sandra S. K., Clayton, Marcella T., Heath, Perry C., Kolis, Stanley P., Larsen, Samuel D., Linder, Ryan J., Reutzel-Edens, Susan M., Smith, Justin C., Tameze, Shella L., Wa

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 380 KB

english, 2009

23

Development of an Efficient Palladium-Catalyzed Intramolecular Carbometalation Reaction for the Synthesis of a Dibenzoxapine Containing Tetra-substituted Exocyclic Alkene †

Richey, Rachel N., Yu, Hannah

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 130 KB

english, 2009

24

Second-Generation Process for the HCV Protease Inhibitor BILN 2061: A Greener Approach to Ru-Catalyzed Ring-Closing Metathesis †

Farina, Vittorio, Shu, Chutian, Zeng, Xingzhong, Wei, Xudong, Han, Zhengxu, Yee, Nathan K., Senanayake, Chris H.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 350 KB

english, 2009

25

Development of an Acyl Sulfonamide Anti-Proliferative Agent, LY573636·Na †

Yates, Matthew H., Kallman, Neil J., Ley, Christopher P., Wei, Jeffrey N.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

26

A Practical Palladium-Catalyzed Telomerization for the Synthesis of Functionalized Alcohols

Jackstell, Ralf, Grotevendt, Anne, Andreu, Mario Gomez, Beller, Matthias

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 239 KB

english, 2009

27

The Newman−Kwart Rearrangement Revisited: Continuous Process under Supercritical Conditions †

Tilstam, Ulf, Defrance, Thierry, Giard, Thierry, Johnson, Martin D.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 279 KB

english, 2009

28

Special Issue Dedicated to Chris Schmid, Former Associate Editor of Organic Process Research and Development , Who Died in 2007

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 46 KB

english, 2009

29

Identifying Scale Sensitivity for API Crystallizations from Desupersaturation Measurements

Singh, Utpal K., Pietz, Mark A., Kopach, Michael E.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 668 KB

english, 2009

30

A Scalable Synthesis of the INOS Inhibitor PHA-399733 †

Wuts, Peter G. M., Ashford, Scott W., Conway, Brian, Havens, Jeffrey L., Taylor, Bill, Hritzko, Ben, Xiang, Yanqiao, Zakarias, Peter S.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 122 KB

english, 2009

31

Christopher Randall Schmid 1959−2007

Hansen, Marvin M.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 107 KB

english, 2009

32

Preparation of a Corticotropin-Releasing Factor Antagonist by Nucleophilic Aromatic Substitution and Copper-Mediated Ether Formation †

Caron, Stéphane, Do, Nga M., Sieser, Janice E., Whritenour, David C., Hill, Paul D.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 167 KB

english, 2009

33

The Role of New Technologies in Defining a Manufacturing Process for PPARα Agonist LY518674 †

Argentine, Mark D., Braden, Timothy M., Czarnik, Jeffrey, Conder, Edward W., Dunlap, Steven E., Fennell, Jared W., LaPack, Mark A., Rothhaar, Roger R., Scherer, R. Brian, Schmid, Christopher R., Vicen

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 748 KB

english, 2009

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